Project overview

This is a project to examine sex specific metabolite difference in lung cancer using published cell line data from Molecular Cell paper: Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells by Chen et al.  In part 1, we examine correlation among metabolites data and between metabolite with drug IC50. In part 2, we identify genes showing differential expression (DE) between drug (to be selected) sensitive and resistant lines.

Part I: Metabolite and Drug IC50

Read in TableS1 to prepare the relative abundance data

We start by reading in the downloaded TableS1 from the reference paper on metabolite data involving.

6 Metabolites: Cit (Citrate) Ser (Serine) Gly (Glycine) Lac (Lactate) Mal (Malate) Fum (Fumarate)

2 nutrients G=glucose and Q=glutamine

2 time points: 6 hr and 24 hr

G6 = glucose labeling performed at 6 hours G24 = glucose labeling performed at 24 hours Q6 = glutamine labeling performed at 6 hours Q24 = glutamine labeling performed at 24 hours

M0=unlabeled at all carbon positions. M1=labeled at 1 position M2=labeled at 2 positions M3=labeled at 3 positions M4=labeled at 4 positions M5=labeled at 5 positions M6=labeled at 6 positions

Therefore, M0=fractional unlabeled metabolite. The sum of M1.Mn=fractional total labeled metabolite. The values for each of these species for a given metabolite add up to 100%. The metabolites level indicate how much a cell line is utilizing the feeded nutrient (glucose or glutamine).

TableS1 = read_excel("C:/Users/jingqinluo/Box/Sex Differences in Lung Cancer/TableS1_metabolic data.xlsx",sheet=1)
dim(TableS1) #87 cells and 99 columns (1st columns is Cell line ID)
## [1]  87 113
names(TableS1)[1] = "CellID" ##Cell line ID

##following Joe Ippolito's step of arranging the data##
TableS1 = TableS1 %>% dplyr::select(!(Glc:last_col()))#Got rid of the extraneous columns at the end, like Glc, Lac, Gln, Glu, Glu/Gln, and columns with Day in them. 
TableS1 = TableS1 %>% arrange(CellID) ##arrange by Cell ID 
TableS1[1:5,]
## # A tibble: 5 x 99
##   CellID  CitG6m0 CitG6m1 CitG6m2 CitG6m3 CitG6m4 CitG6m5 CitG6m6 CitG24m0
##   <chr>     <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>   <dbl>    <dbl>
## 1 A549       25.7    2.92    35.0    8.12   14.8    10.3    3.12     19.5 
## 2 Calu-1     27.2    2.52    54.4    1.99    6.59    5.19   2.10     18.3 
## 3 Calu-3     34.0    4.96    38.0    5.14   10.6     6.33   0.917    18.8 
## 4 Calu-6     14.9    2.59    42.3    5.22   16.5    12.7    5.84      6.39
## 5 DFCI024    13.1    2.28    50.8    3.70   16.7     9.86   3.60      5.91
## # ... with 90 more variables: CitG24m1 <dbl>, CitG24m2 <dbl>, CitG24m3 <dbl>,
## #   CitG24m4 <dbl>, CitG24m5 <dbl>, CitG24m6 <dbl>, CitQ6m0 <dbl>,
## #   CitQ6m1 <dbl>, CitQ6m2 <dbl>, CitQ6m3 <dbl>, CitQ6m4 <dbl>, CitQ6m5 <dbl>,
## #   CitQ6m6 <dbl>, CitQ24m0 <dbl>, CitQ24m1 <dbl>, CitQ24m2 <dbl>,
## #   CitQ24m3 <dbl>, CitQ24m4 <dbl>, CitQ24m5 <dbl>, CitQ24m6 <dbl>,
## #   FumG6m0 <dbl>, FumG6m1 <dbl>, FumG6m2 <dbl>, FumG6m3 <dbl>, FumG6m4 <dbl>,
## #   FumG24m0 <dbl>, FumG24m1 <dbl>, FumG24m2 <dbl>, FumG24m3 <dbl>,
## #   FumG24m4 <dbl>, FumQ6m0 <dbl>, FumQ6m1 <dbl>, FumQ6m2 <dbl>, FumQ6m3 <dbl>,
## #   FumQ6m4 <dbl>, FumQ24m0 <dbl>, FumQ24m1 <dbl>, FumQ24m2 <dbl>,
## #   FumQ24m3 <dbl>, FumQ24m4 <dbl>, MalG6m0 <dbl>, MalG6m1 <dbl>,
## #   MalG6m2 <dbl>, MalG6m3 <dbl>, MalG6m4 <dbl>, MalG24m0 <dbl>,
## #   MalG24m1 <dbl>, MalG24m2 <dbl>, MalG24m3 <dbl>, MalG24m4 <dbl>,
## #   MalQ6m0 <dbl>, MalQ6m1 <dbl>, MalQ6m2 <dbl>, MalQ6m3 <dbl>, MalQ6m4 <dbl>,
## #   MalQ24m0 <dbl>, MalQ24m1 <dbl>, MalQ24m2 <dbl>, MalQ24m3 <dbl>,
## #   MalQ24m4 <dbl>, LacG6m0 <dbl>, LacG6m1 <dbl>, LacG6m2 <dbl>, LacG6m3 <dbl>,
## #   LacG24m0 <dbl>, LacG24m1 <dbl>, LacG24m2 <dbl>, LacG24m3 <dbl>,
## #   LacQ6m0 <dbl>, LacQ6m1 <dbl>, LacQ6m2 <dbl>, LacQ6m3 <dbl>, LacQ24m0 <dbl>,
## #   LacQ24m1 <dbl>, LacQ24m2 <dbl>, LacQ24m3 <dbl>, SerG6m0 <dbl>,
## #   SerG6m1 <dbl>, SerG6m2 <dbl>, SerG6m3 <dbl>, SerG24m0 <dbl>,
## #   SerG24m1 <dbl>, SerG24m2 <dbl>, SerG24m3 <dbl>, GlyG6m0 <dbl>,
## #   GlyG6m1 <dbl>, GlyG6m2 <dbl>, GlyG24m0 <dbl>, GlyG24m1 <dbl>,
## #   GlyG24m2 <dbl>
TableS1_m0 = TableS1 %>% dplyr::select(ends_with("m0"))
TableS1_new = 100-TableS1_m0 ##1-m0 to get the sum of m_1:m_k
names(TableS1_new) = gsub("m0", "", names(TableS1_new))
TableS1_new = data.frame(CellID= TableS1$CellID, TableS1_new,check.names=F)
TableS1_new = TableS1_new %>% arrange(CellID) ##arrange in sorting cell number
TableS1_new[1:5,]
##    CellID  CitG6 CitG24  CitQ6 CitQ24  FumG6 FumG24  FumQ6 FumQ24  MalG6 MalG24
## 1    A549 74.290 80.467 59.287 56.433 47.943 58.867 57.090 54.043 48.227 57.540
## 2  Calu-1 72.807 81.747 68.990 75.660 25.993 31.723 66.717 71.513 23.107 30.777
## 3  Calu-3 65.950 81.233 75.877 73.407 35.837 57.937 66.520 63.840 33.837 57.847
## 4  Calu-6 85.063 93.613 79.320 72.383 33.773 69.290 77.477 70.793 35.560 70.683
## 5 DFCI024 86.923 94.087 76.160 77.190 33.707 49.973 65.747 64.153 33.683 49.760
##    MalQ6 MalQ24  LacG6 LacG24  LacQ6 LacQ24  SerG6 SerG24  GlyG6 GlyG24
## 1 57.030 52.870 90.330 92.013 11.607 12.797 26.890 53.153  9.227 34.037
## 2 67.013 72.163 88.713 92.703 16.387 13.310  4.487 12.210  4.563  7.775
## 3 65.803 62.730 90.043 91.597  6.090 12.623 23.185 20.617 12.023 19.775
## 4 76.360 69.543 90.457 92.260  8.813  8.540 36.620 67.130 28.273 41.850
## 5 68.590 65.810 84.453 93.500 12.910  7.010 10.353  8.793 12.440 15.200
write.csv(TableS1_new,file="metaboliteData_clean.csv",row.names=F)

Read in TableS4

Table S4 contains drugs’ IC50 information (note: already in log scale) for cell lines and cell info such as gender, rae, subtype. So we arrange TableS4 in the same order as in TableS1 and we extract cell info.

TableS4 = read_excel("C:/Users/jingqinluo/Box/Sex Differences in Lung Cancer/TableS4_Drug Tox and Protein Levels.xlsx",sheet=1)
names(TableS4)
##  [1] "Sort"                          "Cell Line"                    
##  [3] "RRID (Cellosaurus)"            "Tumor Type"                   
##  [5] "Tumor Subtype"                 "Age"                          
##  [7] "Race"                          "Gender"                       
##  [9] "Source"                        "ATCC ID"                      
## [11] "Illumina Microarray"           "RNAseq"                       
## [13] "RPPA"                          "450K Methylation"             
## [15] "Whole-exome Sequencing"        "8-Cl-adenosine (uM)"          
## [17] "AZD6244 (MEK) (uM)"            "Carboplatin (uM)"             
## [19] "Cisplatin (uM)"                "Crizotinib (ALK) (uM)"        
## [21] "Docetaxel (nM)"                "Doxorubicin (nM)"             
## [23] "Erlotinib (EGFR) (uM)"         "Etoposide (uM)"               
## [25] "Gefitinib (EGFR) (uM)"         "Gemcitabine (nM)"             
## [27] "Gemcitabine/Cisplatin (nM)"    "MK-2206 (AKT) (uM)"           
## [29] "Paclitaxel (nM)"               "Paclitaxel/Carboplatin (nM)"  
## [31] "Pemetrexed (uM)"               "Pemetrexed/Cisplatin (uM)"    
## [33] "SCH772984 (ERK) (uM)"          "Sorafenib (multi-kinase) (uM)"
## [35] "Vinorelbine (nM)"              "EGFR-pY1173"                  
## [37] "E-cadherin"                    "Beta-catenin"                 
## [39] "CDH1"
#head(TableS4)
#tail(TableS4)
#dim(TableS4)##89 39, last rows are NAs
TableS4 = TableS4[1:87,]
TableS4 = TableS4 %>% reshape::rename(c("Cell Line"="CellID")) %>% arrange (CellID)
all.equal(TableS1$CellID, TableS4$CellID)#TableS1 and TableS4 are now in the same order
## [1] TRUE
all.equal(TableS1_new$CellID, TableS4$CellID)#TableS1 and TableS4 are now in the same order
## [1] TRUE
##one cell line is missing sex info and Joe checked it is Male, add to data: HCC2302 = MALE
TableS4$Gender[which(TableS4$CellID=="HCC2302")]
## [1] NA
TableS4$Gender[which(TableS4$CellID=="HCC2302")] = "M"
#str(TableS4)
TableS4$CDH1 = as.numeric(TableS4$CDH1) 
TableS4$"EGFR-pY1173" = as.numeric(TableS4$"EGFR-pY1173")
TableS4$"8-Cl-adenosine (uM)"  = as.numeric(TableS4$"8-Cl-adenosine (uM)")


###step 2.1 extract the cell line info data
cellInfo = TableS4 %>% dplyr::select(CellID, "Tumor Subtype", Age, Race, Gender)

cellInfo
## # A tibble: 87 x 5
##    CellID  `Tumor Subtype`      Age   Race      Gender
##    <chr>   <chr>                <chr> <chr>     <chr> 
##  1 A549    Adenocarcinoma       58    Caucasian M     
##  2 Calu-1  Epidermoid carcinoma 47    Caucasian M     
##  3 Calu-3  Adenocarcinoma       25    Caucasian M     
##  4 Calu-6  Adenocarcinoma       61    Caucasian F     
##  5 DFCI024 Adenocarcinoma       <NA>  <NA>      F     
##  6 DFCI032 Adenocarcinoma       <NA>  <NA>      F     
##  7 H1155   Large Cell           36    Caucasian M     
##  8 H1299   Large Cell           43    Caucasian M     
##  9 H1355   Adenocarcinoma       53    Caucasian M     
## 10 H1373   Adenocarcinoma       56    Black     M     
## # ... with 77 more rows
cellInfo %>% dplyr::count(Gender)#30 female and 56 male, 1 NA
## # A tibble: 2 x 2
##   Gender     n
##   <chr>  <int>
## 1 F         30
## 2 M         57
TableS1_new = dplyr::bind_cols(cellInfo,dplyr::select(TableS1_new,!CellID))##add cell line info with TableS1

Pairwise correlation among metabolites overall and by sex

We now calculate the nonparametric Spearman correlation matrix, as well as accompnaying p values on the correlation matrix, among all, male, and female cell lines and save to files.

We visualize the correlation matrix in circle where color indicates cor, metabolites are ordered by hierarchical clustering, significance is indicated by "*".

#pdf("CorrPlot.pdf",height=15,width=15)
par(mfrow=c(1,1))
#type = "upper" if only want upper triangle, can circle the main clusters "addrect=5"
corrplot(Cor_all, tl.col="black",tl.cex=2.5, cl.cex=2, method="circle",order="hclust")#, p.mat = CorP_all$p, insig = "label_sig", pch="*", sig.leel=0.05)#can order by "FPC" first principal component
title("Correlation among all cell lines",cex.main=3,font.main=2)

corrplot(Cor_male, tl.col="black",tl.cex=2.5, cl.cex=2,method="circle",order="hclust")#, p.mat = CorP_male$p, insig = "p-value", sig.level = -1)
title("Correlation among male lines",cex.main=3,font.main=2)

corrplot(Cor_female, tl.col="black",tl.cex=2.5, cl.cex=2,method="circle",order="hclust")#, p.mat = CorP_female$p, insig = "p-value", sig.level = -1)
title("Correlation among female cell lines",cex.main=3,font.main=2)

#dev.off()

The correlation plots are now in colors only with the non-significant correlations’ color blank out.

#pdf("CorrPlot_inColr_insignificantBlankOut.pdf",height=15,width=15)
par(mfrow=c(1,1))
#type = "upper" if only want upper triangle, can circle the main clusters "addrect=5"
corrplot(Cor_all, tl.col="black",tl.cex=2.5, cl.cex=2,method="color",order="hclust", p.mat = CorP_all$p, insig = "blank", sig.level = 0.05,diag=FALSE)#can order by "FPC" first principal component
title("Correlation among all cell lines",cex.main=3,font.main=2)

corrplot(Cor_male,tl.col="black",tl.cex=2.5, cl.cex=2, method="color",order="hclust", p.mat = CorP_male$p, insig = "blank", sig.level = 0.05,diag=FALSE)#can order by "FPC" first principal component
title("Correlation among male cell lines",cex.main=3,font.main=2)

corrplot(Cor_female,tl.col="black",tl.cex=2.5, cl.cex=2, method="color",order="hclust", p.mat = CorP_female$p, insig = "blank", sig.level = 0.05,diag=FALSE)#can order by "FPC" first principal component
title("Correlation among female cell lines",cex.main=3,font.main=2)

#dev.off()

The following gives the pairwise scatterplot with fitted linear lines, besides correlation in all and by sex

pm <- ggpairs(TableS1_new, columns = c(6:ncol(TableS1_new)), ggplot2::aes(colour=Gender), lower=list(continuous=line_fn), upper = list(continuous = wrap('cor', method = "spearman")))
print(pm)

#ggsave("PairsPlot_spearman.pdf",height=30, width=30)

Sex-differential abundance analyses using multiple method

Sex-differential abundance analyses using conventional t-test

To compare to Joe’s results, we run conventional 2-sided two sample t test to compare the metabolite abundance by sex.

ttest.p=apply(dplyr::select(TableS1_new,!(CellID:Gender)),2,function(xx) t.test(xx~TableS1_new$Gender)$p.value)
ttest.p= data.frame(metabolite=names(ttest.p), ttest.p,FDR.p=p.adjust(ttest.p,method="fdr"))
ttest.p = ttest.p %>% arrange(ttest.p)
ttest.p
##        metabolite      ttest.p       FDR.p
## SerG6       SerG6 6.327993e-05 0.001265599
## GlyG24     GlyG24 2.642736e-03 0.023388969
## SerG24     SerG24 3.508345e-03 0.023388969
## GlyG6       GlyG6 7.800372e-03 0.039001859
## LacQ6       LacQ6 1.433492e-01 0.435187064
## LacQ24     LacQ24 1.550213e-01 0.435187064
## LacG24     LacG24 1.719488e-01 0.435187064
## CitG6       CitG6 1.740748e-01 0.435187064
## MalQ24     MalQ24 3.713748e-01 0.802069389
## CitG24     CitG24 4.010347e-01 0.802069389
## FumG6       FumG6 4.779447e-01 0.826797939
## LacG6       LacG6 4.960788e-01 0.826797939
## MalG6       MalG6 6.049756e-01 0.930731667
## CitQ6       CitQ6 7.874913e-01 0.951325842
## FumQ24     FumQ24 8.238751e-01 0.951325842
## MalQ6       MalQ6 8.486538e-01 0.951325842
## CitQ24     CitQ24 8.749424e-01 0.951325842
## MalG24     MalG24 9.028659e-01 0.951325842
## FumQ6       FumQ6 9.037595e-01 0.951325842
## FumG24     FumG24 9.669013e-01 0.966901336
write.csv(ttest.p, file= "conventional2sampleTtest_Pvalue.csv",row.names=F)

Sex-differential abundance analyses using conventional Wilcoxon rank sum test

Nonparametric Wilcoxon rank sum test are also run.

wilcox.p=apply(dplyr::select(TableS1_new,!(CellID:Gender)),2,function(xx) wilcox.test(xx~TableS1_new$Gender)$p.value)
wilcox.p= data.frame(metabolite=names(wilcox.p), wilcox.p,FDR.p=p.adjust(wilcox.p,method="fdr"))
wilcox.p = wilcox.p %>% arrange(wilcox.p)
wilcox.p
##        metabolite    wilcox.p      FDR.p
## SerG6       SerG6 0.000790398 0.01580796
## GlyG6       GlyG6 0.003867628 0.02594636
## GlyG24     GlyG24 0.003891954 0.02594636
## SerG24     SerG24 0.012379290 0.06189645
## LacQ6       LacQ6 0.174377493 0.60252749
## CitG6       CitG6 0.180758246 0.60252749
## LacQ24     LacQ24 0.233952833 0.66843667
## MalQ24     MalQ24 0.403435994 0.98109424
## LacG6       LacG6 0.534733117 0.98109424
## CitG24     CitG24 0.534784923 0.98109424
## CitQ6       CitQ6 0.614026902 0.98109424
## FumQ24     FumQ24 0.657460507 0.98109424
## CitQ24     CitQ24 0.748924422 0.98109424
## FumG6       FumG6 0.761589604 0.98109424
## LacG24     LacG24 0.779432353 0.98109424
## MalG6       MalG6 0.892326926 0.98109424
## MalG24     MalG24 0.892326926 0.98109424
## FumQ6       FumQ6 0.907105709 0.98109424
## FumG24     FumG24 0.966492000 0.98109424
## MalQ6       MalQ6 0.981094241 0.98109424
write.csv(wilcox.p, file= "conventionalWilcoxTest_Pvalue.csv",row.names=F)

Sex-differential abundance analyses using LIMMA moderated T-test

LIMMA adopts robust moderated t-test in an empirical bayes linear model framework and is very popular for microarray and RNA-seq high dimensional data.
The LIMMA DE results output the mean by sex, the average expression (“AeExpr”), the difference in mean (“logFC”), the moderated t statistic (“t”), moderated t test p value (“P.Value”) and FDR P value (“adj.P.val”) and B-statistic (lods) which is the log-odds that that gene is differentially expressed. Suppose for example that B=1.5. The odds of differential expression is exp(1.5)=4.48, i.e, about four and a half to one. The probability that the gene is differentially expressed is 4.48/(1+4.48)=0.82, i.e., the probability is about 82% that this gene is differentially expressed. A B-statistic of zero corresponds to a 50-50 chance that the gene is differentially expressed. The B-statistic is automatically adjusted for multiple testing, as described by the authors of LIMMA.

sampleInfo=data.frame(cellInfo,row.names=cellInfo$CellID)
gene=t(as.matrix(dplyr::select(TableS1_new,!(CellID:Gender)))); colnames(gene)=TableS1_new$CellID

sampleInfo[1:5,1:5]
##          CellID        Tumor.Subtype  Age      Race Gender
## A549       A549       Adenocarcinoma   58 Caucasian      M
## Calu-1   Calu-1 Epidermoid carcinoma   47 Caucasian      M
## Calu-3   Calu-3       Adenocarcinoma   25 Caucasian      M
## Calu-6   Calu-6       Adenocarcinoma   61 Caucasian      F
## DFCI024 DFCI024       Adenocarcinoma <NA>      <NA>      F
gene[1:5,1:5]
##          A549 Calu-1 Calu-3 Calu-6 DFCI024
## CitG6  74.290 72.807 65.950 85.063  86.923
## CitG24 80.467 81.747 81.233 93.613  94.087
## CitQ6  59.287 68.990 75.877 79.320  76.160
## CitQ24 56.433 75.660 73.407 72.383  77.190
## FumG6  47.943 25.993 35.837 33.773  33.707
##remove the 1 cell line with gender missing
gene = gene [,which(!is.na(sampleInfo$Gender))]
sampleInfo = sampleInfo %>% filter( !is.na(sampleInfo$Gender)) 

limma.res = RunLIMMA(sample.info=sampleInfo,grpID="Gender", gene=gene,protein.annot=NULL,proteinID="metabolite", geneLabelID="metabolite", save=TRUE,saveplot=FALSE,file_prefix = "BySex")
##         GenderF GenderM
## A549          0       1
## Calu-1        0       1
## Calu-3        0       1
## Calu-6        1       0
## DFCI024       1       0
## DFCI032       1       0
## H1155         0       1
## H1299         0       1
## H1355         0       1
## H1373         0       1
## H1395         1       0
## H1437         0       1
## H1568         1       0
## H157          0       1
## H1581         0       1
## H1648         0       1
## H1650         0       1
## H1693         1       0
## H1703         0       1
## H1755         1       0
## H1781         1       0
## H1792         0       1
## H1819         1       0
## H1869         0       1
## H1915         1       0
## H1944         1       0
## H1975         1       0
## H1993         1       0
## H2009         1       0
## H2023         0       1
## H2030         0       1
## H2073         1       0
## H2085         0       1
## H2087         0       1
## H2122         1       0
## H2126         0       1
## H2170         0       1
## H2172         1       0
## H2228         1       0
## H2250         0       1
## H2258         0       1
## H2291         0       1
## H23           0       1
## H2347         1       0
## H2405         0       1
## H2444         0       1
## H2882         1       0
## H2887         0       1
## H322          0       1
## H358          0       1
## H441          0       1
## H460          0       1
## H522          0       1
## H596          0       1
## H647          0       1
## H650          0       1
## H661          0       1
## H810          0       1
## H820          0       1
## H838          0       1
## H920          0       1
## HCC1171       0       1
## HCC1195       0       1
## HCC15         0       1
## HCC1588       1       0
## HCC1833       1       0
## HCC1897       0       1
## HCC193        1       0
## HCC2108       0       1
## HCC2279       1       0
## HCC2302       0       1
## HCC2450       0       1
## HCC2814       0       1
## HCC2935       0       1
## HCC366        1       0
## HCC4006       0       1
## HCC4011       0       1
## HCC4017       1       0
## HCC4018       1       0
## HCC4019       0       1
## HCC44         1       0
## HCC461        0       1
## HCC515        1       0
## HCC78         0       1
## HCC827        1       0
## HCC95         0       1
## PC-9          0       1
## attr(,"assign")
## [1] 1 1
## attr(,"contrasts")
## attr(,"contrasts")$Gender
## [1] "contr.treatment"

#print table in nice html format
kbl(limma.res$DE.res) %>%
  kable_paper(full_width = F) %>%
  scroll_box(width = "1000px", height = "500px")
metabolite Mean_F Mean_M logFC AveExpr t P.Value adj.P.Val B
SerG6 SerG6 11.789600 22.781851 10.9922511 18.965097 3.7283206 0.0003789 0.0075785 -0.2207127
GlyG24 GlyG24 13.316517 21.620571 8.3040542 18.533167 2.8764196 0.0051741 0.0414865 -2.1897145
SerG24 SerG24 22.867750 36.169184 13.3014337 31.332299 2.8124530 0.0062230 0.0414865 -2.3323565
GlyG6 GlyG6 9.451414 14.294979 4.8435649 12.446776 2.6909865 0.0087415 0.0437074 -2.5885327
LacQ6 LacQ6 11.125733 9.798963 -1.3267704 10.272809 -1.5995285 0.1134285 0.3828997 -4.4631138
LacG24 LacG24 91.592767 92.753130 1.1603630 92.338714 1.5930758 0.1148699 0.3828997 -4.4716797
LacQ24 LacQ24 10.210900 9.134111 -1.0767889 9.518679 -1.4591345 0.1482283 0.4235095 -4.6421503
CitG6 CitG6 73.678655 70.024793 -3.6538627 71.317012 -1.3425995 0.1830769 0.4576923 -4.7702059
MalQ24 MalQ24 64.192567 61.745519 -2.4470481 62.619464 -0.9169588 0.3617688 0.7637047 -5.1854478
LacG6 LacG6 88.326800 89.214426 0.8876259 88.897417 0.8030709 0.4241825 0.7637047 -5.2688858
CitG24 CitG24 86.091276 84.489226 -1.6020494 85.055805 -0.8029927 0.4242817 0.7637047 -5.2579924
FumG6 FumG6 36.226533 34.406741 -1.8197926 35.056667 -0.7451863 0.4582228 0.7637047 -5.3071323
MalG6 MalG6 33.057867 31.696630 -1.3612370 32.182786 -0.5387526 0.5914713 0.9099559 -5.4205162
CitQ6 CitQ6 68.709828 68.042245 -0.6675823 68.278341 -0.2802010 0.7800233 0.9479646 -5.4994342
FumQ24 FumQ24 63.535500 62.941667 -0.5938333 63.153750 -0.2426730 0.8088457 0.9479646 -5.5198235
MalQ6 MalQ6 67.485533 66.947000 -0.5385333 67.141651 -0.2037028 0.8390804 0.9479646 -5.5244639
CitQ24 CitQ24 66.667517 66.269868 -0.3976493 66.410500 -0.1663410 0.8682948 0.9479646 -5.5212050
FumQ6 FumQ6 65.956967 65.616167 -0.3408000 65.737881 -0.1282347 0.8982674 0.9479646 -5.5380763
MalG24 MalG24 52.065667 52.449037 0.3833704 52.312119 0.1253212 0.9005664 0.9479646 -5.5383941
FumG24 FumG24 53.152733 53.266518 0.1137852 53.225881 0.0430669 0.9657496 0.9657496 -5.5443525

The vocalno plots -log Pvalue versus log2 fold change from the LIMMA DE results show the top metaboites.

volcanoplot(limma.res$bayes.res,coef=1,highlight=8,names=rownames(limma.res$bayes.res$coef),cex=0.5,main="M vs F")

From the above two sample t-test, wilcoxon test, LIMMA analyses, all identifed the 4 significant metabolites at FDR p<0.05:SerG6, GlyG24, SerG24, GlyG6

The box plots of the 4 metabolites are presented as below.

#

#{r, fig.align="center", fig.cap=c("Boxplots of LIMMA significant metabolites"), echo=FALSE} #knitr::include_graphics("limmaSignificantMetabolite_boxplot.pdf") #

We list the cell lines by increasing SerG6 by Sex below

TableS1_new %>% dplyr::select(CellID,Gender, SerG6) %>% arrange(Gender,SerG6) %>% kbl() %>%
  kable_paper(full_width = F) %>%
  scroll_box(width = "1000px", height = "500px")
CellID Gender SerG6
H2347 F -1.013
H2882 F 2.393
HCC44 F 2.957
HCC193 F 3.507
H1395 F 4.747
HCC515 F 5.297
H2073 F 6.760
H2228 F 7.055
H1755 F 7.543
H1993 F 8.610
H1975 F 9.430
DFCI032 F 9.698
HCC1833 F 9.857
DFCI024 F 10.353
H2009 F 12.150
H1944 F 12.260
HCC366 F 13.963
HCC1588 F 15.185
HCC827 F 15.957
H1693 F 18.043
H1915 F 18.913
H2172 F 19.745
H1568 F 19.887
H2122 F 24.823
Calu-6 F 36.620
H1781 F NA
H1819 F NA
HCC2279 F NA
HCC4017 F NA
HCC4018 F NA
HCC461 M 2.915
H650 M 3.627
Calu-1 M 4.487
HCC1171 M 5.813
H661 M 6.063
HCC2302 M 6.590
HCC1897 M 6.770
H2126 M 7.877
H2030 M 8.590
H157 M 8.645
H2291 M 9.090
HCC2450 M 10.223
H1650 M 10.470
HCC1195 M 10.855
H1355 M 13.117
H838 M 14.560
H322 M 15.383
H1792 M 15.770
H1373 M 17.437
H1581 M 17.770
H358 M 18.850
H647 M 19.343
H2258 M 20.665
HCC2935 M 20.867
H1869 M 21.117
HCC4006 M 21.283
Calu-3 M 23.185
A549 M 26.890
H2087 M 27.160
H2023 M 27.330
H1437 M 29.360
HCC4011 M 29.615
H1648 M 32.085
H810 M 32.430
H1703 M 34.700
H2405 M 34.757
HCC2814 M 34.830
HCC95 M 35.767
HCC15 M 37.500
H1299 M 37.873
H920 M 38.227
H460 M 39.145
H2170 M 42.166
PC-9 M 42.320
H522 M 45.880
H1155 M 47.933
H596 M 53.417
H2085 M NA
H2250 M NA
H23 M NA
H2444 M NA
H2887 M NA
H441 M NA
H820 M NA
HCC2108 M NA
HCC4019 M NA
HCC78 M NA

We calculate mean and SD of SerinG6 for the selected cell lines (3 high Serine/3 low Serine)

TableS1_new %>% dplyr::select(CellID,Gender, SerG6) %>% filter(CellID%in%c("H522","PC-9","H2170"))  %>% summarise(mean=mean(SerG6,na.rm=T),sd=sd(SerG6, na.rm=T)) #-> male_hi
## # A tibble: 1 x 2
##    mean    sd
##   <dbl> <dbl>
## 1  43.5  2.10
TableS1_new %>% dplyr::select(CellID,Gender, SerG6) %>% filter(CellID%in%c("Calu-1","H661","H650"))   %>% summarise(mean=mean(SerG6,na.rm=T),sd=sd(SerG6, na.rm=T))## -> male_lo
## # A tibble: 1 x 2
##    mean    sd
##   <dbl> <dbl>
## 1  4.73  1.24
TableS1_new %>% dplyr::select(CellID,Gender, SerG6) %>% filter(CellID%in%c("Calu-6","H2122","H1568")) %>%  summarise(mean=mean(SerG6,na.rm=T),sd=sd(SerG6, na.rm=T))#-> female_hi
## # A tibble: 1 x 2
##    mean    sd
##   <dbl> <dbl>
## 1  27.1  8.60
TableS1_new %>% dplyr::select(CellID,Gender, SerG6) %>% filter(CellID%in%c("H1975","H2347","H1395")) %>% summarise(mean=mean(SerG6,na.rm=T),sd=sd(SerG6, na.rm=T)) #-> female_low
## # A tibble: 1 x 2
##    mean    sd
##   <dbl> <dbl>
## 1  4.39  5.23

sex-stratified Spearman Cor analyses between drug toxicity (IC50) and metabolites

Corr between total abundance with IC50

We calculate the correlation matrix among metabolite total abundance and IC50 of drugs among all, male, and female.

combine_dat = dplyr::bind_cols(TableS1_new, TableS4 %>% dplyr::select("AZD6244 (MEK) (uM)":CDH1) )

write.csv(combine_dat,file="Metabolite_IC50.csv",row.names=F)

combine_dat %>% dplyr::select(!(CellID:Gender)) %>% cor(use="pairwise.complete.obs",method="spearman") -> Cor2IC50_all
combine_dat %>% filter(Gender =="M") %>% dplyr::select(!(CellID:Gender))  %>% cor(use="pairwise.complete.obs",method="spearman") -> Cor2IC50_male
combine_dat %>% filter(Gender =="F") %>% dplyr::select(!(CellID:Gender))  %>% cor(use="pairwise.complete.obs",method="spearman") -> Cor2IC50_female

#pdf("Corr2IC50Plot.pdf",height=15,width=15)
par(mfrow=c(1,1))
#type = "upper" if only want upper triangle, can circle the main clusters "addrect=5"
corrplot(Cor2IC50_all, tl.col="black",tl.cex=1.5, cl.cex=2, method="circle",order="hclust")#, p.mat = CorP_all$p, insig = "label_sig", pch="*", sig.leel=0.05)#can order by "FPC" first principal component
title("Correlation among all cell lines",cex.main=3,font.main=2)

corrplot(Cor2IC50_male, tl.col="black",tl.cex=1.5, cl.cex=2,method="circle",order="hclust")#, p.mat = CorP_male$p, insig = "p-value", sig.level = -1)
title("Correlation among male lines",cex.main=3,font.main=2)

corrplot(Cor2IC50_female, tl.col="black",tl.cex=1.5, cl.cex=2,method="circle",order="hclust")#, p.mat = CorP_female$p, insig = "p-value", sig.level = -1)
title("Correlation among female cell lines",cex.main=3,font.main=2)

#dev.off()

Corr of the metabolite data at the deconvolute leve with drug IC50

We use the deconvolute values as in the original Table S1 (removing the unlabeled m0 columns).

TableS1_convolute = TableS1 %>% dplyr::select(!ends_with("m0")) 
write.csv(TableS1_convolute,file="metaboliteData_convolute.csv",row.names=F)

78 metabolites measurements across species, metabolites and time points are generated.

Corr between each species (1, 2, 3 etc position labeled) with IC50

We calculate the correlation between each metabolite and each drug’s IC50 for male and female separately and the correlation difference between sex and the p value testing the difference against 0.

The scatterplots on the pairs of metabolite and drug which show sigificant correlation difference between sex are plotted.

use the cor pair (SerG24m3, Pemetrexed) as an example to double check the data

all.metID = setdiff(names(TableS1_convolute),"CellID")
all.IC50_ID = names(dplyr::select(TableS4,"8-Cl-adenosine (uM)":"CDH1"))

metID = "SerG6m3"
#metID = "SerG24m3"
IC50_ID = "Pemetrexed (uM)"
#bind_cols(TableS1_convolute[,c("CellID",metID)], TableS4[,c("CellID",IC50_ID)])

cor(TableS1_convolute[,metID],TableS4[,IC50_ID],use="pairwise.complete.obs",method="pearson")
##         Pemetrexed (uM)
## SerG6m3      -0.3532843
##pearson cor= -.2711364  and =-0.3532843 for SerG24m3 and SerG6m3 with Pemetrexed, same as excel
cor(TableS1_convolute[,metID],TableS4[,IC50_ID],use="pairwise.complete.obs",method="spearman")
##         Pemetrexed (uM)
## SerG6m3      -0.2676139

we calculate the spearman cor and cor difference between sex here.

all.out = NULL 
for (idx1 in 1:length(all.metID))
  {
    metID = all.metID[idx1]
    
   for (idx2 in 1:length(all.IC50_ID))
    {
     
      IC50_ID = all.IC50_ID[idx2]
      #cat("metabolite=",metID, "Drug=",IC50_ID,"\n")
      cor.res=CorDiff(met_Dat=TableS1_convolute, IC50_Dat=TableS4, metID=metID,IC50_ID=IC50_ID, plot=TRUE,method0="spearman")
      out= data.frame(metabolite=metID, drug=IC50_ID, cor.res)
      #print(out)
      all.out = bind_rows(all.out,out)
      
    }
  }

all.out$FDR.P= with(all.out, p.adjust(CorDiff.pvalue,method="fdr"))
all.out = all.out %>% arrange(CorDiff.pvalue)
write.csv(all.out,file="Metabolite_DrugIC50_SpearsonCorSexDiff.csv",row.names=F)
options(width = 300)
#print(data.frame(all.out),digits=4)

#print table in nice html format
kbl(all.out) %>%
  kable_paper(full_width = F) %>%
  scroll_box(width = "1000px", height = "500px")
metabolite drug allN allCor allCor.P maleN maleCor maleCor.P femaleN femaleCor femaleCor.P M2FcorDifference CorDiff.pvalue FDR.P
rho…1 FumG24m2 Vinorelbine (nM) 72 -0.1130206 0.3445257 47 0.1320766 0.3761702 25 -0.5520696 0.0042194 0.6841461 0.0038722 0.9911425
rho…2 LacQ6m3 Vinorelbine (nM) 72 0.1197366 0.3164273 47 -0.1416180 0.3423472 25 0.5325377 0.0061341 -0.6741557 0.0048076 0.9911425
rho…3 CitG24m5 Crizotinib (ALK) (uM) 73 -0.1091872 0.3578094 48 -0.3676033 0.0101584 25 0.3202464 0.1185983 -0.6878498 0.0058099 0.9911425
rho…4 FumG24m3 Crizotinib (ALK) (uM) 75 -0.1403119 0.2298761 49 -0.4077841 0.0036330 26 0.2576121 0.2038920 -0.6653962 0.0063847 0.9911425
rho…5 MalG6m3 Pemetrexed/Cisplatin (uM) 67 -0.0613226 0.6220369 45 -0.2369643 0.1170472 22 0.4696244 0.0274409 -0.7065887 0.0065914 0.9911425
rho…6 CitQ24m5 Crizotinib (ALK) (uM) 73 -0.0539068 0.6505774 48 0.1945336 0.1851910 25 -0.4680525 0.0182961 0.6625861 0.0067581 0.9911425
rho…7 CitG24m6 Crizotinib (ALK) (uM) 73 -0.0615620 0.6048780 48 -0.3133730 0.0300950 25 0.3622018 0.0751956 -0.6755748 0.0068304 0.9911425
rho…8 GlyG24m2 Pemetrexed/Cisplatin (uM) 63 -0.1497600 0.2413978 41 -0.4197047 0.0063004 22 0.2983895 0.1773875 -0.7180942 0.0072018 0.9911425
rho…9 FumG24m4 Crizotinib (ALK) (uM) 75 -0.1485930 0.2032609 49 -0.3831659 0.0065779 26 0.2743757 0.1749588 -0.6575416 0.0072813 0.9911425
rho…10 FumG24m1 Vinorelbine (nM) 72 0.0155695 0.8967192 47 0.2808316 0.0558611 25 -0.3892206 0.0544693 0.6700522 0.0073898 0.9911425
rho…11 CitG6m1 CDH1 64 -0.0856282 0.5010988 42 0.1328037 0.4017975 22 -0.5424216 0.0091050 0.6752252 0.0080683 0.9911425
rho…12 LacG6m1 Etoposide (uM) 71 -0.0032701 0.9784074 47 0.1860869 0.2104361 24 -0.4727115 0.0196635 0.6587983 0.0081412 0.9911425
rho…13 GlyG24m1 Vinorelbine (nM) 67 0.0195235 0.8753913 43 0.2562989 0.0971197 24 -0.4201827 0.0409226 0.6764816 0.0084156 0.9911425
rho…14 LacG6m2 Erlotinib (EGFR) (uM) 73 -0.0283096 0.8120748 48 0.2041581 0.1639606 25 -0.4412387 0.0272472 0.6453968 0.0088677 0.9911425
rho…15 MalG24m2 Beta-catenin 59 -0.2173030 0.0982812 37 -0.4310355 0.0077360 22 0.2738566 0.2166605 -0.7048921 0.0095648 0.9911425
rho…16 SerG24m3 Pemetrexed (uM) 65 -0.2841987 0.0217700 43 -0.5093812 0.0004855 22 0.1538923 0.4941168 -0.6632735 0.0100698 0.9911425
rho…17 GlyG6m2 Pemetrexed/Cisplatin (uM) 61 -0.2177385 0.0918532 40 -0.5269478 0.0004770 21 0.1358467 0.5571091 -0.6627945 0.0119195 0.9911425
rho…18 LacQ24m1 Docetaxel (nM) 69 0.0097769 0.9364512 46 0.1514254 0.3151084 23 -0.4829462 0.0195808 0.6343716 0.0120647 0.9911425
rho…19 SerG24m3 AZD6244 (MEK) (uM) 66 0.0783299 0.5318675 43 0.2160468 0.1640849 23 -0.4219368 0.0460851 0.6379836 0.0144910 0.9911425
rho…20 SerG24m3 Pemetrexed/Cisplatin (uM) 62 -0.1703226 0.1856616 41 -0.4020210 0.0091730 21 0.2664935 0.2429219 -0.6685145 0.0145484 0.9911425
rho…21 LacG24m1 Etoposide (uM) 71 -0.1130900 0.3477225 47 0.1166045 0.4350717 24 -0.4844532 0.0164384 0.6010577 0.0148775 0.9911425
rho…22 CitQ6m2 Beta-catenin 57 -0.3299250 0.0122000 36 -0.4970719 0.0020418 21 0.1649351 0.4732477 -0.6620069 0.0151222 0.9911425
rho…23 CitG24m2 Crizotinib (ALK) (uM) 73 0.1156535 0.3298761 48 0.3565725 0.0128587 25 -0.2478831 0.2321967 0.6044556 0.0160953 0.9911425
rho…24 LacG6m3 Docetaxel (nM) 69 -0.1425308 0.2426871 46 -0.3476893 0.0179019 23 0.2807712 0.1943800 -0.6284605 0.0161073 0.9911425
rho…25 LacG24m1 Gefitinib (EGFR) (uM) 72 0.1030903 0.3888306 47 0.3184026 0.0291689 25 -0.2824707 0.1712813 0.6008733 0.0175341 0.9911425
rho…26 CitG24m3 MK-2206 (AKT) (uM) 69 -0.0580131 0.6358646 46 -0.2412166 0.1063250 23 0.3767615 0.0763800 -0.6179781 0.0176312 0.9911425
rho…27 CitQ6m4 Pemetrexed (uM) 68 -0.2170644 0.0753975 46 -0.3824878 0.0087070 22 0.2353296 0.2917637 -0.6178174 0.0196277 0.9911425
rho…28 GlyG6m2 Erlotinib (EGFR) (uM) 67 -0.2317478 0.0591580 43 -0.4840086 0.0010074 24 0.0991520 0.6448334 -0.5831606 0.0198457 0.9911425
rho…29 CitG6m2 Etoposide (uM) 69 0.0100302 0.9348079 46 -0.1810220 0.2286130 23 0.4195701 0.0462574 -0.6005921 0.0198891 0.9911425
rho…30 CitG24m2 Pemetrexed/Cisplatin (uM) 65 0.2071422 0.0977946 44 0.4072025 0.0060821 21 -0.2209946 0.3357049 0.6281971 0.0201538 0.9911425
rho…31 CitQ6m5 Sorafenib (multi-kinase) (uM) 71 0.0757239 0.5302414 47 0.2335522 0.1141123 24 -0.3592085 0.0847280 0.5927607 0.0206304 0.9911425
rho…32 CitQ6m1 Beta-catenin 57 -0.2473141 0.0636332 36 -0.4689833 0.0042854 21 0.1662338 0.4697217 -0.6352170 0.0209469 0.9911425
rho…33 CitG24m6 Pemetrexed/Cisplatin (uM) 65 -0.1776398 0.1568702 44 -0.3261567 0.0307211 21 0.3022426 0.1829800 -0.6283993 0.0214103 0.9911425
rho…34 FumG6m1 Beta-catenin 59 -0.1125966 0.3958419 37 -0.3347757 0.0428337 22 0.3009599 0.1731526 -0.6357356 0.0214526 0.9911425
rho…35 MalQ6m2 Beta-catenin 58 -0.2684570 0.0415929 36 -0.4630929 0.0044523 22 0.1586674 0.4789449 -0.6217603 0.0216659 0.9911425
rho…36 CitG6m4 Sorafenib (multi-kinase) (uM) 71 -0.1245052 0.3008977 47 -0.2839874 0.0530479 24 0.3048489 0.1474875 -0.5888363 0.0221316 0.9911425
rho…37 MalG24m2 Etoposide (uM) 71 -0.1301723 0.2792552 47 0.0389731 0.7947944 24 -0.5135899 0.0102589 0.5525630 0.0221940 0.9911425
rho…38 LacG6m3 Paclitaxel (nM) 73 -0.1622525 0.1702299 48 -0.3385543 0.0185866 25 0.2316276 0.2652443 -0.5701818 0.0237180 0.9911425
rho…39 SerG24m3 MK-2206 (AKT) (uM) 66 0.0999603 0.4245407 43 -0.0483676 0.7580808 23 0.5066733 0.0136150 -0.5550409 0.0267484 0.9911425
rho…40 CitG24m1 Paclitaxel/Carboplatin (nM) 68 0.2656077 0.0285870 45 0.4053903 0.0057338 23 -0.1667080 0.4470980 0.5720983 0.0276331 0.9911425
rho…41 MalG24m2 Vinorelbine (nM) 72 -0.0213112 0.8589692 47 0.1748735 0.2397247 25 -0.3776710 0.0627029 0.5525445 0.0279229 0.9911425
rho…42 MalG24m2 Doxorubicin (nM) 73 -0.1242334 0.2950104 48 0.0366479 0.8046803 25 -0.4892308 0.0140281 0.5258787 0.0279742 0.9911425
rho…43 MalQ6m3 Carboplatin (uM) 68 0.0198723 0.8722125 45 -0.1104303 0.4701986 23 0.4508157 0.0308546 -0.5612459 0.0280923 0.9911425
rho…44 CitG24m4 Crizotinib (ALK) (uM) 73 0.0791395 0.5057036 48 -0.1370430 0.3529791 25 0.4068515 0.0435510 -0.5438945 0.0285187 0.9911425
rho…45 LacG6m2 Paclitaxel (nM) 73 0.1675822 0.1564380 48 0.3244388 0.0244637 25 -0.2273952 0.2743206 0.5518340 0.0289965 0.9911425
rho…46 LacQ24m1 Paclitaxel/Carboplatin (nM) 70 0.1466249 0.2258102 46 0.2969772 0.0450449 24 -0.2668119 0.2075518 0.5637891 0.0294634 0.9911425
rho…47 CitG24m5 Pemetrexed/Cisplatin (uM) 65 -0.1634321 0.1933161 44 -0.3091723 0.0411406 21 0.2859930 0.2088316 -0.5951653 0.0299356 0.9911425
rho…48 CitQ24m1 E-cadherin 57 -0.1840161 0.1702016 36 -0.3858430 0.0207597 21 0.2246753 0.3259659 -0.6105183 0.0301012 0.9911425
rho…49 FumQ6m3 Erlotinib (EGFR) (uM) 73 -0.1800258 0.1274901 48 -0.3260775 0.0237102 25 0.2196999 0.2913240 -0.5457774 0.0308159 0.9911425
rho…50 MalG24m4 Crizotinib (ALK) (uM) 75 -0.1238607 0.2897219 49 -0.3116606 0.0292635 26 0.2240849 0.2711199 -0.5357455 0.0311621 0.9911425
rho…51 CitG6m2 Cisplatin (uM) 68 -0.0670955 0.5866897 45 -0.2549827 0.0909491 23 0.3100124 0.1499790 -0.5649952 0.0323843 0.9911425
rho…52 LacG24m2 Gefitinib (EGFR) (uM) 72 0.1205654 0.3130644 47 0.3134397 0.0319242 25 -0.2297480 0.2692509 0.5431877 0.0325131 0.9911425
rho…53 CitQ6m1 CDH1 64 0.3233216 0.0091608 42 0.4706503 0.0016580 22 -0.0865386 0.7017729 0.5571889 0.0326599 0.9911425
rho…54 MalQ24m3 CDH1 66 -0.2353623 0.0571218 43 -0.4030370 0.0073683 23 0.1509529 0.4917497 -0.5539898 0.0343776 0.9911425
rho…55 FumQ24m2 Vinorelbine (nM) 72 -0.1306505 0.2739984 47 0.0793385 0.5960374 25 -0.4385831 0.0282980 0.5179216 0.0351813 0.9911425
rho…56 MalG24m2 Docetaxel (nM) 69 0.1245032 0.3080701 46 0.2975967 0.0445779 23 -0.2540781 0.2420471 0.5516748 0.0362961 0.9911425
rho…57 CitQ24m2 Beta-catenin 57 -0.2999741 0.0237532 36 -0.4674389 0.0044276 21 0.1038961 0.6531558 -0.5713350 0.0370317 0.9911425
rho…58 MalG24m2 Gemcitabine (nM) 71 -0.0338606 0.7792237 47 0.1136390 0.4469198 24 -0.4113938 0.0457971 0.5250328 0.0376142 0.9911425
rho…59 CitQ6m4 Erlotinib (EGFR) (uM) 71 0.0649205 0.5906545 47 -0.1011333 0.4987849 24 0.4200913 0.0409711 -0.5212247 0.0383608 0.9911425
rho…60 LacQ6m2 EGFR-pY1173 59 -0.0808311 0.5427973 37 -0.3038350 0.0675175 22 0.2682101 0.2265818 -0.5720450 0.0398603 0.9911425
rho…61 CitG24m3 Pemetrexed/Cisplatin (uM) 65 -0.1744034 0.1646878 44 -0.3043800 0.0445530 21 0.2580437 0.2587482 -0.5624237 0.0408082 0.9911425
rho…62 GlyG24m2 Pemetrexed (uM) 66 -0.2287693 0.0646595 43 -0.4407324 0.0030967 23 0.0859212 0.6966796 -0.5266536 0.0411340 0.9911425
rho…63 LacG6m2 EGFR-pY1173 59 0.1053770 0.4259951 37 -0.2133713 0.2040576 22 0.3472614 0.1137360 -0.5606327 0.0432264 0.9911425
rho…64 LacG6m3 Etoposide (uM) 71 -0.0043265 0.9714348 47 -0.1683194 0.2580725 24 0.3474668 0.0961798 -0.5157863 0.0446766 0.9911425
rho…65 CitQ24m4 Gemcitabine/Cisplatin (nM) 65 0.0512277 0.6852839 44 -0.0888779 0.5661609 21 0.4441558 0.0450675 -0.5330338 0.0451139 0.9911425
rho…66 LacG24m3 Gefitinib (EGFR) (uM) 72 0.0581680 0.6274319 47 -0.1419153 0.3413243 25 0.3625169 0.0749235 -0.5044322 0.0453238 0.9911425
rho…67 LacG24m3 Etoposide (uM) 71 0.1270102 0.2912001 47 -0.0558559 0.7092163 24 0.4370515 0.0327169 -0.4929075 0.0479832 0.9911425
rho…68 LacG6m3 Gefitinib (EGFR) (uM) 72 0.0628161 0.6001380 47 -0.0844321 0.5725773 25 0.4060035 0.0440332 -0.4904356 0.0483790 0.9911425
rho…69 CitQ24m1 Beta-catenin 57 -0.2787788 0.0360753 36 -0.4576577 0.0054280 21 0.0818182 0.7240686 -0.5394758 0.0491900 0.9911425
rho…70 FumG6m1 E-cadherin 59 -0.0540920 0.6840840 37 -0.2277281 0.1752389 22 0.3190288 0.1478121 -0.5467569 0.0496092 0.9911425
rho…71 CitG6m3 Gefitinib (EGFR) (uM) 70 0.1829701 0.1294931 46 0.3385460 0.0213713 24 -0.1666304 0.4364480 0.5051765 0.0505026 0.9911425
rho…72 LacG24m2 Erlotinib (EGFR) (uM) 73 0.1540752 0.1930925 48 0.3341114 0.0202917 25 -0.1596461 0.4458971 0.4937575 0.0506357 0.9911425
rho…73 MalG24m3 Crizotinib (ALK) (uM) 75 -0.1620976 0.1647002 49 -0.3378622 0.0175839 26 0.1447144 0.4806005 -0.4825766 0.0514429 0.9911425
rho…74 CitG24m1 Docetaxel (nM) 67 0.0694752 0.5763986 45 0.1653429 0.2777293 22 -0.3548023 0.1051791 0.5201452 0.0517538 0.9911425
rho…75 LacQ24m2 Erlotinib (EGFR) (uM) 73 0.0388855 0.7439499 48 0.2168933 0.1386701 25 -0.2769763 0.1801217 0.4938697 0.0523276 0.9911425
rho…76 CitG24m2 Vinorelbine (nM) 70 -0.0692848 0.5687279 46 0.1260678 0.4038075 24 -0.3690971 0.0759057 0.4951648 0.0534635 0.9911425
rho…77 GlyG24m2 CDH1 61 0.0216877 0.8682346 38 -0.1814898 0.2754961 23 0.3428999 0.1092037 -0.5243897 0.0536477 0.9911425
rho…78 SerG24m1 Pemetrexed/Cisplatin (uM) 62 -0.1247387 0.3340519 41 -0.4197918 0.0062885 21 0.1020475 0.6598231 -0.5218393 0.0546506 0.9911425
rho…79 SerG24m2 CDH1 60 0.1057825 0.4211594 38 -0.0972032 0.5615356 22 0.4202495 0.0514935 -0.5174527 0.0555798 0.9911425
rho…80 FumQ24m2 Beta-catenin 59 -0.3249949 0.0120218 37 -0.4691797 0.0037345 22 0.0389720 0.8632883 -0.5081517 0.0557189 0.9911425
rho…81 LacG24m3 Docetaxel (nM) 69 -0.0609810 0.6186563 46 -0.2510027 0.0924548 23 0.2540781 0.2420471 -0.5050808 0.0564703 0.9911425
rho…82 FumG6m1 Paclitaxel/Carboplatin (nM) 70 0.0065630 0.9569974 46 0.1728307 0.2507191 24 -0.3212189 0.1258861 0.4940497 0.0565688 0.9911425
rho…83 FumG6m2 Beta-catenin 59 -0.3084746 0.0178002 37 -0.4850640 0.0026219 22 0.0163749 0.9438117 -0.5014389 0.0566402 0.9911425
rho…84 GlyG6m1 8-Cl-adenosine (uM) 64 -0.1518329 0.2310408 41 0.0219589 0.8916051 23 -0.4645416 0.0255343 0.4865005 0.0573530 0.9911425
rho…85 GlyG6m2 CDH1 60 0.0824903 0.5309248 38 -0.1114334 0.5053764 22 0.4049780 0.0615314 -0.5164114 0.0574052 0.9911425
rho…86 LacQ24m1 AZD6244 (MEK) (uM) 71 -0.0337481 0.7799390 47 -0.0907304 0.5441698 24 0.3909546 0.0588905 -0.4816849 0.0574469 0.9911425
rho…87 CitG24m5 Vinorelbine (nM) 70 -0.0326386 0.7885235 46 -0.2325223 0.1199362 24 0.2598478 0.2201117 -0.4923701 0.0589404 0.9911425
rho…88 MalQ24m4 Gefitinib (EGFR) (uM) 72 -0.3451481 0.0029853 47 -0.4960097 0.0003918 25 -0.0511834 0.8080256 -0.4448263 0.0591372 0.9911425
rho…89 FumG24m1 Cisplatin (uM) 70 0.1615031 0.1816507 46 0.0217753 0.8857847 24 0.4807484 0.0174056 -0.4589731 0.0592539 0.9911425
rho…90 CitG24m2 Doxorubicin (nM) 71 -0.0195371 0.8715293 47 0.1425597 0.3391142 24 -0.3417391 0.1025969 0.4842988 0.0596126 0.9911425
rho…91 SerG24m1 MK-2206 (AKT) (uM) 66 0.0107749 0.9315731 43 -0.1971736 0.2050341 23 0.3040040 0.1584555 -0.5011776 0.0606795 0.9911425
rho…92 CitG6m2 Pemetrexed (uM) 68 -0.1305205 0.2887393 46 -0.3241189 0.0279859 22 0.1769225 0.4309049 -0.5010414 0.0615316 0.9911425
rho…93 CitQ6m6 Erlotinib (EGFR) (uM) 71 -0.1782510 0.1369491 47 -0.2876720 0.0499093 24 0.1965645 0.3572674 -0.4842365 0.0619013 0.9911425
rho…94 LacG6m3 Doxorubicin (nM) 73 -0.0723923 0.5427603 48 -0.2168956 0.1386658 25 0.2576923 0.2127915 -0.4745879 0.0628004 0.9911425
rho…95 CitQ6m1 Gefitinib (EGFR) (uM) 70 0.0232758 0.8483231 46 0.2173833 0.1467218 24 -0.2671308 0.2069885 0.4845141 0.0631495 0.9911425
rho…96 LacQ24m3 Vinorelbine (nM) 72 -0.0486542 0.6848459 47 -0.2387093 0.1061164 25 0.2340713 0.2600927 -0.4727806 0.0649609 0.9911425
rho…97 MalG6m2 Gefitinib (EGFR) (uM) 72 0.2024058 0.0881739 47 0.3758385 0.0092289 25 -0.0862036 0.6820146 0.4620421 0.0651139 0.9911425
rho…98 FumG24m3 Pemetrexed/Cisplatin (uM) 67 -0.0310009 0.8033318 45 -0.1454593 0.3403894 22 0.3481211 0.1123663 -0.4935804 0.0651970 0.9911425
rho…99 FumQ24m2 8-Cl-adenosine (uM) 71 0.0655369 0.5871254 47 0.2102250 0.1560953 24 -0.2679426 0.2055592 0.4781676 0.0657507 0.9911425
rho…100 GlyG24m1 Beta-catenin 53 -0.2287626 0.0994277 32 -0.3858491 0.0291758 21 0.1441558 0.5314781 -0.5300050 0.0657861 0.9911425
rho…101 CitQ24m3 Crizotinib (ALK) (uM) 73 -0.0132878 0.9111596 48 0.1526424 0.3003206 25 -0.3137029 0.1267466 0.4663453 0.0658696 0.9911425
rho…102 CitQ6m1 E-cadherin 57 -0.2233313 0.0949343 36 -0.3840412 0.0214010 21 0.1324675 0.5656666 -0.5165087 0.0663254 0.9911425
rho…103 FumG24m2 Beta-catenin 59 -0.1925774 0.1436731 37 -0.3636795 0.0275488 22 0.1417278 0.5276805 -0.5054073 0.0674395 0.9911425
rho…104 FumG6m2 E-cadherin 59 -0.1023378 0.4395189 37 -0.2275960 0.1749578 22 0.2828910 0.2014071 -0.5104870 0.0681403 0.9911425
rho…105 CitQ6m3 Carboplatin (uM) 67 -0.0489168 0.6942445 45 -0.1610385 0.2906046 22 0.3282486 0.1358470 -0.4892871 0.0686910 0.9911425
rho…106 LacG6m1 Carboplatin (uM) 69 0.0372299 0.7613485 46 0.1731956 0.2497049 23 -0.3064756 0.1549290 0.4796711 0.0693165 0.9911425
rho…107 LacG6m3 Crizotinib (ALK) (uM) 75 0.0800105 0.4950059 49 -0.0882068 0.5467185 26 0.3581937 0.0723726 -0.4464005 0.0696807 0.9911425
rho…108 MalQ24m2 Beta-catenin 59 -0.2694331 0.0393693 37 -0.4103841 0.0121990 22 0.0818746 0.7166897 -0.4922587 0.0704642 0.9911425
rho…109 LacQ6m3 Gefitinib (EGFR) (uM) 72 -0.1026431 0.3909026 47 0.0519315 0.7288379 25 -0.3962664 0.0498760 0.4481979 0.0711496 0.9911425
rho…110 LacG24m2 EGFR-pY1173 59 0.0148451 0.9110389 37 -0.2486961 0.1374958 22 0.2557877 0.2494708 -0.5044838 0.0718382 0.9911425
rho…111 FumG6m1 Vinorelbine (nM) 72 0.0767214 0.5218122 47 0.2509904 0.0888062 25 -0.2102022 0.3132007 0.4611926 0.0719558 0.9911425
rho…112 LacG6m1 Docetaxel (nM) 69 0.0153693 0.9002528 46 0.1401993 0.3527282 23 -0.3321800 0.1214797 0.4723793 0.0723163 0.9911425
rho…113 LacG24m3 Vinorelbine (nM) 72 -0.2112603 0.0748480 47 -0.0320361 0.8307272 25 -0.4615979 0.0201928 0.4295618 0.0735190 0.9911425
rho…114 LacG6m1 Crizotinib (ALK) (uM) 75 -0.0897396 0.4438780 49 0.0506194 0.7297863 26 -0.3848786 0.0521947 0.4354980 0.0738881 0.9911425
rho…115 LacG6m2 Paclitaxel/Carboplatin (nM) 70 0.1678859 0.1647643 46 0.3139227 0.0336229 24 -0.1497281 0.4849839 0.4636507 0.0739301 0.9911425
rho…116 FumG6m2 Erlotinib (EGFR) (uM) 73 0.0003548 0.9976228 48 0.1315275 0.3728707 25 -0.3208309 0.1178896 0.4523585 0.0739479 0.9911425
rho…117 CitG6m4 CDH1 64 0.2934764 0.0185916 42 0.4649938 0.0019179 22 0.0050905 0.9820628 0.4599033 0.0747382 0.9911425
rho…118 CitG6m2 Vinorelbine (nM) 70 -0.2536183 0.0341339 46 -0.1257594 0.4049677 24 -0.5371059 0.0068023 0.4113465 0.0752157 0.9911425
rho…119 CitQ6m2 Doxorubicin (nM) 71 -0.1363671 0.2568111 47 -0.2811660 0.0555574 24 0.1808696 0.3959415 -0.4620355 0.0752477 0.9911425
rho…120 CitQ6m4 Etoposide (uM) 69 -0.0659736 0.5901672 46 -0.2128473 0.1555480 23 0.2574747 0.2355939 -0.4703220 0.0764267 0.9911425
rho…121 CitG6m5 Crizotinib (ALK) (uM) 73 -0.0645863 0.5872202 48 -0.2132262 0.1456338 25 0.2367206 0.2545812 -0.4499469 0.0784168 0.9911425
rho…122 CitQ6m3 Sorafenib (multi-kinase) (uM) 71 -0.1336542 0.2664844 47 0.0097747 0.9480075 24 -0.4266145 0.0376218 0.4363892 0.0792277 0.9911425
rho…123 MalG24m4 Pemetrexed/Cisplatin (uM) 67 -0.0237069 0.8489767 45 -0.1902566 0.2106293 22 0.2842612 0.1998003 -0.4745178 0.0794494 0.9911425
rho…124 CitG6m6 Gemcitabine/Cisplatin (nM) 65 -0.0542011 0.6680542 44 0.1062203 0.4925574 21 -0.3701299 0.0993410 0.4763501 0.0798812 0.9911425
rho…125 CitG6m2 Sorafenib (multi-kinase) (uM) 71 -0.0648894 0.5908324 47 -0.2561671 0.0822047 24 0.1991737 0.3507918 -0.4553408 0.0802983 0.9911425
rho…126 MalQ24m4 Doxorubicin (nM) 73 -0.0608665 0.6089714 48 0.0969651 0.5120601 25 -0.3430769 0.0936460 0.4400420 0.0803918 0.9911425
rho…127 MalQ6m1 Gefitinib (EGFR) (uM) 71 0.1352464 0.2607778 46 0.2777521 0.0616335 25 -0.1709007 0.4140479 0.4486528 0.0807011 0.9911425
rho…128 LacG6m1 Paclitaxel (nM) 73 0.0312080 0.7932418 48 0.1583777 0.2823064 25 -0.2854944 0.1665476 0.4438721 0.0813746 0.9911425
rho…129 MalQ6m3 Cisplatin (uM) 69 -0.0872766 0.4757887 45 -0.1958162 0.1973520 24 0.2588645 0.2219251 -0.4546807 0.0830256 0.9911425
rho…130 CitQ24m6 Etoposide (uM) 69 -0.1114288 0.3620159 46 -0.2514571 0.0918465 23 0.2090437 0.3384342 -0.4605009 0.0830377 0.9911425
rho…131 CitQ24m4 Gefitinib (EGFR) (uM) 70 -0.1487898 0.2189568 46 -0.3236691 0.0282168 24 0.1244290 0.5623917 -0.4480981 0.0834619 0.9911425
rho…132 FumG6m3 Pemetrexed/Cisplatin (uM) 67 -0.0410081 0.7417870 45 -0.1862380 0.2206064 22 0.2820007 0.2035555 -0.4682387 0.0836424 0.9911425
rho…133 CitG24m2 Erlotinib (EGFR) (uM) 71 0.1737235 0.1473712 47 0.3261825 0.0252492 24 -0.1195912 0.5777988 0.4457737 0.0837174 0.9911425
rho…134 SerG6m2 Gemcitabine (nM) 60 -0.3152882 0.0141365 41 -0.3320389 0.0339284 19 -0.6947368 0.0013280 0.3626979 0.0858344 0.9911425
rho…135 LacG6m3 Carboplatin (uM) 69 -0.1029975 0.3996905 46 -0.2326127 0.1197882 23 0.2214533 0.3098647 -0.4540660 0.0877395 0.9911425
rho…136 LacQ24m3 Docetaxel (nM) 69 -0.2130900 0.0787520 46 -0.0663294 0.6614081 23 -0.4834405 0.0194379 0.4171111 0.0884943 0.9911425
rho…137 CitG6m2 Carboplatin (uM) 67 -0.0207161 0.8678460 45 -0.1444338 0.3438412 22 0.3135594 0.1553147 -0.4579932 0.0891832 0.9911425
rho…138 FumG24m4 Pemetrexed/Cisplatin (uM) 67 -0.0518439 0.6769310 45 -0.1778056 0.2425925 22 0.2814355 0.2045016 -0.4592411 0.0898542 0.9911425
rho…139 MalG24m4 Doxorubicin (nM) 73 -0.0883297 0.4574105 48 -0.2515338 0.0846015 25 0.1800000 0.3875358 -0.4315338 0.0914828 0.9911425
rho…140 LacG6m3 Gemcitabine (nM) 71 -0.0804075 0.5050406 47 -0.2182201 0.1405942 24 0.2217874 0.2976101 -0.4400075 0.0916899 0.9911425
rho…141 CitQ6m4 Gemcitabine/Cisplatin (nM) 65 -0.1264315 0.3155813 44 -0.2223005 0.1469629 21 0.2441558 0.2848250 -0.4664564 0.0927862 0.9911425
rho…142 MalQ6m4 Gemcitabine/Cisplatin (nM) 66 -0.0103337 0.9343687 44 -0.1396250 0.3660252 22 0.3133823 0.1554253 -0.4530073 0.0939517 0.9911425
rho…143 CitG6m4 MK-2206 (AKT) (uM) 69 0.2348319 0.0521034 46 0.1107375 0.4637739 23 0.5107542 0.0127577 -0.4000166 0.0945129 0.9911425
rho…144 LacG6m1 Paclitaxel/Carboplatin (nM) 70 0.1971927 0.1017902 46 0.3346494 0.0230129 24 -0.0966268 0.6533191 0.4312763 0.0946290 0.9911425
rho…145 CitG24m2 Paclitaxel (nM) 71 0.0666790 0.5806129 47 0.2011218 0.1752290 24 -0.2348848 0.2692403 0.4360066 0.0946790 0.9911425
rho…146 CitG24m4 Sorafenib (multi-kinase) (uM) 71 -0.2676920 0.0240120 47 -0.3828914 0.0078990 24 0.0373994 0.8622597 -0.4202908 0.0964750 0.9911425
rho…147 CitG24m4 Pemetrexed/Cisplatin (uM) 65 -0.1283985 0.3080499 44 -0.2195990 0.1520664 21 0.2417941 0.2909858 -0.4613931 0.0965212 0.9911425
rho…148 MalG24m2 E-cadherin 59 -0.0916437 0.4899919 37 -0.2188371 0.1931609 22 0.2478826 0.2648030 -0.4667196 0.0968354 0.9911425
rho…149 MalQ6m2 E-cadherin 58 -0.0845946 0.5278041 36 -0.2368235 0.1643260 22 0.2320723 0.2972675 -0.4688958 0.0971019 0.9911425
rho…150 FumQ24m4 Gefitinib (EGFR) (uM) 72 -0.3608469 0.0018461 47 -0.5097733 0.0002522 25 -0.1293303 0.5378010 -0.3804431 0.0977560 0.9911425
rho…151 MalQ6m2 Gefitinib (EGFR) (uM) 71 -0.0811998 0.5008389 46 0.0594078 0.6949244 25 -0.3575140 0.0793323 0.4169218 0.0981639 0.9911425
rho…152 MalG24m2 Gemcitabine/Cisplatin (nM) 67 0.1279135 0.3022792 45 0.2408170 0.1110387 22 -0.2060982 0.3558112 0.4469152 0.1000258 0.9911425
rho…153 CitG6m5 Vinorelbine (nM) 70 0.0881154 0.4682285 46 -0.0626638 0.6790811 24 0.3582157 0.0856546 -0.4208795 0.1002443 0.9911425
rho…154 CitG6m5 Doxorubicin (nM) 71 0.0092403 0.9390373 47 -0.1238216 0.4069810 24 0.3017391 0.1516835 -0.4255608 0.1002884 0.9911425
rho…155 SerG24m2 SCH772984 (ERK) (uM) 72 0.0362733 0.7622695 46 -0.1184541 0.4330099 26 0.2953406 0.1429784 -0.4137947 0.1011986 0.9911425
rho…156 GlyG6m2 Doxorubicin (nM) 66 -0.1873623 0.1319565 42 -0.3536516 0.0215867 24 0.0730435 0.7339465 -0.4266951 0.1018585 0.9911425
rho…157 CitG24m6 Paclitaxel/Carboplatin (nM) 68 -0.1903739 0.1199419 45 -0.3394834 0.0225211 23 0.0905269 0.6812295 -0.4300103 0.1019807 0.9911425
rho…158 CitQ6m5 Erlotinib (EGFR) (uM) 71 -0.1499790 0.2118885 47 -0.2710189 0.0653825 24 0.1535116 0.4738893 -0.4245305 0.1028030 0.9911425
rho…159 GlyG6m1 MK-2206 (AKT) (uM) 64 -0.0215728 0.8656386 41 -0.2170692 0.1728018 23 0.2229914 0.3064297 -0.4400606 0.1053489 0.9911425
rho…160 FumG6m2 Sorafenib (multi-kinase) (uM) 73 -0.0700994 0.5556483 48 -0.1882992 0.1999523 25 0.2254280 0.2786058 -0.4137272 0.1064754 0.9911425
rho…161 CitG24m1 Crizotinib (ALK) (uM) 73 -0.0253490 0.8314222 48 0.0819998 0.5795307 25 -0.3252503 0.1126309 0.4072501 0.1066830 0.9911425
rho…162 MalG24m1 MK-2206 (AKT) (uM) 71 -0.0190431 0.8747516 47 -0.1564488 0.2936439 24 0.2636503 0.2131926 -0.4200991 0.1067793 0.9911425
rho…163 LacG6m1 Pemetrexed (uM) 70 0.1444142 0.2329613 47 0.2892083 0.0486460 23 -0.1360833 0.5358317 0.4252916 0.1070340 0.9911425
rho…164 CitG24m5 Paclitaxel/Carboplatin (nM) 68 -0.1269975 0.3020637 45 -0.2776753 0.0647777 23 0.1513729 0.4905314 -0.4290481 0.1071544 0.9911425
rho…165 LacG24m3 Cisplatin (uM) 70 0.0555040 0.6481235 46 -0.1101002 0.4663661 24 0.3080270 0.1431008 -0.4181273 0.1071578 0.9911425
rho…166 LacQ6m3 Cisplatin (uM) 70 -0.0077167 0.9494470 46 0.1298998 0.3895516 24 -0.2889469 0.1708750 0.4188467 0.1078618 0.9911425
rho…167 CitQ6m2 E-cadherin 57 -0.2280307 0.0880064 36 -0.3356715 0.0453446 21 0.1207792 0.6008166 -0.4564508 0.1082785 0.9911425
rho…168 CitG24m1 Vinorelbine (nM) 70 0.2282027 0.0574257 46 0.3695800 0.0114769 24 -0.0391730 0.8557927 0.4087530 0.1086252 0.9911425
rho…169 SerG24m1 AZD6244 (MEK) (uM) 66 -0.0686639 0.5838175 43 0.0181990 0.9077860 23 -0.3972332 0.0615538 0.4154322 0.1092892 0.9911425
rho…170 FumQ6m2 Beta-catenin 59 -0.2664602 0.0413533 37 -0.3917966 0.0164774 22 0.0446202 0.8436959 -0.4364167 0.1093826 0.9911425
rho…171 LacQ24m3 Etoposide (uM) 71 -0.1149551 0.3397776 47 0.0411113 0.7837990 24 -0.3648619 0.0795946 0.4059733 0.1102260 0.9911425
rho…172 SerG24m2 Carboplatin (uM) 65 -0.1261188 0.3167893 43 -0.2453080 0.1128471 22 0.1920362 0.3919083 -0.4373441 0.1103446 0.9911425
rho…173 GlyG24m2 MK-2206 (AKT) (uM) 67 0.0274365 0.8255654 43 -0.1241734 0.4275778 24 0.2962802 0.1597887 -0.4204537 0.1103516 0.9911425
rho…174 MalQ24m4 Crizotinib (ALK) (uM) 75 -0.0080971 0.9450327 49 0.1450535 0.3200116 26 -0.2552173 0.2082763 0.4002708 0.1109372 0.9911425
rho…175 GlyG6m2 Etoposide (uM) 64 -0.2826428 0.0236398 41 -0.4264309 0.0054331 23 -0.0158142 0.9429068 -0.4106167 0.1114533 0.9911425
rho…176 CitQ6m3 Erlotinib (EGFR) (uM) 71 -0.2110272 0.0773058 47 -0.3365907 0.0207025 24 0.0717547 0.7389915 -0.4083455 0.1114892 0.9911425
rho…177 MalG6m1 Docetaxel (nM) 69 0.0810201 0.5081009 46 -0.0754350 0.6183036 23 0.3405833 0.1117762 -0.4160184 0.1118477 0.9911425
rho…178 CitQ24m6 Gefitinib (EGFR) (uM) 70 -0.1413171 0.2432419 46 -0.2679662 0.0717808 24 0.1470525 0.4929078 -0.4150187 0.1122565 0.9911425
rho…179 SerG24m2 Crizotinib (ALK) (uM) 70 -0.0318233 0.7936878 45 -0.1573272 0.3020114 25 0.2536567 0.2211466 -0.4109840 0.1122596 0.9911425
rho…180 GlyG6m2 Carboplatin (uM) 63 -0.1861459 0.1440974 41 -0.3492921 0.0251936 22 0.0807910 0.7207859 -0.4300831 0.1127577 0.9911425
rho…181 FumG6m4 CDH1 66 0.1112538 0.3738278 43 0.2910781 0.0582628 23 -0.1326078 0.5463939 0.4236858 0.1137425 0.9911425
rho…182 LacG24m3 Gemcitabine (nM) 71 -0.0080768 0.9467017 47 -0.1553825 0.2969878 24 0.2565775 0.2261811 -0.4119600 0.1140800 0.9911425
rho…183 MalG24m3 Pemetrexed/Cisplatin (uM) 67 0.0444804 0.7207829 45 -0.0545473 0.7219287 22 0.3645099 0.0953442 -0.4190571 0.1142392 0.9911425
rho…184 LacG6m1 Doxorubicin (nM) 73 0.0460107 0.6991002 48 0.2010045 0.1707120 25 -0.2030769 0.3286978 0.4040814 0.1152685 0.9911425
rho…185 CitQ6m2 Cisplatin (uM) 68 -0.1639704 0.1815069 45 -0.2470844 0.1017698 23 0.1735476 0.4284029 -0.4206320 0.1154836 0.9911425
rho…186 FumQ6m2 8-Cl-adenosine (uM) 71 -0.1090801 0.3651918 47 -0.0042220 0.9775305 24 -0.3979991 0.0540871 0.3937772 0.1158566 0.9911425
rho…187 SerG6m2 Docetaxel (nM) 60 -0.2797504 0.0304046 41 -0.3841395 0.0131536 19 0.0632134 0.7971084 -0.4473528 0.1161707 0.9911425
rho…188 MalG24m2 MK-2206 (AKT) (uM) 71 0.0266234 0.8255675 47 -0.0689725 0.6450367 24 0.3341310 0.1105397 -0.4031035 0.1162887 0.9911425
rho…189 LacG24m3 EGFR-pY1173 59 -0.1213910 0.3587737 37 0.1303936 0.4403061 22 -0.3066064 0.1649263 0.4370000 0.1178538 0.9911425
rho…190 MalQ24m1 E-cadherin 59 -0.2296318 0.0802932 37 -0.3786155 0.0214692 22 0.0479955 0.8324846 -0.4266109 0.1190566 0.9911425
rho…191 LacG24m2 Vinorelbine (nM) 72 0.1793018 0.1318000 47 0.0395536 0.7918053 25 0.4173245 0.0379324 -0.3777710 0.1210100 0.9911425
rho…192 CitG24m5 Doxorubicin (nM) 71 -0.0866678 0.4723460 47 -0.2247990 0.1287213 24 0.1782609 0.4028894 -0.4030599 0.1231579 0.9911425
rho…193 FumG24m2 Docetaxel (nM) 69 0.1238259 0.3107298 46 0.2567409 0.0850002 23 -0.1532378 0.4851399 0.4099787 0.1233289 0.9911425
rho…194 FumQ6m2 Doxorubicin (nM) 73 -0.2124960 0.0710898 48 -0.3283655 0.0226907 25 0.0588575 0.7798894 -0.3872230 0.1242238 0.9911425
rho…195 SerG6m2 Crizotinib (ALK) (uM) 65 -0.1806066 0.1499485 43 -0.3467447 0.0227302 22 0.0661391 0.7699564 -0.4128838 0.1245318 0.9911425
rho…196 MalG6m3 Gemcitabine (nM) 71 -0.1369358 0.2548137 47 -0.2165375 0.1437575 24 0.1843879 0.3884009 -0.4009254 0.1253261 0.9911425
rho…197 MalQ24m2 Gefitinib (EGFR) (uM) 72 -0.2973714 0.0111875 47 -0.1740689 0.2419278 25 -0.5195306 0.0077769 0.3454616 0.1257055 0.9911425
rho…198 MalQ6m3 CDH1 66 -0.1585074 0.2036681 43 -0.2987838 0.0516263 23 0.1083623 0.6226064 -0.4071461 0.1278662 0.9911425
rho…199 CitG6m3 AZD6244 (MEK) (uM) 69 -0.1187357 0.3311911 46 0.0054896 0.9711167 23 -0.3853755 0.0702885 0.3908651 0.1280966 0.9911425
rho…200 LacQ24m3 Gemcitabine (nM) 71 -0.0635071 0.5987818 47 0.0529159 0.7238993 24 -0.3365949 0.1077748 0.3895108 0.1284494 0.9911425
rho…201 FumQ24m4 Crizotinib (ALK) (uM) 75 0.0141450 0.9041282 49 0.1547067 0.2885097 26 -0.2277160 0.2632252 0.3824227 0.1289394 0.9911425
rho…202 MalG24m1 Crizotinib (ALK) (uM) 75 -0.0216800 0.8535249 49 -0.1501610 0.3030826 26 0.2295587 0.2592762 -0.3797197 0.1316345 0.9911425
rho…203 MalG24m2 Carboplatin (uM) 69 -0.0235522 0.8476703 46 0.0940719 0.5340409 23 -0.3030154 0.1598817 0.3970873 0.1324695 0.9911425
rho…204 GlyG24m2 Erlotinib (EGFR) (uM) 69 -0.1654289 0.1743268 45 -0.3127100 0.0364866 24 0.0782779 0.7161801 -0.3909879 0.1325584 0.9911425
rho…205 FumG6m1 AZD6244 (MEK) (uM) 71 -0.0884074 0.4634676 47 0.0427931 0.7751801 24 -0.3417391 0.1025969 0.3845322 0.1326052 0.9911425
rho…206 CitG24m4 Paclitaxel/Carboplatin (nM) 68 -0.1158098 0.3469838 45 -0.2662098 0.0771299 23 0.1345537 0.5404685 -0.4007635 0.1330090 0.9911425
rho…207 SerG6m1 Sorafenib (multi-kinase) (uM) 62 -0.1561925 0.2254016 42 -0.3658102 0.0172000 20 0.0526316 0.8263162 -0.4184418 0.1333331 0.9911425
rho…208 GlyG24m2 AZD6244 (MEK) (uM) 67 0.0290658 0.8153844 43 0.0982443 0.5308124 24 -0.2965217 0.1591572 0.3947660 0.1335711 0.9911425
rho…209 FumQ24m2 Gemcitabine (nM) 71 -0.2116454 0.0764224 47 -0.1023505 0.4936050 24 -0.4619400 0.0230566 0.3595895 0.1343765 0.9911425
rho…210 LacG24m1 Vinorelbine (nM) 72 0.1176031 0.3251893 47 -0.0298693 0.8420250 25 0.3457172 0.0905048 -0.3755865 0.1348341 0.9911425
rho…211 FumQ24m3 Crizotinib (ALK) (uM) 75 0.0712375 0.5436219 49 0.2177845 0.1327758 26 -0.1590832 0.4376091 0.3768677 0.1349283 0.9911425
rho…212 CitG24m4 Beta-catenin 57 -0.3651154 0.0054808 36 -0.4906049 0.0026728 21 -0.0987013 0.6696047 -0.3919036 0.1351163 0.9911425
rho…213 SerG6m1 Beta-catenin 50 -0.1433373 0.3196538 32 -0.2463343 0.1735832 18 0.2198142 0.3792219 -0.4661486 0.1353271 0.9911425
rho…214 FumG24m4 Doxorubicin (nM) 73 -0.0242386 0.8387051 48 -0.1702590 0.2472861 25 0.2130769 0.3050148 -0.3833359 0.1355122 0.9911425
rho…215 CitG6m6 Cisplatin (uM) 68 -0.0655983 0.5950849 45 0.0727746 0.6347300 23 -0.3203956 0.1360950 0.3931702 0.1360408 0.9911425
rho…216 LacG6m2 Gefitinib (EGFR) (uM) 72 0.0032807 0.9781802 47 0.1212700 0.4167911 25 -0.2601501 0.2091459 0.3814201 0.1371575 0.9911425
rho…217 LacQ24m1 Paclitaxel (nM) 73 -0.0055857 0.9625923 48 0.0797025 0.5902339 25 -0.2974793 0.1486884 0.3771818 0.1372339 0.9911425
rho…218 SerG24m2 Docetaxel (nM) 65 -0.0652763 0.6054252 43 -0.1743466 0.2634950 22 0.2333334 0.2959952 -0.4076800 0.1374482 0.9911425
rho…219 CitQ6m2 Etoposide (uM) 69 -0.1768553 0.1460242 46 -0.2883797 0.0519472 23 0.1042748 0.6358632 -0.3926545 0.1380084 0.9911425
rho…220 FumQ24m2 E-cadherin 59 -0.2442503 0.0622759 37 -0.3549075 0.0317443 22 0.0530923 0.8144772 -0.4079999 0.1386216 0.9911425
rho…221 CitQ24m5 Sorafenib (multi-kinase) (uM) 71 0.1978214 0.0981942 47 0.2913329 0.0469416 24 -0.0921940 0.6683164 0.3835269 0.1389336 0.9911425
rho…222 LacQ6m1 Pemetrexed/Cisplatin (uM) 67 -0.0498987 0.6884185 45 -0.1372620 0.3685798 22 0.2639165 0.2353039 -0.4011785 0.1395917 0.9911425
rho…223 CitQ6m4 Carboplatin (uM) 67 -0.1442556 0.2441543 45 -0.2261391 0.1352474 22 0.1751413 0.4356333 -0.4012804 0.1409192 0.9911425
rho…224 GlyG6m2 Pemetrexed (uM) 63 -0.1056067 0.4100825 41 -0.3119660 0.0470726 22 0.0907295 0.6880166 -0.4026955 0.1409197 0.9911425
rho…225 LacG6m2 Docetaxel (nM) 69 0.1933226 0.1114801 46 0.2946875 0.0468057 23 -0.0944142 0.6682846 0.3891018 0.1410414 0.9911425
rho…226 MalQ24m1 Vinorelbine (nM) 72 -0.0220187 0.8543375 47 0.1094663 0.4638878 25 -0.2671801 0.1966584 0.3766464 0.1416758 0.9911425
rho…227 LacG6m1 Gemcitabine (nM) 71 -0.0285556 0.8131291 47 0.1201156 0.4212729 24 -0.2626658 0.2149698 0.3827814 0.1417849 0.9911425
rho…228 CitG6m1 Beta-catenin 57 -0.1311252 0.3299809 36 -0.2640927 0.1195321 21 0.1584416 0.4910812 -0.4225342 0.1419721 0.9911425
rho…229 CitQ24m1 Gemcitabine/Cisplatin (nM) 65 -0.1758876 0.1610679 44 -0.0620947 0.6888479 21 -0.4428571 0.0457553 0.3807624 0.1435196 0.9911425
rho…230 FumG6m1 Erlotinib (EGFR) (uM) 73 -0.0262661 0.8254180 48 0.1108819 0.4530857 25 -0.2619735 0.2058569 0.3728554 0.1445540 0.9911425
rho…231 SerG6m1 Gefitinib (EGFR) (uM) 61 -0.1762715 0.1741750 41 -0.0835511 0.6035144 20 -0.4695261 0.0367355 0.3859749 0.1445656 0.9911425
rho…232 FumQ24m3 CDH1 66 -0.2840677 0.0208039 43 -0.3959357 0.0085841 23 -0.0192974 0.9303585 -0.3766383 0.1446090 0.9911425
rho…233 LacG6m2 MK-2206 (AKT) (uM) 71 -0.0960950 0.4253432 47 0.0067669 0.9639934 24 -0.3628454 0.0813979 0.3696123 0.1446097 0.9911425
rho…234 MalQ6m1 Erlotinib (EGFR) (uM) 72 0.0480789 0.6883798 47 0.1667100 0.2627179 25 -0.2093113 0.3153032 0.3760213 0.1448154 0.9911425
rho…235 FumQ24m1 Vinorelbine (nM) 72 -0.0495702 0.6792332 47 0.0816515 0.5853315 25 -0.2891243 0.1609872 0.3707758 0.1461792 0.9911425
rho…236 MalG24m1 Vinorelbine (nM) 72 -0.0638772 0.5939818 47 0.0803793 0.5912090 25 -0.2902792 0.1592457 0.3706586 0.1462003 0.9911425
rho…237 SerG6m1 Gemcitabine (nM) 60 -0.2600446 0.0447932 41 -0.2740964 0.0828857 19 -0.6122807 0.0063322 0.3381843 0.1478599 0.9911425
rho…238 MalQ6m3 Erlotinib (EGFR) (uM) 72 -0.2510492 0.0334089 47 -0.3693767 0.0106126 25 -0.0100019 0.9621543 -0.3593747 0.1480436 0.9911425
rho…239 MalG24m1 SCH772984 (ERK) (uM) 78 -0.2204330 0.0524640 51 -0.3475504 0.0124575 27 -0.0012532 0.9950504 -0.3462972 0.1482875 0.9911425
rho…240 MalQ6m4 Cisplatin (uM) 69 -0.1768188 0.1461089 45 -0.3277220 0.0279741 24 0.0456820 0.8321396 -0.3734039 0.1486732 0.9911425
rho…241 SerG6m1 Erlotinib (EGFR) (uM) 63 -0.2070886 0.1034175 43 -0.3660461 0.0157768 20 0.0338473 0.8873461 -0.3998935 0.1490901 0.9911425
rho…242 CitG6m3 Cisplatin (uM) 68 -0.0491339 0.6907062 45 0.0774857 0.6129097 23 -0.3040792 0.1583474 0.3815649 0.1494183 0.9911425
rho…243 FumQ6m1 CDH1 66 0.2885332 0.0187999 43 0.4042457 0.0071769 23 0.0341416 0.8770967 0.3701042 0.1496623 0.9911425
rho…244 LacG6m3 Paclitaxel/Carboplatin (nM) 70 -0.2540799 0.0337979 46 -0.3822096 0.0087599 24 -0.0195865 0.9276198 -0.3626231 0.1501927 0.9911425
rho…245 MalQ24m2 E-cadherin 59 -0.1525424 0.2480342 37 -0.2989569 0.0726042 22 0.1033315 0.6462494 -0.4022883 0.1502500 0.9911425
rho…246 CitG6m5 Pemetrexed/Cisplatin (uM) 65 0.0320177 0.8001207 44 -0.0470771 0.7615452 21 0.3438416 0.1269680 -0.3909186 0.1514759 0.9911425
rho…247 LacQ24m2 8-Cl-adenosine (uM) 71 0.1060010 0.3789629 47 0.0298999 0.8418650 24 0.3883453 0.0607508 -0.3584454 0.1519999 0.9911425
rho…248 MalG6m2 Carboplatin (uM) 69 -0.0334734 0.7848164 46 0.0848163 0.5751844 23 -0.2936234 0.1738812 0.3784397 0.1521807 0.9911425
rho…249 LacG6m1 Gefitinib (EGFR) (uM) 72 0.1290950 0.2798010 47 0.2517857 0.0877660 25 -0.1135271 0.5889719 0.3653127 0.1549936 0.9911425
rho…250 LacQ24m3 Gefitinib (EGFR) (uM) 72 -0.2308101 0.0511002 47 -0.1127689 0.4504296 25 -0.4491053 0.0243177 0.3363364 0.1561179 0.9911425
rho…251 CitG24m4 Doxorubicin (nM) 71 -0.0484991 0.6879466 47 -0.1829854 0.2182739 24 0.1886957 0.3755141 -0.3716810 0.1562352 0.9911425
rho…252 MalG6m2 Erlotinib (EGFR) (uM) 73 -0.0148105 0.9010275 48 0.1084030 0.4633107 25 -0.2542797 0.2199758 0.3626827 0.1562756 0.9911425
rho…253 MalQ24m2 Vinorelbine (nM) 72 -0.0431692 0.7188025 47 0.1178512 0.4301437 25 -0.2463909 0.2351109 0.3642420 0.1565209 0.9911425
rho…254 FumQ6m2 MK-2206 (AKT) (uM) 71 -0.0385057 0.7498674 47 -0.1584199 0.2875278 24 0.2112707 0.3216839 -0.3696905 0.1582128 0.9911425
rho…255 CitQ6m1 8-Cl-adenosine (uM) 69 0.0017174 0.9888258 46 -0.1020263 0.4998685 23 0.2723005 0.2087543 -0.3743268 0.1584290 0.9911425
rho…256 LacQ6m3 Erlotinib (EGFR) (uM) 73 -0.2880836 0.0134531 48 -0.4083544 0.0039596 25 -0.0669488 0.7505127 -0.3414055 0.1587924 0.9911425
rho…257 MalG6m4 Pemetrexed/Cisplatin (uM) 67 -0.0925527 0.4563197 45 -0.2160150 0.1541037 22 0.1684092 0.4537509 -0.3844242 0.1588981 0.9911425
rho…258 CitQ24m2 E-cadherin 57 -0.2523334 0.0585075 36 -0.3631918 0.0301103 21 0.0311688 0.8945081 -0.3943606 0.1599718 0.9911425
rho…259 LacG24m1 Docetaxel (nM) 69 -0.0188236 0.8779900 46 0.1291189 0.3924325 23 -0.2451805 0.2594934 0.3742993 0.1601889 0.9911425
rho…260 FumQ24m1 8-Cl-adenosine (uM) 71 -0.1001484 0.4059855 47 0.0090799 0.9516989 24 -0.3470320 0.0966250 0.3561118 0.1617108 0.9911425
rho…261 MalG6m2 Beta-catenin 59 -0.3060783 0.0187419 37 -0.4298246 0.0084204 22 -0.0592885 0.7933723 -0.3705360 0.1622271 0.9911425
rho…262 FumQ6m3 Paclitaxel (nM) 73 -0.0545908 0.6464384 48 -0.1518499 0.3028666 25 0.2074274 0.3197776 -0.3592773 0.1623109 0.9911425
rho…263 SerG6m3 Erlotinib (EGFR) (uM) 63 -0.1398274 0.2743933 43 -0.2950572 0.0547554 20 0.1000376 0.6747554 -0.3950948 0.1624068 0.9911425
rho…264 CitG6m6 Sorafenib (multi-kinase) (uM) 71 -0.0999270 0.4070292 47 -0.1747643 0.2400229 24 0.1909111 0.3715359 -0.3656754 0.1631691 0.9911425
rho…265 CitG6m4 AZD6244 (MEK) (uM) 69 -0.0584544 0.6332936 46 0.0636526 0.6742964 23 -0.3033597 0.1591503 0.3670123 0.1637006 0.9911425
rho…266 FumQ24m2 AZD6244 (MEK) (uM) 71 0.0610982 0.6127458 47 0.1989129 0.1801164 24 -0.1661231 0.4378659 0.3650360 0.1638322 0.9911425
rho…267 FumQ24m1 E-cadherin 59 -0.2572180 0.0494892 37 -0.3878615 0.0183037 22 -0.0107284 0.9638624 -0.3771331 0.1640936 0.9911425
rho…268 CitQ24m6 Carboplatin (uM) 67 0.1357323 0.2734352 45 0.0570619 0.7096584 22 0.4146893 0.0549900 -0.3576274 0.1647153 0.9911425
rho…269 FumQ24m4 Doxorubicin (nM) 73 -0.0806159 0.4977722 48 0.0326836 0.8254593 25 -0.3173687 0.1221332 0.3500524 0.1647525 0.9911425
rho…270 FumG24m2 Erlotinib (EGFR) (uM) 73 0.0054768 0.9633211 48 0.1204538 0.4147827 25 -0.2358146 0.2564575 0.3562684 0.1647929 0.9911425
rho…271 MalQ24m3 Etoposide (uM) 71 0.1229709 0.3069404 47 0.0213369 0.8867992 24 0.3710309 0.0742651 -0.3496940 0.1649760 0.9911425
rho…272 FumQ24m2 MK-2206 (AKT) (uM) 71 -0.1135885 0.3455876 47 -0.2286293 0.1221648 24 0.1346823 0.5303628 -0.3633116 0.1650099 0.9911425
rho…273 CitG24m3 Gemcitabine/Cisplatin (nM) 65 0.0509217 0.6870661 44 0.1624612 0.2920469 21 -0.2246753 0.3259659 0.3871366 0.1650988 0.9911425
rho…274 CitG6m4 Pemetrexed/Cisplatin (uM) 65 0.0235819 0.8520841 44 -0.0094436 0.9514869 21 0.3652910 0.1034581 -0.3747346 0.1651700 0.9911425
rho…275 FumG6m2 Gemcitabine/Cisplatin (nM) 67 -0.0893589 0.4720731 45 0.0303729 0.8429983 22 -0.3382270 0.1239353 0.3685999 0.1665543 0.9911425
rho…276 MalG6m4 Carboplatin (uM) 69 -0.1165175 0.3403684 46 -0.0098079 0.9484201 23 -0.3662877 0.0856107 0.3564799 0.1666643 0.9911425
rho…277 CitG24m5 Paclitaxel (nM) 71 -0.0915494 0.4476652 47 -0.2074250 0.1618098 24 0.1539800 0.4725249 -0.3614050 0.1679609 0.9911425
rho…278 CitQ24m2 Pemetrexed (uM) 68 -0.3271197 0.0064724 46 -0.4431664 0.0020393 22 -0.0981013 0.6640511 -0.3450652 0.1702981 0.9911425
rho…279 CitG24m4 Pemetrexed (uM) 68 -0.0065482 0.9577343 46 -0.1005692 0.5060432 22 0.2699202 0.2244255 -0.3704895 0.1703640 0.9911425
rho…280 LacQ24m2 Paclitaxel (nM) 73 0.1687407 0.1535530 48 0.2942071 0.0423806 25 -0.0527126 0.8023993 0.3469197 0.1712575 0.9911425
rho…281 CitG6m3 Carboplatin (uM) 67 -0.0298670 0.8103887 45 0.0869135 0.5702365 22 -0.2824859 0.2027454 0.3693995 0.1721168 0.9911425
rho…282 CitQ6m3 Gefitinib (EGFR) (uM) 70 -0.2422800 0.0433029 46 -0.3683302 0.0117813 24 -0.0230585 0.9148313 -0.3452716 0.1722149 0.9911425
rho…283 MalQ6m3 Etoposide (uM) 70 0.1154021 0.3414411 46 -0.0027138 0.9857192 24 0.3457273 0.0979697 -0.3484411 0.1723690 0.9911425
rho…284 LacQ6m3 Etoposide (uM) 71 0.0683688 0.5710380 47 0.1941658 0.1909494 24 -0.1633319 0.4457098 0.3574977 0.1729257 0.9911425
rho…285 FumQ6m4 Cisplatin (uM) 70 -0.1711141 0.1566773 46 -0.2957594 0.0459745 24 0.0574288 0.7898210 -0.3531882 0.1734802 0.9911425
rho…286 CitG24m2 Paclitaxel/Carboplatin (nM) 68 0.1386624 0.2594473 45 0.2621903 0.0818739 23 -0.1009152 0.6468406 0.3631055 0.1735560 0.9911425
rho…287 FumG24m3 Doxorubicin (nM) 73 -0.0500127 0.6743417 48 -0.1856235 0.2065355 25 0.1646154 0.4299374 -0.3502389 0.1736756 0.9911425
rho…288 CitG24m6 Doxorubicin (nM) 71 -0.0741915 0.5386205 47 -0.2027645 0.1716571 24 0.1539130 0.4709984 -0.3566775 0.1737719 0.9911425
rho…289 CitQ24m3 Sorafenib (multi-kinase) (uM) 71 0.1118929 0.3528825 47 0.2258083 0.1269685 24 -0.1300283 0.5447936 0.3558366 0.1740381 0.9911425
rho…290 CitG24m6 Vinorelbine (nM) 70 -0.0677978 0.5770726 46 -0.1935424 0.1974785 24 0.1640915 0.4435677 -0.3576339 0.1743778 0.9911425
rho…291 GlyG6m1 Pemetrexed (uM) 63 0.0119655 0.9258441 41 -0.1530249 0.3394881 22 0.2228543 0.3188255 -0.3758792 0.1752228 0.9911425
rho…292 FumQ6m1 Beta-catenin 59 -0.2326125 0.0763656 37 -0.3608345 0.0288557 22 0.0095991 0.9678755 -0.3704336 0.1761652 0.9911425
rho…293 MalQ6m4 Erlotinib (EGFR) (uM) 72 -0.2074898 0.0803111 47 -0.3338152 0.0218417 25 0.0053857 0.9796165 -0.3392008 0.1770231 0.9911425
rho…294 MalQ6m1 Carboplatin (uM) 68 0.0476586 0.6995440 45 0.1485191 0.3302182 23 -0.2133498 0.3283485 0.3618689 0.1775629 0.9911425
rho…295 LacQ24m2 Docetaxel (nM) 69 0.1507438 0.2163191 46 0.2658728 0.0741141 23 -0.0919427 0.6765047 0.3578155 0.1779279 0.9911425
rho…296 FumG6m1 EGFR-pY1173 59 -0.0564590 0.6710333 37 -0.2340110 0.1633112 22 0.1462451 0.5144551 -0.3802561 0.1780861 0.9911425
rho…297 CitG24m3 Crizotinib (ALK) (uM) 73 -0.1733722 0.1424142 48 -0.3051135 0.0349672 25 0.0350270 0.8679845 -0.3401404 0.1782641 0.9911425
rho…298 FumQ6m3 Sorafenib (multi-kinase) (uM) 73 -0.1292983 0.2756065 48 -0.0344238 0.8163228 25 -0.3666795 0.0713996 0.3322557 0.1783207 0.9911425
rho…299 MalQ6m1 Vinorelbine (nM) 71 0.0170170 0.8879865 46 0.1501403 0.3192808 25 -0.1986909 0.3410298 0.3488312 0.1785108 0.9911425
rho…300 CitQ6m3 Pemetrexed/Cisplatin (uM) 65 -0.2305734 0.0646230 44 -0.3219282 0.0330851 21 0.0461489 0.8425473 -0.3680771 0.1789866 0.9911425
rho…301 SerG24m2 Pemetrexed/Cisplatin (uM) 62 -0.1765935 0.1697465 41 -0.3602073 0.0207014 21 0.0071498 0.9754621 -0.3673572 0.1792729 0.9911425
rho…302 MalG24m2 Paclitaxel (nM) 73 0.0276117 0.8166260 48 0.1375753 0.3510940 25 -0.2073875 0.3198727 0.3449628 0.1798765 0.9911425
rho…303 LacQ6m1 Paclitaxel/Carboplatin (nM) 70 0.2381036 0.0471562 46 0.3343615 0.0231382 24 -0.0091404 0.9661888 0.3435019 0.1800841 0.9911425
rho…304 SerG6m1 MK-2206 (AKT) (uM) 61 -0.1694108 0.1918161 41 -0.3478754 0.0258320 20 0.0278405 0.9072471 -0.3757159 0.1803807 0.9911425
rho…305 MalQ24m3 Gemcitabine (nM) 71 0.0820034 0.4965968 47 0.1439563 0.3343544 24 -0.2070465 0.3316766 0.3510029 0.1806866 0.9911425
rho…306 MalQ24m1 Crizotinib (ALK) (uM) 75 0.0830054 0.4789467 49 -0.0512795 0.7263987 26 0.2825865 0.1618884 -0.3338659 0.1807422 0.9911425
rho…307 GlyG6m1 CDH1 60 0.1483324 0.2580220 38 -0.0179519 0.9148088 22 0.3478512 0.1126640 -0.3658031 0.1812713 0.9911425
rho…308 LacQ6m2 Erlotinib (EGFR) (uM) 73 0.1017472 0.3916936 48 0.2132349 0.1456171 25 -0.1304097 0.5343835 0.3436446 0.1813517 0.9911425
rho…309 FumQ6m2 SCH772984 (ERK) (uM) 78 0.0027364 0.9810306 51 0.1090042 0.4464060 27 -0.2190238 0.2723690 0.3280280 0.1840862 0.9911425
rho…310 CitQ6m6 Sorafenib (multi-kinase) (uM) 71 -0.0773675 0.5213270 47 0.0015616 0.9916880 24 -0.3361600 0.1082591 0.3377217 0.1853081 0.9911425
rho…311 MalQ6m1 E-cadherin 58 -0.1701094 0.2017292 36 -0.2767053 0.1023979 22 0.0965829 0.6689623 -0.3732882 0.1858433 0.9911425
rho…312 CitQ24m2 MK-2206 (AKT) (uM) 69 0.0317199 0.7958381 46 -0.0942040 0.5334642 23 0.2576020 0.2353542 -0.3518061 0.1859069 0.9911425
rho…313 CitG24m1 Pemetrexed (uM) 68 -0.0376816 0.7603068 46 0.0867444 0.5664954 22 -0.2704873 0.2234155 0.3572317 0.1859599 0.9911425
rho…314 CitG6m1 Pemetrexed (uM) 68 -0.1344301 0.2744126 46 -0.0068045 0.9642024 22 -0.3549791 0.1049936 0.3481746 0.1859935 0.9911425
rho…315 MalG24m2 Paclitaxel/Carboplatin (nM) 70 0.1361580 0.2610506 46 0.2444095 0.1016349 24 -0.1014146 0.6372662 0.3458241 0.1870758 0.9911425
rho…316 SerG24m3 Doxorubicin (nM) 67 -0.1416768 0.2527769 44 -0.2605048 0.0876594 23 0.0928854 0.6724886 -0.3533902 0.1871052 0.9911425
rho…317 MalG24m2 Cisplatin (uM) 70 -0.0176033 0.8849961 46 0.0770417 0.6108226 24 -0.2671308 0.2069885 0.3441725 0.1873982 0.9911425
rho…318 CitG6m3 Gemcitabine/Cisplatin (nM) 65 -0.1262116 0.3164307 44 -0.0225543 0.8844586 21 -0.3753247 0.0944111 0.3527704 0.1882292 0.9911425
rho…319 MalQ6m2 Cisplatin (uM) 69 -0.0531311 0.6645905 45 -0.1395579 0.3605468 24 0.2075267 0.3305315 -0.3470846 0.1889990 0.9911425
rho…320 SerG6m1 Vinorelbine (nM) 61 -0.2518023 0.0502744 41 -0.1947011 0.2225195 20 -0.5229497 0.0179862 0.3282486 0.1891174 0.9911425
rho…321 SerG6m1 CDH1 56 0.1621114 0.2326016 37 0.0176697 0.9173283 19 0.3933276 0.0957093 -0.3756579 0.1891858 0.9911425
rho…322 SerG24m3 8-Cl-adenosine (uM) 66 -0.2215333 0.0738339 43 -0.1373164 0.3799003 23 -0.4600939 0.0271709 0.3227775 0.1896001 0.9911425
rho…323 CitQ6m4 Pemetrexed/Cisplatin (uM) 65 -0.2296664 0.0657115 44 -0.2886642 0.0573895 21 0.0727982 0.7538309 -0.3614624 0.1906303 0.9911425
rho…324 FumQ24m1 AZD6244 (MEK) (uM) 71 -0.0204412 0.8656386 47 0.0792761 0.5963274 24 -0.2608696 0.2173672 0.3401456 0.1914306 0.9911425
rho…325 FumG24m3 Vinorelbine (nM) 72 0.0259031 0.8289997 47 -0.1029897 0.4908962 25 0.2325314 0.2633314 -0.3355210 0.1925941 0.9911425
rho…326 FumG24m3 Docetaxel (nM) 69 -0.0090458 0.9411943 46 -0.1333375 0.3770177 23 0.2150272 0.3244692 -0.3483647 0.1926946 0.9911425
rho…327 SerG24m2 Etoposide (uM) 66 -0.0567021 0.6511160 43 -0.1399985 0.3705729 23 0.2124506 0.3288662 -0.3524491 0.1928003 0.9911425
rho…328 CitQ24m4 Pemetrexed (uM) 68 -0.1217960 0.3224554 46 -0.2321645 0.1205232 22 0.1207836 0.5923573 -0.3529481 0.1939339 0.9911425
rho…329 FumQ24m2 CDH1 66 0.1704445 0.1712256 43 0.2966685 0.0533843 23 -0.0489978 0.8243031 0.3456663 0.1950064 0.9911425
rho…330 CitG6m2 Gemcitabine/Cisplatin (nM) 65 0.0357108 0.7776267 44 -0.0761207 0.6233522 21 0.2818182 0.2150867 -0.3579388 0.1956046 0.9911425
rho…331 CitG24m6 Pemetrexed (uM) 68 0.0094949 0.9387450 46 -0.0882712 0.5596584 22 0.2614143 0.2399375 -0.3496855 0.1960913 0.9911425
rho…332 CitQ24m4 Etoposide (uM) 69 0.0033069 0.9784859 46 -0.1359978 0.3674850 23 0.2095379 0.3372674 -0.3455357 0.1965576 0.9911425
rho…333 MalQ6m4 Carboplatin (uM) 68 -0.1541677 0.2093880 45 -0.2598669 0.0847184 23 0.0845279 0.7013768 -0.3443948 0.1967572 0.9911425
rho…334 FumQ6m1 Vinorelbine (nM) 72 0.0195418 0.8705728 47 0.1571156 0.2915655 25 -0.1767085 0.3981180 0.3338241 0.1968239 0.9911425
rho…335 CitG6m4 Erlotinib (EGFR) (uM) 71 0.1101711 0.3603864 47 0.2474269 0.0935853 24 -0.0891498 0.6786876 0.3365767 0.1971659 0.9911425
rho…336 CitQ6m1 Gemcitabine/Cisplatin (nM) 65 -0.2762449 0.0259150 44 -0.1547082 0.3159918 21 -0.4779221 0.0298648 0.3232139 0.1975623 0.9911425
rho…337 SerG6m3 Beta-catenin 50 -0.1518848 0.2914074 32 -0.2049120 0.2594466 18 0.1991744 0.4265572 -0.4040864 0.1976456 0.9911425
rho…338 MalQ6m1 Gemcitabine/Cisplatin (nM) 66 -0.1003549 0.4227053 44 -0.0112423 0.9422611 22 -0.3524428 0.1076778 0.3412005 0.1983343 0.9911425
rho…339 CitG6m1 Docetaxel (nM) 67 0.1371712 0.2683343 45 0.2204720 0.1455783 22 -0.1293786 0.5660778 0.3498505 0.2000804 0.9911425
rho…340 CitG24m3 Beta-catenin 57 -0.0509796 0.7064669 36 -0.1853282 0.2780425 21 0.1857143 0.4185091 -0.3710425 0.2001511 0.9911425
rho…341 CitG6m3 Pemetrexed (uM) 68 0.0650779 0.5980156 46 0.2152535 0.1508187 22 -0.1332589 0.5543853 0.3485125 0.2003923 0.9911425
rho…342 CitQ6m3 Etoposide (uM) 69 -0.1441883 0.2371957 46 -0.2529990 0.0898059 23 0.0874722 0.6914633 -0.3404712 0.2007163 0.9911425
rho…343 LacQ24m2 Doxorubicin (nM) 73 0.1239248 0.2962208 48 0.2443196 0.0942200 25 -0.0830769 0.6921470 0.3273965 0.2010286 0.9911425
rho…344 CitG6m4 8-Cl-adenosine (uM) 69 -0.2291122 0.0582710 46 -0.1394689 0.3552673 23 -0.4511984 0.0306952 0.3117295 0.2013549 0.9911425
rho…345 SerG6m2 SCH772984 (ERK) (uM) 67 -0.0643830 0.6047249 44 -0.1998971 0.1932682 23 0.1438635 0.5125388 -0.3437607 0.2026428 0.9911425
rho…346 CitG24m4 Carboplatin (uM) 67 -0.2009141 0.1030435 45 -0.2795770 0.0628905 22 0.0632768 0.7796690 -0.3428538 0.2047874 0.9911425
rho…347 FumG6m1 8-Cl-adenosine (uM) 71 0.0645564 0.5927430 47 0.1879175 0.2059032 24 -0.1448141 0.4995860 0.3327316 0.2051930 0.9911425
rho…348 CitG6m4 Beta-catenin 57 -0.3976277 0.0021922 36 -0.5250965 0.0011840 21 -0.2103896 0.3583276 -0.3147069 0.2069671 0.9911425
rho…349 FumG24m4 Gemcitabine/Cisplatin (nM) 67 -0.0567324 0.6483879 45 0.0316906 0.8362780 22 -0.3066064 0.1649263 0.3382970 0.2074972 0.9911425
rho…350 MalQ24m3 Pemetrexed/Cisplatin (uM) 67 -0.0929736 0.4542653 45 -0.0324132 0.8325976 22 -0.3634823 0.0963519 0.3310690 0.2075346 0.9911425
rho…351 CitQ24m1 CDH1 64 0.3923922 0.0013416 42 0.5007298 0.0007320 22 0.1951360 0.3841623 0.3055937 0.2075464 0.9911425
rho…352 FumG24m2 E-cadherin 59 -0.0403857 0.7608134 37 -0.1472262 0.3831264 22 0.2094862 0.3478100 -0.3567123 0.2076273 0.9911425
rho…353 FumQ6m1 E-cadherin 59 -0.0952075 0.4721775 37 -0.2093409 0.2128885 22 0.1462451 0.5144551 -0.3555860 0.2090849 0.9911425
rho…354 MalG6m3 Crizotinib (ALK) (uM) 75 -0.1621972 0.1644374 49 -0.2519027 0.0807975 26 0.0622648 0.7625238 -0.3141675 0.2104887 0.9911425
rho…355 FumG24m1 AZD6244 (MEK) (uM) 71 -0.0768283 0.5242434 47 0.0257626 0.8635224 24 -0.2956522 0.1604280 0.3214148 0.2127065 0.9911425
rho…356 CitQ24m5 Pemetrexed (uM) 68 -0.0983574 0.4248842 46 -0.0508777 0.7370290 22 -0.3748262 0.0856553 0.3239485 0.2129499 0.9911425
rho…357 FumG24m4 Paclitaxel (nM) 73 -0.1053078 0.3752459 48 -0.1915904 0.1920593 25 0.1292805 0.5379588 -0.3208709 0.2129735 0.9911425
rho…358 FumG24m3 Paclitaxel (nM) 73 -0.0743795 0.5317101 48 -0.1707973 0.2457726 25 0.1500577 0.4740246 -0.3208550 0.2134095 0.9911425
rho…359 CitQ6m4 Cisplatin (uM) 68 -0.2370413 0.0516200 45 -0.3484105 0.0190037 23 -0.0262052 0.9055232 -0.3222053 0.2142408 0.9911425
rho…360 CitQ24m2 Carboplatin (uM) 67 -0.0952181 0.4433964 45 -0.1738873 0.2532980 22 0.1655367 0.4615989 -0.3394240 0.2150938 0.9911425
rho…361 FumG6m3 Gemcitabine (nM) 71 -0.0976938 0.4176458 47 -0.1810281 0.2233232 24 0.1443792 0.5008886 -0.3254073 0.2155940 0.9911425
rho…362 GlyG6m1 Beta-catenin 53 -0.1801322 0.1962477 32 -0.3192815 0.0752972 21 0.0402597 0.8633429 -0.3595413 0.2161497 0.9911425
rho…363 MalQ24m4 Gemcitabine/Cisplatin (nM) 67 0.1847044 0.1345686 45 0.0970484 0.5259502 22 0.4127612 0.0574055 -0.3157128 0.2166590 0.9911425
rho…364 MalQ6m2 Vinorelbine (nM) 71 -0.0795998 0.5093420 46 0.0402196 0.7907145 25 -0.2760348 0.1816678 0.3162544 0.2169730 0.9911425
rho…365 MalG24m4 Paclitaxel (nM) 73 -0.1917760 0.1040818 48 -0.2829067 0.0513699 25 0.0296268 0.8882014 -0.3125335 0.2179886 0.9911425
rho…366 CitG24m1 8-Cl-adenosine (uM) 69 0.0268031 0.8269500 46 -0.0368885 0.8077051 23 0.2881147 0.1824757 -0.3250032 0.2179994 0.9911425
rho…367 LacG24m3 Carboplatin (uM) 69 0.0564042 0.6452754 46 -0.0405885 0.7888388 23 0.2842314 0.1887067 -0.3248198 0.2187239 0.9911425
rho…368 MalG6m1 Cisplatin (uM) 70 0.0926892 0.4453591 46 0.0054899 0.9711149 24 0.3202089 0.1271484 -0.3147190 0.2201986 0.9911425
rho…369 SerG6m2 Vinorelbine (nM) 61 -0.3634007 0.0039937 41 -0.3336384 0.0330261 20 -0.6072236 0.0045199 0.2735852 0.2203734 0.9911425
rho…370 MalG6m2 Vinorelbine (nM) 72 0.0517415 0.6659984 47 0.1862603 0.2100036 25 -0.1305102 0.5340659 0.3167705 0.2207897 0.9911425
rho…371 SerG24m2 MK-2206 (AKT) (uM) 66 -0.0671135 0.5923597 43 -0.2230200 0.1505693 23 0.1077608 0.6245504 -0.3307808 0.2212188 0.9911425
rho…372 CitQ6m5 EGFR-pY1173 57 0.3902645 0.0028735 36 0.4319176 0.0090480 21 0.6753247 0.0010605 -0.2434070 0.2215133 0.9911425
rho…373 FumG6m2 Vinorelbine (nM) 72 0.0241256 0.8405740 47 0.1516220 0.3089751 25 -0.1643889 0.4323197 0.3160110 0.2222728 0.9911425
rho…374 GlyG6m1 Etoposide (uM) 64 -0.0000458 0.9997135 41 -0.1047130 0.5146916 23 0.2278231 0.2957922 -0.3325360 0.2225176 0.9911425
rho…375 CitQ24m6 Gemcitabine/Cisplatin (nM) 65 -0.0106433 0.9329400 44 -0.0759092 0.6243202 21 0.2623377 0.2495526 -0.3382469 0.2228385 0.9911425
rho…376 MalG6m2 Cisplatin (uM) 70 -0.0077867 0.9489895 46 0.0934464 0.5367756 24 -0.2266696 0.2868256 0.3201160 0.2230303 0.9911425
rho…377 CitQ24m4 Sorafenib (multi-kinase) (uM) 71 0.0880343 0.4653642 47 -0.0019087 0.9898409 24 0.3100674 0.1403341 -0.3119761 0.2239699 0.9911425
rho…378 LacG6m2 Doxorubicin (nM) 73 0.0382942 0.7477129 48 0.1365981 0.3545590 25 -0.1769231 0.3958160 0.3135212 0.2240986 0.9911425
rho…379 MalQ24m1 EGFR-pY1173 59 -0.1739334 0.1871961 37 -0.3487435 0.0349982 22 -0.0163749 0.9438117 -0.3323686 0.2248710 0.9911425
rho…380 MalG6m2 Gemcitabine/Cisplatin (nM) 67 -0.1189524 0.3376831 45 -0.0384767 0.8018609 22 -0.3574252 0.1030205 0.3189484 0.2250399 0.9911425
rho…381 LacG6m2 Sorafenib (multi-kinase) (uM) 73 0.0296568 0.8033071 48 -0.0610289 0.6802956 25 0.2488940 0.2302359 -0.3099229 0.2254544 0.9911425
rho…382 FumG24m2 AZD6244 (MEK) (uM) 71 0.1231334 0.3062966 47 0.2149300 0.1468284 24 -0.1026087 0.6321323 0.3175387 0.2257315 0.9911425
rho…383 MalQ24m1 AZD6244 (MEK) (uM) 71 0.0205418 0.8649835 47 0.1451949 0.3301683 24 -0.1730435 0.4169914 0.3182383 0.2261287 0.9911425
rho…384 CitQ24m4 MK-2206 (AKT) (uM) 69 0.0644448 0.5988281 46 0.1941454 0.1960587 23 -0.1290482 0.5573093 0.3231937 0.2278181 0.9911425
rho…385 CitG24m4 Erlotinib (EGFR) (uM) 71 -0.0036053 0.9761952 47 -0.1024055 0.4933718 24 0.2135247 0.3164275 -0.3159301 0.2281647 0.9911425
rho…386 CitG6m3 Etoposide (uM) 69 -0.1270508 0.2981977 46 -0.0413865 0.7847846 23 -0.3513714 0.1001650 0.3099849 0.2289827 0.9911425
rho…387 CitG24m2 AZD6244 (MEK) (uM) 69 0.1365841 0.2631060 46 0.0476778 0.7530302 23 0.3567194 0.0953451 -0.3090416 0.2292535 0.9911425
rho…388 LacG6m3 SCH772984 (ERK) (uM) 78 0.1107250 0.3345048 51 -0.0218690 0.8789328 27 0.2716233 0.1705184 -0.2934923 0.2293821 0.9911425
rho…389 SerG24m2 Pemetrexed (uM) 65 -0.1093769 0.3857662 43 -0.2327920 0.1330294 22 0.0971055 0.6672705 -0.3298975 0.2298571 0.9911425
rho…390 SerG6m2 Gefitinib (EGFR) (uM) 61 -0.0767919 0.5563810 41 0.0147245 0.9271973 20 -0.3235516 0.1640541 0.3382761 0.2298855 0.9911425
rho…391 MalQ24m1 Beta-catenin 59 -0.3790766 0.0032576 37 -0.4774775 0.0031105 22 -0.1744777 0.4356491 -0.3029998 0.2305302 0.9911425
rho…392 LacQ6m2 E-cadherin 59 -0.1349815 0.3080591 37 -0.2411238 0.1505277 22 0.0965556 0.6682064 -0.3376794 0.2313540 0.9911425
rho…393 SerG6m3 MK-2206 (AKT) (uM) 61 -0.0821001 0.5293358 41 -0.2250600 0.1571431 20 0.1196389 0.6153854 -0.3446988 0.2314054 0.9911425
rho…394 FumG24m2 Gemcitabine (nM) 71 -0.0335329 0.7813071 47 0.0576157 0.7004769 24 -0.2535334 0.2319295 0.3111491 0.2322101 0.9911425
rho…395 SerG24m2 Beta-catenin 53 -0.0536204 0.7022148 33 -0.1166444 0.5164989 20 0.2406015 0.3054439 -0.3572459 0.2323189 0.9911425
rho…396 CitQ6m5 Carboplatin (uM) 67 -0.0361633 0.7714077 45 -0.1244688 0.4152779 22 0.2016949 0.3680608 -0.3261637 0.2331870 0.9911425
rho…397 LacG6m3 Pemetrexed (uM) 70 -0.0423305 0.7278842 47 -0.1733929 0.2437895 23 0.1450231 0.5091097 -0.3184160 0.2336148 0.9911425
rho…398 CitG6m1 Paclitaxel/Carboplatin (nM) 68 0.1042975 0.3973152 45 0.1985372 0.1910738 23 -0.1216919 0.5801741 0.3202291 0.2337440 0.9911425
rho…399 MalG24m4 EGFR-pY1173 59 -0.0323203 0.8075812 37 -0.1529161 0.3648427 22 0.1846414 0.4089850 -0.3375575 0.2339716 0.9911425
rho…400 CitQ24m2 Pemetrexed/Cisplatin (uM) 65 -0.0868083 0.4917106 44 -0.1396103 0.3660764 21 0.1930453 0.4018041 -0.3326555 0.2346618 0.9911425
rho…401 CitG24m1 Pemetrexed/Cisplatin (uM) 65 -0.0534040 0.6726569 44 0.0518359 0.7382537 21 -0.2762432 0.2254544 0.3280792 0.2354059 0.9911425
rho…402 LacG24m1 EGFR-pY1173 59 0.0027472 0.9835249 37 -0.1581506 0.3498522 22 0.1778656 0.4266577 -0.3360162 0.2362316 0.9911425
rho…403 FumQ6m2 Cisplatin (uM) 70 -0.0819364 0.5001075 46 -0.1547311 0.3045354 24 0.1579635 0.4610032 -0.3126945 0.2363047 0.9911425
rho…404 LacG24m3 Paclitaxel (nM) 73 -0.1028699 0.3864617 48 -0.2295394 0.1165520 25 0.0734898 0.7270070 -0.3030292 0.2374632 0.9911425
rho…405 FumQ24m3 Etoposide (uM) 71 0.0859766 0.4758987 47 -0.0075168 0.9600061 24 0.2965862 0.1593374 -0.3041031 0.2375216 0.9911425
rho…406 MalG6m2 Sorafenib (multi-kinase) (uM) 73 -0.1643316 0.1647473 48 -0.2634994 0.0703602 25 0.0373149 0.8594427 -0.3008143 0.2376591 0.9911425
rho…407 LacG24m2 Pemetrexed/Cisplatin (uM) 67 0.0825950 0.5063813 45 0.0134392 0.9301789 22 0.3272112 0.1371618 -0.3137720 0.2379777 0.9911425
rho…408 LacG6m2 SCH772984 (ERK) (uM) 78 0.0675719 0.5566556 51 -0.0030401 0.9831082 27 0.2838416 0.1513442 -0.2868817 0.2381665 0.9911425
rho…409 CitQ6m1 Sorafenib (multi-kinase) (uM) 71 -0.1829617 0.1267060 47 -0.2613725 0.0759606 24 0.0452272 0.8337878 -0.3065998 0.2381965 0.9911425
rho…410 GlyG6m1 Sorafenib (multi-kinase) (uM) 66 0.1172983 0.3482591 42 0.0053500 0.9731756 24 0.3135464 0.1357051 -0.3081965 0.2383857 0.9911425
rho…411 CitQ6m2 Carboplatin (uM) 67 -0.1250262 0.3134128 45 -0.1611096 0.2903885 22 0.1615819 0.4725174 -0.3226916 0.2390229 0.9911425
rho…412 CitG24m4 8-Cl-adenosine (uM) 69 -0.1868691 0.1241779 46 -0.1109089 0.4630781 23 -0.4052385 0.0550728 0.2943295 0.2392409 0.9911425
rho…413 CitG6m2 AZD6244 (MEK) (uM) 69 0.2085118 0.0855523 46 0.1208906 0.4235387 23 0.4130435 0.0512517 -0.2921528 0.2403391 0.9911425
rho…414 LacG24m1 Cisplatin (uM) 70 -0.0947319 0.4353501 46 0.0354686 0.8149747 24 -0.2697412 0.2024162 0.3052098 0.2411149 0.9911425
rho…415 FumQ6m3 Carboplatin (uM) 69 -0.0485753 0.6918401 46 -0.1185578 0.4326045 23 0.1935723 0.3761660 -0.3121301 0.2442475 0.9911425
rho…416 SerG24m2 Erlotinib (EGFR) (uM) 68 -0.2013247 0.0997038 45 -0.3136325 0.0359084 23 -0.0084013 0.9696520 -0.3052312 0.2445237 0.9911425
rho…417 FumQ6m4 Erlotinib (EGFR) (uM) 73 -0.2008825 0.0883557 48 -0.2867767 0.0481321 25 0.0076938 0.9708838 -0.2944705 0.2445289 0.9911425
rho…418 MalG6m2 Etoposide (uM) 71 -0.1006993 0.4033951 47 -0.0085576 0.9544740 24 -0.3065884 0.1450748 0.2980308 0.2452021 0.9911425
rho…419 CitQ6m4 Crizotinib (ALK) (uM) 73 -0.0487758 0.6819587 48 -0.1123187 0.4472161 25 0.1866821 0.3715816 -0.2990008 0.2461729 0.9911425
rho…420 FumQ24m3 Carboplatin (uM) 69 0.1491609 0.2212373 46 0.0571199 0.7061344 23 0.3549185 0.0965493 -0.2977985 0.2461777 0.9911425
rho…421 MalG24m1 Cisplatin (uM) 70 0.1023299 0.3992544 46 0.0222051 0.8835460 24 0.3193388 0.1282431 -0.2971337 0.2462281 0.9911425
rho…422 CitG6m3 Erlotinib (EGFR) (uM) 71 0.0545573 0.6513516 47 0.1318993 0.3768169 24 -0.1726462 0.4198257 0.3045455 0.2469714 0.9911425
rho…423 SerG6m2 MK-2206 (AKT) (uM) 61 -0.1217648 0.3498792 41 -0.2592835 0.1016277 20 0.0714823 0.7645754 -0.3307659 0.2481869 0.9911425
rho…424 FumG6m4 Cisplatin (uM) 70 -0.0070167 0.9540275 46 0.1222514 0.4183007 24 -0.1822928 0.3939081 0.3045442 0.2485040 0.9911425
rho…425 CitG6m4 E-cadherin 57 -0.2869829 0.0304317 36 -0.4066924 0.0144396 21 -0.0935065 0.6862042 -0.3131859 0.2488916 0.9911425
rho…426 MalG24m4 Docetaxel (nM) 69 -0.0502175 0.6819705 46 -0.1628309 0.2796011 23 0.1463174 0.5052954 -0.3091483 0.2495180 0.9911425
rho…427 CitG6m1 Vinorelbine (nM) 70 0.0987557 0.4160098 46 0.2185833 0.1444499 24 -0.0826986 0.7008522 0.3012819 0.2518514 0.9911425
rho…428 FumG24m4 Vinorelbine (nM) 72 -0.0328270 0.7842807 47 -0.1405771 0.3459428 25 0.1559192 0.4567230 -0.2964963 0.2526260 0.9911425
rho…429 FumQ6m1 Sorafenib (multi-kinase) (uM) 73 -0.1956703 0.0971094 48 -0.2954256 0.0414934 25 -0.0073091 0.9723390 -0.2881165 0.2532903 0.9911425
rho…430 CitG6m4 Cisplatin (uM) 68 -0.0260749 0.8328336 45 0.0637127 0.6775609 23 -0.2412856 0.2673777 0.3049983 0.2539434 0.9911425
rho…431 MalQ24m3 Paclitaxel (nM) 73 0.1866099 0.1139244 48 0.1161844 0.4316335 25 0.3913796 0.0530282 -0.2751953 0.2540485 0.9911425
rho…432 CitQ6m4 Gefitinib (EGFR) (uM) 70 0.0247810 0.8386419 46 -0.0611930 0.6862213 24 0.2375463 0.2636940 -0.2987393 0.2543692 0.9911425
rho…433 MalQ24m4 Paclitaxel (nM) 73 0.0510569 0.6679368 48 0.1459323 0.3223164 25 -0.1481339 0.4797755 0.2940662 0.2548547 0.9911425
rho…434 CitQ6m5 CDH1 64 -0.4279122 0.0004201 42 -0.5025945 0.0006940 22 -0.2302040 0.3027046 -0.2723906 0.2551418 0.9911425
rho…435 FumQ24m2 SCH772984 (ERK) (uM) 78 0.0756815 0.5101816 51 0.1856413 0.1921490 27 -0.0963517 0.6325915 0.2819930 0.2551696 0.9911425
rho…436 MalG24m3 Gefitinib (EGFR) (uM) 72 0.1913190 0.1074212 47 0.2781633 0.0583322 25 -0.0107754 0.9592297 0.2889388 0.2562166 0.9911425
rho…437 CitQ24m2 AZD6244 (MEK) (uM) 69 0.0041289 0.9731394 46 0.1228027 0.4161889 23 -0.1818182 0.4046231 0.3046209 0.2562344 0.9911425
rho…438 CitG24m6 Paclitaxel (nM) 71 -0.1296528 0.2811951 47 -0.2393454 0.1051607 24 0.0569813 0.7914233 -0.2963267 0.2562363 0.9911425
rho…439 CitQ6m2 Vinorelbine (nM) 70 -0.0190670 0.8755064 46 0.0648862 0.6683451 24 -0.2324267 0.2744282 0.2973129 0.2570571 0.9911425
rho…440 SerG6m3 Pemetrexed (uM) 60 -0.2676139 0.0387161 41 -0.4761535 0.0016505 19 -0.1783704 0.4650202 -0.2977832 0.2571539 0.9911425
rho…441 LacQ6m3 E-cadherin 59 0.1664840 0.2075815 37 0.2569938 0.1245315 22 -0.0615645 0.7854948 0.3185584 0.2572115 0.9911425
rho…442 CitG6m5 Gemcitabine (nM) 69 -0.1011779 0.4081131 46 -0.1701758 0.2581832 23 0.1339264 0.5423754 -0.3041022 0.2573262 0.9911425
rho…443 CitG24m6 EGFR-pY1173 57 -0.1201731 0.3732409 36 -0.2589447 0.1271178 21 0.0662338 0.7755468 -0.3251784 0.2581898 0.9911425
rho…444 CitQ6m1 Doxorubicin (nM) 71 -0.0498910 0.6794714 47 -0.1685848 0.2573117 24 0.1286957 0.5474259 -0.2972805 0.2586121 0.9911425
rho…445 CitG24m4 E-cadherin 57 -0.2934924 0.0270708 36 -0.4082368 0.0140449 21 -0.1025974 0.6572536 -0.3056394 0.2593034 0.9911425
rho…446 LacQ6m1 Vinorelbine (nM) 72 0.0535759 0.6548957 47 -0.0800948 0.5925270 25 0.2105872 0.3122948 -0.2906820 0.2601082 0.9911425
rho…447 FumG6m4 Gemcitabine (nM) 71 -0.0908260 0.4512768 47 -0.1357131 0.3630513 24 0.1600348 0.4550704 -0.2957479 0.2612357 0.9911425
rho…448 MalQ24m2 Gemcitabine (nM) 71 -0.2297097 0.0539714 47 -0.1388462 0.3519731 24 -0.4113938 0.0457971 0.2725475 0.2619392 0.9911425
rho…449 CitG6m3 CDH1 64 0.1565996 0.2165529 42 0.2573375 0.0999187 22 -0.0503394 0.8239472 0.3076769 0.2622694 0.9911425
rho…450 LacG6m3 E-cadherin 59 -0.1881940 0.1531485 37 -0.2790422 0.0945651 22 0.0344438 0.8799341 -0.3134860 0.2622728 0.9911425
rho…451 SerG6m2 CDH1 56 0.0265636 0.8459136 37 -0.0948767 0.5764574 19 0.2396840 0.3229877 -0.3345607 0.2626409 0.9911425
rho…452 FumQ24m4 Gemcitabine/Cisplatin (nM) 67 0.1870211 0.1296634 45 0.1058110 0.4890793 22 0.3931093 0.0703138 -0.2872983 0.2633210 0.9911425
rho…453 CitG6m4 Gemcitabine (nM) 69 -0.2036380 0.0932930 46 -0.2224233 0.1373548 23 0.0756116 0.7316815 -0.2980348 0.2645712 0.9911425
rho…454 CitQ24m1 Vinorelbine (nM) 70 0.0570519 0.6389854 46 0.1415487 0.3480668 24 -0.1532101 0.4747687 0.2947588 0.2647013 0.9911425
rho…455 MalQ6m4 Pemetrexed/Cisplatin (uM) 66 -0.1955492 0.1155965 44 -0.3026886 0.0458110 22 -0.0033908 0.9880515 -0.2992978 0.2654034 0.9911425
rho…456 FumQ6m3 Etoposide (uM) 71 -0.0189746 0.8751987 47 -0.1169736 0.4336094 24 0.1759461 0.4108570 -0.2929197 0.2655336 0.9911425
rho…457 LacG6m3 Sorafenib (multi-kinase) (uM) 73 -0.0865255 0.4666864 48 -0.1987783 0.1755975 25 0.0877092 0.6767523 -0.2864875 0.2659542 0.9911425
rho…458 FumG6m1 Docetaxel (nM) 69 0.0180737 0.8828160 46 0.1099010 0.4671781 23 -0.1883342 0.3894645 0.2982351 0.2661630 0.9911425
rho…459 MalG24m2 AZD6244 (MEK) (uM) 71 0.0421488 0.7270870 47 0.1467025 0.3251172 24 -0.1460870 0.4941011 0.2927895 0.2661803 0.9911425
rho…460 MalQ6m1 Pemetrexed/Cisplatin (uM) 66 0.0010334 0.9934294 44 0.0845726 0.5851894 22 -0.2198983 0.3254527 0.3044708 0.2665829 0.9911425
rho…461 FumG24m2 Etoposide (uM) 71 0.0284239 0.8139759 47 0.1270924 0.3946030 24 -0.1652533 0.4403021 0.2923457 0.2667356 0.9911425
rho…462 FumG6m2 8-Cl-adenosine (uM) 71 -0.0310574 0.7970928 47 0.0496790 0.7401792 24 -0.2400522 0.2585396 0.2897312 0.2667627 0.9911425
rho…463 CitQ24m3 8-Cl-adenosine (uM) 69 0.0272048 0.8243975 46 -0.0238727 0.8748675 23 0.2693353 0.2139503 -0.2932080 0.2676464 0.9911425
rho…464 LacG24m3 Doxorubicin (nM) 73 0.0594933 0.6170884 48 -0.0463652 0.7543352 25 0.2369231 0.2530035 -0.2832882 0.2684157 0.9911425
rho…465 MalQ24m3 Carboplatin (uM) 69 0.1131667 0.3545299 46 0.0390784 0.7965250 23 0.3260816 0.1288939 -0.2870032 0.2687407 0.9911425
rho…466 CitQ24m1 Gefitinib (EGFR) (uM) 70 0.0726099 0.5502747 46 0.1618654 0.2825007 24 -0.1300849 0.5446171 0.2919503 0.2692392 0.9911425
rho…467 MalQ24m1 Gefitinib (EGFR) (uM) 72 0.0946898 0.4288345 47 0.2041406 0.1687053 25 -0.0812007 0.6996034 0.2853414 0.2693328 0.9911425
rho…468 LacG24m2 Docetaxel (nM) 69 0.1767845 0.1461884 46 0.2310730 0.1223276 23 -0.0632724 0.7742586 0.2943454 0.2697965 0.9911425
rho…469 LacQ6m2 Gemcitabine/Cisplatin (nM) 67 -0.0231683 0.8523686 45 -0.1049615 0.4925943 22 0.1959345 0.3804643 -0.3008960 0.2717691 0.9911425
rho…470 CitG24m5 Erlotinib (EGFR) (uM) 71 -0.0949778 0.4307697 47 -0.1950387 0.1889233 24 0.0934986 0.6638895 -0.2885373 0.2720051 0.9911425
rho…471 MalG6m4 Doxorubicin (nM) 73 0.0165859 0.8892338 48 -0.0489169 0.7412712 25 0.2323077 0.2625800 -0.2812246 0.2723030 0.9911425
rho…472 CitG6m6 Erlotinib (EGFR) (uM) 71 0.1462169 0.2237075 47 0.2520022 0.0874845 24 -0.0330507 0.8781520 0.2850529 0.2732082 0.9911425
rho…473 CitQ6m3 Beta-catenin 57 0.1777641 0.1858618 36 0.0903475 0.5990153 21 0.3896104 0.0818011 -0.2992629 0.2736764 0.9911425
rho…474 MalG24m3 Docetaxel (nM) 69 -0.0293849 0.8105770 46 -0.1433331 0.3419608 23 0.1502719 0.4937282 -0.2936050 0.2745297 0.9911425
rho…475 CitQ24m2 Erlotinib (EGFR) (uM) 71 0.0458120 0.7044158 47 -0.0459119 0.7592682 24 0.2387476 0.2612149 -0.2846594 0.2752313 0.9911425
rho…476 CitG24m5 Docetaxel (nM) 67 0.0031339 0.9799201 45 -0.1049961 0.4924509 22 0.1937853 0.3875267 -0.2987814 0.2752535 0.9911425
rho…477 SerG6m1 Gemcitabine/Cisplatin (nM) 59 -0.0067219 0.9597018 40 -0.0103204 0.9496042 19 -0.3245614 0.1750370 0.3142410 0.2753058 0.9911425
rho…478 MalG24m1 AZD6244 (MEK) (uM) 71 -0.1721250 0.1511891 47 -0.2496241 0.0906155 24 0.0339130 0.8755658 -0.2835372 0.2759813 0.9911425
rho…479 LacG24m2 Pemetrexed (uM) 70 0.0564814 0.6423474 47 -0.0215206 0.8858309 23 0.2657101 0.2204193 -0.2872307 0.2760152 0.9911425
rho…480 MalQ24m3 Doxorubicin (nM) 73 0.0635289 0.5933673 48 -0.0317344 0.8304529 25 0.2462012 0.2354831 -0.2779356 0.2764775 0.9911425
rho…481 LacQ6m2 Pemetrexed (uM) 70 0.0066212 0.9566168 47 -0.0906784 0.5444015 23 0.1996551 0.3610540 -0.2903334 0.2767759 0.9911425
rho…482 FumQ24m3 EGFR-pY1173 59 0.0697848 0.5994448 37 -0.0206259 0.9036119 22 0.2828910 0.2014071 -0.3035169 0.2768842 0.9911425
rho…483 FumG24m1 Paclitaxel/Carboplatin (nM) 70 -0.0385292 0.7514928 46 0.0621858 0.6813989 24 -0.2232863 0.2942726 0.2854721 0.2770475 0.9911425
rho…484 LacG24m3 Crizotinib (ALK) (uM) 75 0.0946174 0.4194006 49 -0.0286021 0.8453257 26 0.2439275 0.2298040 -0.2725296 0.2771043 0.9911425
rho…485 MalG24m3 Cisplatin (uM) 70 -0.1458568 0.2282771 46 -0.0478643 0.7520947 24 -0.3249946 0.1212476 0.2771303 0.2771433 0.9911425
rho…486 MalQ6m4 SCH772984 (ERK) (uM) 77 0.1801269 0.1169731 50 0.2757553 0.0525828 27 0.0106519 0.9579461 0.2651034 0.2775340 0.9911425
rho…487 CitQ24m2 Cisplatin (uM) 68 -0.1426472 0.2458713 45 -0.2231593 0.1406091 23 0.0677380 0.7587700 -0.2908973 0.2778425 0.9911425
rho…488 FumG6m3 Cisplatin (uM) 70 -0.2174491 0.0705667 46 -0.1307016 0.3866064 24 -0.3972157 0.0546058 0.2665140 0.2778672 0.9911425
rho…489 CitQ24m2 Gemcitabine (nM) 69 -0.2848784 0.0176665 46 -0.2058328 0.1699535 23 -0.4630591 0.0260708 0.2572262 0.2800243 0.9911425
rho…490 FumQ6m3 Paclitaxel/Carboplatin (nM) 70 -0.1446110 0.2323186 46 -0.2305842 0.1231423 24 0.0526774 0.8068757 -0.2832616 0.2801231 0.9911425
rho…491 FumG6m4 Pemetrexed (uM) 70 0.1602983 0.1849744 47 0.2792416 0.0573232 23 -0.0039732 0.9856450 0.2832148 0.2808392 0.9911425
rho…492 LacQ6m2 Etoposide (uM) 71 0.1200037 0.3188476 47 0.0097725 0.9480195 24 0.2870189 0.1738765 -0.2772465 0.2816650 0.9911425
rho…493 FumQ6m1 MK-2206 (AKT) (uM) 71 0.0728846 0.5458171 47 -0.0229613 0.8782439 24 0.2566892 0.2259720 -0.2796505 0.2816914 0.9911425
rho…494 SerG6m1 SCH772984 (ERK) (uM) 67 -0.0227305 0.8551279 44 -0.1778771 0.2480182 23 0.1130717 0.6074725 -0.2909488 0.2821365 0.9911425
rho…495 FumG6m4 Carboplatin (uM) 69 0.0147451 0.9042843 46 0.0959196 0.5260031 23 -0.1922887 0.3794005 0.2882083 0.2824234 0.9911425
rho…496 FumQ6m1 Erlotinib (EGFR) (uM) 73 0.0063870 0.9572305 48 0.0984692 0.5055051 25 -0.1784959 0.3932857 0.2769651 0.2831338 0.9911425
rho…497 FumG6m1 Pemetrexed (uM) 70 -0.2623300 0.0282449 47 -0.1390188 0.3513690 23 -0.4047733 0.0553792 0.2657545 0.2831830 0.9911425
rho…498 FumG24m3 Gemcitabine/Cisplatin (nM) 67 -0.1237229 0.3185238 45 -0.0346554 0.8212002 22 -0.3190288 0.1478121 0.2843734 0.2845172 0.9911425
rho…499 CitG6m1 Crizotinib (ALK) (uM) 73 -0.1465654 0.2159622 48 -0.0434169 0.7695145 25 -0.3110086 0.1302172 0.2675917 0.2848625 0.9911425
rho…500 LacG24m1 Gemcitabine (nM) 71 -0.0610160 0.6132248 47 0.0463621 0.7569789 24 -0.2326593 0.2739346 0.2790214 0.2852993 0.9911425
rho…501 CitQ24m6 Pemetrexed (uM) 68 -0.2239475 0.0663763 46 -0.2775487 0.0618321 22 0.0090729 0.9680354 -0.2866216 0.2857035 0.9911425
rho…502 LacQ6m1 Doxorubicin (nM) 73 0.0889482 0.4542539 48 0.0057824 0.9688857 25 0.2761538 0.1809306 -0.2703715 0.2857052 0.9911425
rho…503 MalQ24m1 Erlotinib (EGFR) (uM) 73 0.0931826 0.4329703 48 0.2031267 0.1661469 25 -0.0715522 0.7339460 0.2746789 0.2858176 0.9911425
rho…504 CitG6m1 AZD6244 (MEK) (uM) 69 -0.0380557 0.7562171 46 0.0501449 0.7406837 23 -0.2341897 0.2807953 0.2843347 0.2859509 0.9911425
rho…505 LacQ6m1 Pemetrexed (uM) 70 0.0764692 0.5292248 47 0.0212002 0.8875197 23 0.2989859 0.1657878 -0.2777857 0.2868875 0.9911425
rho…506 CitG6m6 8-Cl-adenosine (uM) 69 0.0068150 0.9556798 46 0.1141509 0.4500231 23 -0.1709909 0.4353416 0.2851417 0.2884053 0.9911425
rho…507 MalG24m3 CDH1 66 0.1519090 0.2233698 43 0.0571882 0.7156668 23 0.3339934 0.1193358 -0.2768052 0.2895222 0.9911425
rho…508 FumQ6m4 Gemcitabine/Cisplatin (nM) 67 0.0038713 0.9751965 45 -0.0903940 0.5548363 22 0.1981931 0.3749020 -0.2885871 0.2917459 0.9911425
rho…509 MalQ6m1 EGFR-pY1173 58 -0.2252026 0.0891937 36 -0.3225225 0.0555523 22 -0.0310647 0.8908461 -0.2914579 0.2921207 0.9911425
rho…510 MalG24m1 Gemcitabine/Cisplatin (nM) 67 0.1560105 0.2074151 45 0.2234155 0.1401420 22 -0.0638058 0.7778584 0.2872212 0.2923287 0.9911425
rho…511 LacG24m2 Paclitaxel (nM) 73 0.0936275 0.4307670 48 0.1766606 0.2296920 25 -0.0950366 0.6513551 0.2716972 0.2924777 0.9911425
rho…512 FumG6m4 E-cadherin 59 -0.0848042 0.5220864 37 -0.1896633 0.2598254 22 0.1089780 0.6281709 -0.2986413 0.2926813 0.9911425
rho…513 FumQ6m2 Vinorelbine (nM) 72 -0.1735949 0.1447526 47 -0.0662426 0.6582041 25 -0.3280709 0.1093659 0.2618284 0.2934489 0.9911425
rho…514 MalG6m1 Doxorubicin (nM) 73 0.0765896 0.5195533 48 -0.0471278 0.7504234 25 0.2223077 0.2841354 -0.2694355 0.2935586 0.9911425
rho…515 MalG6m3 Cisplatin (uM) 70 -0.1663021 0.1688423 46 -0.0919661 0.5432744 24 -0.3554493 0.0882766 0.2634832 0.2938801 0.9911425
rho…516 CitQ24m5 8-Cl-adenosine (uM) 69 0.2511625 0.0373705 46 0.2105913 0.1600800 23 0.4595997 0.0273578 -0.2490085 0.2957225 0.9911425
rho…517 SerG6m2 Carboplatin (uM) 60 -0.2167037 0.0962931 41 -0.3609114 0.0204363 19 -0.0667252 0.7860794 -0.2941862 0.2965222 0.9911425
rho…518 MalG24m4 Sorafenib (multi-kinase) (uM) 73 -0.3670380 0.0014026 48 -0.4523416 0.0012473 25 -0.2131179 0.3063802 -0.2392236 0.2971780 0.9911425
rho…519 GlyG24m1 Pemetrexed/Cisplatin (uM) 63 -0.0088696 0.9449959 41 0.0165955 0.9179757 22 -0.2690026 0.2260663 0.2855982 0.2980579 0.9911425
rho…520 MalG6m1 Gefitinib (EGFR) (uM) 72 -0.1011885 0.3976870 47 0.0130126 0.9308218 25 -0.2528382 0.2226914 0.2658508 0.2985273 0.9911425
rho…521 FumG24m1 Etoposide (uM) 71 -0.0394422 0.7439900 47 -0.1317585 0.3773308 24 0.1417700 0.5087394 -0.2735285 0.2993528 0.9911425
rho…522 FumQ24m4 Paclitaxel (nM) 73 0.0679299 0.5679754 48 0.1490269 0.3120492 25 -0.1185299 0.5725475 0.2675568 0.3007012 0.9911425
rho…523 FumQ6m3 EGFR-pY1173 59 0.1725040 0.1913836 37 0.0526316 0.7563832 22 0.3354985 0.1269084 -0.2828669 0.3008746 0.9911425
rho…524 LacQ24m1 8-Cl-adenosine (uM) 71 -0.2256247 0.0585075 47 -0.2845865 0.0525271 24 -0.0182688 0.9324780 -0.2663177 0.3008749 0.9911425
rho…525 CitG24m6 Docetaxel (nM) 67 -0.0459504 0.7119510 45 -0.1548906 0.3096547 22 0.1288136 0.5677893 -0.2837042 0.3014736 0.9911425
rho…526 FumQ6m2 AZD6244 (MEK) (uM) 71 -0.0501983 0.6776056 47 0.0516957 0.7300225 24 -0.2183083 0.3054466 0.2700041 0.3022403 0.9911425
rho…527 FumQ6m4 Carboplatin (uM) 69 -0.1685913 0.1661214 46 -0.2438393 0.1024606 23 0.0296589 0.8931368 -0.2734982 0.3034580 0.9911425
rho…528 CitQ6m4 SCH772984 (ERK) (uM) 76 0.1029058 0.3763750 50 0.2267285 0.1133395 26 -0.0310769 0.8802088 0.2578054 0.3035249 0.9911425
rho…529 MalG24m3 Doxorubicin (nM) 73 -0.0477370 0.6883804 48 -0.1395298 0.3442266 25 0.1253846 0.5488477 -0.2649145 0.3056485 0.9911425
rho…530 FumQ24m3 Gemcitabine (nM) 71 0.1434690 0.2326267 47 0.1776628 0.2321925 24 -0.0917591 0.6697945 0.2694219 0.3058496 0.9911425
rho…531 FumG6m3 Crizotinib (ALK) (uM) 75 -0.0511153 0.6631841 49 -0.1618572 0.2665265 26 0.0975026 0.6356082 -0.2593598 0.3065746 0.9911425
rho…532 GlyG6m2 Docetaxel (nM) 63 -0.3017921 0.0162269 41 -0.3985883 0.0098447 22 -0.1344253 0.5508922 -0.2641630 0.3075085 0.9911425
rho…533 CitQ24m6 Sorafenib (multi-kinase) (uM) 71 -0.0175767 0.8843272 47 -0.0994245 0.5061041 24 0.1691672 0.4293960 -0.2685917 0.3076750 0.9911425
rho…534 LacQ6m3 AZD6244 (MEK) (uM) 71 -0.3053627 0.0096107 47 -0.2412397 0.1023536 24 -0.4748859 0.0190304 0.2336461 0.3081995 0.9911425
rho…535 FumQ24m3 E-cadherin 59 0.2105817 0.1093971 37 0.2904220 0.0814620 22 0.0073405 0.9759039 0.2830815 0.3085144 0.9911425
rho…536 CitQ6m1 Cisplatin (uM) 68 -0.0415362 0.7366360 45 -0.0887498 0.5620870 23 0.1854141 0.3969913 -0.2741639 0.3086807 0.9911425
rho…537 CitQ6m3 EGFR-pY1173 57 0.2983909 0.0241633 36 0.1804376 0.2910952 21 0.4467532 0.0437165 -0.2663157 0.3088224 0.9911425
rho…538 MalG24m1 Gefitinib (EGFR) (uM) 72 -0.0266800 0.8239523 47 0.0565579 0.7057253 25 -0.2058880 0.3234621 0.2624460 0.3092692 0.9911425
rho…539 CitQ6m1 Crizotinib (ALK) (uM) 73 -0.0063738 0.9573189 48 0.0765093 0.6052552 25 -0.1855274 0.3746003 0.2620367 0.3095374 0.9911425
rho…540 FumG24m2 Sorafenib (multi-kinase) (uM) 73 -0.0403500 0.7346565 48 -0.1300937 0.3781497 25 0.1327178 0.5271103 -0.2628115 0.3095734 0.9911425
rho…541 FumG24m2 MK-2206 (AKT) (uM) 71 0.0753331 0.5323721 47 -0.0021400 0.9886099 24 0.2610399 0.2179267 -0.2631798 0.3098243 0.9911425
rho…542 MalG24m1 Beta-catenin 59 -0.0956764 0.4710100 37 -0.1514936 0.3693634 22 0.1372106 0.5410674 -0.2887042 0.3100696 0.9911425
rho…543 CitG6m2 SCH772984 (ERK) (uM) 76 0.1398645 0.2281892 50 0.0536648 0.7112809 26 0.3013414 0.1346529 -0.2476767 0.3119994 0.9911425
rho…544 FumQ6m2 CDH1 66 0.2397315 0.0525318 43 0.3136781 0.0405276 23 0.0480080 0.8278004 0.2656702 0.3125391 0.9911425
rho…545 LacG24m3 MK-2206 (AKT) (uM) 71 -0.0268496 0.8241093 47 0.0524002 0.7264851 24 -0.2118774 0.3202640 0.2642776 0.3130315 0.9911425
rho…546 CitG24m3 Paclitaxel/Carboplatin (nM) 68 0.0309001 0.8024758 45 0.0962045 0.5295717 23 -0.1756123 0.4228435 0.2718168 0.3132739 0.9911425
rho…547 LacG6m3 Erlotinib (EGFR) (uM) 73 -0.0404514 0.7340140 48 -0.1334817 0.3657474 25 0.1273322 0.5441539 -0.2608139 0.3133043 0.9911425
rho…548 CitQ6m2 AZD6244 (MEK) (uM) 69 0.0077281 0.9497482 46 0.0752506 0.6191649 23 -0.1946640 0.3717267 0.2699146 0.3138979 0.9911425
rho…549 FumG24m4 EGFR-pY1173 59 -0.0337814 0.7990533 37 -0.1412992 0.4027379 22 0.1451158 0.5177461 -0.2864149 0.3139996 0.9911425
rho…550 SerG6m2 Paclitaxel (nM) 62 -0.2930924 0.0207849 42 -0.3539328 0.0214756 20 -0.0774727 0.7454475 -0.2764601 0.3145269 0.9911425
rho…551 CitQ6m4 Doxorubicin (nM) 71 -0.1220453 0.3106234 47 -0.2283847 0.1225758 24 0.0339130 0.8755658 -0.2622978 0.3151588 0.9911425
rho…552 GlyG24m1 Doxorubicin (nM) 68 -0.0511511 0.6786880 44 0.0253464 0.8702707 24 -0.2391304 0.2592278 0.2644768 0.3157658 0.9911425
rho…553 CitQ24m5 Gefitinib (EGFR) (uM) 70 -0.2765440 0.0204783 46 -0.3860342 0.0080554 24 -0.1400914 0.5138213 -0.2459428 0.3175120 0.9911425
rho…554 MalQ6m2 Doxorubicin (nM) 72 -0.1806223 0.1289322 47 -0.2541858 0.0846843 25 0.0007692 0.9985325 -0.2549551 0.3181722 0.9911425
rho…555 CitQ24m1 AZD6244 (MEK) (uM) 69 -0.0210467 0.8637112 46 0.0487263 0.7477753 23 -0.2173913 0.3175224 0.2661176 0.3190602 0.9911425
rho…556 FumQ6m3 Docetaxel (nM) 69 -0.0916916 0.4536683 46 -0.1723947 0.2519350 23 0.0951792 0.6657478 -0.2675739 0.3192028 0.9911425
rho…557 GlyG6m2 Crizotinib (ALK) (uM) 68 -0.0955355 0.4383546 43 -0.2418333 0.1182010 25 0.0173177 0.9345184 -0.2591510 0.3198568 0.9911425
rho…558 SerG24m1 Etoposide (uM) 66 -0.2441153 0.0482336 43 -0.2207204 0.1549330 23 -0.4584980 0.0290154 0.2377776 0.3224027 0.9911425
rho…559 CitG24m6 Sorafenib (multi-kinase) (uM) 71 -0.3185798 0.0067753 47 -0.3941699 0.0061161 24 -0.1530768 0.4751578 -0.2410931 0.3224296 0.9911425
rho…560 SerG24m3 SCH772984 (ERK) (uM) 72 -0.0283783 0.8129428 46 0.0234056 0.8772971 26 -0.2281057 0.2623868 0.2515113 0.3224503 0.9911425
rho…561 CitQ6m5 Gefitinib (EGFR) (uM) 70 -0.2589034 0.0304501 46 -0.3290358 0.0255627 24 -0.0783120 0.7160615 -0.2507239 0.3227015 0.9911425
rho…562 CitG6m1 MK-2206 (AKT) (uM) 69 0.1671326 0.1698701 46 0.0914279 0.5456465 23 0.3436342 0.1083974 -0.2522063 0.3247595 0.9911425
rho…563 MalQ6m2 Pemetrexed/Cisplatin (uM) 66 -0.1966180 0.1135810 44 -0.2729579 0.0730228 22 -0.0067816 0.9761054 -0.2661763 0.3247829 0.9911425
rho…564 FumG24m2 8-Cl-adenosine (uM) 71 -0.1530902 0.2024534 47 -0.0710196 0.6352325 24 -0.3205045 0.1267780 0.2494849 0.3249585 0.9911425
rho…565 FumG6m3 Doxorubicin (nM) 73 -0.0667911 0.5744965 48 -0.1582605 0.2826672 25 0.0961538 0.6464110 -0.2544143 0.3249859 0.9911425
rho…566 CitG24m4 Paclitaxel (nM) 71 -0.0612454 0.6118887 47 -0.1540508 0.3011980 24 0.1048282 0.6259163 -0.2588790 0.3260124 0.9911425
rho…567 CitQ24m5 EGFR-pY1173 57 0.2608245 0.0503183 36 0.2694981 0.1119411 21 0.5103896 0.0194245 -0.2408915 0.3274603 0.9911425
rho…568 GlyG24m1 CDH1 61 0.1131095 0.3854341 38 -0.0063492 0.9698216 23 0.2617519 0.2276295 -0.2681011 0.3277245 0.9911425
rho…569 CitG24m2 MK-2206 (AKT) (uM) 69 -0.0821868 0.5019914 46 0.0126469 0.9335190 23 -0.2462300 0.2573946 0.2588769 0.3292829 0.9911425
rho…570 LacQ24m3 Doxorubicin (nM) 73 -0.0904525 0.4466272 48 0.0007601 0.9959091 25 -0.2476923 0.2315673 0.2484524 0.3294288 0.9911425
rho…571 FumG24m1 MK-2206 (AKT) (uM) 71 0.0410301 0.7340584 47 -0.0614570 0.6815337 24 0.1944747 0.3625039 -0.2559317 0.3297097 0.9911425
rho…572 FumQ6m2 E-cadherin 59 -0.1050001 0.4286777 37 -0.1657282 0.3269450 22 0.1112680 0.6220375 -0.2769962 0.3300275 0.9911425
rho…573 FumG24m3 SCH772984 (ERK) (uM) 78 -0.1379948 0.2282674 51 -0.2239856 0.1140906 27 0.0153513 0.9394213 -0.2393369 0.3306511 0.9911425
rho…574 LacQ24m2 Cisplatin (uM) 70 0.1414723 0.2427195 46 0.1019584 0.5001557 24 0.3458778 0.0978139 -0.2439195 0.3316660 0.9911425
rho…575 CitQ6m1 Erlotinib (EGFR) (uM) 71 0.0072106 0.9524106 47 0.0845380 0.5720942 24 -0.1704718 0.4257934 0.2550098 0.3327595 0.9911425
rho…576 CitQ24m1 Crizotinib (ALK) (uM) 73 0.1506243 0.2033755 48 0.0582514 0.6941174 25 0.3006159 0.1442488 -0.2423645 0.3329363 0.9911425
rho…577 SerG24m2 Doxorubicin (nM) 67 -0.1152534 0.3530261 44 -0.2056543 0.1804890 23 0.0553360 0.8020650 -0.2609902 0.3330368 0.9911425
rho…578 FumG24m2 Crizotinib (ALK) (uM) 75 0.1362126 0.2439125 49 0.2103786 0.1468000 26 -0.0335272 0.8708386 0.2439058 0.3332354 0.9911425
rho…579 SerG24m1 Erlotinib (EGFR) (uM) 68 -0.1773116 0.1480285 45 -0.2912960 0.0522075 23 -0.0375587 0.8649003 -0.2537374 0.3341113 0.9911425
rho…580 FumG24m4 Docetaxel (nM) 69 0.0400753 0.7437131 46 -0.0484359 0.7492299 23 0.2095897 0.3371452 -0.2580256 0.3344876 0.9911425
rho…581 CitG6m3 MK-2206 (AKT) (uM) 69 0.0794010 0.5166419 46 -0.0036708 0.9806839 23 0.2516688 0.2466937 -0.2553396 0.3351385 0.9911425
rho…582 SerG6m3 E-cadherin 50 0.0026411 0.9856870 32 -0.0388563 0.8325684 18 0.2610939 0.2941027 -0.2999502 0.3357284 0.9911425
rho…583 FumQ6m2 Gemcitabine/Cisplatin (nM) 67 -0.1683047 0.1733742 45 -0.1023884 0.5033190 22 -0.3530076 0.1070757 0.2506192 0.3357711 0.9911425
rho…584 CitG6m5 Cisplatin (uM) 68 -0.1411392 0.2509506 45 -0.0662164 0.6656189 23 -0.3159457 0.1419280 0.2497293 0.3370341 0.9911425
rho…585 MalG6m4 AZD6244 (MEK) (uM) 71 0.0038904 0.9743133 47 0.0703134 0.6386079 24 -0.1817391 0.3936408 0.2520525 0.3378326 0.9911425
rho…586 SerG24m2 Paclitaxel (nM) 67 -0.0214736 0.8630593 44 -0.0773189 0.6178792 23 0.1814138 0.4074337 -0.2587326 0.3387524 0.9911425
rho…587 FumQ24m1 Gefitinib (EGFR) (uM) 72 0.1163681 0.3303312 47 0.2048346 0.1672308 25 -0.0419473 0.8421955 0.2467819 0.3388434 0.9911425
rho…588 MalG6m4 SCH772984 (ERK) (uM) 78 -0.1165047 0.3097278 51 -0.0342255 0.8115483 27 -0.2666106 0.1788584 0.2323851 0.3391275 0.9911425
rho…589 LacQ24m3 E-cadherin 59 0.1026915 0.4389540 37 0.2041252 0.2247081 22 -0.0660644 0.7701323 0.2701895 0.3401935 0.9911425
rho…590 LacQ24m2 Gemcitabine/Cisplatin (nM) 67 0.0524221 0.6735303 45 -0.0413757 0.7872668 22 0.2185206 0.3270070 -0.2598963 0.3405607 0.9911425
rho…591 CitQ6m5 Crizotinib (ALK) (uM) 73 0.0274395 0.8177495 48 0.0979189 0.5078986 25 -0.1485759 0.4784512 0.2464948 0.3405962 0.9911425
rho…592 GlyG24m2 Crizotinib (ALK) (uM) 71 -0.1028299 0.3934675 45 -0.2019131 0.1834832 26 0.0400274 0.8460663 -0.2419405 0.3453620 0.9911425
rho…593 SerG24m3 Beta-catenin 53 -0.1937591 0.1640834 33 -0.2416444 0.1749359 20 0.0390977 0.8711872 -0.2807421 0.3467475 0.9911425
rho…594 MalG6m2 Paclitaxel (nM) 73 0.0009721 0.9934877 48 0.1128152 0.4451975 25 -0.1304348 0.5343042 0.2432500 0.3473340 0.9911425
rho…595 MalG24m1 CDH1 66 0.1651389 0.1851448 43 0.0718441 0.6470794 23 0.3176649 0.1396538 -0.2458208 0.3478734 0.9911425
rho…596 FumG6m2 MK-2206 (AKT) (uM) 71 0.0571036 0.6362069 47 -0.0489300 0.7439627 24 0.1970851 0.3559698 -0.2460151 0.3484721 0.9911425
rho…597 LacQ24m3 SCH772984 (ERK) (uM) 78 -0.1256853 0.2728792 51 -0.0382462 0.7898858 27 -0.2659840 0.1799205 0.2277378 0.3487129 0.9911425
rho…598 CitQ24m2 8-Cl-adenosine (uM) 69 -0.1538180 0.2069878 46 -0.0891343 0.5558108 23 -0.3301211 0.1239474 0.2409868 0.3487851 0.9911425
rho…599 FumG24m1 Gefitinib (EGFR) (uM) 72 -0.0388707 0.7458026 47 -0.1371562 0.3579226 25 0.1050606 0.6172184 -0.2422169 0.3511083 0.9911425
rho…600 MalQ6m3 MK-2206 (AKT) (uM) 70 0.0236772 0.8457387 46 0.1127769 0.4555314 24 -0.1340005 0.5324657 0.2467773 0.3514340 0.9911425
rho…601 LacG6m2 AZD6244 (MEK) (uM) 71 0.1715953 0.1524702 47 0.1513820 0.3097507 24 0.3791304 0.0685462 -0.2277485 0.3527101 0.9911425
rho…602 CitQ24m2 Gefitinib (EGFR) (uM) 70 -0.0816752 0.5014795 46 -0.1738326 0.2479407 24 0.0713509 0.7404110 -0.2451835 0.3533431 0.9911425
rho…603 LacQ24m3 CDH1 66 -0.2723562 0.0269417 43 -0.3704767 0.0144646 23 -0.1340922 0.5418711 -0.2363846 0.3535446 0.9911425
rho…604 FumQ6m4 EGFR-pY1173 59 0.0864407 0.5140633 37 -0.0429113 0.8004493 22 0.2185206 0.3270070 -0.2614319 0.3548025 0.9911425
rho…605 CitQ24m2 Etoposide (uM) 69 -0.2762609 0.0215739 46 -0.3584667 0.0144357 23 -0.1245367 0.5712838 -0.2339300 0.3557735 0.9911425
rho…606 CitQ24m4 Vinorelbine (nM) 70 -0.1111461 0.3596597 46 -0.0099300 0.9477786 24 -0.2502722 0.2381940 0.2403422 0.3559119 0.9911425
rho…607 LacG24m3 SCH772984 (ERK) (uM) 78 0.1450187 0.2052265 51 0.0521718 0.7161626 27 0.2753828 0.1644456 -0.2232110 0.3566124 0.9911425
rho…608 CitG6m2 Gemcitabine (nM) 69 -0.0014632 0.9904799 46 -0.0875331 0.5629588 23 0.1601186 0.4655077 -0.2476517 0.3570697 0.9911425
rho…609 GlyG6m1 EGFR-pY1173 53 -0.0169328 0.9041017 32 0.1356305 0.4576314 21 -0.1389610 0.5465505 0.2745915 0.3570875 0.9911425
rho…610 FumG24m2 Doxorubicin (nM) 73 -0.0732712 0.5378594 48 0.0077637 0.9582326 25 -0.2276923 0.2723913 0.2354560 0.3572066 0.9911425
rho…611 MalG24m1 EGFR-pY1173 59 -0.1792253 0.1743916 37 -0.2034139 0.2263543 22 0.0570299 0.8011587 -0.2604439 0.3578179 0.9911425
rho…612 SerG24m1 Pemetrexed (uM) 65 -0.1745122 0.1644202 43 -0.3449310 0.0234984 22 -0.1033520 0.6471706 -0.2415790 0.3582824 0.9911425
rho…613 MalG24m2 CDH1 66 0.2843913 0.0206528 43 0.3432177 0.0242440 23 0.1068779 0.6274079 0.2363398 0.3604513 0.9911425
rho…614 LacQ6m2 Beta-catenin 59 -0.0420520 0.7518228 37 -0.1102484 0.5159622 22 0.1496330 0.5046442 -0.2598813 0.3613329 0.9911425
rho…615 CitQ6m4 Gemcitabine (nM) 69 -0.1934872 0.1111700 46 -0.2116519 0.1579376 23 0.0321226 0.8843158 -0.2437744 0.3613925 0.9911425
rho…616 CitQ24m5 Pemetrexed/Cisplatin (uM) 65 -0.1015605 0.4208176 44 -0.1296734 0.4015009 21 -0.3698409 0.0989103 0.2401676 0.3618319 0.9911425
rho…617 FumG6m1 Crizotinib (ALK) (uM) 75 -0.0260207 0.8246265 49 0.0684460 0.6402840 26 -0.1628464 0.4267029 0.2312924 0.3618540 0.9911425
rho…618 CitQ6m5 Vinorelbine (nM) 70 -0.0159780 0.8955514 46 -0.1181115 0.4343514 24 0.1227422 0.5677428 -0.2408536 0.3632856 0.9911425
rho…619 MalQ6m4 Vinorelbine (nM) 71 -0.2461820 0.0384979 46 -0.3227856 0.0286750 25 -0.0962464 0.6471968 -0.2265392 0.3634806 0.9911425
rho…620 GlyG24m1 E-cadherin 53 -0.0253598 0.8569571 32 -0.1130969 0.5376958 21 0.1571429 0.4946883 -0.2702397 0.3646170 0.9911425
rho…621 CitQ6m3 E-cadherin 57 0.1053945 0.4352384 36 0.0229086 0.8945260 21 0.2805195 0.2172785 -0.2576109 0.3651881 0.9911425
rho…622 CitG6m4 SCH772984 (ERK) (uM) 76 -0.1945279 0.0922056 50 -0.1027193 0.4778001 26 -0.3212446 0.1095501 0.2185253 0.3661814 0.9911425
rho…623 CitQ6m3 Cisplatin (uM) 68 -0.1379909 0.2617841 45 -0.1939055 0.2018468 23 0.0489493 0.8244743 -0.2428548 0.3664198 0.9911425
rho…624 LacQ24m1 Gemcitabine/Cisplatin (nM) 67 0.0744739 0.5492022 45 0.0365026 0.8118380 22 0.2783738 0.2089387 -0.2418712 0.3670285 0.9911425
rho…625 MalQ24m2 EGFR-pY1173 59 0.1274109 0.3352974 37 0.0021337 0.9905061 22 0.2546584 0.2516245 -0.2525247 0.3672562 0.9911425
rho…626 FumQ6m3 CDH1 66 -0.2216329 0.0737008 43 -0.3388986 0.0262113 23 -0.1059145 0.6305320 -0.2329841 0.3680050 0.9911425
rho…627 MalQ6m2 Gemcitabine/Cisplatin (nM) 66 -0.2738072 0.0261068 44 -0.2093745 0.1725599 22 -0.4319593 0.0459595 0.2225849 0.3680997 0.9911425
rho…628 CitQ24m3 Erlotinib (EGFR) (uM) 71 -0.1885067 0.1154084 47 -0.2597219 0.0778987 24 -0.0273973 0.8988795 -0.2323246 0.3687223 0.9911425
rho…629 CitG6m6 Carboplatin (uM) 67 -0.0878355 0.4796892 45 -0.0085332 0.9556344 22 -0.2514125 0.2590488 0.2428793 0.3689779 0.9911425
rho…630 LacG24m2 CDH1 66 0.0346415 0.7824445 43 -0.0376974 0.8103309 23 0.2053441 0.3472448 -0.2430415 0.3690037 0.9911425
rho…631 LacQ6m1 Gefitinib (EGFR) (uM) 72 0.2873547 0.0143863 47 0.3316176 0.0227806 25 0.1096787 0.6017423 0.2219389 0.3691031 0.9911425
rho…632 CitQ6m4 Beta-catenin 57 -0.3121648 0.0180795 36 -0.4223938 0.0108348 21 -0.1857143 0.4185091 -0.2366795 0.3699525 0.9911425
rho…633 CitG6m4 Gefitinib (EGFR) (uM) 70 0.2490790 0.0375883 46 0.3461230 0.0184599 24 0.1222537 0.5692968 0.2238693 0.3709996 0.9911425
rho…634 CitQ24m6 Gemcitabine (nM) 69 -0.0439133 0.7201338 46 -0.0903807 0.5502759 23 0.1502347 0.4938362 -0.2406155 0.3712423 0.9911425
rho…635 FumQ6m1 Pemetrexed (uM) 70 -0.1097140 0.3659218 47 -0.0232165 0.8769007 23 -0.2577636 0.2350502 0.2345471 0.3725198 0.9911425
rho…636 CitG24m6 Erlotinib (EGFR) (uM) 71 -0.1243911 0.3013446 47 -0.1976986 0.1828445 24 0.0360948 0.8670222 -0.2337934 0.3726702 0.9911425
rho…637 LacG6m3 EGFR-pY1173 59 -0.1319112 0.3183960 37 -0.0187293 0.9124900 22 -0.2670807 0.2286022 0.2483515 0.3733503 0.9911425
rho…638 MalG24m1 E-cadherin 59 0.0002046 0.9987731 37 -0.0704125 0.6778144 22 0.1823828 0.4148296 -0.2527954 0.3733701 0.9911425
rho…639 CitQ6m6 Pemetrexed/Cisplatin (uM) 65 -0.1106084 0.3804070 44 -0.0420734 0.7862612 21 -0.2853430 0.2099136 0.2432696 0.3739482 0.9911425
rho…640 MalG6m1 Gemcitabine (nM) 71 -0.0982244 0.4151092 47 -0.0486251 0.7455046 24 -0.2770167 0.1900354 0.2283916 0.3740111 0.9911425
rho…641 MalQ24m1 Pemetrexed (uM) 70 -0.1809381 0.1338784 47 -0.2463174 0.0951132 23 -0.0119197 0.9569521 -0.2343977 0.3743563 0.9911425
rho…642 FumQ6m1 Cisplatin (uM) 70 0.0664929 0.5844419 46 0.1390285 0.3568035 24 -0.0961497 0.6549273 0.2351782 0.3745890 0.9911425
rho…643 LacQ24m2 Paclitaxel/Carboplatin (nM) 70 0.1659608 0.1697308 46 0.2414410 0.1059901 24 0.0100109 0.9629707 0.2314301 0.3747707 0.9911425
rho…644 MalQ6m1 Beta-catenin 58 -0.3054278 0.0197298 36 -0.3719434 0.0261514 22 -0.1349901 0.5492042 -0.2369533 0.3761718 0.9911425
rho…645 FumG24m1 SCH772984 (ERK) (uM) 78 -0.1242961 0.2782579 51 -0.0544323 0.7044142 27 -0.2684903 0.1756982 0.2140581 0.3772361 0.9911425
rho…646 MalG24m4 Vinorelbine (nM) 72 -0.0286774 0.8110080 47 -0.1231134 0.4096904 25 0.1058711 0.6144906 -0.2289845 0.3783866 0.9911425
rho…647 CitG24m1 Paclitaxel (nM) 71 0.1129503 0.3483223 47 0.1615729 0.2779176 24 -0.0704654 0.7435263 0.2320384 0.3784868 0.9911425
rho…648 FumQ24m1 Beta-catenin 59 -0.3533606 0.0063032 37 -0.4234234 0.0095341 22 -0.1970638 0.3776772 -0.2263596 0.3786327 0.9911425
rho…649 LacQ6m1 Gemcitabine (nM) 71 -0.2013016 0.0923035 47 -0.2232229 0.1314947 24 0.0056534 0.9790839 -0.2288763 0.3802957 0.9911425
rho…650 LacQ6m2 CDH1 66 -0.0190856 0.8791053 43 0.0662184 0.6731042 23 -0.1721922 0.4320739 0.2384106 0.3803596 0.9911425
rho…651 CitQ6m3 Docetaxel (nM) 67 -0.2479765 0.0430424 45 -0.3350251 0.0244727 22 -0.1056497 0.6398355 -0.2293754 0.3805657 0.9911425
rho…652 CitQ24m1 Doxorubicin (nM) 71 -0.0105819 0.9302068 47 -0.0772656 0.6057039 24 0.1539130 0.4709984 -0.2311787 0.3805680 0.9911425
rho…653 FumG24m2 Gemcitabine/Cisplatin (nM) 67 0.0936293 0.4510749 45 0.1676110 0.2710982 22 -0.0728402 0.7470858 0.2404512 0.3810680 0.9911425
rho…654 FumG24m1 8-Cl-adenosine (uM) 71 0.0679524 0.5733905 47 0.1277076 0.3922999 24 -0.1035008 0.6303203 0.2312083 0.3811509 0.9911425
rho…655 CitG6m3 SCH772984 (ERK) (uM) 76 -0.2943825 0.0098427 50 -0.2064796 0.1502473 26 -0.4071427 0.0389860 0.2006630 0.3815121 0.9911425
rho…656 MalQ24m2 Crizotinib (ALK) (uM) 75 0.1641977 0.1592245 49 0.0745187 0.6108412 26 0.2890866 0.1520420 -0.2145680 0.3827310 0.9911425
rho…657 CitQ6m3 Pemetrexed (uM) 68 -0.1888010 0.1230901 46 -0.1053137 0.4860809 22 -0.3328638 0.1301065 0.2275501 0.3829625 0.9911425
rho…658 GlyG6m1 E-cadherin 53 0.0317691 0.8209457 32 -0.0868768 0.6351836 21 0.1727273 0.4522988 -0.2596041 0.3833590 0.9911425
rho…659 CitG24m2 SCH772984 (ERK) (uM) 76 0.1095687 0.3460862 50 0.0358974 0.8045272 26 0.2521072 0.2140649 -0.2162098 0.3835272 0.9911425
rho…660 LacQ24m3 EGFR-pY1173 59 0.0171250 0.8975677 37 -0.1280228 0.4487228 22 0.1202710 0.5926473 -0.2482938 0.3835582 0.9911425
rho…661 FumQ6m1 Paclitaxel/Carboplatin (nM) 70 -0.0067378 0.9558530 46 0.0866079 0.5671089 24 -0.1440697 0.5018167 0.2306776 0.3837050 0.9911425
rho…662 SerG6m3 CDH1 56 0.0454336 0.7395139 37 -0.0742366 0.6623520 19 0.1870062 0.4433177 -0.2612428 0.3845726 0.9911425
rho…663 CitQ6m2 Crizotinib (ALK) (uM) 73 0.0678586 0.5683824 48 0.1361229 0.3562514 25 -0.0889146 0.6725497 0.2250375 0.3847318 0.9911425
rho…664 CitQ6m2 SCH772984 (ERK) (uM) 76 -0.0609375 0.6010280 50 0.0208500 0.8857230 26 -0.1976353 0.3331568 0.2184853 0.3848701 0.9911425
rho…665 LacQ6m2 Crizotinib (ALK) (uM) 75 -0.1423418 0.2231382 49 -0.2064563 0.1546573 26 0.0119740 0.9537050 -0.2184303 0.3858780 0.9911425
rho…666 LacG24m1 MK-2206 (AKT) (uM) 71 0.1608637 0.1801970 47 0.0857192 0.5667169 24 0.3054166 0.1466969 -0.2196974 0.3867706 0.9911425
rho…667 GlyG24m2 Beta-catenin 53 -0.1223190 0.3818287 32 -0.1451613 0.4263718 21 0.1129870 0.6247528 -0.2581483 0.3868371 0.9911425
rho…668 MalQ24m3 EGFR-pY1173 59 0.0446237 0.7371767 37 -0.0229967 0.8925309 22 0.2208416 0.3233290 -0.2438383 0.3874650 0.9911425
rho…669 CitG6m3 E-cadherin 57 -0.1198470 0.3735377 36 -0.2079794 0.2226620 21 0.0415584 0.8589060 -0.2495378 0.3885734 0.9911425
rho…670 MalQ6m4 Sorafenib (multi-kinase) (uM) 72 -0.0270342 0.8216531 47 0.0633314 0.6723596 25 -0.1600308 0.4447875 0.2233622 0.3892100 0.9911425
rho…671 MalQ6m1 Cisplatin (uM) 69 0.1418262 0.2450481 45 0.2268235 0.1340378 24 0.0013055 0.9951696 0.2255180 0.3904330 0.9911425
rho…672 FumG24m3 Beta-catenin 59 -0.2823244 0.0302761 37 -0.3492176 0.0347385 22 -0.1180124 0.5996821 -0.2312052 0.3904515 0.9911425
rho…673 MalG6m1 Gemcitabine/Cisplatin (nM) 67 -0.0459376 0.7120279 45 0.0185149 0.9039155 22 -0.2151327 0.3347169 0.2336476 0.3912037 0.9911425
rho…674 FumQ24m3 Beta-catenin 59 0.2791683 0.0322561 37 0.3423423 0.0386635 22 0.1112366 0.6209973 0.2311058 0.3922706 0.9911425
rho…675 SerG24m1 Paclitaxel (nM) 67 -0.1229544 0.3215621 44 -0.0809839 0.6012654 23 -0.3044983 0.1577457 0.2235144 0.3923261 0.9911425
rho…676 CitQ24m5 Docetaxel (nM) 67 -0.0932772 0.4527867 45 -0.0349987 0.8194585 22 -0.2644068 0.2344027 0.2294081 0.3936788 0.9911425
rho…677 FumQ6m1 Carboplatin (uM) 69 -0.0072355 0.9529477 46 0.0619313 0.6826336 23 -0.1670786 0.4460741 0.2290100 0.3940708 0.9911425
rho…678 CitQ24m1 MK-2206 (AKT) (uM) 69 0.0580131 0.6358646 46 -0.0178291 0.9063815 23 0.2096416 0.3370230 -0.2274706 0.3941594 0.9911425
rho…679 CitQ6m2 MK-2206 (AKT) (uM) 69 -0.0318390 0.7950885 46 -0.1014868 0.5021503 23 0.1280594 0.5603591 -0.2295462 0.3942078 0.9911425
rho…680 LacG24m2 Etoposide (uM) 71 0.0279711 0.8168872 47 0.0935558 0.5316501 24 -0.1313329 0.5407302 0.2248887 0.3943164 0.9911425
rho…681 FumG24m4 Beta-catenin 59 -0.3171829 0.0147116 37 -0.3733997 0.0234495 22 -0.1473744 0.5111744 -0.2260254 0.3944617 0.9911425
rho…682 MalG24m4 AZD6244 (MEK) (uM) 71 0.0192674 0.8732885 47 0.0678848 0.6502704 24 -0.1565217 0.4634253 0.2244066 0.3945626 0.9911425
rho…683 MalG24m4 CDH1 66 0.2523256 0.0409597 43 0.1965702 0.2064515 23 0.4072246 0.0537793 -0.2106543 0.3946453 0.9911425
rho…684 CitQ6m4 Docetaxel (nM) 67 -0.0699536 0.5737693 45 -0.1741366 0.2526075 22 0.0593220 0.7931411 -0.2334586 0.3946952 0.9911425
rho…685 SerG24m1 Vinorelbine (nM) 66 -0.0005639 0.9964149 43 -0.1152030 0.4619554 23 0.1166584 0.5960495 -0.2318615 0.3950679 0.9911425
rho…686 LacQ6m3 Pemetrexed/Cisplatin (uM) 67 0.1388504 0.2624628 45 0.0760895 0.6193432 22 0.3013002 0.1729940 -0.2252108 0.3959199 0.9911425
rho…687 CitQ6m1 Etoposide (uM) 69 -0.1307402 0.2842712 46 -0.2135258 0.1542037 23 0.0128490 0.9535993 -0.2263748 0.3960383 0.9911425
rho…688 FumG24m4 CDH1 66 0.1748572 0.1602445 43 0.0952633 0.5434129 23 0.3166753 0.1409597 -0.2214120 0.3961126 0.9911425
rho…689 LacG24m1 Carboplatin (uM) 69 -0.1645364 0.1766951 46 -0.0880294 0.5607388 23 -0.3074642 0.1535339 0.2194348 0.3965068 0.9911425
rho…690 FumQ24m3 Vinorelbine (nM) 72 0.0032007 0.9787121 47 -0.0787024 0.5989965 25 0.1412898 0.5005191 -0.2199921 0.3971207 0.9911425
rho…691 CitQ24m6 8-Cl-adenosine (uM) 69 -0.0105968 0.9311342 46 0.0399716 0.7919762 23 -0.1868050 0.3933960 0.2267767 0.3974686 0.9911425
rho…692 SerG24m3 Sorafenib (multi-kinase) (uM) 67 -0.1998343 0.1049465 44 -0.2917372 0.0546705 23 -0.0696812 0.7520574 -0.2220559 0.3977026 0.9911425
rho…693 CitG24m3 Sorafenib (multi-kinase) (uM) 71 -0.1316081 0.2739407 47 -0.0252755 0.8660793 24 -0.2444010 0.2497496 0.2191255 0.3980053 0.9911425
rho…694 FumQ24m1 Sorafenib (multi-kinase) (uM) 73 -0.2573139 0.0279709 48 -0.3056332 0.0346425 25 -0.0957877 0.6487724 -0.2098456 0.3985088 0.9911425
rho…695 MalG6m2 Paclitaxel/Carboplatin (nM) 70 0.0883094 0.4672455 46 0.1705632 0.2570849 24 -0.0517955 0.8100511 0.2223587 0.3999383 0.9911425
rho…696 MalQ6m3 EGFR-pY1173 58 0.1948076 0.1425523 36 0.1024453 0.5507844 22 0.3314512 0.1320144 -0.2290059 0.4014043 0.9911425
rho…697 CitQ6m2 Pemetrexed (uM) 68 -0.2179599 0.0741712 46 -0.2864845 0.0535781 22 -0.0635106 0.7788745 -0.2229739 0.4014468 0.9911425
rho…698 MalG24m3 Paclitaxel (nM) 73 -0.0829585 0.4853221 48 -0.1384945 0.3478539 25 0.0784917 0.7091913 -0.2169863 0.4019439 0.9911425
rho…699 MalG6m2 CDH1 66 0.2691557 0.0288629 43 0.3688903 0.0149234 23 0.1563584 0.4761851 0.2125319 0.4020500 0.9911425
rho…700 SerG6m2 Beta-catenin 50 -0.2485534 0.0817688 32 -0.2727523 0.1309577 18 -0.0134159 0.9606477 -0.2593364 0.4022061 0.9911425
rho…701 LacQ6m2 Doxorubicin (nM) 73 0.2119267 0.0718677 48 0.2723423 0.0611131 25 0.0615385 0.7697914 0.2108038 0.4025231 0.9911425
rho…702 FumG24m2 Paclitaxel/Carboplatin (nM) 70 -0.0098005 0.9358219 46 0.0588489 0.6976568 24 -0.1623505 0.4484853 0.2211994 0.4028292 0.9911425
rho…703 FumQ6m2 Gemcitabine (nM) 71 -0.3094835 0.0086323 47 -0.2370841 0.1085886 24 -0.4327969 0.0346509 0.1957128 0.4033255 0.9911425
rho…704 CitG24m1 Beta-catenin 57 0.1342408 0.3194652 36 0.0437609 0.7999436 21 0.2805195 0.2172785 -0.2367586 0.4041245 0.9911425
rho…705 FumQ24m1 Doxorubicin (nM) 73 0.0303947 0.7985154 48 -0.0321407 0.8283146 25 0.1823077 0.3813922 -0.2144484 0.4052404 0.9911425
rho…706 GlyG24m2 Etoposide (uM) 67 -0.1590349 0.1986323 43 -0.0847240 0.5890769 24 -0.2996304 0.1548963 0.2149064 0.4054526 0.9911425
rho…707 GlyG24m1 Paclitaxel/Carboplatin (nM) 64 0.0527846 0.6786958 41 0.1394153 0.3846593 23 -0.0890208 0.6862685 0.2284361 0.4059327 0.9911425
rho…708 CitQ6m3 Paclitaxel (nM) 71 -0.2194924 0.0658939 47 -0.3013358 0.0395574 24 -0.0904741 0.6741687 -0.2108617 0.4062701 0.9911425
rho…709 CitG24m1 CDH1 64 -0.0817598 0.5207021 42 0.0078648 0.9605750 22 -0.2205886 0.3238978 0.2284533 0.4066833 0.9911425
rho…710 MalG6m1 Vinorelbine (nM) 72 0.0024448 0.9837390 47 0.0714781 0.6330448 25 -0.1439847 0.4922987 0.2154628 0.4068294 0.9911425
rho…711 CitG24m2 Docetaxel (nM) 67 0.0566290 0.6489863 45 0.1330741 0.3835070 22 -0.0949153 0.6743714 0.2279894 0.4073743 0.9911425
rho…712 FumQ6m4 Pemetrexed/Cisplatin (uM) 67 -0.1714958 0.1652463 45 -0.2484272 0.0998637 22 -0.0248658 0.9125367 -0.2235614 0.4077943 0.9911425
rho…713 CitQ24m5 Doxorubicin (nM) 71 -0.0196210 0.8709826 47 0.0122029 0.9351167 24 -0.2043478 0.3365599 0.2165507 0.4079701 0.9911425
rho…714 FumQ24m4 Etoposide (uM) 71 -0.0106737 0.9296030 47 -0.1164532 0.4356719 24 0.1020009 0.6353112 -0.2184541 0.4082444 0.9911425
rho…715 FumG6m4 Gemcitabine/Cisplatin (nM) 67 -0.1075779 0.3862102 45 -0.0175254 0.9090284 22 -0.2411067 0.2784220 0.2235814 0.4087030 0.9911425
rho…716 CitQ6m5 Gemcitabine (nM) 69 0.0374570 0.7599362 46 0.0397428 0.7931411 23 -0.1808747 0.4088522 0.2206175 0.4107204 0.9911425
rho…717 LacG6m1 AZD6244 (MEK) (uM) 71 -0.1667393 0.1645948 47 -0.0452508 0.7626328 24 -0.2573913 0.2237343 0.2121405 0.4110495 0.9911425
rho…718 FumQ24m1 SCH772984 (ERK) (uM) 78 -0.0835082 0.4672946 51 -0.0207903 0.8848633 27 -0.2224366 0.2647795 0.2016463 0.4112481 0.9911425
rho…719 LacG24m3 AZD6244 (MEK) (uM) 71 0.0842968 0.4845923 47 0.0049150 0.9738434 24 0.2191304 0.3021303 -0.2142154 0.4114861 0.9911425
rho…720 FumQ6m1 Gefitinib (EGFR) (uM) 72 0.1317101 0.2700920 47 0.2030419 0.1710591 25 -0.0084664 0.9679612 0.2115083 0.4116611 0.9911425
rho…721 LacG6m1 Sorafenib (multi-kinase) (uM) 73 -0.0415323 0.7271809 48 0.0542463 0.7142214 25 -0.1573380 0.4525857 0.2115843 0.4130175 0.9911425
rho…722 MalG24m1 Gemcitabine (nM) 71 0.0115695 0.9237116 47 0.0774591 0.6047986 24 -0.1382909 0.5192994 0.2157501 0.4137012 0.9911425
rho…723 FumQ6m1 EGFR-pY1173 59 -0.1696084 0.1985301 37 -0.2527264 0.1310786 22 -0.0242801 0.9158000 -0.2284463 0.4138820 0.9911425
rho…724 CitQ24m3 Carboplatin (uM) 67 0.1195877 0.3350906 45 0.0787757 0.6069909 22 0.2954803 0.1818546 -0.2167046 0.4144724 0.9911425
rho…725 CitG6m6 Etoposide (uM) 69 0.0466259 0.7036222 46 0.1209523 0.4233005 23 -0.0988386 0.6536619 0.2197910 0.4148113 0.9911425
rho…726 GlyG24m1 Erlotinib (EGFR) (uM) 69 0.0980953 0.4226160 45 0.1462836 0.3376305 24 -0.0704501 0.7435803 0.2167337 0.4148801 0.9911425
rho…727 FumQ24m1 CDH1 66 0.4170347 0.0004950 43 0.4618872 0.0018213 23 0.2696688 0.2133617 0.1922184 0.4150637 0.9911425
rho…728 MalQ6m3 Sorafenib (multi-kinase) (uM) 72 0.0097458 0.9352426 47 0.1034702 0.4888645 25 -0.1084824 0.6057356 0.2119526 0.4151975 0.9911425
rho…729 FumG6m2 Docetaxel (nM) 69 0.1454625 0.2330325 46 0.2447708 0.1011143 23 0.0296589 0.8931368 0.2151119 0.4159426 0.9911425
rho…730 LacG24m1 Paclitaxel/Carboplatin (nM) 70 0.2665372 0.0257227 46 0.3714065 0.0110441 24 0.1719261 0.4217970 0.1994804 0.4162969 0.9911425
rho…731 SerG6m2 Cisplatin (uM) 60 -0.1521787 0.2457434 41 -0.2230451 0.1609903 19 0.0149254 0.9516424 -0.2379705 0.4171907 0.9911425
rho…732 LacG24m1 Doxorubicin (nM) 73 -0.1484405 0.2100811 48 -0.0725106 0.6242957 25 -0.2761538 0.1809306 0.2036433 0.4175957 0.9911425
rho…733 FumG24m2 Pemetrexed/Cisplatin (uM) 67 0.0959850 0.4397165 45 0.1499391 0.3255632 22 -0.0729020 0.7471420 0.2228410 0.4176056 0.9911425
rho…734 LacG6m2 Vinorelbine (nM) 72 0.0655574 0.5842917 47 0.1413867 0.3431442 25 -0.0689124 0.7434324 0.2102991 0.4182533 0.9911425
rho…735 SerG6m1 Crizotinib (ALK) (uM) 65 -0.0552555 0.6619847 43 -0.1908725 0.2201750 22 0.0322216 0.8868057 -0.2230942 0.4183745 0.9911425
rho…736 CitG6m2 Docetaxel (nM) 67 0.0279452 0.8223833 45 -0.0559584 0.7150345 22 0.1661017 0.4600498 -0.2220601 0.4185156 0.9911425
rho…737 SerG24m1 Sorafenib (multi-kinase) (uM) 67 -0.1282996 0.3008101 44 -0.2933587 0.0532780 23 -0.0815419 0.7114794 -0.2118169 0.4188048 0.9911425
rho…738 LacQ24m3 Erlotinib (EGFR) (uM) 73 -0.2259326 0.0546079 48 -0.2992618 0.0387990 25 -0.0980958 0.6408604 -0.2011660 0.4188759 0.9911425
rho…739 CitG24m6 Carboplatin (uM) 67 -0.3177994 0.0087758 45 -0.3672125 0.0130872 22 -0.1604520 0.4756609 -0.2067605 0.4191927 0.9911425
rho…740 CitQ24m5 Gemcitabine (nM) 69 0.1407383 0.2487240 46 0.1262235 0.4032224 23 -0.0914258 0.6782284 0.2176493 0.4193238 0.9911425
rho…741 LacG24m3 Gemcitabine/Cisplatin (nM) 67 -0.0952657 0.4431679 45 -0.1579918 0.2999478 22 0.0638058 0.7778584 -0.2217976 0.4194586 0.9911425
rho…742 CitQ24m6 Crizotinib (ALK) (uM) 73 -0.0518234 0.6632505 48 0.0305929 0.8364670 25 -0.1774442 0.3961247 0.2080371 0.4196534 0.9911425
rho…743 CitG24m3 Vinorelbine (nM) 70 -0.0413980 0.7336535 46 -0.1068246 0.4798113 24 0.1070730 0.6184970 -0.2138975 0.4199339 0.9911425
rho…744 SerG24m1 Docetaxel (nM) 65 -0.2372552 0.0570450 43 -0.2124188 0.1714551 22 -0.4135594 0.0557224 0.2011406 0.4210235 0.9911425
rho…745 LacQ24m3 AZD6244 (MEK) (uM) 71 -0.2468327 0.0379718 47 -0.1739910 0.2421420 24 -0.3704348 0.0755451 0.1964438 0.4216068 0.9911425
rho…746 MalQ24m3 Beta-catenin 59 0.2444220 0.0620863 37 0.3124704 0.0601556 22 0.0931940 0.6799708 0.2192763 0.4223572 0.9911425
rho…747 SerG6m3 Doxorubicin (nM) 62 -0.1940383 0.1307454 42 -0.2725246 0.0807969 20 -0.0466165 0.8462017 -0.2259081 0.4228414 0.9911425
rho…748 FumQ6m4 Doxorubicin (nM) 73 -0.1475299 0.2129229 48 -0.1101037 0.4562823 25 -0.3084615 0.1335499 0.1983578 0.4233227 0.9911425
rho…749 FumG24m3 Gemcitabine (nM) 71 -0.0902558 0.4541346 47 -0.1487100 0.3184674 24 0.0617526 0.7743818 -0.2104625 0.4248714 0.9911425
rho…750 MalQ6m3 Gemcitabine/Cisplatin (nM) 66 0.0222958 0.8589643 44 -0.0365802 0.8136351 22 0.1823828 0.4148296 -0.2189630 0.4257585 0.9911425
rho…751 SerG6m1 E-cadherin 50 0.0739016 0.6090228 32 0.0076979 0.9672413 18 0.2549020 0.3060426 -0.2472040 0.4264149 0.9911425
rho…752 CitG6m2 MK-2206 (AKT) (uM) 69 -0.0608270 0.6195442 46 -0.0035165 0.9814960 23 -0.2150804 0.3243466 0.2115639 0.4270382 0.9911425
rho…753 CitG6m4 Carboplatin (uM) 67 -0.0607219 0.6254597 45 0.0221395 0.8852205 22 -0.1949153 0.3847110 0.2170548 0.4270698 0.9911425
rho…754 MalG24m2 EGFR-pY1173 59 -0.0623621 0.6389120 37 -0.1763974 0.2963127 22 0.0491248 0.8285540 -0.2255222 0.4271971 0.9911425
rho…755 CitG24m5 Pemetrexed (uM) 68 0.0528283 0.6687559 46 0.0065548 0.9655152 22 0.2205861 0.3239034 -0.2140313 0.4293357 0.9911425
rho…756 FumG6m2 Doxorubicin (nM) 73 -0.0518869 0.6628625 48 -0.1063033 0.4720679 25 0.0984615 0.6384645 -0.2047648 0.4295919 0.9911425
rho…757 SerG24m2 Paclitaxel/Carboplatin (nM) 63 -0.0585312 0.6486310 41 -0.1083907 0.4999507 22 0.1124930 0.6181834 -0.2208837 0.4299051 0.9911425
rho…758 CitQ24m6 Cisplatin (uM) 68 0.0421852 0.7326737 45 -0.0254324 0.8682896 23 0.1864030 0.3944333 -0.2118354 0.4307767 0.9911425
rho…759 CitG24m1 EGFR-pY1173 57 0.1135310 0.4004183 36 0.1103031 0.5218991 21 -0.1194805 0.6047788 0.2297836 0.4308747 0.9911425
rho…760 CitQ6m4 Paclitaxel (nM) 71 -0.1431866 0.2335571 47 -0.2170821 0.1427280 24 -0.0117442 0.9565647 -0.2053378 0.4310348 0.9911425
rho…761 MalG24m1 Carboplatin (uM) 69 -0.0366439 0.7649962 46 0.0165932 0.9128451 23 -0.1937716 0.3756651 0.2103648 0.4316285 0.9911425
rho…762 MalG24m3 Vinorelbine (nM) 72 0.0697478 0.5604444 47 0.0062453 0.9667673 25 0.2082773 0.3177542 -0.2020320 0.4321213 0.9911425
rho…763 LacQ6m1 MK-2206 (AKT) (uM) 71 0.1841935 0.1241262 47 0.2169588 0.1429606 24 0.0126169 0.9533404 0.2043418 0.4332493 0.9911425
rho…764 CitG6m2 Doxorubicin (nM) 71 -0.0561127 0.6420833 47 -0.1490949 0.3172021 24 0.0573913 0.7898432 -0.2064862 0.4336383 0.9911425
rho…765 LacG24m2 Carboplatin (uM) 69 0.0699982 0.5676419 46 0.1435401 0.3412571 23 -0.0672269 0.7605382 0.2107670 0.4337542 0.9911425
rho…766 LacQ24m2 Gemcitabine (nM) 71 0.0026195 0.9827028 47 -0.0197274 0.8952886 24 0.1856925 0.3849937 -0.2054200 0.4337866 0.9911425
rho…767 LacQ6m3 Gemcitabine (nM) 71 0.0499556 0.6790793 47 0.0948657 0.5258938 24 -0.1117877 0.6030320 0.2066534 0.4342150 0.9911425
rho…768 LacQ6m3 Paclitaxel (nM) 73 -0.0496382 0.6766448 48 -0.1128726 0.4449646 25 0.0896671 0.6699309 -0.2025397 0.4346014 0.9911425
rho…769 FumQ24m3 Pemetrexed (uM) 70 -0.0280732 0.8175529 47 0.0236259 0.8747473 23 -0.1847554 0.3987004 0.2083813 0.4349945 0.9911425
rho…770 CitG6m3 EGFR-pY1173 57 -0.1435053 0.2860447 36 -0.2478764 0.1446440 21 -0.0246753 0.9168661 -0.2232011 0.4355599 0.9911425
rho…771 CitQ6m6 EGFR-pY1173 57 -0.0069354 0.9592209 36 -0.1490347 0.3842200 21 0.0779221 0.7368381 -0.2269568 0.4360325 0.9911425
rho…772 LacQ6m2 Paclitaxel (nM) 73 0.2320915 0.0481736 48 0.2804246 0.0535377 25 0.0854175 0.6847680 0.1950071 0.4362929 0.9911425
rho…773 CitQ6m6 8-Cl-adenosine (uM) 69 0.0710351 0.5619041 46 0.0327545 0.8289128 23 0.2386953 0.2727047 -0.2059408 0.4364560 0.9911425
rho…774 CitQ24m3 Paclitaxel/Carboplatin (nM) 68 0.0947049 0.4423644 45 0.1517248 0.3197678 23 -0.0583725 0.7913495 0.2100974 0.4366166 0.9911425
rho…775 MalG6m2 E-cadherin 59 -0.1711864 0.1943391 37 -0.2259365 0.1781892 22 -0.0073405 0.9759039 -0.2185960 0.4371489 0.9911425
rho…776 MalQ24m3 E-cadherin 59 0.2126857 0.1058180 37 0.2743006 0.1004839 22 0.0593053 0.7931983 0.2149953 0.4380331 0.9911425
rho…777 MalQ6m2 EGFR-pY1173 58 -0.0739203 0.5813181 36 -0.1633310 0.3411919 22 0.0581592 0.7972631 -0.2214902 0.4386585 0.9911425
rho…778 SerG24m1 Beta-catenin 53 -0.2135946 0.1244508 33 -0.2279412 0.2012728 20 0.0030075 0.9923917 -0.2309487 0.4388171 0.9911425
rho…779 SerG6m1 AZD6244 (MEK) (uM) 61 -0.1380350 0.2887477 41 -0.2724105 0.0848719 20 -0.0541353 0.8213606 -0.2182752 0.4400774 0.9911425
rho…780 CitQ24m4 Crizotinib (ALK) (uM) 73 0.0594781 0.6171788 48 0.1528013 0.2998118 25 -0.0465743 0.8250387 0.1993756 0.4406120 0.9911425
rho…781 LacG6m1 EGFR-pY1173 59 0.0655805 0.6216685 37 -0.0745702 0.6609251 22 0.1451158 0.5177461 -0.2196860 0.4406712 0.9911425
rho…782 FumQ6m2 Etoposide (uM) 71 -0.1159780 0.3354687 47 -0.1683821 0.2578927 24 0.0337103 0.8757382 -0.2020924 0.4424235 0.9911425
rho…783 LacQ24m1 Sorafenib (multi-kinase) (uM) 73 -0.0021757 0.9854247 48 -0.0057286 0.9691752 25 0.1916122 0.3588525 -0.1973407 0.4426116 0.9911425
rho…784 LacG24m3 Paclitaxel/Carboplatin (nM) 70 -0.2614981 0.0287675 46 -0.3603726 0.0138864 24 -0.1719261 0.4217970 -0.1884465 0.4442661 0.9911425
rho…785 CitG24m4 AZD6244 (MEK) (uM) 69 -0.0150725 0.9021696 46 0.0445322 0.7688606 23 -0.1610672 0.4610973 0.2055994 0.4442929 0.9911425
rho…786 FumQ6m4 Crizotinib (ALK) (uM) 75 -0.0209897 0.8581396 49 0.0627203 0.6685564 26 -0.1317140 0.5212723 0.1944343 0.4444509 0.9911425
rho…787 FumQ24m3 Paclitaxel/Carboplatin (nM) 70 0.0782646 0.5195707 46 -0.0150515 0.9209156 24 0.1862896 0.3834403 -0.2013411 0.4445347 0.9911425
rho…788 CitG6m4 Doxorubicin (nM) 71 -0.0786188 0.5145914 47 -0.1345787 0.3671136 24 0.0669565 0.7555427 -0.2015352 0.4452670 0.9911425
rho…789 CitQ24m3 Gemcitabine (nM) 69 0.0371830 0.7616400 46 0.0525586 0.7286667 23 -0.1527057 0.4866750 0.2052644 0.4454533 0.9911425
rho…790 CitG6m2 Beta-catenin 57 -0.3726990 0.0045334 36 -0.4558559 0.0056323 21 -0.2623377 0.2495526 -0.1935182 0.4457100 0.9911425
rho…791 MalG6m2 MK-2206 (AKT) (uM) 71 0.0959105 0.4262365 47 0.0052632 0.9719912 24 0.2044812 0.3378351 -0.1992181 0.4459760 0.9911425
rho…792 CitQ6m6 Docetaxel (nM) 67 -0.0278255 0.8231322 45 -0.0585948 0.7022139 22 0.1508475 0.5028019 -0.2094423 0.4460775 0.9911425
rho…793 CitQ24m4 Carboplatin (uM) 67 0.1130404 0.3624080 45 0.0558759 0.7154369 22 0.2604520 0.2417352 -0.2045762 0.4460999 0.9911425
rho…794 MalQ24m3 Gefitinib (EGFR) (uM) 72 -0.3013863 0.0100905 47 -0.2709713 0.0654316 25 -0.4436105 0.0263356 0.1726392 0.4464385 0.9911425
rho…795 GlyG6m1 Vinorelbine (nM) 65 0.0374294 0.7672197 41 0.0953460 0.5531908 24 -0.1109178 0.6058733 0.2062638 0.4464608 0.9911425
rho…796 MalQ24m2 Doxorubicin (nM) 73 -0.0563463 0.6358636 48 0.0285575 0.8472128 25 -0.1676923 0.4212583 0.1962498 0.4469231 0.9911425
rho…797 LacQ24m2 EGFR-pY1173 59 -0.0056108 0.9664274 37 -0.1415363 0.4019424 22 0.0750988 0.7394498 -0.2166351 0.4471607 0.9911425
rho…798 CitQ6m2 CDH1 64 0.3590404 0.0035736 42 0.4030892 0.0081252 22 0.2115388 0.3446371 0.1915504 0.4474185 0.9911425
rho…799 CitQ24m5 Vinorelbine (nM) 70 0.0057927 0.9620407 46 -0.0586548 0.6986067 24 0.1423287 0.5070532 -0.2009835 0.4479417 0.9911425
rho…800 MalG6m3 Pemetrexed (uM) 70 0.1398527 0.2482098 47 0.1026907 0.4921621 23 0.2979926 0.1672667 -0.1953019 0.4487979 0.9911425
rho…801 GlyG6m1 Erlotinib (EGFR) (uM) 67 0.0554375 0.6559016 43 -0.0358721 0.8193580 24 0.1661231 0.4378659 -0.2019951 0.4500092 0.9911425
rho…802 FumQ24m2 Docetaxel (nM) 69 -0.0653405 0.5937468 46 0.0254828 0.8665018 23 -0.1765142 0.4204273 0.2019970 0.4513050 0.9911425
rho…803 FumQ6m3 Gefitinib (EGFR) (uM) 72 -0.1979608 0.0955351 47 -0.2377978 0.1074975 25 -0.0459969 0.8271755 -0.1918009 0.4519367 0.9911425
rho…804 LacQ24m2 Pemetrexed (uM) 70 -0.1855110 0.1241638 47 -0.2598847 0.0777058 23 -0.0630751 0.7749448 -0.1968096 0.4519919 0.9911425
rho…805 MalQ6m1 Sorafenib (multi-kinase) (uM) 72 -0.1475016 0.2162862 47 -0.2127881 0.1509953 25 -0.0200077 0.9243735 -0.1927804 0.4526963 0.9911425
rho…806 SerG6m3 Crizotinib (ALK) (uM) 65 -0.2582381 0.0378056 43 -0.3725191 0.0138917 22 -0.1803280 0.4219417 -0.1921911 0.4531361 0.9911425
rho…807 FumG6m4 Doxorubicin (nM) 73 0.0672077 0.5721069 48 0.0166133 0.9107649 25 0.2084615 0.3158081 -0.1918483 0.4536323 0.9911425
rho…808 LacG6m2 Crizotinib (ALK) (uM) 75 -0.1710769 0.1422325 49 -0.0982686 0.5017421 26 -0.2819022 0.1629505 0.1836336 0.4541329 0.9911425
rho…809 LacG24m1 Gemcitabine/Cisplatin (nM) 67 0.0148377 0.9051388 45 0.0755090 0.6220262 22 -0.1304348 0.5614433 0.2059438 0.4543986 0.9911425
rho…810 LacG24m2 AZD6244 (MEK) (uM) 71 0.1058112 0.3798218 47 0.2100150 0.1565186 24 0.0147826 0.9465021 0.1952324 0.4544323 0.9911425
rho…811 CitG24m2 CDH1 64 -0.0300924 0.8133955 42 0.0728069 0.6468002 22 -0.1351812 0.5486338 0.2079881 0.4551505 0.9911425
rho…812 FumG24m3 Cisplatin (uM) 70 -0.2362879 0.0489171 46 -0.1665998 0.2684694 24 -0.3510986 0.0925213 0.1844988 0.4558347 0.9911425
rho…813 LacQ6m3 Sorafenib (multi-kinase) (uM) 73 -0.0248121 0.8349416 48 0.0619265 0.6758509 25 -0.1312043 0.5318743 0.1931308 0.4558978 0.9911425
rho…814 CitQ6m1 Docetaxel (nM) 67 -0.0294423 0.8130358 45 -0.0974822 0.5240930 22 0.1079096 0.6326528 -0.2053918 0.4559510 0.9911425
rho…815 MalG6m3 Carboplatin (uM) 69 -0.1625434 0.1820682 46 -0.0940073 0.5343229 23 -0.2871973 0.1839348 0.1931899 0.4572040 0.9911425
rho…816 SerG24m2 Sorafenib (multi-kinase) (uM) 67 -0.1403950 0.2571389 44 -0.2566977 0.0925617 23 -0.0597974 0.7863696 -0.1969003 0.4573684 0.9911425
rho…817 LacG6m1 8-Cl-adenosine (uM) 71 -0.1878281 0.1167479 47 -0.0948553 0.5259395 24 -0.2839748 0.1786897 0.1891195 0.4579522 0.9911425
rho…818 MalQ6m1 CDH1 66 0.2684618 0.0292943 43 0.3246204 0.0336831 23 0.1336304 0.5432762 0.1909900 0.4599397 0.9911425
rho…819 CitG24m3 8-Cl-adenosine (uM) 69 -0.0962847 0.4312698 46 -0.1482898 0.3253501 23 0.0504077 0.8193273 -0.1986975 0.4602987 0.9911425
rho…820 CitQ6m2 Pemetrexed/Cisplatin (uM) 65 -0.1905345 0.1284364 44 -0.2487138 0.1035287 21 -0.0454989 0.8447388 -0.2032149 0.4608502 0.9911425
rho…821 FumG6m1 Doxorubicin (nM) 73 0.1010993 0.3947318 48 0.0432469 0.7703922 25 0.2307692 0.2658243 -0.1875223 0.4611244 0.9911425
rho…822 CitG24m2 Pemetrexed (uM) 68 -0.0456639 0.7115571 46 0.0157315 0.9173549 22 -0.1848613 0.4101683 0.2005928 0.4617454 0.9911425
rho…823 CitQ24m6 EGFR-pY1173 57 -0.0799844 0.5532385 36 -0.2283140 0.1798921 21 -0.0168831 0.9437762 -0.2114309 0.4620105 0.9911425
rho…824 FumG6m1 Gefitinib (EGFR) (uM) 72 0.0632031 0.5978895 47 0.1263989 0.3972091 25 -0.0646527 0.7588168 0.1910516 0.4625705 0.9911425
rho…825 MalQ6m3 Vinorelbine (nM) 71 -0.0979730 0.4163100 46 -0.1524180 0.3119096 25 0.0384986 0.8550293 -0.1909165 0.4635729 0.9911425
rho…826 LacG24m2 Beta-catenin 59 -0.0042081 0.9748613 37 -0.1102418 0.5145841 22 0.0988142 0.6608564 -0.2090561 0.4638252 0.9911425
rho…827 LacG6m3 AZD6244 (MEK) (uM) 71 0.0367827 0.7607178 47 -0.0435411 0.7713552 24 0.1495652 0.4837628 -0.1931063 0.4638997 0.9911425
rho…828 LacG6m2 CDH1 66 0.0014199 0.9909722 43 -0.0158646 0.9195726 23 0.1825831 0.4043658 -0.1984477 0.4640503 0.9911425
rho…829 FumG6m4 Erlotinib (EGFR) (uM) 73 0.0175874 0.8825914 48 0.1199110 0.4169041 25 -0.0696288 0.7408545 0.1895398 0.4646278 0.9911425
rho…830 MalQ6m2 MK-2206 (AKT) (uM) 70 -0.1107329 0.3614597 46 -0.1816079 0.2270850 24 0.0108767 0.9597707 -0.1924845 0.4649794 0.9911425
rho…831 FumQ6m2 Pemetrexed/Cisplatin (uM) 67 -0.1992876 0.1059205 45 -0.2881942 0.0548812 22 -0.0944036 0.6760341 -0.1937906 0.4652135 0.9911425
rho…832 FumG6m3 Erlotinib (EGFR) (uM) 73 0.0801000 0.5005365 48 0.0427749 0.7728310 25 0.2285055 0.2719206 -0.1857305 0.4656175 0.9911425
rho…833 LacQ24m2 CDH1 66 -0.0593855 0.6357493 43 0.0079323 0.9597370 23 -0.1895104 0.3864556 0.1974427 0.4657407 0.9911425
rho…834 LacQ24m2 Gefitinib (EGFR) (uM) 72 -0.0438873 0.7143240 47 0.0368378 0.8058135 25 -0.1523956 0.4670837 0.1892335 0.4657845 0.9911425
rho…835 CitG6m6 Gefitinib (EGFR) (uM) 70 0.2390095 0.0462973 46 0.3075784 0.0375813 24 0.1231238 0.5665302 0.1844546 0.4659095 0.9911425
rho…836 LacQ24m1 Gemcitabine (nM) 71 -0.1086605 0.3670500 47 -0.0779278 0.6026084 24 0.1143727 0.5946223 -0.1923005 0.4669023 0.9911425
rho…837 MalQ24m1 Gemcitabine/Cisplatin (nM) 67 -0.1687603 0.1721962 45 -0.1066017 0.4858201 22 -0.2987013 0.1765227 0.1920996 0.4670399 0.9911425
rho…838 FumG6m2 CDH1 66 0.3173072 0.0094310 43 0.4024326 0.0074656 23 0.2236519 0.3049619 0.1787807 0.4673286 0.9911425
rho…839 MalQ24m3 Crizotinib (ALK) (uM) 75 0.0487040 0.6781780 49 0.1256992 0.3894583 26 -0.0590248 0.7745592 0.1847240 0.4677010 0.9911425
rho…840 LacG6m2 Cisplatin (uM) 70 0.1400549 0.2475196 46 0.1141712 0.4499421 24 0.2984556 0.1565997 -0.1842844 0.4681290 0.9911425
rho…841 LacQ6m3 Crizotinib (ALK) (uM) 75 -0.1991917 0.0866588 49 -0.2627884 0.0681157 26 -0.0840034 0.6832799 -0.1787850 0.4690500 0.9911425
rho…842 FumQ24m3 Erlotinib (EGFR) (uM) 73 -0.2286153 0.0517239 48 -0.1799479 0.2210003 25 -0.3539142 0.0826243 0.1739663 0.4699258 0.9911425
rho…843 FumQ6m1 8-Cl-adenosine (uM) 71 -0.0836974 0.4877151 47 -0.0137066 0.9271419 24 -0.2022179 0.3433250 0.1885113 0.4706624 0.9911425
rho…844 FumG6m2 Gefitinib (EGFR) (uM) 72 0.1116079 0.3506288 47 0.1824543 0.2196360 25 -0.0038484 0.9854340 0.1863027 0.4706651 0.9911425
rho…845 LacG6m1 Cisplatin (uM) 70 0.1744392 0.1486593 46 0.2619209 0.0786817 24 0.0761366 0.7236432 0.1857843 0.4710518 0.9911425
rho…846 MalQ6m3 Docetaxel (nM) 68 -0.0255835 0.8359399 45 -0.1134873 0.4579200 23 0.0815620 0.7114110 -0.1950494 0.4712688 0.9911425
rho…847 FumG6m3 Vinorelbine (nM) 72 0.1367603 0.2519890 47 0.0275834 0.8539780 25 0.2117422 0.3095868 -0.1841587 0.4729402 0.9911425
rho…848 FumQ6m3 Vinorelbine (nM) 72 -0.0661450 0.5809200 47 -0.1052449 0.4813999 25 0.0814401 0.6987581 -0.1866850 0.4732879 0.9911425
rho…849 LacQ24m3 Pemetrexed/Cisplatin (uM) 67 -0.0281675 0.8209941 45 -0.1156165 0.4494721 22 0.0813789 0.7188333 -0.1969954 0.4745822 0.9911425
rho…850 CitQ6m1 Paclitaxel (nM) 71 -0.0052491 0.9653467 47 -0.0888221 0.5527050 24 0.1000435 0.6418476 -0.1888656 0.4750810 0.9911425
rho…851 MalG24m4 Paclitaxel/Carboplatin (nM) 70 -0.1787364 0.1387557 46 -0.2441552 0.1020025 24 -0.0591948 0.7835053 -0.1849604 0.4755979 0.9911425
rho…852 CitG24m2 Cisplatin (uM) 68 0.2061350 0.0917028 45 0.1455444 0.3401041 23 0.3278122 0.1267577 -0.1822678 0.4756578 0.9911425
rho…853 FumG24m2 Pemetrexed (uM) 70 -0.0666512 0.5835455 47 -0.0142691 0.9241602 23 -0.2036283 0.3513764 0.1893592 0.4759306 0.9911425
rho…854 FumQ24m3 Pemetrexed/Cisplatin (uM) 67 0.0049789 0.9681032 45 -0.0028328 0.9852655 22 -0.1972309 0.3789769 0.1943982 0.4760990 0.9911425
rho…855 FumG6m2 Etoposide (uM) 71 0.0188654 0.8759109 47 0.0888722 0.5524800 24 -0.0987171 0.6462917 0.1875893 0.4780912 0.9911425
rho…856 LacG24m1 Pemetrexed/Cisplatin (uM) 67 0.0889969 0.4738773 45 0.0097177 0.9494836 22 0.2028822 0.3651881 -0.1931646 0.4783368 0.9911425
rho…857 FumQ24m1 Erlotinib (EGFR) (uM) 73 0.0693161 0.5600840 48 0.1378243 0.3502145 25 -0.0453933 0.8294106 0.1832177 0.4790714 0.9911425
rho…858 LacG24m1 8-Cl-adenosine (uM) 71 -0.2424616 0.0416238 47 -0.2465009 0.0948592 24 -0.0639269 0.7666484 -0.1825739 0.4792084 0.9911425
rho…859 CitG24m5 Carboplatin (uM) 67 -0.3188441 0.0085446 45 -0.3428986 0.0211160 22 -0.1604520 0.4756609 -0.1824466 0.4794501 0.9911425
rho…860 MalQ6m4 Etoposide (uM) 70 -0.0981487 0.4188953 46 -0.1885466 0.2095211 24 -0.0026093 0.9903456 -0.1859373 0.4795651 0.9911425
rho…861 MalG24m3 SCH772984 (ERK) (uM) 78 -0.1479223 0.1962031 51 -0.2105504 0.1380650 27 -0.0372816 0.8535285 -0.1732688 0.4803167 0.9911425
rho…862 CitQ6m6 Cisplatin (uM) 68 -0.1823891 0.1365788 45 -0.2265195 0.1345741 23 -0.0390606 0.8595490 -0.1874589 0.4810314 0.9911425
rho…863 GlyG6m2 MK-2206 (AKT) (uM) 64 -0.0910090 0.4744801 41 -0.2207306 0.1654933 23 -0.0301607 0.8913392 -0.1905699 0.4819470 0.9911425
rho…864 MalQ24m2 Carboplatin (uM) 69 0.0251599 0.8374096 46 0.1052956 0.4861560 23 -0.0840336 0.7030459 0.1893292 0.4828689 0.9911425
rho…865 FumQ6m4 MK-2206 (AKT) (uM) 71 -0.0124102 0.9181870 47 0.0875072 0.5586225 24 -0.0978899 0.6490691 0.1853972 0.4832779 0.9911425
rho…866 CitQ6m2 8-Cl-adenosine (uM) 69 -0.1802112 0.1384041 46 -0.1524891 0.3116812 23 -0.3301211 0.1239474 0.1776320 0.4843526 0.9911425
rho…867 LacG6m2 Gemcitabine/Cisplatin (nM) 67 0.0767274 0.5371475 45 0.0453947 0.7671536 22 0.2343309 0.2924825 -0.1889362 0.4843671 0.9911425
rho…868 MalG24m4 Pemetrexed (uM) 70 0.0921463 0.4480402 47 0.0363160 0.8085122 23 0.2210112 0.3108564 -0.1846952 0.4848285 0.9911425
rho…869 LacQ6m1 EGFR-pY1173 59 0.0439522 0.7409923 37 -0.0418494 0.8057359 22 0.1564088 0.4853057 -0.1982582 0.4859469 0.9911425
rho…870 CitQ24m4 Doxorubicin (nM) 71 -0.0370116 0.7592739 47 0.0185646 0.9014295 24 -0.1643478 0.4410977 0.1829124 0.4868553 0.9911425
rho…871 SerG6m3 Paclitaxel/Carboplatin (nM) 59 -0.2450602 0.0613861 40 -0.1641175 0.3115675 19 -0.3571742 0.1332977 0.1930567 0.4868951 0.9911425
rho…872 CitQ24m1 Paclitaxel (nM) 71 -0.0126784 0.9164250 47 -0.0745967 0.6182492 24 0.1091779 0.6115726 -0.1837746 0.4870168 0.9911425
rho…873 CitG24m4 Docetaxel (nM) 67 0.0042517 0.9727602 45 -0.0703928 0.6458808 22 0.1209040 0.5919858 -0.1912968 0.4873857 0.9911425
rho…874 SerG6m3 Gemcitabine (nM) 60 -0.2199371 0.0913090 41 -0.2987914 0.0577441 19 -0.4736842 0.0421715 0.1748929 0.4881199 0.9911425
rho…875 MalG24m2 Erlotinib (EGFR) (uM) 73 0.1922754 0.1031665 48 0.2710420 0.0624083 25 0.0977111 0.6421765 0.1733309 0.4890771 0.9911425
rho…876 MalQ24m3 Paclitaxel/Carboplatin (nM) 70 0.1527503 0.2068003 46 0.0868881 0.5658503 24 0.2646932 0.2113206 -0.1778050 0.4893758 0.9911425
rho…877 MalQ6m4 Crizotinib (ALK) (uM) 74 -0.1052920 0.3719530 48 -0.0402098 0.7861235 26 -0.2138215 0.2942470 0.1736117 0.4899991 0.9911425
rho…878 CitQ24m3 Gefitinib (EGFR) (uM) 70 -0.2714887 0.0230009 46 -0.3320687 0.0241573 24 -0.1601045 0.4548716 -0.1719643 0.4902802 0.9911425
rho…879 CitG6m1 Pemetrexed/Cisplatin (uM) 65 0.0136594 0.9140005 44 0.1201593 0.4372048 21 -0.0740982 0.7495693 0.1942575 0.4904577 0.9911425
rho…880 MalQ6m3 Paclitaxel/Carboplatin (nM) 69 -0.0816629 0.5047302 45 -0.1389035 0.3628254 24 0.0443961 0.8368018 -0.1832996 0.4906121 0.9911425
rho…881 LacQ24m1 SCH772984 (ERK) (uM) 78 -0.1649053 0.1490799 51 -0.1540216 0.2805339 27 0.0169203 0.9332426 -0.1709419 0.4910018 0.9911425
rho…882 FumG24m3 Pemetrexed (uM) 70 0.0957755 0.4302859 47 0.0615209 0.6812205 23 0.2423673 0.2651728 -0.1808465 0.4911044 0.9911425
rho…883 CitQ6m2 Gemcitabine/Cisplatin (nM) 65 -0.2479456 0.0464337 44 -0.1960881 0.2020676 21 -0.3740260 0.0956260 0.1779379 0.4916645 0.9911425
rho…884 CitG6m1 Carboplatin (uM) 67 0.0837824 0.5002674 45 0.1406780 0.3566662 22 -0.0480226 0.8319355 0.1887006 0.4926866 0.9911425
rho…885 CitG6m4 Gemcitabine/Cisplatin (nM) 65 -0.1014293 0.4214208 44 -0.0171976 0.9117748 21 -0.2077922 0.3644089 0.1905946 0.4933844 0.9911425
rho…886 CitG6m1 Etoposide (uM) 69 -0.0158949 0.8968599 46 0.0410152 0.7866703 23 -0.1433160 0.5141618 0.1843312 0.4934676 0.9911425
rho…887 CitQ24m1 Gemcitabine (nM) 69 -0.2054285 0.0903879 46 -0.1536473 0.3079765 23 -0.3276501 0.1269566 0.1740029 0.4935329 0.9911425
rho…888 CitQ24m2 Vinorelbine (nM) 70 -0.0523092 0.6671486 46 0.0322571 0.8314732 24 -0.1488575 0.4875549 0.1811146 0.4936351 0.9911425
rho…889 FumG6m2 Cisplatin (uM) 70 0.0486448 0.6892301 46 0.1022051 0.4991137 24 -0.0791821 0.7130361 0.1813872 0.4944149 0.9911425
rho…890 FumG6m3 Docetaxel (nM) 69 -0.0412631 0.7363892 46 -0.1166163 0.4402316 23 0.0672269 0.7605382 -0.1838432 0.4954985 0.9911425
rho…891 CitQ24m6 Pemetrexed/Cisplatin (uM) 65 -0.1681091 0.1807043 44 -0.1789351 0.2451703 21 0.0116997 0.9598568 -0.1906348 0.4957999 0.9911425
rho…892 GlyG6m2 EGFR-pY1173 53 0.0509595 0.7163611 32 0.2349707 0.1947770 21 0.0350649 0.8811301 0.1999057 0.4958264 0.9911425
rho…893 MalG24m1 Paclitaxel/Carboplatin (nM) 70 0.1083139 0.3721081 46 0.1742644 0.2467496 24 -0.0052231 0.9806757 0.1794875 0.4959040 0.9911425
rho…894 FumQ6m1 Gemcitabine/Cisplatin (nM) 67 -0.1458917 0.2387896 45 -0.0844644 0.5811901 22 -0.2659514 0.2306345 0.1814871 0.4968947 0.9911425
rho…895 MalQ24m1 8-Cl-adenosine (uM) 71 -0.1028986 0.3931497 47 -0.0415245 0.7816792 24 -0.2178735 0.3064350 0.1763490 0.4976546 0.9911425
rho…896 LacG24m3 Pemetrexed/Cisplatin (uM) 67 -0.0575710 0.6435399 45 0.0009223 0.9952025 22 -0.1842329 0.4117895 0.1851552 0.4981622 0.9911425
rho…897 LacG6m3 Vinorelbine (nM) 72 -0.1952906 0.1001833 47 -0.1203377 0.4204085 25 -0.2891243 0.1609872 0.1687866 0.4986226 0.9911425
rho…898 LacQ6m1 Erlotinib (EGFR) (uM) 73 0.1352942 0.2537621 48 0.0888907 0.5479663 25 0.2588959 0.2114288 -0.1700052 0.4991896 0.9911425
rho…899 FumQ6m2 Carboplatin (uM) 69 -0.1181458 0.3336164 46 -0.1465671 0.3310646 23 0.0348579 0.8745378 -0.1814250 0.5001262 0.9911425
rho…900 CitQ24m2 Paclitaxel/Carboplatin (nM) 68 -0.1574868 0.1996277 45 -0.2254876 0.1364065 23 -0.0465002 0.8331338 -0.1789875 0.5008150 0.9911425
rho…901 FumG6m4 Vinorelbine (nM) 72 0.1731900 0.1457065 47 0.0903834 0.5457169 25 0.2602504 0.2089642 -0.1698670 0.5009112 0.9911425
rho…902 LacQ24m1 Crizotinib (ALK) (uM) 75 -0.2456134 0.0336701 49 -0.1648790 0.2575808 26 -0.3257485 0.1043854 0.1608695 0.5014506 0.9911425
rho…903 FumQ24m1 Crizotinib (ALK) (uM) 75 0.0950585 0.4172259 49 0.0291639 0.8423257 26 0.1977421 0.3328903 -0.1685782 0.5025909 0.9911425
rho…904 CitQ6m2 Gefitinib (EGFR) (uM) 70 -0.1177974 0.3314465 46 -0.0682274 0.6523273 24 -0.2418969 0.2547868 0.1736696 0.5026548 0.9911425
rho…905 MalQ6m2 Gemcitabine (nM) 70 -0.3437542 0.0035726 46 -0.2955509 0.0461353 24 -0.4483583 0.0279921 0.1528075 0.5037286 0.9911425
rho…906 CitG6m1 Gemcitabine (nM) 69 -0.0945754 0.4395313 46 0.0050143 0.9736166 23 -0.1739560 0.4273001 0.1789703 0.5042327 0.9911425
rho…907 GlyG6m1 Cisplatin (uM) 64 0.1139312 0.3700344 41 0.1934219 0.2256326 23 0.0118665 0.9571441 0.1815554 0.5053232 0.9911425
rho…908 LacQ24m1 Gefitinib (EGFR) (uM) 72 0.2010759 0.0903278 47 0.2659187 0.0708186 25 0.0983449 0.6400088 0.1675738 0.5056574 0.9911425
rho…909 LacQ6m2 Gefitinib (EGFR) (uM) 72 0.0388064 0.7462090 47 0.1064716 0.4762755 25 -0.0665769 0.7518561 0.1730485 0.5062717 0.9911425
rho…910 MalG6m2 Docetaxel (nM) 69 -0.0201199 0.8696590 46 0.0621337 0.6816517 23 -0.1166584 0.5960495 0.1787921 0.5074264 0.9911425
rho…911 FumQ24m2 Crizotinib (ALK) (uM) 75 0.1220694 0.2968075 49 0.1782523 0.2204256 26 0.0114628 0.9556795 0.1667895 0.5088393 0.9911425
rho…912 SerG6m1 Etoposide (uM) 61 -0.2387444 0.0638863 41 -0.2052444 0.1979832 20 -0.3805942 0.0978313 0.1753499 0.5093113 0.9911425
rho…913 FumG24m4 Erlotinib (EGFR) (uM) 73 -0.0618183 0.6033725 48 -0.1482467 0.3146179 25 0.0223120 0.9156924 -0.1705586 0.5093389 0.9911425
rho…914 MalQ24m2 MK-2206 (AKT) (uM) 71 -0.0787382 0.5139511 47 -0.1178716 0.4300631 24 0.0561236 0.7944970 -0.1739952 0.5103343 0.9911425
rho…915 FumQ6m2 Erlotinib (EGFR) (uM) 73 -0.1094141 0.3568053 48 -0.1699644 0.2481170 25 -0.0003848 0.9985436 -0.1695797 0.5103698 0.9911425
rho…916 CitQ6m5 Cisplatin (uM) 68 -0.0344354 0.7804141 45 -0.0529732 0.7296450 23 0.1250927 0.5695532 -0.1780659 0.5105160 0.9911425
rho…917 MalG24m4 Gemcitabine (nM) 71 -0.1899303 0.1126368 47 -0.2590675 0.0786778 24 -0.0904544 0.6742357 -0.1686130 0.5108153 0.9911425
rho…918 FumG6m1 Pemetrexed/Cisplatin (uM) 67 -0.0575229 0.6438179 45 0.0181513 0.9057938 22 -0.1621928 0.4708225 0.1803440 0.5108463 0.9911425
rho…919 SerG24m1 Gefitinib (EGFR) (uM) 66 -0.2709401 0.0277780 43 -0.2561740 0.0972884 23 -0.4148332 0.0490398 0.1586592 0.5123584 0.9911425
rho…920 FumG24m4 SCH772984 (ERK) (uM) 78 -0.1218435 0.2879250 51 -0.1838761 0.1964856 27 -0.0222437 0.9123098 -0.1616325 0.5124827 0.9911425
rho…921 FumQ24m2 Doxorubicin (nM) 73 -0.1610479 0.1734668 48 -0.0939790 0.5251992 25 -0.2585113 0.2121323 0.1645322 0.5128180 0.9911425
rho…922 FumQ24m1 Gemcitabine/Cisplatin (nM) 67 -0.1202295 0.3324844 45 -0.0482936 0.7527383 22 -0.2252964 0.3119169 0.1770029 0.5129258 0.9911425
rho…923 MalQ24m2 AZD6244 (MEK) (uM) 71 0.1244089 0.3012748 47 0.2169539 0.1429698 24 0.0469565 0.8277062 0.1699973 0.5130959 0.9911425
rho…924 SerG6m2 Pemetrexed (uM) 60 -0.1844144 0.1583775 41 -0.2845399 0.0713763 19 -0.0980154 0.6897474 -0.1865246 0.5144551 0.9911425
rho…925 SerG24m3 Crizotinib (ALK) (uM) 70 -0.1209039 0.3187623 45 -0.1827239 0.2295951 25 -0.0134719 0.9490390 -0.1692520 0.5150566 0.9911425
rho…926 FumG24m4 Paclitaxel/Carboplatin (nM) 70 -0.1099580 0.3648503 46 -0.1669237 0.2675268 24 0.0047878 0.9822858 -0.1717115 0.5151023 0.9911425
rho…927 CitQ6m6 Paclitaxel (nM) 71 -0.0930587 0.4401820 47 -0.1538195 0.3019332 24 0.0173989 0.9356867 -0.1712183 0.5155655 0.9911425
rho…928 CitG6m6 CDH1 64 0.2025856 0.1083975 42 0.2690936 0.0848446 22 0.0938915 0.6776997 0.1752021 0.5160030 0.9911425
rho…929 CitG6m6 Crizotinib (ALK) (uM) 73 0.0098000 0.9344178 48 -0.0524929 0.7230845 25 0.1158584 0.5812929 -0.1683513 0.5161237 0.9911425
rho…930 MalQ6m3 Paclitaxel (nM) 72 -0.0157602 0.8954610 47 -0.0766851 0.6084233 25 0.0923432 0.6606484 -0.1690283 0.5163919 0.9911425
rho…931 CitQ6m5 8-Cl-adenosine (uM) 69 0.1588607 0.1923068 46 0.1416279 0.3477945 23 0.3078824 0.1529465 -0.1662545 0.5164318 0.9911425
rho…932 FumQ6m3 Cisplatin (uM) 70 -0.1415610 0.2424211 46 -0.1716577 0.2539989 24 -0.0008703 0.9967797 -0.1707874 0.5170065 0.9911425
rho…933 MalG24m3 Gemcitabine/Cisplatin (nM) 67 -0.1176154 0.3431798 45 -0.0646989 0.6728476 22 -0.2388481 0.2830598 0.1741492 0.5179122 0.9911425
rho…934 CitG24m2 Gemcitabine/Cisplatin (nM) 65 0.1624687 0.1959905 44 0.1176346 0.4469663 21 0.2922078 0.1980910 -0.1745732 0.5179537 0.9911425
rho…935 CitG24m6 AZD6244 (MEK) (uM) 69 -0.0668585 0.5851802 46 -0.0336150 0.8244881 23 -0.2055336 0.3451594 0.1719186 0.5182061 0.9911425
rho…936 LacG24m3 8-Cl-adenosine (uM) 71 0.0607062 0.6150317 47 0.0873865 0.5591673 24 -0.0834964 0.6980980 0.1708829 0.5183687 0.9911425
rho…937 CitG24m2 Sorafenib (multi-kinase) (uM) 71 0.3199356 0.0065309 47 0.2785506 0.0579682 24 0.4279191 0.0369787 -0.1493685 0.5185267 0.9911425
rho…938 FumG24m3 Paclitaxel/Carboplatin (nM) 70 -0.0780633 0.5206485 46 -0.1226328 0.4168390 24 0.0483134 0.8226159 -0.1709462 0.5191946 0.9911425
rho…939 MalQ6m2 8-Cl-adenosine (uM) 70 -0.1538529 0.2035029 46 -0.0913045 0.5461911 24 -0.2570124 0.2253676 0.1657079 0.5198201 0.9911425
rho…940 SerG6m3 Vinorelbine (nM) 61 -0.3208773 0.0116907 41 -0.3023358 0.0546995 20 -0.4620016 0.0402874 0.1596659 0.5198993 0.9911425
rho…941 SerG24m1 Cisplatin (uM) 65 -0.1981248 0.1136344 43 -0.1455328 0.3517646 22 -0.3146893 0.1537515 0.1691565 0.5201947 0.9911425
rho…942 CitG6m2 Crizotinib (ALK) (uM) 73 0.0304798 0.7979630 48 -0.0183122 0.9016819 25 0.1478060 0.4807591 -0.1661183 0.5203834 0.9911425
rho…943 MalQ6m2 AZD6244 (MEK) (uM) 70 0.0425824 0.7263282 46 0.1144831 0.4486968 24 -0.0556522 0.7961236 0.1701353 0.5214060 0.9911425
rho…944 MalG24m3 Carboplatin (uM) 69 -0.1379134 0.2584442 46 -0.0579218 0.7021980 23 -0.2273851 0.2967469 0.1694633 0.5216387 0.9911425
rho…945 FumQ6m1 SCH772984 (ERK) (uM) 78 -0.0720009 0.5310252 51 -0.0233400 0.8708563 27 -0.1813955 0.3651994 0.1580555 0.5219620 0.9911425
rho…946 MalQ6m1 Paclitaxel/Carboplatin (nM) 69 0.0893949 0.4651042 45 0.1710323 0.2612953 24 0.0017414 0.9935566 0.1692909 0.5223156 0.9911425
rho…947 MalQ24m4 Docetaxel (nM) 69 -0.0322539 0.7924772 46 0.0201765 0.8941215 23 -0.1512605 0.4908571 0.1714370 0.5236431 0.9911425
rho…948 FumG24m1 Carboplatin (uM) 69 0.0190851 0.8763082 46 -0.0317705 0.8339792 23 0.1398913 0.5243698 -0.1716618 0.5236757 0.9911425
rho…949 MalQ24m4 SCH772984 (ERK) (uM) 78 0.2089377 0.0663852 51 0.2680178 0.0572326 27 0.1149778 0.5679513 0.1530400 0.5241548 0.9911425
rho…950 LacQ24m3 Cisplatin (uM) 70 -0.1715983 0.1554901 46 -0.1007864 0.5051204 24 -0.2640853 0.2124103 0.1632989 0.5246610 0.9911425
rho…951 CitG24m1 Carboplatin (uM) 67 0.2032232 0.0990635 45 0.2613996 0.0828335 22 0.0915254 0.6854145 0.1698741 0.5248081 0.9911425
rho…952 FumG24m2 Paclitaxel (nM) 73 0.0106774 0.9285611 48 0.0761150 0.6071216 25 -0.0888803 0.6726689 0.1649953 0.5249665 0.9911425
rho…953 CitG24m1 Cisplatin (uM) 68 0.2950159 0.0145946 45 0.2611188 0.0831763 23 0.4133499 0.0499373 -0.1522311 0.5258610 0.9911425
rho…954 MalG24m2 Gefitinib (EGFR) (uM) 72 0.1374364 0.2496297 47 0.1962236 0.1861980 25 0.0334809 0.8737650 0.1627427 0.5266793 0.9911425
rho…955 LacG24m3 Sorafenib (multi-kinase) (uM) 73 0.0153839 0.8972159 48 -0.0610832 0.6800264 25 0.1030968 0.6238487 -0.1641800 0.5268584 0.9911425
rho…956 CitG6m3 Crizotinib (ALK) (uM) 73 -0.1020734 0.3901691 48 -0.1642169 0.2647089 25 -0.0011547 0.9956292 -0.1630622 0.5270116 0.9911425
rho…957 SerG6m3 Pemetrexed/Cisplatin (uM) 59 -0.1953386 0.1381686 40 -0.4104320 0.0085255 19 -0.2423179 0.3175367 -0.1681141 0.5278361 0.9911425
rho…958 MalQ24m1 Carboplatin (uM) 69 -0.0630002 0.6070634 46 -0.0031459 0.9834455 23 -0.1720218 0.4325366 0.1688759 0.5284799 0.9911425
rho…959 CitQ24m5 Paclitaxel/Carboplatin (nM) 68 -0.0259073 0.8338927 45 0.0183843 0.9045899 23 -0.1513729 0.4905314 0.1697572 0.5292396 0.9911425
rho…960 CitQ6m2 Paclitaxel (nM) 71 -0.0906278 0.4522691 47 -0.1444557 0.3326627 24 0.0213136 0.9212559 -0.1657693 0.5294448 0.9911425
rho…961 FumG24m4 Sorafenib (multi-kinase) (uM) 73 -0.3178466 0.0061390 48 -0.3594408 0.0121034 25 -0.2096557 0.3144894 -0.1497851 0.5298537 0.9911425
rho…962 CitQ24m6 Erlotinib (EGFR) (uM) 71 -0.1281462 0.2868707 47 -0.1752053 0.2388201 24 -0.0104371 0.9613955 -0.1647682 0.5299282 0.9911425
rho…963 LacQ24m3 Sorafenib (multi-kinase) (uM) 73 0.0173592 0.8841042 48 0.1025655 0.4878727 25 -0.0603962 0.7742788 0.1629617 0.5299420 0.9911425
rho…964 MalG6m4 Gefitinib (EGFR) (uM) 72 0.0205365 0.8640459 47 0.0891164 0.5513846 25 -0.0742736 0.7242058 0.1633900 0.5305487 0.9911425
rho…965 LacQ6m2 Cisplatin (uM) 70 0.2241743 0.0620937 46 0.1904512 0.2048708 24 0.3450077 0.0987174 -0.1545565 0.5305647 0.9911425
rho…966 FumQ24m1 Carboplatin (uM) 69 -0.0412205 0.7366513 46 -0.0014804 0.9922092 23 -0.1695502 0.4392776 0.1680698 0.5306097 0.9911425
rho…967 CitQ6m3 MK-2206 (AKT) (uM) 69 -0.0472880 0.6996127 46 -0.0881582 0.5601632 23 0.0810878 0.7130199 -0.1692460 0.5307774 0.9911425
rho…968 CitG24m5 EGFR-pY1173 57 -0.0626134 0.6427355 36 -0.1652510 0.3341249 21 0.0168831 0.9437762 -0.1821341 0.5307850 0.9911425
rho…969 CitG6m6 Gemcitabine (nM) 69 -0.0701875 0.5665921 46 -0.0484109 0.7493549 23 0.1205832 0.5836553 -0.1689941 0.5308557 0.9911425
rho…970 FumQ24m3 AZD6244 (MEK) (uM) 71 -0.1185481 0.3247953 47 -0.0647623 0.6653873 24 -0.2269565 0.2848384 0.1621942 0.5310874 0.9911425
rho…971 FumQ6m3 Doxorubicin (nM) 73 -0.0367516 0.7575570 48 -0.1084207 0.4632374 25 0.0538565 0.7981967 -0.1622772 0.5315550 0.9911425
rho…972 MalQ6m2 Etoposide (uM) 70 -0.1757588 0.1455635 46 -0.2277255 0.1279887 24 -0.0652316 0.7620187 -0.1624939 0.5317853 0.9911425
rho…973 CitG24m5 Gemcitabine (nM) 69 -0.1295085 0.2888721 46 -0.1969805 0.1894803 23 -0.0306400 0.8896226 -0.1663405 0.5325088 0.9911425
rho…974 GlyG24m1 Docetaxel (nM) 66 0.0756750 0.5459054 43 0.1672017 0.2838668 23 -0.0019773 0.9928560 0.1691790 0.5329290 0.9911425
rho…975 LacG24m2 Paclitaxel/Carboplatin (nM) 70 0.2340042 0.0512082 46 0.2720992 0.0673449 24 0.1131666 0.5985401 0.1589326 0.5342255 0.9911425
rho…976 LacQ6m2 Paclitaxel/Carboplatin (nM) 70 0.2009503 0.0953036 46 0.2532079 0.0895322 24 0.0931448 0.6650890 0.1600631 0.5343593 0.9911425
rho…977 CitG24m5 CDH1 64 0.1625311 0.1994314 42 0.0934814 0.5559701 22 0.2613126 0.2401271 -0.1678311 0.5345460 0.9911425
rho…978 FumQ6m4 Gemcitabine (nM) 71 -0.0977441 0.4174046 47 -0.0504790 0.7361450 24 -0.2117852 0.3204795 0.1613062 0.5350696 0.9911425
rho…979 MalG24m2 Crizotinib (ALK) (uM) 75 0.0966744 0.4093162 49 0.1056772 0.4698819 26 -0.0520014 0.8008201 0.1576786 0.5358048 0.9911425
rho…980 MalQ24m2 8-Cl-adenosine (uM) 71 0.0250792 0.8355389 47 0.0911457 0.5423205 24 -0.0726245 0.7359372 0.1637702 0.5359777 0.9911425
rho…981 GlyG6m1 Doxorubicin (nM) 66 0.0414435 0.7410994 42 -0.0158061 0.9208603 24 0.1504348 0.4811958 -0.1662409 0.5362804 0.9911425
rho…982 SerG6m1 Doxorubicin (nM) 62 -0.3010062 0.0174393 42 -0.3754712 0.0142741 20 -0.2120301 0.3678291 -0.1634411 0.5368634 0.9911425
rho…983 FumQ6m4 Sorafenib (multi-kinase) (uM) 73 -0.0737872 0.5349922 48 0.0078729 0.9576456 25 -0.1515676 0.4695360 0.1594406 0.5369646 0.9911425
rho…984 SerG24m2 Vinorelbine (nM) 66 -0.0856862 0.4939261 43 -0.1542588 0.3233177 23 0.0133465 0.9518047 -0.1676053 0.5375358 0.9911425
rho…985 FumG6m3 Carboplatin (uM) 69 -0.1591997 0.1913472 46 -0.1095519 0.4686027 23 -0.2698962 0.2129608 0.1603444 0.5378136 0.9911425
rho…986 FumQ6m4 SCH772984 (ERK) (uM) 78 0.1406566 0.2193319 51 0.2085891 0.1418581 27 0.0576455 0.7751854 0.1509435 0.5379308 0.9911425
rho…987 CitG24m6 CDH1 64 0.1695847 0.1803543 42 0.1167505 0.4615365 22 0.2816746 0.2041010 -0.1649241 0.5381895 0.9911425
rho…988 MalG6m3 SCH772984 (ERK) (uM) 78 -0.1729439 0.1299817 51 -0.2089813 0.1410934 27 -0.0582721 0.7728045 -0.1507092 0.5385079 0.9911425
rho…989 CitG24m3 Etoposide (uM) 69 -0.2056655 0.0900087 46 -0.1667746 0.2679605 23 -0.3227082 0.1331324 0.1559336 0.5388834 0.9911425
rho…990 CitQ24m3 EGFR-pY1173 57 0.1431812 0.2871430 36 0.0954955 0.5782656 21 0.2688312 0.2376840 -0.1733357 0.5394317 0.9911425
rho…991 FumG24m3 8-Cl-adenosine (uM) 71 -0.1978417 0.0981589 47 -0.2453300 0.0964893 24 -0.0882801 0.6816613 -0.1570499 0.5415184 0.9911425
rho…992 FumG6m1 Cisplatin (uM) 70 0.2038234 0.0905658 46 0.1750355 0.2446324 24 0.3262998 0.1196734 -0.1512644 0.5432843 0.9911425
rho…993 CitG24m4 MK-2206 (AKT) (uM) 69 0.1531912 0.2088669 46 0.0885283 0.5585108 23 0.2477133 0.2544471 -0.1591850 0.5440349 0.9911425
rho…994 GlyG6m2 AZD6244 (MEK) (uM) 64 -0.0620714 0.6260779 41 -0.0866800 0.5899733 23 -0.2490119 0.2507546 0.1623318 0.5443908 0.9911425
rho…995 MalQ24m1 SCH772984 (ERK) (uM) 78 -0.0732854 0.5237030 51 0.0080415 0.9553378 27 -0.1422341 0.4791260 0.1502756 0.5451876 0.9911425
rho…996 MalG6m3 Sorafenib (multi-kinase) (uM) 73 -0.1234416 0.2981229 48 -0.1470341 0.3186367 25 0.0092325 0.9650637 -0.1562666 0.5453038 0.9911425
rho…997 FumQ24m2 EGFR-pY1173 59 -0.0411175 0.7571672 37 -0.1394026 0.4091344 22 0.0327591 0.8849295 -0.1721617 0.5456531 0.9911425
rho…998 CitG6m5 EGFR-pY1173 57 -0.0640394 0.6351694 36 -0.1693694 0.3220826 21 0.0051948 0.9842460 -0.1745642 0.5475914 0.9911425
rho…999 FumG6m2 Carboplatin (uM) 69 -0.0188927 0.8775454 46 0.0273880 0.8566219 23 -0.1344538 0.5407719 0.1618418 0.5478346 0.9911425
rho…1000 SerG24m1 Gemcitabine/Cisplatin (nM) 62 0.0104767 0.9355872 41 -0.0817216 0.6114941 21 0.0896104 0.6987487 -0.1713319 0.5483278 0.9911425
rho…1001 SerG6m3 SCH772984 (ERK) (uM) 67 -0.0057034 0.9634648 44 -0.0871067 0.5739545 23 0.0762224 0.7295923 -0.1633291 0.5483813 0.9911425
rho…1002 MalG24m4 MK-2206 (AKT) (uM) 71 0.1888862 0.1146644 47 0.2271834 0.1246096 24 0.0722210 0.7373535 0.1549623 0.5491767 0.9911425
rho…1003 SerG6m3 Carboplatin (uM) 60 -0.2365971 0.0687503 41 -0.3655136 0.0187727 19 -0.2019316 0.4070846 -0.1635821 0.5492271 0.9911425
rho…1004 CitG6m5 Docetaxel (nM) 67 0.0039523 0.9746779 45 -0.0591221 0.6996594 22 0.1056497 0.6398355 -0.1647718 0.5500774 0.9911425
rho…1005 GlyG24m2 8-Cl-adenosine (uM) 67 -0.1676678 0.1750305 43 -0.1209970 0.4395838 24 -0.2748424 0.1936798 0.1538454 0.5514428 0.9911425
rho…1006 LacQ6m1 Sorafenib (multi-kinase) (uM) 73 -0.2079714 0.0774631 48 -0.1182635 0.4233800 25 -0.2669744 0.1970164 0.1487109 0.5518542 0.9911425
rho…1007 FumQ6m1 Docetaxel (nM) 69 -0.0664084 0.5877145 46 0.0045042 0.9762995 23 -0.1552150 0.4794563 0.1597193 0.5519854 0.9911425
rho…1008 SerG24m2 8-Cl-adenosine (uM) 66 -0.1328657 0.2875526 43 -0.1408664 0.3675845 23 0.0207561 0.9251080 -0.1616225 0.5527689 0.9911425
rho…1009 FumQ6m1 AZD6244 (MEK) (uM) 71 0.0161148 0.8938894 47 0.0708338 0.6361198 24 -0.0860870 0.6883552 0.1569208 0.5532505 0.9911425
rho…1010 LacG6m3 Cisplatin (uM) 70 -0.1194520 0.3246516 46 -0.1909021 0.2037807 24 -0.0361105 0.8669648 -0.1547916 0.5550012 0.9911425
rho…1011 CitG6m3 Beta-catenin 57 -0.1681359 0.2106341 36 -0.2175032 0.2018297 21 -0.0480519 0.8367867 -0.1694513 0.5550415 0.9911425
rho…1012 MalQ6m4 Doxorubicin (nM) 72 -0.1652449 0.1653910 47 -0.1440014 0.3342015 25 -0.2900000 0.1593548 0.1459986 0.5564797 0.9911425
rho…1013 SerG6m1 EGFR-pY1173 50 -0.0041777 0.9772070 32 0.1917155 0.2919034 18 0.0072239 0.9803183 0.1844916 0.5567729 0.9911425
rho…1014 FumQ24m1 Paclitaxel/Carboplatin (nM) 70 -0.0205460 0.8659359 46 0.0317069 0.8343071 24 -0.1240480 0.5635986 0.1557548 0.5568643 0.9911425
rho…1015 LacQ24m3 MK-2206 (AKT) (uM) 71 0.0499182 0.6793059 47 -0.0019086 0.9898412 24 0.1527083 0.4762339 -0.1546169 0.5568706 0.9911425
rho…1016 CitG6m2 EGFR-pY1173 57 -0.3561706 0.0068195 36 -0.3472329 0.0386058 21 -0.4883117 0.0261248 0.1410787 0.5582436 0.9911425
rho…1017 FumG6m3 Paclitaxel (nM) 73 -0.0935812 0.4309959 48 -0.1450637 0.3252363 25 0.0061562 0.9767008 -0.1512199 0.5583818 0.9911425
rho…1018 FumQ24m4 SCH772984 (ERK) (uM) 78 0.1585073 0.1657233 51 0.2286929 0.1064890 27 0.0863248 0.6685546 0.1423680 0.5584952 0.9911425
rho…1019 CitG6m4 EGFR-pY1173 57 -0.1788012 0.1832663 36 -0.2213642 0.1937885 21 -0.3766234 0.0932078 0.1552592 0.5594331 0.9911425
rho…1020 GlyG6m1 Crizotinib (ALK) (uM) 68 0.1367820 0.2660268 43 0.0461283 0.7689668 25 0.1981913 0.3422699 -0.1520630 0.5600434 0.9911425
rho…1021 CitG24m1 Erlotinib (EGFR) (uM) 71 -0.0872657 0.4692844 47 -0.1041143 0.4861486 24 0.0500109 0.8164852 -0.1541251 0.5601036 0.9911425
rho…1022 MalG6m2 8-Cl-adenosine (uM) 71 -0.1626322 0.1753921 47 -0.1028859 0.4913354 24 -0.2522288 0.2344224 0.1493429 0.5601169 0.9911425
rho…1023 FumG6m4 Paclitaxel (nM) 73 -0.0074217 0.9503101 48 -0.0460925 0.7557355 25 0.1050404 0.6172865 -0.1511329 0.5601821 0.9911425
rho…1024 GlyG6m2 Gemcitabine/Cisplatin (nM) 61 -0.1552253 0.2322731 40 -0.2443235 0.1286695 21 -0.0818182 0.7240686 -0.1625053 0.5602970 0.9911425
rho…1025 MalQ6m1 Pemetrexed (uM) 69 -0.0844428 0.4902860 46 -0.0538617 0.7222055 23 -0.2081496 0.3405512 0.1542879 0.5610659 0.9911425
rho…1026 FumQ6m4 Pemetrexed (uM) 70 -0.1330905 0.2720473 47 -0.1583051 0.2878815 23 -0.0029799 0.9892335 -0.1553252 0.5612810 0.9911425
rho…1027 SerG24m1 EGFR-pY1173 53 0.0212869 0.8795488 33 0.2349599 0.1874554 20 0.0631579 0.7917740 0.1718020 0.5616524 0.9911425
rho…1028 CitG24m5 Sorafenib (multi-kinase) (uM) 71 -0.2711469 0.0221841 47 -0.3203100 0.0281640 24 -0.1765601 0.4091998 -0.1437499 0.5626014 0.9911425
rho…1029 FumQ24m3 Cisplatin (uM) 70 0.0891974 0.4627613 46 0.0382421 0.8007901 24 0.1896890 0.3746629 -0.1514469 0.5635769 0.9911425
rho…1030 MalQ6m3 SCH772984 (ERK) (uM) 77 0.0021749 0.9850225 50 -0.0437881 0.7626961 27 0.1005664 0.6177089 -0.1443545 0.5640391 0.9911425
rho…1031 FumQ24m4 E-cadherin 59 -0.0337235 0.7998320 37 0.0125652 0.9414112 22 -0.1513697 0.5013071 0.1639349 0.5643252 0.9911425
rho…1032 LacG24m3 E-cadherin 59 -0.0904150 0.4948436 37 -0.1562352 0.3544252 22 0.0073405 0.9759039 -0.1635757 0.5648959 0.9911425
rho…1033 GlyG6m1 Pemetrexed/Cisplatin (uM) 61 -0.0126930 0.9226559 40 -0.1016933 0.5323700 21 0.0630485 0.7860046 -0.1647418 0.5654338 0.9911425
rho…1034 MalG24m3 EGFR-pY1173 59 -0.0453835 0.7328669 37 -0.1403509 0.4059288 22 0.0231508 0.9197964 -0.1635016 0.5659055 0.9911425
rho…1035 LacQ24m3 Crizotinib (ALK) (uM) 75 -0.2726639 0.0179469 49 -0.2133920 0.1409669 26 -0.3475882 0.0818741 0.1341962 0.5675880 0.9911425
rho…1036 LacG6m1 Gemcitabine/Cisplatin (nM) 67 -0.0444622 0.7208923 45 -0.0055019 0.9713863 22 -0.1620553 0.4694849 0.1565534 0.5676938 0.9911425
rho…1037 SerG6m2 Doxorubicin (nM) 62 -0.2759524 0.0299329 42 -0.3540451 0.0214314 20 -0.2015038 0.3925602 -0.1525413 0.5684358 0.9911425
rho…1038 CitQ6m6 Gefitinib (EGFR) (uM) 70 -0.2012740 0.0947602 46 -0.2028252 0.1764171 24 -0.0539482 0.8023055 -0.1488770 0.5688578 0.9911425
rho…1039 CitQ6m3 CDH1 64 -0.2524419 0.0441721 42 -0.2994163 0.0540630 22 -0.1498871 0.5055567 -0.1495292 0.5726040 0.9911425
rho…1040 CitG24m1 Gemcitabine/Cisplatin (nM) 65 0.0937264 0.4577107 44 0.1995419 0.1940773 21 0.0428571 0.8544732 0.1566847 0.5729883 0.9911425
rho…1041 CitQ6m3 8-Cl-adenosine (uM) 69 0.0517238 0.6729638 46 0.1110323 0.4625776 23 -0.0410180 0.8525834 0.1520503 0.5730512 0.9911425
rho…1042 FumG6m3 MK-2206 (AKT) (uM) 71 0.1438574 0.2313513 47 0.0940428 0.5295062 24 0.2388515 0.2610012 -0.1448087 0.5736649 0.9911425
rho…1043 LacQ6m3 SCH772984 (ERK) (uM) 78 -0.1892427 0.0970366 51 -0.1590651 0.2648903 27 -0.2917184 0.1398313 0.1326533 0.5754355 0.9911425
rho…1044 CitQ24m4 Paclitaxel/Carboplatin (nM) 68 -0.0595468 0.6295503 45 -0.1330390 0.3836335 23 0.0183033 0.9339384 -0.1513423 0.5754860 0.9911425
rho…1045 MalG6m4 Erlotinib (EGFR) (uM) 73 0.0104290 0.9302183 48 0.0856585 0.5626692 25 -0.0596269 0.7770828 0.1452853 0.5757839 0.9911425
rho…1046 FumG24m1 Erlotinib (EGFR) (uM) 73 -0.1349481 0.2549899 48 -0.1029831 0.4860933 25 -0.2438931 0.2400430 0.1409100 0.5758017 0.9911425
rho…1047 CitG6m3 Docetaxel (nM) 67 -0.0021957 0.9859304 45 0.0467983 0.7601639 22 -0.1073446 0.6344455 0.1541429 0.5760628 0.9911425
rho…1048 CitG6m1 Gemcitabine/Cisplatin (nM) 65 -0.1697901 0.1763204 44 -0.1033268 0.5044842 21 -0.2558442 0.2618039 0.1525174 0.5763934 0.9911425
rho…1049 MalQ6m4 AZD6244 (MEK) (uM) 70 0.0084515 0.9446406 46 0.0577931 0.7028294 24 -0.0904348 0.6733849 0.1482279 0.5768764 0.9911425
rho…1050 CitQ6m5 Pemetrexed (uM) 68 -0.1569443 0.2012004 46 -0.1008814 0.5047172 22 -0.2495061 0.2627987 0.1486247 0.5769823 0.9911425
rho…1051 FumQ6m2 Pemetrexed (uM) 70 -0.2167834 0.0714535 47 -0.1609999 0.2796483 23 -0.3027857 0.1602144 0.1417858 0.5776317 0.9911425
rho…1052 CitQ6m1 Paclitaxel/Carboplatin (nM) 68 0.0292102 0.8130773 45 -0.0472457 0.7579400 23 0.1028940 0.6403662 -0.1501396 0.5795031 0.9911425
rho…1053 MalQ6m1 Etoposide (uM) 70 0.0308593 0.7998055 46 0.1012151 0.5033016 24 -0.0456720 0.8321756 0.1468871 0.5801472 0.9911425
rho…1054 CitQ24m4 Gemcitabine (nM) 69 0.0671959 0.5832838 46 0.0588094 0.6978503 23 0.2055844 0.3466685 -0.1467750 0.5802502 0.9911425
rho…1055 CitG24m4 Gemcitabine/Cisplatin (nM) 65 -0.1759094 0.1610151 44 -0.1380744 0.3714251 21 -0.2870130 0.2064696 0.1489386 0.5802950 0.9911425
rho…1056 CitQ24m3 Doxorubicin (nM) 71 -0.0237802 0.8439477 47 0.0142275 0.9243809 24 -0.1313043 0.5392584 0.1455318 0.5812352 0.9911425
rho…1057 FumQ24m2 Paclitaxel (nM) 73 -0.0378034 0.7508407 48 0.0073835 0.9602766 25 -0.1350779 0.5197225 0.1424614 0.5817631 0.9911425
rho…1058 CitG6m5 Pemetrexed (uM) 68 0.2120452 0.0825723 46 0.1833469 0.2225907 22 0.3249250 0.1400913 -0.1415781 0.5818523 0.9911425
rho…1059 FumQ6m3 Gemcitabine (nM) 71 -0.0463369 0.7011877 47 -0.0174646 0.9072438 24 -0.1615920 0.4506366 0.1441274 0.5831504 0.9911425
rho…1060 LacQ24m2 Pemetrexed/Cisplatin (uM) 67 -0.0143080 0.9085105 45 0.0088936 0.9537628 22 -0.1418480 0.5288997 0.1507416 0.5832104 0.9911425
rho…1061 FumG24m4 Pemetrexed (uM) 70 0.0824709 0.4973060 47 0.0450880 0.7634622 23 0.1902186 0.3846501 -0.1451306 0.5845559 0.9911425
rho…1062 SerG24m2 EGFR-pY1173 53 0.1736817 0.2129551 33 0.2540107 0.1533798 20 0.4015038 0.0804202 -0.1474931 0.5850800 0.9911425
rho…1063 MalQ24m1 CDH1 66 0.4005387 0.0008606 43 0.4526706 0.0023046 23 0.3265714 0.1282867 0.1260992 0.5862202 0.9911425
rho…1064 CitQ24m2 CDH1 64 0.0902543 0.4781673 42 0.1473975 0.3515854 22 -0.0033937 0.9880413 0.1507911 0.5872373 0.9911425
rho…1065 LacQ6m1 AZD6244 (MEK) (uM) 71 -0.1522131 0.2050825 47 -0.1386688 0.3525948 24 0.0043478 0.9854000 -0.1430167 0.5873981 0.9911425
rho…1066 MalG24m1 8-Cl-adenosine (uM) 71 -0.0177424 0.8832438 47 0.0378231 0.8007239 24 -0.1056751 0.6231128 0.1434983 0.5874073 0.9911425
rho…1067 CitQ6m6 Etoposide (uM) 69 -0.1093095 0.3712748 46 -0.1577081 0.2952104 23 -0.0123548 0.9553822 -0.1453533 0.5878610 0.9911425
rho…1068 CitG6m5 AZD6244 (MEK) (uM) 69 -0.0768788 0.5300910 46 -0.0334300 0.8254391 23 -0.1778656 0.4150666 0.1444356 0.5887387 0.9911425
rho…1069 CitG6m4 Crizotinib (ALK) (uM) 73 0.0439453 0.7120036 48 0.0119546 0.9357256 25 0.1508853 0.4715615 -0.1389308 0.5902275 0.9911425
rho…1070 FumG24m1 Sorafenib (multi-kinase) (uM) 73 -0.1043645 0.3795621 48 -0.1954822 0.1830153 25 -0.0580881 0.7826988 -0.1373941 0.5907949 0.9911425
rho…1071 CitQ6m6 Gemcitabine (nM) 69 -0.1586255 0.1929744 46 -0.1154521 0.4448405 23 -0.2554979 0.2393358 0.1400458 0.5913357 0.9911425
rho…1072 MalG6m3 Doxorubicin (nM) 73 -0.0510692 0.6678616 48 -0.0962593 0.5151507 25 0.0430769 0.8381740 -0.1393362 0.5913669 0.9911425
rho…1073 GlyG24m1 Gemcitabine (nM) 66 -0.0664291 0.5961488 43 -0.0872378 0.5780320 23 -0.2302372 0.2891805 0.1429994 0.5914788 0.9911425
rho…1074 SerG6m1 Cisplatin (uM) 60 -0.0719189 0.5850177 41 -0.0496602 0.7578258 19 -0.2063214 0.3967428 0.1566612 0.5922219 0.9911425
rho…1075 MalG24m4 Etoposide (uM) 71 -0.1422702 0.2365939 47 -0.1905808 0.1994318 24 -0.0508806 0.8133480 -0.1397002 0.5923428 0.9911425
rho…1076 MalQ24m3 Vinorelbine (nM) 72 -0.0490000 0.6827249 47 -0.0947231 0.5265187 25 0.0435118 0.8363863 -0.1382349 0.5956991 0.9911425
rho…1077 CitQ6m4 Sorafenib (multi-kinase) (uM) 71 -0.2035925 0.0885799 47 -0.2122676 0.1520210 24 -0.0747989 0.7283183 -0.1374687 0.5960214 0.9911425
rho…1078 FumQ6m3 Pemetrexed/Cisplatin (uM) 67 -0.1473614 0.2340404 45 -0.1765539 0.2459784 22 -0.0319390 0.8877926 -0.1446150 0.5962641 0.9911425
rho…1079 SerG6m2 Paclitaxel/Carboplatin (nM) 59 -0.1904504 0.1485030 40 -0.2136255 0.1856418 19 -0.0587977 0.8110280 -0.1548278 0.5972250 0.9911425
rho…1080 MalG6m3 8-Cl-adenosine (uM) 71 -0.1395907 0.2456302 47 -0.1149153 0.4417992 24 -0.2500544 0.2386163 0.1351391 0.5974867 0.9911425
rho…1081 MalG24m3 Sorafenib (multi-kinase) (uM) 73 -0.3320372 0.0041065 48 -0.3596037 0.0120617 25 -0.2346605 0.2588603 -0.1249431 0.5976146 0.9911425
rho…1082 LacG6m3 MK-2206 (AKT) (uM) 71 -0.0335664 0.7810938 47 0.0076923 0.9590733 24 -0.1313901 0.5405524 0.1390824 0.5980078 0.9911425
rho…1083 LacQ24m1 Doxorubicin (nM) 73 -0.0615699 0.6048313 48 -0.0415083 0.7793868 25 -0.1765724 0.3984871 0.1350641 0.5986938 0.9911425
rho…1084 GlyG24m1 Sorafenib (multi-kinase) (uM) 68 0.0185007 0.8809660 44 -0.0813384 0.5996691 24 0.0595782 0.7821360 -0.1409165 0.5988427 0.9911425
rho…1085 LacG6m2 Beta-catenin 59 0.0231444 0.8616110 37 -0.0775249 0.6472601 22 0.0728402 0.7470858 -0.1503651 0.5989199 0.9911425
rho…1086 CitG6m6 Vinorelbine (nM) 70 0.0841617 0.4884984 46 0.0475544 0.7536492 24 0.1854190 0.3857066 -0.1378646 0.5989793 0.9911425
rho…1087 CitG6m3 Vinorelbine (nM) 70 0.2507153 0.0363110 46 0.2009807 0.1804677 24 0.3307945 0.1143664 -0.1298138 0.5990647 0.9911425
rho…1088 CitQ24m5 Carboplatin (uM) 67 0.1420389 0.2515539 45 0.0981122 0.5214019 22 0.2389831 0.2841170 -0.1408709 0.5992952 0.9911425
rho…1089 FumG24m3 CDH1 66 0.1561182 0.2106541 43 0.0695022 0.6578651 23 0.2102922 0.3354913 -0.1407900 0.5993663 0.9911425
rho…1090 MalQ6m2 Carboplatin (uM) 68 -0.1258042 0.3066660 45 -0.1512915 0.3211680 23 -0.0098863 0.9642907 -0.1414052 0.5997270 0.9911425
rho…1091 CitG6m5 Paclitaxel (nM) 71 -0.0243506 0.8402534 47 -0.0729197 0.6261875 24 0.0652458 0.7619683 -0.1381654 0.6018318 0.9911425
rho…1092 LacG6m1 E-cadherin 59 0.1433185 0.2788536 37 0.1783047 0.2910370 22 0.0310559 0.8918670 0.1472488 0.6025269 0.9911425
rho…1093 FumQ24m2 Pemetrexed (uM) 70 -0.2735836 0.0219252 47 -0.2339781 0.1134350 23 -0.3616537 0.0899511 0.1276756 0.6026508 0.9911425
rho…1094 LacQ24m1 MK-2206 (AKT) (uM) 71 -0.0398226 0.7416072 47 0.0098618 0.9475451 24 -0.1275022 0.5527014 0.1373640 0.6026878 0.9911425
rho…1095 MalG24m3 Beta-catenin 59 -0.2799866 0.0317327 37 -0.3202940 0.0537697 22 -0.1812535 0.4177693 -0.1390404 0.6036685 0.9911425
rho…1096 CitQ24m2 Docetaxel (nM) 67 -0.0572877 0.6451760 45 -0.1078302 0.4807779 22 0.0350283 0.8770155 -0.1428585 0.6042636 0.9911425
rho…1097 FumQ6m3 8-Cl-adenosine (uM) 71 0.0755899 0.5309717 47 0.0666243 0.6563569 24 0.2013919 0.3453416 -0.1347677 0.6042708 0.9911425
rho…1098 CitG6m2 Gefitinib (EGFR) (uM) 70 0.0166080 0.8914574 46 -0.0426871 0.7781901 24 0.0948445 0.6593339 -0.1375315 0.6046162 0.9911425
rho…1099 LacQ6m3 Carboplatin (uM) 69 0.0159420 0.8965557 46 0.0737748 0.6260744 23 -0.0660074 0.7647620 0.1397822 0.6049437 0.9911425
rho…1100 FumG6m4 Paclitaxel/Carboplatin (nM) 70 0.0811166 0.5044201 46 0.1473691 0.3283966 24 0.0108814 0.9597532 0.1364877 0.6053378 0.9911425
rho…1101 CitQ24m3 Pemetrexed (uM) 68 -0.1793639 0.1433173 46 -0.1415255 0.3481468 22 -0.2772920 0.2115290 0.1357665 0.6055546 0.9911425
rho…1102 CitQ6m6 Beta-catenin 57 -0.1054576 0.4339115 36 -0.1891892 0.2680141 21 -0.0402597 0.8633429 -0.1489294 0.6058111 0.9911425
rho…1103 CitG24m6 8-Cl-adenosine (uM) 69 -0.2061736 0.0892001 46 -0.1645745 0.2744142 23 -0.2965159 0.1694823 0.1319414 0.6059814 0.9911425
rho…1104 MalQ24m4 Vinorelbine (nM) 72 -0.0552316 0.6449378 47 0.0044527 0.9763030 25 -0.1293552 0.5377219 0.1338079 0.6063878 0.9911425
rho…1105 CitQ6m3 SCH772984 (ERK) (uM) 76 0.1195866 0.3035024 50 0.0576016 0.6911220 26 0.1864616 0.3617446 -0.1288600 0.6066864 0.9911425
rho…1106 GlyG24m1 Crizotinib (ALK) (uM) 71 0.0215561 0.8583843 45 0.0767861 0.6161295 26 -0.0564489 0.7841644 0.1332350 0.6069408 0.9911425
rho…1107 SerG24m3 Gemcitabine (nM) 65 -0.2482325 0.0461730 43 -0.3530966 0.0202034 22 -0.2219085 0.3194070 -0.1311881 0.6069974 0.9911425
rho…1108 CitQ24m1 Pemetrexed (uM) 68 -0.0677158 0.5832274 46 -0.0811546 0.5918514 22 0.0601083 0.7904581 -0.1412629 0.6074569 0.9911425
rho…1109 SerG24m1 SCH772984 (ERK) (uM) 72 -0.0991481 0.4073194 46 -0.1039310 0.4918557 26 -0.2323299 0.2534101 0.1283989 0.6084381 0.9911425
rho…1110 SerG6m3 8-Cl-adenosine (uM) 61 -0.2020442 0.1184005 41 -0.2238683 0.1594104 20 -0.0781955 0.7431018 -0.1456728 0.6087118 0.9911425
rho…1111 FumG6m1 Paclitaxel (nM) 73 0.0478255 0.6878322 48 0.1031600 0.4853408 25 -0.0292420 0.8896446 0.1324020 0.6097732 0.9911425
rho…1112 FumG6m4 Sorafenib (multi-kinase) (uM) 73 -0.1073787 0.3658748 48 -0.1408986 0.3394669 25 -0.0092325 0.9650637 -0.1316661 0.6102287 0.9911425
rho…1113 SerG6m2 AZD6244 (MEK) (uM) 61 -0.1834697 0.1569671 41 -0.2703315 0.0873720 20 -0.1278195 0.5900555 -0.1425119 0.6103209 0.9911425
rho…1114 CitG24m4 Vinorelbine (nM) 70 -0.0633871 0.6021509 46 -0.1172480 0.4377420 24 0.0178455 0.9340392 -0.1350935 0.6104115 0.9911425
rho…1115 LacG24m1 E-cadherin 59 0.0578952 0.6631616 37 0.1231772 0.4676460 22 -0.0220215 0.9237947 0.1451987 0.6106616 0.9911425
rho…1116 CitQ24m3 MK-2206 (AKT) (uM) 69 -0.1735659 0.1537939 46 -0.2060584 0.1694758 23 -0.0711990 0.7468266 -0.1348593 0.6108384 0.9911425
rho…1117 SerG24m3 Vinorelbine (nM) 66 -0.0268148 0.8307649 43 -0.0873277 0.5776386 23 0.0514088 0.8157983 -0.1387365 0.6117522 0.9911425
rho…1118 CitQ24m4 Erlotinib (EGFR) (uM) 71 0.0854699 0.4785121 47 0.0190239 0.8990029 24 0.1522070 0.4777001 -0.1331831 0.6124147 0.9911425
rho…1119 LacG24m1 Paclitaxel (nM) 73 0.0249666 0.8339285 48 0.0880093 0.5519572 25 -0.0430935 0.8379386 0.1311028 0.6136039 0.9911425
rho…1120 MalG24m3 8-Cl-adenosine (uM) 71 -0.2376429 0.0459820 47 -0.2673067 0.0693049 24 -0.1391607 0.5166496 -0.1281460 0.6136889 0.9911425
rho…1121 FumQ6m4 Docetaxel (nM) 69 -0.1067030 0.3828571 46 -0.1642500 0.2753746 23 -0.0291646 0.8949082 -0.1350854 0.6138281 0.9911425
rho…1122 FumG6m3 CDH1 66 0.1689897 0.1749637 43 0.2063157 0.1843867 23 0.0712519 0.7466444 0.1350637 0.6144637 0.9911425
rho…1123 MalQ6m3 Pemetrexed/Cisplatin (uM) 66 -0.0620238 0.6207889 44 -0.0768174 0.6201674 22 0.0627296 0.7815296 -0.1395470 0.6144970 0.9911425
rho…1124 MalG6m4 Paclitaxel/Carboplatin (nM) 70 0.0232937 0.8482078 46 0.0900006 0.5519610 24 -0.0435256 0.8399611 0.1335262 0.6152612 0.9911425
rho…1125 CitQ24m1 Sorafenib (multi-kinase) (uM) 71 -0.1978214 0.0981942 47 -0.2168947 0.1430816 24 -0.0869754 0.6861305 -0.1299192 0.6155229 0.9911425
rho…1126 MalQ6m2 Erlotinib (EGFR) (uM) 72 -0.0303910 0.7999426 47 -0.0730932 0.6253643 25 0.0577034 0.7841045 -0.1307966 0.6159077 0.9911425
rho…1127 FumG24m3 Erlotinib (EGFR) (uM) 73 0.0287572 0.8091591 48 -0.0524916 0.7230912 25 0.0777073 0.7119759 -0.1301988 0.6161813 0.9911425
rho…1128 MalG24m3 Gemcitabine (nM) 71 -0.1199185 0.3191937 47 -0.1525974 0.3058366 24 -0.0208741 0.9228750 -0.1317233 0.6162598 0.9911425
rho…1129 FumG6m2 EGFR-pY1173 59 -0.1048510 0.4283186 37 -0.1453295 0.3893395 22 -0.0028233 0.9919670 -0.1425063 0.6162726 0.9911425
rho…1130 MalG6m3 Vinorelbine (nM) 72 0.1508818 0.2058266 47 0.1084832 0.4679350 25 0.2352263 0.2576806 -0.1267431 0.6164154 0.9911425
rho…1131 GlyG24m2 Paclitaxel (nM) 68 -0.1203577 0.3282453 44 -0.0909219 0.5572285 24 -0.2218356 0.2975023 0.1309137 0.6164469 0.9911425
rho…1132 GlyG24m1 Paclitaxel (nM) 68 -0.0025198 0.9837292 44 0.0813773 0.5994938 24 -0.0526316 0.8070407 0.1340089 0.6169040 0.9911425
rho…1133 LacG6m3 Beta-catenin 59 -0.2220923 0.0909471 37 -0.2600759 0.1199586 22 -0.1225296 0.5856485 -0.1375462 0.6175046 0.9911425
rho…1134 LacQ6m1 Beta-catenin 59 0.0562261 0.6723135 37 0.1203320 0.4780686 22 -0.0220215 0.9237947 0.1423534 0.6177468 0.9911425
rho…1135 GlyG24m2 Vinorelbine (nM) 67 -0.0437673 0.7250803 43 -0.1075732 0.4923254 24 0.0260983 0.9036515 -0.1336715 0.6187597 0.9911425
rho…1136 CitQ24m5 Paclitaxel (nM) 71 0.0330376 0.7844587 47 0.0616434 0.6806193 24 -0.0700305 0.7450581 0.1316739 0.6190608 0.9911425
rho…1137 MalQ6m4 Docetaxel (nM) 68 -0.2061190 0.0917284 45 -0.2895838 0.0536701 23 -0.1616411 0.4612197 -0.1279427 0.6191474 0.9911425
rho…1138 MalQ6m2 Crizotinib (ALK) (uM) 74 0.0299719 0.7998851 48 -0.0152697 0.9179561 26 0.1115293 0.5875304 -0.1267989 0.6195344 0.9911425
rho…1139 LacQ24m3 Paclitaxel/Carboplatin (nM) 70 0.0403665 0.7400521 46 0.0842638 0.5776857 24 -0.0474429 0.8257638 0.1317067 0.6201705 0.9911425
rho…1140 MalQ6m1 Gemcitabine (nM) 70 -0.2030685 0.0917923 46 -0.1387325 0.3578383 24 -0.2648978 0.2109547 0.1261653 0.6207195 0.9911425
rho…1141 CitG6m6 Pemetrexed/Cisplatin (uM) 65 0.0654027 0.6047256 44 0.0873916 0.5726975 21 0.2235945 0.3299041 -0.1362029 0.6209453 0.9911425
rho…1142 LacQ6m1 Paclitaxel (nM) 73 0.0623525 0.6002403 48 0.0970763 0.5115740 25 -0.0311658 0.8824321 0.1282421 0.6211813 0.9911425
rho…1143 FumG6m4 EGFR-pY1173 59 -0.0166569 0.9002128 37 -0.1498340 0.3746799 22 -0.0095991 0.9678755 -0.1402349 0.6216173 0.9911425
rho…1144 FumQ24m3 Paclitaxel (nM) 73 0.1254137 0.2904104 48 0.0798610 0.5894924 25 0.2050789 0.3254092 -0.1252179 0.6227067 0.9911425
rho…1145 LacQ6m2 Vinorelbine (nM) 72 0.1593216 0.1812929 47 0.2032732 0.1705616 25 0.0777671 0.7117633 0.1255061 0.6233945 0.9911425
rho…1146 MalQ24m1 Sorafenib (multi-kinase) (uM) 73 -0.2322707 0.0479961 48 -0.2422153 0.0971795 25 -0.1188690 0.5714416 -0.1233463 0.6235352 0.9911425
rho…1147 MalG6m4 MK-2206 (AKT) (uM) 71 0.1166053 0.3328434 47 0.1659341 0.2649776 24 0.0374157 0.8622003 0.1285184 0.6239008 0.9911425
rho…1148 CitQ6m1 EGFR-pY1173 57 -0.0720455 0.5943286 36 -0.1956242 0.2518400 21 -0.0545455 0.8147885 -0.1410787 0.6241318 0.9911425
rho…1149 LacQ24m1 Erlotinib (EGFR) (uM) 73 -0.0161915 0.8918519 48 -0.0129200 0.9305470 25 0.1138681 0.5878459 -0.1267881 0.6246440 0.9911425
rho…1150 MalQ24m2 Cisplatin (uM) 70 0.0166407 0.8912452 46 0.0724749 0.6321865 24 -0.0574288 0.7898210 0.1299037 0.6250782 0.9911425
rho…1151 GlyG24m2 EGFR-pY1173 53 -0.0346718 0.8048744 32 0.1033724 0.5720420 21 -0.0428571 0.8544732 0.1462296 0.6250890 0.9911425
rho…1152 MalQ6m2 Sorafenib (multi-kinase) (uM) 72 -0.1622172 0.1733859 47 -0.1900052 0.2008181 25 -0.0650125 0.7575138 -0.1249927 0.6260561 0.9911425
rho…1153 FumG6m3 Sorafenib (multi-kinase) (uM) 73 -0.1247223 0.2930994 48 -0.1543641 0.2948368 25 -0.0288517 0.8911090 -0.1255124 0.6261047 0.9911425
rho…1154 FumG6m3 SCH772984 (ERK) (uM) 78 -0.1138419 0.3209912 51 -0.1733829 0.2237009 27 -0.0541993 0.7883153 -0.1191836 0.6286702 0.9911425
rho…1155 LacQ24m1 Etoposide (uM) 71 0.0435508 0.7183812 47 0.0515512 0.7307491 24 -0.0763375 0.7229419 0.1278887 0.6291554 0.9911425
rho…1156 CitQ24m2 SCH772984 (ERK) (uM) 76 0.0597569 0.6081098 50 0.1259257 0.3835446 26 0.0041901 0.9837922 0.1217356 0.6304952 0.9911425
rho…1157 CitQ6m6 CDH1 64 0.0236342 0.8529364 42 0.0942922 0.5525338 22 -0.0395928 0.8611309 0.1338850 0.6314919 0.9911425
rho…1158 FumQ24m1 Gemcitabine (nM) 71 -0.2575502 0.0301313 47 -0.1860760 0.2104631 24 -0.3052838 0.1468817 0.1192078 0.6318791 0.9911425
rho…1159 LacQ24m1 E-cadherin 59 -0.0585622 0.6587292 37 -0.0742058 0.6614510 22 0.0626765 0.7817293 -0.1368822 0.6321865 0.9911425
rho…1160 SerG24m3 E-cadherin 53 -0.1528786 0.2735864 33 -0.1951872 0.2751627 20 -0.0526316 0.8263162 -0.1425556 0.6328008 0.9911425
rho…1161 MalQ6m2 Docetaxel (nM) 68 -0.1934378 0.1139869 45 -0.2257374 0.1359613 23 -0.0998517 0.6503307 -0.1258857 0.6335800 0.9911425
rho…1162 MalG6m3 MK-2206 (AKT) (uM) 71 0.1549762 0.1968817 47 0.1194910 0.4237092 24 0.2414619 0.2556687 -0.1219708 0.6340412 0.9911425
rho…1163 MalQ24m1 Gemcitabine (nM) 71 -0.2723940 0.0215541 47 -0.1986087 0.1807971 24 -0.3161557 0.1323061 0.1175470 0.6345111 0.9911425
rho…1164 FumQ24m2 Gefitinib (EGFR) (uM) 72 -0.2226002 0.0601868 47 -0.2625492 0.0746023 25 -0.1437644 0.4929679 -0.1187847 0.6346597 0.9911425
rho…1165 LacG24m2 MK-2206 (AKT) (uM) 71 -0.0379181 0.7535625 47 -0.0855408 0.5675278 24 0.0400261 0.8526854 -0.1255669 0.6352865 0.9911425
rho…1166 CitQ6m5 Docetaxel (nM) 67 -0.1945986 0.1145636 45 -0.2171105 0.1519751 22 -0.0892656 0.6928113 -0.1278449 0.6353286 0.9911425
rho…1167 LacG6m2 E-cadherin 59 -0.0045587 0.9727525 37 -0.0962541 0.5696072 22 0.0389610 0.8640639 -0.1352152 0.6360850 0.9911425
rho…1168 SerG6m2 Sorafenib (multi-kinase) (uM) 62 -0.1040176 0.4210775 42 -0.2283468 0.1458099 20 -0.0947368 0.6906615 -0.1336099 0.6363216 0.9911425
rho…1169 FumQ24m1 Pemetrexed (uM) 70 -0.0918639 0.4494390 47 -0.1339775 0.3692776 23 -0.0074498 0.9730877 -0.1265277 0.6367972 0.9911425
rho…1170 CitQ6m5 SCH772984 (ERK) (uM) 76 0.2154818 0.0615645 50 0.1530171 0.2887395 26 0.2671219 0.1871041 -0.1141048 0.6385438 0.9911425
rho…1171 CitQ24m6 Paclitaxel/Carboplatin (nM) 68 -0.0304893 0.8050495 45 0.0107406 0.9441739 23 -0.1162504 0.5973444 0.1269910 0.6388015 0.9911425
rho…1172 CitG24m6 Cisplatin (uM) 68 -0.2598043 0.0323896 45 -0.2317246 0.1256100 23 -0.3480842 0.1036043 0.1163596 0.6395078 0.9911425
rho…1173 CitG24m5 Cisplatin (uM) 68 -0.2954684 0.0144368 45 -0.2423983 0.1086417 23 -0.3579729 0.0935140 0.1155746 0.6395410 0.9911425
rho…1174 SerG6m3 AZD6244 (MEK) (uM) 61 0.0383431 0.7692307 41 0.0323199 0.8410109 20 -0.1037594 0.6626175 0.1360793 0.6400069 0.9911425
rho…1175 CitG6m6 Doxorubicin (nM) 71 0.0977293 0.4174757 47 0.0722651 0.6292974 24 0.1939130 0.3622460 -0.1216479 0.6401041 0.9911425
rho…1176 FumQ6m3 Gemcitabine/Cisplatin (nM) 67 -0.0278376 0.8230560 45 -0.0560680 0.7144997 22 0.0728608 0.7472804 -0.1289288 0.6404976 0.9911425
rho…1177 CitQ24m3 Cisplatin (uM) 68 0.0853734 0.4887989 45 0.1494037 0.3273134 23 0.0237330 0.9144027 0.1256707 0.6407135 0.9911425
rho…1178 LacG24m3 Erlotinib (EGFR) (uM) 73 0.0147796 0.9012327 48 -0.0679622 0.6462516 25 0.0530871 0.8010227 -0.1210494 0.6412830 0.9911425
rho…1179 FumQ24m4 Vinorelbine (nM) 72 -0.1123701 0.3473275 47 -0.0464350 0.7566087 25 -0.1655757 0.4289575 0.1191407 0.6440539 0.9911425
rho…1180 LacQ24m3 Beta-catenin 59 0.0757182 0.5686930 37 0.0357990 0.8330956 22 0.1665726 0.4570250 -0.1307736 0.6440978 0.9911425
rho…1181 GlyG24m2 E-cadherin 53 0.0096759 0.9452118 32 0.0861437 0.6380547 21 -0.0519481 0.8235723 0.1380917 0.6447432 0.9911425
rho…1182 CitG6m5 CDH1 64 0.1752642 0.1659828 42 0.1532350 0.3326228 22 0.2760185 0.2137208 -0.1227835 0.6449514 0.9911425
rho…1183 MalG24m1 Etoposide (uM) 71 0.0325158 0.7877826 47 0.0793316 0.5960693 24 -0.0426180 0.8432577 0.1219495 0.6451450 0.9911425
rho…1184 MalQ6m3 Doxorubicin (nM) 72 0.0064162 0.9573408 47 -0.0647139 0.6656230 25 0.0553846 0.7924238 -0.1200985 0.6451528 0.9911425
rho…1185 SerG6m3 Gefitinib (EGFR) (uM) 61 -0.0875936 0.5020508 41 -0.0998432 0.5345388 20 -0.2302484 0.3287642 0.1304052 0.6453858 0.9911425
rho…1186 FumG6m3 E-cadherin 59 -0.1603156 0.2245273 37 -0.1884780 0.2628583 22 -0.0592885 0.7933723 -0.1291894 0.6464144 0.9911425
rho…1187 FumG6m4 8-Cl-adenosine (uM) 71 0.0112189 0.9260171 47 -0.0322711 0.8295036 24 0.0887149 0.6801738 -0.1209861 0.6476126 0.9911425
rho…1188 FumG6m4 Beta-catenin 59 -0.1291642 0.3286463 37 -0.1953532 0.2455944 22 -0.0671937 0.7662773 -0.1281596 0.6484183 0.9911425
rho…1189 CitQ6m1 Pemetrexed/Cisplatin (uM) 65 -0.2527537 0.0422207 44 -0.2194581 0.1523362 21 -0.3379917 0.1339934 0.1185337 0.6488879 0.9911425
rho…1190 FumG6m4 Etoposide (uM) 71 -0.0007882 0.9947953 47 0.0573015 0.7020346 24 -0.0630572 0.7697392 0.1203586 0.6495809 0.9911425
rho…1191 MalQ24m4 Paclitaxel/Carboplatin (nM) 70 0.0051628 0.9661661 46 0.0395411 0.7941681 24 -0.0809576 0.7068757 0.1204987 0.6502845 0.9911425
rho…1192 FumG24m3 MK-2206 (AKT) (uM) 71 0.1107953 0.3576550 47 0.0673222 0.6529844 24 0.1853383 0.3859172 -0.1180161 0.6507320 0.9911425
rho…1193 FumG6m3 Paclitaxel/Carboplatin (nM) 70 -0.0390970 0.7479515 46 -0.0908642 0.5481361 24 0.0291622 0.8924012 -0.1200264 0.6513961 0.9911425
rho…1194 LacG6m2 Pemetrexed/Cisplatin (uM) 67 0.0025343 0.9837610 45 0.0557989 0.7158122 22 -0.0689461 0.7604638 0.1247450 0.6514157 0.9911425
rho…1195 CitG6m1 Gefitinib (EGFR) (uM) 70 -0.0442239 0.7162166 46 -0.0061687 0.9675456 24 -0.1257342 0.5582669 0.1195656 0.6515356 0.9911425
rho…1196 FumQ6m1 Crizotinib (ALK) (uM) 75 -0.0624996 0.5942466 49 -0.0153225 0.9167765 26 -0.1296613 0.5278420 0.1143388 0.6522813 0.9911425
rho…1197 MalG24m3 Paclitaxel/Carboplatin (nM) 70 -0.0447764 0.7128245 46 -0.0779717 0.6065099 24 0.0417846 0.8462869 -0.1197563 0.6523347 0.9911425
rho…1198 LacQ6m3 Doxorubicin (nM) 73 0.0834863 0.4825399 48 0.1280235 0.3858497 25 0.0119254 0.9548830 0.1160981 0.6534382 0.9911425
rho…1199 FumQ6m1 Doxorubicin (nM) 73 -0.0755392 0.5253134 48 -0.0909387 0.5387463 25 0.0253846 0.9048255 -0.1163233 0.6540572 0.9911425
rho…1200 FumQ24m2 Gemcitabine/Cisplatin (nM) 67 -0.0111851 0.9284195 45 0.0180524 0.9063044 22 -0.1050551 0.6417308 0.1231075 0.6551048 0.9911425
rho…1201 MalG24m4 Beta-catenin 59 -0.3422560 0.0082567 37 -0.3781413 0.0216433 22 -0.2636928 0.2347355 -0.1144485 0.6554276 0.9911425
rho…1202 LacQ24m1 Cisplatin (uM) 70 0.0373504 0.7588615 46 0.0107640 0.9433996 24 0.1287797 0.5486958 -0.1180157 0.6556006 0.9911425
rho…1203 GlyG24m1 Cisplatin (uM) 66 0.0614861 0.6238255 43 0.0480740 0.7595055 23 0.1686033 0.4418750 -0.1205292 0.6556619 0.9911425
rho…1204 MalQ24m1 Paclitaxel/Carboplatin (nM) 70 0.0157683 0.8969149 46 0.0357782 0.8133886 24 -0.0826986 0.7008522 0.1184768 0.6557443 0.9911425
rho…1205 FumQ24m2 Paclitaxel/Carboplatin (nM) 70 -0.0969390 0.4246793 46 -0.0598976 0.6925325 24 -0.1763170 0.4098555 0.1164194 0.6570252 0.9911425
rho…1206 FumG24m4 Gemcitabine (nM) 71 -0.1204464 0.3170523 47 -0.1653042 0.2668213 24 -0.0491411 0.8196252 -0.1161631 0.6573350 0.9911425
rho…1207 MalG24m4 Gefitinib (EGFR) (uM) 72 0.0503844 0.6742588 47 0.0946681 0.5267603 25 -0.0207812 0.9214584 0.1154493 0.6575940 0.9911425
rho…1208 FumG24m2 Cisplatin (uM) 70 0.0678052 0.5770308 46 0.0996762 0.5098468 24 -0.0178377 0.9340679 0.1175139 0.6580077 0.9911425
rho…1209 LacQ24m1 Pemetrexed (uM) 70 -0.1130088 0.3516138 47 -0.1427285 0.3385368 23 -0.0243361 0.9122357 -0.1183924 0.6580323 0.9911425
rho…1210 MalQ24m1 Pemetrexed/Cisplatin (uM) 67 -0.0719588 0.5628087 45 -0.0706216 0.6448065 22 0.0514270 0.8202032 -0.1220485 0.6584693 0.9911425
rho…1211 FumQ6m2 Sorafenib (multi-kinase) (uM) 73 -0.1233663 0.2984198 48 -0.1496444 0.3100257 25 -0.0361678 0.8637235 -0.1134766 0.6595804 0.9911425
rho…1212 LacG6m3 Gemcitabine/Cisplatin (nM) 67 -0.1390884 0.2616374 45 -0.1813809 0.2330956 22 -0.0615471 0.7856053 -0.1198338 0.6595859 0.9911425
rho…1213 LacQ24m3 Paclitaxel (nM) 73 -0.1128470 0.3418254 48 -0.0737805 0.6182217 25 -0.1862255 0.3727737 0.1124450 0.6598134 0.9911425
rho…1214 MalQ6m1 Crizotinib (ALK) (uM) 74 -0.0040521 0.9726667 48 -0.0406727 0.7837199 26 0.0718563 0.7272182 -0.1125290 0.6602359 0.9911425
rho…1215 GlyG24m1 Gemcitabine/Cisplatin (nM) 63 0.1731559 0.1747378 41 0.1752124 0.2732038 22 0.0536420 0.8128733 0.1215704 0.6606687 0.9911425
rho…1216 LacG24m3 CDH1 66 0.0930038 0.4576376 43 0.1400620 0.3703539 23 0.0207818 0.9250155 0.1192802 0.6607174 0.9911425
rho…1217 SerG6m2 Gemcitabine/Cisplatin (nM) 59 -0.0567871 0.6692319 40 -0.1189717 0.4646656 19 -0.2456140 0.3094012 0.1266424 0.6610282 0.9911425
rho…1218 CitG24m3 AZD6244 (MEK) (uM) 69 -0.1867527 0.1244168 46 -0.1504348 0.3183215 23 -0.2638340 0.2229165 0.1133992 0.6611420 0.9911425
rho…1219 CitQ6m4 E-cadherin 57 -0.3833676 0.0032441 36 -0.4483912 0.0065511 21 -0.3402597 0.1314926 -0.1081315 0.6614916 0.9911425
rho…1220 CitQ24m6 Vinorelbine (nM) 70 -0.0586094 0.6298437 46 0.0023437 0.9876664 24 -0.1136018 0.5971250 0.1159455 0.6618432 0.9911425
rho…1221 FumQ6m4 Beta-catenin 59 0.0954997 0.4708138 37 0.0509720 0.7638568 22 0.1744777 0.4356491 -0.1235057 0.6618728 0.9911425
rho…1222 FumQ24m1 EGFR-pY1173 59 -0.1528346 0.2471210 37 -0.2313893 0.1677309 22 -0.1101073 0.6245799 -0.1212820 0.6622873 0.9911425
rho…1223 FumQ24m2 Cisplatin (uM) 70 -0.0779642 0.5211796 46 -0.0394140 0.7948150 24 -0.1542646 0.4716969 0.1148506 0.6628415 0.9911425
rho…1224 CitQ6m1 Pemetrexed (uM) 68 -0.0663291 0.5909804 46 -0.0993207 0.5113648 22 0.0204141 0.9281516 -0.1197349 0.6629463 0.9911425
rho…1225 CitG6m2 Erlotinib (EGFR) (uM) 71 0.1289679 0.2837659 47 0.0816468 0.5853532 24 0.1948250 0.3616231 -0.1131782 0.6631680 0.9911425
rho…1226 CitG24m5 Gemcitabine/Cisplatin (nM) 65 -0.1984636 0.1130055 44 -0.1843107 0.2310431 21 -0.3000000 0.1859661 0.1156893 0.6633484 0.9911425
rho…1227 FumQ6m1 Etoposide (uM) 71 -0.1238744 0.3033728 47 -0.0785799 0.5995670 24 -0.1917808 0.3693196 0.1132009 0.6633748 0.9911425
rho…1228 SerG6m2 Erlotinib (EGFR) (uM) 63 -0.2269819 0.0736203 43 -0.3015256 0.0494174 20 -0.1835277 0.4386197 -0.1179979 0.6645065 0.9911425
rho…1229 MalG6m2 AZD6244 (MEK) (uM) 71 -0.0243986 0.8399422 47 0.0249798 0.8676320 24 -0.0895652 0.6763694 0.1145450 0.6651606 0.9911425
rho…1230 CitG6m2 E-cadherin 57 -0.4351828 0.0008022 36 -0.4926641 0.0025515 21 -0.3909091 0.0807216 -0.1017550 0.6654524 0.9911425
rho…1231 FumQ6m4 Etoposide (uM) 71 -0.0431473 0.7208834 47 -0.0865015 0.5631689 24 0.0278321 0.8972826 -0.1143336 0.6657998 0.9911425
rho…1232 CitG6m3 Paclitaxel (nM) 71 0.0543951 0.6523213 47 0.0780396 0.6020865 24 -0.0361027 0.8669935 0.1141423 0.6664592 0.9911425
rho…1233 MalG6m1 CDH1 66 0.1146168 0.3594649 43 0.0790965 0.6141365 23 0.1947539 0.3732025 -0.1156574 0.6665280 0.9911425
rho…1234 CitG24m1 Gefitinib (EGFR) (uM) 70 -0.0855968 0.4810879 46 -0.0576787 0.7033909 24 -0.1705460 0.4255890 0.1128674 0.6671677 0.9911425
rho…1235 CitG24m1 Etoposide (uM) 69 -0.0893785 0.4651860 46 -0.1275520 0.3982506 23 -0.0118606 0.9571653 -0.1156913 0.6671786 0.9911425
rho…1236 LacQ6m3 Docetaxel (nM) 69 -0.1929955 0.1120988 46 -0.1684458 0.2631262 23 -0.2788628 0.1975580 0.1104170 0.6671984 0.9911425
rho…1237 MalG24m1 Sorafenib (multi-kinase) (uM) 73 -0.0122594 0.9180104 48 0.0238903 0.8719540 25 -0.0877092 0.6767523 0.1115995 0.6672892 0.9911425
rho…1238 MalQ6m4 Gemcitabine (nM) 70 -0.0184515 0.8794947 46 -0.0111428 0.9414108 24 -0.1248097 0.5611871 0.1136669 0.6676203 0.9911425
rho…1239 CitQ24m4 Cisplatin (uM) 68 -0.0192029 0.8764828 45 -0.0773513 0.6135274 23 0.0390606 0.8595490 -0.1164119 0.6678260 0.9911425
rho…1240 MalQ24m1 Doxorubicin (nM) 73 0.0060944 0.9591885 48 -0.0281231 0.8495096 25 0.0830769 0.6921470 -0.1112001 0.6684938 0.9911425
rho…1241 CitQ24m3 AZD6244 (MEK) (uM) 69 -0.0896684 0.4637340 46 -0.0541557 0.7207503 23 -0.1679842 0.4418246 0.1138284 0.6698859 0.9911425
rho…1242 CitQ6m4 AZD6244 (MEK) (uM) 69 0.1118297 0.3602804 46 0.1482144 0.3255989 23 0.0345850 0.8762119 0.1136294 0.6716833 0.9911425
rho…1243 FumG6m1 SCH772984 (ERK) (uM) 78 -0.1825948 0.1095806 51 -0.1386765 0.3317992 27 -0.2406075 0.2266889 0.1019309 0.6720242 0.9911425
rho…1244 FumG24m3 Sorafenib (multi-kinase) (uM) 73 -0.2698067 0.0209752 48 -0.2722411 0.0612131 25 -0.1681093 0.4218278 -0.1041318 0.6736420 0.9911425
rho…1245 FumG6m2 AZD6244 (MEK) (uM) 71 0.0435989 0.7180830 47 0.0653984 0.6622970 24 -0.0460870 0.8308800 0.1114854 0.6738923 0.9911425
rho…1246 CitQ6m5 AZD6244 (MEK) (uM) 69 -0.0212294 0.8625396 46 -0.0425584 0.7788416 23 0.0711462 0.7466506 -0.1137047 0.6740148 0.9911425
rho…1247 FumQ24m4 Docetaxel (nM) 69 -0.0062041 0.9596487 46 0.0244956 0.8716294 23 -0.0889988 0.6863424 0.1134944 0.6743263 0.9911425
rho…1248 FumG6m1 Carboplatin (uM) 69 0.0979471 0.4233203 46 0.1332511 0.3773297 23 0.0207612 0.9250895 0.1124898 0.6755449 0.9911425
rho…1249 CitQ24m1 Pemetrexed/Cisplatin (uM) 65 -0.0963589 0.4451198 44 -0.1028225 0.5065776 21 0.0149496 0.9487185 -0.1177721 0.6760771 0.9911425
rho…1250 MalG6m1 SCH772984 (ERK) (uM) 78 -0.2162810 0.0571869 51 -0.2747969 0.0509926 27 -0.1759397 0.3800378 -0.0988572 0.6766620 0.9911425
rho…1251 GlyG24m2 Carboplatin (uM) 66 -0.2163796 0.0809801 43 -0.2650857 0.0858065 23 -0.1562037 0.4766271 -0.1088820 0.6770057 0.9911425
rho…1252 CitQ6m3 Gemcitabine (nM) 69 -0.1717589 0.1581905 46 -0.1870757 0.2131624 23 -0.2930566 0.1747523 0.1059809 0.6773888 0.9911425
rho…1253 FumG24m3 EGFR-pY1173 59 -0.0056401 0.9661834 37 -0.0896159 0.5966360 22 0.0287973 0.8998354 -0.1184132 0.6786712 0.9911425
rho…1254 GlyG24m1 Carboplatin (uM) 66 0.0713973 0.5688952 43 0.1376888 0.3785968 23 0.0252101 0.9090961 0.1124787 0.6789410 0.9911425
rho…1255 CitG6m1 E-cadherin 57 -0.0982629 0.4660556 36 -0.1410553 0.4104172 21 -0.0207792 0.9303117 -0.1202761 0.6790961 0.9911425
rho…1256 FumQ24m1 Docetaxel (nM) 69 0.0257849 0.8334278 46 0.0594188 0.6948706 23 -0.0523974 0.8123166 0.1118162 0.6791938 0.9911425
rho…1257 CitQ24m3 SCH772984 (ERK) (uM) 76 0.0284970 0.8069495 50 0.0456887 0.7527154 26 -0.0593604 0.7733102 0.1050491 0.6794489 0.9911425
rho…1258 LacG24m2 Cisplatin (uM) 70 0.0654780 0.5902026 46 0.1281110 0.3961690 24 0.0191429 0.9292550 0.1089681 0.6803680 0.9911425
rho…1259 MalQ24m2 CDH1 66 0.2767593 0.0244755 43 0.2460528 0.1117238 23 0.3483428 0.1033306 -0.1022900 0.6816279 0.9911425
rho…1260 CitG24m3 Gemcitabine (nM) 69 -0.0663826 0.5878598 46 -0.1016474 0.5014707 23 0.0088955 0.9678677 -0.1105429 0.6820078 0.9911425
rho…1261 GlyG6m1 Gemcitabine (nM) 64 -0.0643202 0.6135988 41 -0.0341526 0.8321210 23 -0.1462812 0.5054018 0.1121286 0.6820488 0.9911425
rho…1262 MalQ24m4 Etoposide (uM) 71 -0.0252042 0.8347312 47 -0.0758044 0.6125585 24 0.0326158 0.8797438 -0.1084202 0.6822660 0.9911425
rho…1263 LacQ6m1 Cisplatin (uM) 70 0.1317095 0.2770977 46 0.1464964 0.3313005 24 0.2510333 0.2367220 -0.1045369 0.6823415 0.9911425
rho…1264 CitG6m1 SCH772984 (ERK) (uM) 76 -0.1516519 0.1909624 50 -0.0848484 0.5579752 26 -0.1868107 0.3608300 0.1019624 0.6828294 0.9911425
rho…1265 SerG6m2 Pemetrexed/Cisplatin (uM) 59 -0.2002543 0.1283298 40 -0.3188854 0.0449037 19 -0.2054435 0.3987995 -0.1134420 0.6834733 0.9911425
rho…1266 FumQ24m4 Cisplatin (uM) 70 0.0475778 0.6957095 46 0.0103007 0.9458320 24 0.1179286 0.5831360 -0.1076280 0.6844881 0.9911425
rho…1267 CitQ6m6 Paclitaxel/Carboplatin (nM) 68 -0.0223372 0.8565208 45 -0.0029652 0.9845767 23 -0.1127876 0.6083811 0.1098224 0.6847355 0.9911425
rho…1268 LacG6m1 MK-2206 (AKT) (uM) 71 0.1702194 0.1558361 47 0.1473234 0.3230513 24 0.2505983 0.2375626 -0.1032749 0.6848400 0.9911425
rho…1269 FumG24m3 Gefitinib (EGFR) (uM) 72 0.1735725 0.1448051 47 0.1921698 0.1956399 25 0.0885126 0.6739501 0.1036572 0.6852181 0.9911425
rho…1270 SerG6m3 Cisplatin (uM) 60 -0.1441990 0.2716717 41 -0.1810420 0.2573083 19 -0.0623354 0.7998715 -0.1187066 0.6856121 0.9911425
rho…1271 CitQ24m3 Etoposide (uM) 69 0.0094548 0.9385404 46 -0.0207241 0.8912647 23 0.0884606 0.6881462 -0.1091847 0.6860127 0.9911425
rho…1272 CitG24m3 SCH772984 (ERK) (uM) 76 -0.1283651 0.2691190 50 -0.0918931 0.5256287 26 -0.1923976 0.3463828 0.1005045 0.6865976 0.9911425
rho…1273 CitG24m3 Docetaxel (nM) 67 -0.0866901 0.4854586 45 -0.0754021 0.6225210 22 -0.1847458 0.4104661 0.1093437 0.6871480 0.9911425
rho…1274 CitQ24m4 AZD6244 (MEK) (uM) 69 0.1537576 0.2071684 46 0.1392710 0.3559573 23 0.2440711 0.2605223 -0.1048002 0.6873795 0.9911425
rho…1275 FumG24m1 E-cadherin 59 0.1462659 0.2689823 37 0.2239611 0.1826813 22 0.1123659 0.6174232 0.1115952 0.6881095 0.9911425
rho…1276 CitQ24m5 E-cadherin 57 0.3817086 0.0035984 36 0.4574003 0.0054568 21 0.3597403 0.1097749 0.0976600 0.6885917 0.9911425
rho…1277 GlyG6m1 Carboplatin (uM) 63 0.1482157 0.2463403 41 0.1525594 0.3409770 22 0.2593221 0.2438572 -0.1067627 0.6911723 0.9911425
rho…1278 MalG24m4 E-cadherin 59 -0.1976037 0.1333580 37 -0.1635846 0.3320132 22 -0.2715980 0.2205930 0.1080133 0.6918644 0.9911425
rho…1279 FumQ6m2 Paclitaxel/Carboplatin (nM) 70 -0.1967920 0.1025017 46 -0.1342031 0.3738997 24 -0.2359600 0.2669907 0.1017569 0.6919678 0.9911425
rho…1280 FumQ6m2 Crizotinib (ALK) (uM) 75 0.0094277 0.9360170 49 0.0699492 0.6329421 26 -0.0309666 0.8806309 0.1009159 0.6923624 0.9911425
rho…1281 FumG24m1 Docetaxel (nM) 69 0.0018914 0.9876936 46 0.0480084 0.7513721 23 -0.0588235 0.7897723 0.1068319 0.6927695 0.9911425
rho…1282 CitQ6m5 Beta-catenin 57 0.4274695 0.0010105 36 0.4301158 0.0093651 21 0.5194805 0.0171075 -0.0893647 0.6932264 0.9911425
rho…1283 MalQ6m2 Pemetrexed (uM) 69 -0.2670107 0.0265635 46 -0.2943783 0.0470477 23 -0.1941919 0.3746105 -0.1001865 0.6935146 0.9911425
rho…1284 CitQ24m1 Docetaxel (nM) 67 -0.0538544 0.6651337 45 -0.0745452 0.6264917 22 0.0338983 0.8809550 -0.1084435 0.6944838 0.9911425
rho…1285 FumG6m3 Etoposide (uM) 71 -0.1070381 0.3742903 47 -0.0773078 0.6055065 24 -0.1796043 0.4010392 0.1022965 0.6946636 0.9911425
rho…1286 LacQ24m2 Beta-catenin 59 -0.0856809 0.5177805 37 -0.1237553 0.4640932 22 -0.0129870 0.9558389 -0.1107683 0.6973196 0.9911425
rho…1287 MalG6m4 8-Cl-adenosine (uM) 71 -0.1757628 0.1426057 47 -0.1516396 0.3089184 24 -0.2504892 0.2377736 0.0988497 0.6974364 0.9911425
rho…1288 FumQ6m2 Paclitaxel (nM) 73 -0.1545387 0.1917403 48 -0.1586405 0.2814981 25 -0.0588801 0.7798068 -0.0997604 0.6977138 0.9911425
rho…1289 CitQ24m5 CDH1 64 -0.3891173 0.0014838 42 -0.4337604 0.0041073 22 -0.3416295 0.1196854 -0.0921310 0.6979327 0.9911425
rho…1290 MalQ6m4 Gefitinib (EGFR) (uM) 71 -0.1785798 0.1362144 46 -0.2276849 0.1280586 25 -0.1293054 0.5378799 -0.0983795 0.6979936 0.9911425
rho…1291 SerG6m3 EGFR-pY1173 50 -0.2096038 0.1437514 32 -0.1217009 0.5054616 18 0.0010320 1.0000000 -0.1227329 0.6981566 0.9911425
rho…1292 FumG24m4 Cisplatin (uM) 70 -0.1689618 0.1620355 46 -0.1180571 0.4345646 24 -0.2179683 0.3062193 0.0999112 0.6990803 0.9911425
rho…1293 LacQ6m3 Paclitaxel/Carboplatin (nM) 70 0.1158918 0.3393825 46 0.0743322 0.6234607 24 0.1754463 0.4122085 -0.1011141 0.6993613 0.9911425
rho…1294 CitQ24m4 Pemetrexed/Cisplatin (uM) 65 -0.0365417 0.7725902 44 0.0165615 0.9150258 21 -0.0922977 0.6906941 0.1088593 0.6995387 0.9911425
rho…1295 MalQ24m1 Docetaxel (nM) 69 0.0789628 0.5189665 46 0.1127908 0.4554754 23 0.0093920 0.9660751 0.1033988 0.7011214 0.9911425
rho…1296 MalQ6m1 Doxorubicin (nM) 72 0.0272172 0.8204661 47 0.0129836 0.9309751 25 0.1127140 0.5916602 -0.0997304 0.7011434 0.9911425
rho…1297 FumG6m3 Beta-catenin 59 -0.2476914 0.0587877 37 -0.2667141 0.1105423 22 -0.1620553 0.4694849 -0.1046587 0.7014023 0.9911425
rho…1298 CitG6m4 Vinorelbine (nM) 70 0.0663715 0.5851294 46 0.1208869 0.4235531 24 0.0200218 0.9260156 0.1008651 0.7031323 0.9911425
rho…1299 LacQ6m2 Sorafenib (multi-kinase) (uM) 73 0.0439771 0.7118043 48 0.1045258 0.4795494 25 0.0057703 0.9781609 0.0987555 0.7031394 0.9911425
rho…1300 CitQ6m5 Pemetrexed/Cisplatin (uM) 65 -0.1773538 0.1575499 44 -0.2271398 0.1381386 21 -0.1228470 0.5957649 -0.1042928 0.7032704 0.9911425
rho…1301 MalG6m3 Etoposide (uM) 71 -0.1285698 0.2852675 47 -0.0982971 0.5109625 24 -0.1969994 0.3561833 0.0987022 0.7033682 0.9911425
rho…1302 CitG24m3 Paclitaxel (nM) 71 -0.1208483 0.3154287 47 -0.1616839 0.2775832 24 -0.0622010 0.7727852 -0.0994830 0.7038138 0.9911425
rho…1303 CitQ24m6 Beta-catenin 57 0.0611226 0.6506845 36 0.0298584 0.8626207 21 0.1402597 0.5427638 -0.1104013 0.7040037 0.9911425
rho…1304 FumG24m1 EGFR-pY1173 59 -0.0701959 0.5972903 37 0.0559606 0.7421784 22 -0.0525127 0.8167871 0.1084733 0.7046296 0.9911425
rho…1305 SerG24m1 E-cadherin 53 -0.0791808 0.5720171 33 0.0086898 0.9622335 20 -0.1052632 0.6579851 0.1139530 0.7064248 0.9911425
rho…1306 CitQ6m6 Carboplatin (uM) 67 -0.0476789 0.7016142 45 -0.0710968 0.6425770 22 0.0327684 0.8848972 -0.1038651 0.7068077 0.9911425
rho…1307 MalQ6m4 Pemetrexed (uM) 69 -0.1311984 0.2825724 46 -0.1488632 0.3234617 23 -0.0481755 0.8272083 -0.1006877 0.7069239 0.9911425
rho…1308 CitQ6m3 Crizotinib (ALK) (uM) 73 0.0425100 0.7210182 48 0.0710754 0.6311900 25 -0.0265589 0.8997179 0.0976343 0.7070737 0.9911425
rho…1309 CitG6m6 SCH772984 (ERK) (uM) 76 -0.2115700 0.0665524 50 -0.2180054 0.1282849 26 -0.1253552 0.5417509 -0.0926502 0.7073193 0.9911425
rho…1310 MalG6m3 Beta-catenin 59 -0.2719462 0.0375168 37 -0.2989569 0.0726042 22 -0.1981931 0.3749020 -0.1007637 0.7073734 0.9911425
rho…1311 CitQ24m6 Docetaxel (nM) 67 -0.0732764 0.5556609 45 -0.1345241 0.3782986 22 -0.0322034 0.8868693 -0.1023207 0.7091403 0.9911425
rho…1312 CitQ24m3 Docetaxel (nM) 67 -0.0813314 0.5129294 45 -0.0571137 0.7094065 22 -0.1587571 0.4803959 0.1016434 0.7096640 0.9911425
rho…1313 FumG6m1 MK-2206 (AKT) (uM) 71 0.0765090 0.5259741 47 0.0325650 0.8279744 24 0.1305199 0.5432606 -0.0979549 0.7098167 0.9911425
rho…1314 MalG6m4 Cisplatin (uM) 70 -0.0656004 0.5895060 46 -0.0238088 0.8751997 24 -0.1222537 0.5692968 0.0984449 0.7098372 0.9911425
rho…1315 LacG24m1 Erlotinib (EGFR) (uM) 73 -0.1574700 0.1833467 48 -0.1920091 0.1910714 25 -0.0973264 0.6434936 -0.0946827 0.7098585 0.9911425
rho…1316 CitG24m4 Cisplatin (uM) 68 -0.2035962 0.0958603 45 -0.2461538 0.1031072 23 -0.1493202 0.4964999 -0.0968337 0.7104280 0.9911425
rho…1317 FumG6m2 Pemetrexed (uM) 70 -0.0630140 0.6042936 47 -0.0031579 0.9831925 23 -0.1028075 0.6406487 0.0996495 0.7107403 0.9911425
rho…1318 MalQ24m2 Gemcitabine/Cisplatin (nM) 67 -0.0361786 0.7713138 45 -0.0095533 0.9503371 22 -0.1112366 0.6209973 0.1016833 0.7117930 0.9911425
rho…1319 FumQ6m4 Vinorelbine (nM) 72 -0.2469019 0.0365411 47 -0.2661771 0.0705349 25 -0.1747835 0.4033592 -0.0913935 0.7127097 0.9911425
rho…1320 MalG24m3 AZD6244 (MEK) (uM) 71 -0.0200723 0.8680416 47 0.0165954 0.9118416 24 -0.0808696 0.7064733 0.0974649 0.7127630 0.9911425
rho…1321 CitG6m1 Paclitaxel (nM) 71 -0.0152778 0.8993715 47 0.0222055 0.8822226 24 -0.0752501 0.7267402 0.0974556 0.7128800 0.9911425
rho…1322 MalG6m4 Gemcitabine/Cisplatin (nM) 67 -0.0522225 0.6747033 45 -0.0238503 0.8764173 22 -0.1247883 0.5786862 0.1009379 0.7132975 0.9911425
rho…1323 MalG6m1 AZD6244 (MEK) (uM) 71 -0.1650834 0.1688876 47 -0.1354594 0.3639572 24 -0.2295652 0.2792185 0.0941058 0.7133539 0.9911425
rho…1324 FumG6m1 Gemcitabine (nM) 71 -0.1734368 0.1480504 47 -0.1114116 0.4559346 24 -0.2061318 0.3338649 0.0947202 0.7138634 0.9911425
rho…1325 MalG24m3 Pemetrexed (uM) 70 0.1238034 0.3072079 47 0.1211704 0.4171766 23 0.2170380 0.3198554 -0.0958676 0.7141603 0.9911425
rho…1326 MalQ6m4 8-Cl-adenosine (uM) 70 0.0027473 0.9819919 46 -0.0216526 0.8864241 24 0.0756686 0.7252776 -0.0973213 0.7142759 0.9911425
rho…1327 CitG6m4 Pemetrexed (uM) 68 0.0630749 0.6093544 46 0.0804679 0.5950006 22 0.1791907 0.4249237 -0.0987228 0.7152327 0.9911425
rho…1328 LacG6m3 8-Cl-adenosine (uM) 71 -0.1164747 0.3333891 47 -0.1601990 0.2820790 24 -0.0647967 0.7635610 -0.0954023 0.7154076 0.9911425
rho…1329 CitQ24m6 Doxorubicin (nM) 71 0.0328694 0.7855301 47 0.0547684 0.7146359 24 -0.0417391 0.8467871 0.0965075 0.7157360 0.9911425
rho…1330 FumG24m1 Doxorubicin (nM) 73 0.1043086 0.3798190 48 0.1361748 0.3560662 25 0.0423077 0.8410524 0.0938671 0.7158598 0.9911425
rho…1331 CitG24m1 MK-2206 (AKT) (uM) 69 0.0288518 0.8139515 46 0.0357826 0.8133660 23 -0.0622992 0.7776455 0.0980817 0.7168011 0.9911425
rho…1332 SerG6m1 Docetaxel (nM) 60 -0.3270474 0.0107547 41 -0.3368917 0.0312518 19 -0.2388061 0.3248170 -0.0980856 0.7193807 0.9911425
rho…1333 FumG24m1 Pemetrexed (uM) 70 -0.2112236 0.0792139 47 -0.1820345 0.2207169 23 -0.2736566 0.2064065 0.0916220 0.7198423 0.9911425
rho…1334 MalG6m3 Erlotinib (EGFR) (uM) 73 0.0682979 0.5658753 48 0.1149169 0.4367087 25 0.0223120 0.9156924 0.0926050 0.7204056 0.9911425
rho…1335 FumG6m4 Crizotinib (ALK) (uM) 75 -0.0954001 0.4155468 49 -0.0432096 0.7681493 26 -0.1334246 0.5158277 0.0902150 0.7216230 0.9911425
rho…1336 SerG6m2 8-Cl-adenosine (uM) 61 -0.2492562 0.0527240 41 -0.2626580 0.0970967 20 -0.1639098 0.4882419 -0.0987482 0.7226532 0.9911425
rho…1337 MalG6m1 Sorafenib (multi-kinase) (uM) 73 -0.2019766 0.0865997 48 -0.2431787 0.0958158 25 -0.1550298 0.4593268 -0.0881489 0.7240087 0.9911425
rho…1338 CitG6m5 Sorafenib (multi-kinase) (uM) 71 -0.1067682 0.3755028 47 -0.0634489 0.6717860 24 -0.1556860 0.4675725 0.0922371 0.7246469 0.9911425
rho…1339 FumG24m2 Gefitinib (EGFR) (uM) 72 0.0274838 0.8187369 47 -0.0124335 0.9338932 25 0.0792765 0.7064092 -0.0917100 0.7249406 0.9911425
rho…1340 CitG6m6 EGFR-pY1173 57 -0.1691081 0.2079786 36 -0.3395109 0.0433719 21 -0.2454545 0.2822055 -0.0940564 0.7252792 0.9911425
rho…1341 CitQ6m1 Carboplatin (uM) 67 -0.1125813 0.3643729 45 -0.1336277 0.3815137 22 -0.0372881 0.8691451 -0.0963395 0.7253664 0.9911425
rho…1342 LacQ24m2 SCH772984 (ERK) (uM) 78 -0.0349768 0.7611182 51 0.0335390 0.8152612 27 -0.0538860 0.7895118 0.0874250 0.7263691 0.9911425
rho…1343 CitG24m6 MK-2206 (AKT) (uM) 69 0.1757128 0.1486888 46 0.1477529 0.3271245 23 0.2388134 0.2724604 -0.0910605 0.7264977 0.9911425
rho…1344 LacQ6m3 Gemcitabine/Cisplatin (nM) 67 -0.0133701 0.9144845 45 -0.0303070 0.8433346 22 0.0660830 0.7701464 -0.0963901 0.7270776 0.9911425
rho…1345 MalG6m1 Pemetrexed/Cisplatin (uM) 67 -0.0024047 0.9845917 45 0.0199624 0.8964424 22 -0.0762928 0.7357785 0.0962552 0.7273203 0.9911425
rho…1346 CitQ24m2 Crizotinib (ALK) (uM) 73 0.0716700 0.5468046 48 0.0260827 0.8603153 25 0.1162433 0.5800293 -0.0901606 0.7274038 0.9911425
rho…1347 CitG6m3 Paclitaxel/Carboplatin (nM) 68 0.1057485 0.3907449 45 0.1377833 0.3667463 23 0.0440267 0.8418980 0.0937566 0.7276584 0.9911425
rho…1348 SerG24m2 Cisplatin (uM) 65 -0.1428728 0.2562233 43 -0.1193263 0.4459722 22 -0.0231638 0.9185032 -0.0961625 0.7284648 0.9911425
rho…1349 CitG24m3 Cisplatin (uM) 68 -0.0906323 0.4623202 45 -0.0679954 0.6571831 23 -0.1606923 0.4638897 0.0926969 0.7293544 0.9911425
rho…1350 MalQ24m3 Erlotinib (EGFR) (uM) 73 -0.1773890 0.1332552 48 -0.1490107 0.3121024 25 -0.2354752 0.2571626 0.0864645 0.7298088 0.9911425
rho…1351 MalG6m3 AZD6244 (MEK) (uM) 71 -0.0320955 0.7904628 47 -0.0457384 0.7601507 24 0.0452174 0.8340563 -0.0909558 0.7314705 0.9911425
rho…1352 SerG24m1 CDH1 60 0.1181506 0.3686028 38 0.0544032 0.7456344 22 0.1510183 0.5023126 -0.0966152 0.7316416 0.9911425
rho…1353 FumQ24m3 SCH772984 (ERK) (uM) 78 -0.0500437 0.6634820 51 -0.0383443 0.7893593 27 -0.1234366 0.5396127 0.0850923 0.7317301 0.9911425
rho…1354 MalG6m1 Pemetrexed (uM) 70 -0.0425074 0.7267913 47 -0.0184807 0.9018725 23 -0.1102573 0.6164986 0.0917766 0.7323677 0.9911425
rho…1355 LacG6m1 SCH772984 (ERK) (uM) 78 -0.2574553 0.0228712 51 -0.1953275 0.1695635 27 -0.2760093 0.1634486 0.0806819 0.7323897 0.9911425
rho…1356 CitG6m6 MK-2206 (AKT) (uM) 69 0.1971660 0.1044085 46 0.1549756 0.3037622 23 0.2437578 0.2623558 -0.0887822 0.7324459 0.9911425
rho…1357 CitG6m2 8-Cl-adenosine (uM) 69 -0.1062238 0.3850097 46 -0.0873454 0.5637996 23 -0.1779096 0.4167041 0.0905642 0.7332145 0.9911425
rho…1358 CitG6m1 Doxorubicin (nM) 71 0.0260942 0.8289815 47 0.0689376 0.6452044 24 -0.0208696 0.9238618 0.0898072 0.7345894 0.9911425
rho…1359 CitG24m3 Erlotinib (EGFR) (uM) 71 -0.0869631 0.4708325 47 -0.1135654 0.4472162 24 -0.0243531 0.9100679 -0.0892123 0.7352150 0.9911425
rho…1360 CitG24m5 MK-2206 (AKT) (uM) 69 0.1837234 0.1307537 46 0.1595978 0.2893882 23 0.2472189 0.2554272 -0.0876211 0.7353853 0.9911425
rho…1361 MalQ24m3 Docetaxel (nM) 69 0.0953016 0.4360104 46 0.0535279 0.7238589 23 0.1438813 0.5124861 -0.0903534 0.7358500 0.9911425
rho…1362 CitG6m3 Pemetrexed/Cisplatin (uM) 65 0.0717283 0.5701684 44 0.0811163 0.6006690 21 0.1748457 0.4484215 -0.0937294 0.7359030 0.9911425
rho…1363 LacG24m2 SCH772984 (ERK) (uM) 78 -0.0128052 0.9114013 51 0.0541331 0.7059650 27 -0.0294493 0.8840684 0.0835825 0.7379451 0.9911425
rho…1364 LacG24m1 Pemetrexed (uM) 70 0.0691979 0.5692140 47 0.1140424 0.4452978 23 0.0243361 0.9122357 0.0897064 0.7380249 0.9911425
rho…1365 FumQ24m4 Gemcitabine (nM) 71 0.0863601 0.4739255 47 0.1150573 0.4412314 24 0.0269682 0.9004552 0.0880890 0.7383572 0.9911425
rho…1366 MalG6m4 Docetaxel (nM) 69 -0.1032126 0.3987014 46 -0.1168014 0.4395012 23 -0.0271873 0.9019985 -0.0896140 0.7390960 0.9911425
rho…1367 GlyG6m2 8-Cl-adenosine (uM) 64 -0.1807066 0.1530174 41 -0.1699198 0.2881820 23 -0.2574747 0.2355939 0.0875548 0.7396112 0.9911425
rho…1368 CitG6m2 Paclitaxel (nM) 71 -0.1342468 0.2643510 47 -0.1620887 0.2763659 24 -0.0752501 0.7267402 -0.0868386 0.7396546 0.9911425
rho…1369 MalG6m1 Paclitaxel/Carboplatin (nM) 70 0.0471657 0.6982181 46 0.0178902 0.9060619 24 0.1057672 0.6228084 -0.0878770 0.7402126 0.9911425
rho…1370 FumQ24m2 Etoposide (uM) 71 -0.1419121 0.2377882 47 -0.1563503 0.2939519 24 -0.0695955 0.7465908 -0.0867548 0.7402332 0.9911425
rho…1371 MalG24m1 Erlotinib (EGFR) (uM) 73 -0.0844358 0.4775567 48 -0.1138313 0.4410823 25 -0.0280823 0.8939965 -0.0857490 0.7402722 0.9911425
rho…1372 GlyG6m1 Paclitaxel (nM) 66 0.1087299 0.3848312 42 0.0970095 0.5410907 24 0.1848630 0.3871582 -0.0878535 0.7403455 0.9911425
rho…1373 FumQ6m4 8-Cl-adenosine (uM) 71 0.0196876 0.8705486 47 0.0222081 0.8822091 24 0.1095890 0.6102238 -0.0873810 0.7405634 0.9911425
rho…1374 MalG6m2 Pemetrexed (uM) 70 -0.0622902 0.6084614 47 -0.0249709 0.8676784 23 -0.1137339 0.6053569 0.0887629 0.7406783 0.9911425
rho…1375 MalQ6m1 Paclitaxel (nM) 72 0.0652536 0.5860387 47 0.1068764 0.4745907 25 0.0211661 0.9200084 0.0857104 0.7415490 0.9911425
rho…1376 CitG24m3 E-cadherin 57 0.0423911 0.7542074 36 -0.0092664 0.9575906 21 0.0870130 0.7071552 -0.0962794 0.7419032 0.9911425
rho…1377 MalG6m4 Etoposide (uM) 71 -0.0795365 0.5096798 47 -0.0213941 0.8864977 24 -0.1082844 0.6145079 0.0868903 0.7420046 0.9911425
rho…1378 MalQ24m4 E-cadherin 59 -0.0032729 0.9804855 37 0.0004742 0.9983246 22 -0.0931677 0.6792877 0.0936419 0.7430090 0.9911425
rho…1379 MalQ24m3 AZD6244 (MEK) (uM) 71 -0.1257012 0.2962419 47 -0.0978981 0.5126880 24 -0.1830833 0.3918251 0.0851852 0.7430160 0.9911425
rho…1380 MalG6m1 Beta-catenin 59 -0.2008182 0.1270618 37 -0.2311522 0.1681762 22 -0.1405985 0.5310122 -0.0905537 0.7431215 0.9911425
rho…1381 MalQ6m4 CDH1 66 -0.0854240 0.4952537 43 -0.0333913 0.8316638 23 -0.1222169 0.5785290 0.0888256 0.7440143 0.9911425
rho…1382 CitQ6m2 Sorafenib (multi-kinase) (uM) 71 -0.1012931 0.4006136 47 -0.1016832 0.4964416 24 -0.0156556 0.9421195 -0.0860276 0.7446687 0.9911425
rho…1383 FumQ24m1 Cisplatin (uM) 70 0.0369210 0.7615508 46 0.0486045 0.7483854 24 -0.0378508 0.8606131 0.0864553 0.7452121 0.9911425
rho…1384 LacQ6m3 MK-2206 (AKT) (uM) 71 0.1846196 0.1232432 47 0.1619433 0.2768027 24 0.2443429 0.2498656 -0.0823996 0.7457332 0.9911425
rho…1385 CitG6m5 Carboplatin (uM) 67 -0.1260927 0.3092700 45 -0.0958060 0.5312863 22 -0.1836158 0.4133848 0.0878098 0.7458233 0.9911425
rho…1386 CitQ6m3 Vinorelbine (nM) 70 -0.1034293 0.3941816 46 -0.1316804 0.3830292 24 -0.0461371 0.8304906 -0.0855433 0.7458719 0.9911425
rho…1387 MalG6m1 EGFR-pY1173 59 -0.0180012 0.8921921 37 0.0246562 0.8847861 22 0.1168831 0.6032128 -0.0922269 0.7460581 0.9911425
rho…1388 CitQ6m5 Paclitaxel (nM) 71 -0.0969159 0.4213807 47 -0.1269300 0.3952126 24 -0.0417573 0.8463861 -0.0851727 0.7462161 0.9911425
rho…1389 CitQ24m1 8-Cl-adenosine (uM) 69 -0.0918450 0.4529097 46 -0.0622398 0.6811369 23 -0.1487522 0.4981579 0.0865124 0.7463561 0.9911425
rho…1390 FumG24m1 CDH1 66 -0.1192027 0.3404334 43 -0.1336935 0.3927174 23 -0.0460169 0.8348448 -0.0876766 0.7467171 0.9911425
rho…1391 CitQ6m3 Doxorubicin (nM) 71 -0.1543615 0.1986855 47 -0.1871494 0.2077967 24 -0.1034783 0.6292251 -0.0836711 0.7470877 0.9911425
rho…1392 MalG6m3 Gefitinib (EGFR) (uM) 72 0.2538677 0.0314111 47 0.2825006 0.0543587 25 0.2035790 0.3290372 0.0789216 0.7478750 0.9911425
rho…1393 GlyG24m1 MK-2206 (AKT) (uM) 67 0.1466570 0.2363086 43 0.1006387 0.5207957 24 0.1853383 0.3859172 -0.0846996 0.7481488 0.9911425
rho…1394 LacQ24m1 Pemetrexed/Cisplatin (uM) 67 -0.1406079 0.2564111 45 -0.1701090 0.2639170 22 -0.0836395 0.7113424 -0.0864696 0.7504218 0.9911425
rho…1395 CitG24m1 E-cadherin 57 0.1925458 0.1513016 36 0.1453118 0.3977746 21 0.2350649 0.3035931 -0.0897531 0.7504409 0.9911425
rho…1396 FumG6m3 AZD6244 (MEK) (uM) 71 0.0431629 0.7207861 47 0.0045102 0.9759968 24 0.0878261 0.6823528 -0.0833159 0.7527742 0.9911425
rho…1397 MalG6m1 Crizotinib (ALK) (uM) 75 0.1716841 0.1408008 49 0.1460313 0.3167250 26 0.2230586 0.2733786 -0.0770272 0.7547072 0.9911425
rho…1398 MalQ6m4 EGFR-pY1173 58 0.1091698 0.4136119 36 0.0561133 0.7444330 22 0.1451158 0.5177461 -0.0890025 0.7547125 0.9911425
rho…1399 MalG24m4 8-Cl-adenosine (uM) 71 -0.2795502 0.0182256 47 -0.2918281 0.0465514 24 -0.2143944 0.3144133 -0.0774337 0.7549287 0.9911425
rho…1400 CitG24m6 Etoposide (uM) 69 -0.1340300 0.2722217 46 -0.1123138 0.4573959 23 -0.1947121 0.3733070 0.0823983 0.7550535 0.9911425
rho…1401 CitG24m6 Gemcitabine (nM) 69 -0.1274155 0.2968018 46 -0.1667710 0.2679709 23 -0.0840129 0.7031161 -0.0827582 0.7559202 0.9911425
rho…1402 FumG24m4 Etoposide (uM) 71 -0.0303691 0.8014969 47 0.0095984 0.9489440 24 -0.0726245 0.7359372 0.0822229 0.7561872 0.9911425
rho…1403 FumG6m4 MK-2206 (AKT) (uM) 71 0.1089077 0.3659548 47 0.1392713 0.3504864 24 0.0578638 0.7882639 0.0814074 0.7564667 0.9911425
rho…1404 MalG6m4 Gemcitabine (nM) 71 -0.1606456 0.1807961 47 -0.1490581 0.3173230 24 -0.0678408 0.7527831 -0.0812172 0.7565299 0.9911425
rho…1405 FumQ6m4 E-cadherin 59 -0.1439509 0.2759179 37 -0.1901375 0.2586188 22 -0.1033315 0.6462494 -0.0868061 0.7566027 0.9911425
rho…1406 CitG6m6 E-cadherin 57 -0.1956832 0.1443497 36 -0.2404118 0.1574348 21 -0.1532468 0.5055888 -0.0871651 0.7567880 0.9911425
rho…1407 CitQ24m2 EGFR-pY1173 57 -0.1204304 0.3712028 36 -0.2404118 0.1574348 21 -0.1532468 0.5055888 -0.0871651 0.7567880 0.9911425
rho…1408 CitG24m3 Doxorubicin (nM) 71 -0.0688166 0.5685127 47 -0.1060667 0.4779635 24 -0.0243478 0.9109496 -0.0817189 0.7568659 0.9911425
rho…1409 CitG6m3 Gemcitabine (nM) 69 -0.1249555 0.3063020 46 -0.0717497 0.6356075 23 -0.1541883 0.4824034 0.0824386 0.7575425 0.9911425
rho…1410 MalG24m3 Etoposide (uM) 71 -0.0529740 0.6608410 47 -0.0093093 0.9504798 24 -0.0908893 0.6727541 0.0815800 0.7576785 0.9911425
rho…1411 CitG6m6 Beta-catenin 57 -0.2885662 0.0298466 36 -0.3564994 0.0334621 21 -0.2753247 0.2261962 -0.0811747 0.7580704 0.9911425
rho…1412 GlyG24m1 8-Cl-adenosine (uM) 67 0.1477638 0.2327516 43 0.1732004 0.2666959 24 0.0917591 0.6697945 0.0814413 0.7582330 0.9911425
rho…1413 MalG6m1 8-Cl-adenosine (uM) 71 -0.0942135 0.4345044 47 -0.0739734 0.6211946 24 -0.1543814 0.4713573 0.0804080 0.7585802 0.9911425
rho…1414 CitG24m2 Carboplatin (uM) 67 0.3263282 0.0070378 45 0.3283366 0.0276642 22 0.2508475 0.2601565 0.0774891 0.7594866 0.9911425
rho…1415 CitG24m6 Gemcitabine/Cisplatin (nM) 65 -0.1781296 0.1557115 44 -0.2199746 0.1513491 21 -0.1363636 0.5541606 -0.0836110 0.7598996 0.9911425
rho…1416 CitG6m4 Paclitaxel (nM) 71 0.0698911 0.5624755 47 0.0532585 0.7221830 24 0.1335363 0.5338994 -0.0802778 0.7599788 0.9911425
rho…1417 FumG24m4 Gefitinib (EGFR) (uM) 72 0.1011225 0.3979962 47 0.1105714 0.4593606 25 0.0315567 0.8809679 0.0790147 0.7608981 0.9911425
rho…1418 CitG24m5 SCH772984 (ERK) (uM) 76 -0.0590805 0.6121838 50 -0.1006991 0.4865463 26 -0.0237442 0.9083394 -0.0769550 0.7613250 0.9911425
rho…1419 MalQ24m4 Erlotinib (EGFR) (uM) 73 -0.1140252 0.3367763 48 -0.1302247 0.3776654 25 -0.0519331 0.8052662 -0.0782917 0.7614098 0.9911425
rho…1420 CitG6m1 EGFR-pY1173 57 -0.2039150 0.1279653 36 -0.2458172 0.1480930 21 -0.3272727 0.1476090 0.0814555 0.7618101 0.9911425
rho…1421 CitQ24m4 SCH772984 (ERK) (uM) 76 0.1394040 0.2297399 50 0.1888109 0.1891245 26 0.1134832 0.5809604 0.0753277 0.7618139 0.9911425
rho…1422 MalG6m3 Docetaxel (nM) 69 -0.0577647 0.6373139 46 -0.0818165 0.5888227 23 0.0000000 1.0000000 -0.0818165 0.7619169 0.9911425
rho…1423 LacQ6m2 Docetaxel (nM) 69 0.1632386 0.1801805 46 0.1674997 0.2658558 23 0.0869995 0.6930516 0.0805002 0.7622738 0.9911425
rho…1424 FumG24m1 Crizotinib (ALK) (uM) 75 -0.1217216 0.2981963 49 -0.0956966 0.5130557 26 -0.1713993 0.4024762 0.0757026 0.7626708 0.9911425
rho…1425 SerG24m3 Paclitaxel (nM) 67 -0.0435459 0.7264159 44 -0.0845080 0.5854768 23 -0.0024716 0.9910701 -0.0820365 0.7630175 0.9911425
rho…1426 LacG24m3 Pemetrexed (uM) 70 -0.0671455 0.5807507 47 -0.1275447 0.3929090 23 -0.0476788 0.8289640 -0.0798659 0.7652404 0.9911425
rho…1427 LacG6m2 Etoposide (uM) 71 0.1097547 0.3622160 47 0.0767296 0.6082146 24 0.1548163 0.4700940 -0.0780867 0.7652648 0.9911425
rho…1428 SerG24m2 Gemcitabine (nM) 65 -0.0817735 0.5172611 43 -0.1624017 0.2981144 22 -0.0807453 0.7204672 -0.0816563 0.7659748 0.9911425
rho…1429 FumQ24m3 Doxorubicin (nM) 73 0.0182832 0.8779815 48 -0.0203594 0.8907540 25 0.0569231 0.7867493 -0.0772825 0.7662227 0.9911425
rho…1430 CitQ24m5 Erlotinib (EGFR) (uM) 71 -0.1846902 0.1230974 47 -0.2369608 0.1087778 24 -0.1613394 0.4513542 -0.0756214 0.7664174 0.9911425
rho…1431 LacQ24m1 Carboplatin (uM) 69 -0.0698167 0.5686487 46 -0.0917924 0.5440395 23 -0.0118636 0.9571547 -0.0799288 0.7670254 0.9911425
rho…1432 FumQ6m2 Gefitinib (EGFR) (uM) 72 -0.1848394 0.1200909 47 -0.1514039 0.3096799 25 -0.2257506 0.2779001 0.0743467 0.7676984 0.9911425
rho…1433 CitG24m2 EGFR-pY1173 57 0.0012315 0.9929134 36 0.0512227 0.7660981 21 -0.0350649 0.8811301 0.0862876 0.7682363 0.9911425
rho…1434 FumG24m3 E-cadherin 59 -0.1902424 0.1489552 37 -0.2079184 0.2160681 22 -0.1259176 0.5752188 -0.0820009 0.7682397 0.9911425
rho…1435 CitQ6m1 Gemcitabine (nM) 69 -0.3088743 0.0098143 46 -0.2638375 0.0764397 23 -0.1882876 0.3895839 -0.0755498 0.7684932 0.9911425
rho…1436 MalG24m2 8-Cl-adenosine (uM) 71 -0.0786084 0.5146470 47 -0.0537868 0.7195396 24 -0.1308980 0.5420831 0.0771113 0.7692263 0.9911425
rho…1437 FumQ24m1 Etoposide (uM) 71 -0.0270656 0.8227173 47 0.0044523 0.9763051 24 -0.0730594 0.7344114 0.0775116 0.7697238 0.9911425
rho…1438 GlyG6m2 Vinorelbine (nM) 65 -0.0566032 0.6542586 41 -0.1290744 0.4212276 24 -0.0504567 0.8148767 -0.0786177 0.7705642 0.9911425
rho…1439 CitQ24m4 CDH1 64 -0.0673071 0.5971909 42 -0.0441868 0.7811222 22 0.0373304 0.8689981 -0.0815172 0.7706425 0.9911425
rho…1440 MalQ24m1 MK-2206 (AKT) (uM) 71 0.1382057 0.2503922 47 0.1528051 0.3051709 24 0.0765717 0.7221248 0.0762334 0.7707402 0.9911425
rho…1441 CitQ6m5 Etoposide (uM) 69 -0.0403219 0.7421906 46 -0.0385481 0.7992287 23 0.0400297 0.8560993 -0.0785778 0.7714561 0.9911425
rho…1442 FumQ24m4 Carboplatin (uM) 69 0.1213240 0.3206828 46 0.1041853 0.4907910 23 0.1809642 0.4086167 -0.0767789 0.7720319 0.9911425
rho…1443 CitG24m4 Gemcitabine (nM) 69 -0.1355989 0.2665977 46 -0.1538949 0.3071882 23 -0.0766000 0.7283021 -0.0772949 0.7721379 0.9911425
rho…1444 MalG6m2 Doxorubicin (nM) 73 -0.1055019 0.3743616 48 -0.1161844 0.4316335 25 -0.0415385 0.8439328 -0.0746459 0.7726802 0.9911425
rho…1445 FumQ6m3 Crizotinib (ALK) (uM) 75 0.0671534 0.5670212 49 0.0834568 0.5686014 26 0.0102652 0.9603063 0.0731916 0.7738345 0.9911425
rho…1446 FumG6m1 CDH1 66 0.1606406 0.1975712 43 0.1812481 0.2447623 23 0.1044039 0.6354428 0.0768443 0.7744227 0.9911425
rho…1447 MalG24m1 Pemetrexed/Cisplatin (uM) 67 0.0496094 0.6901334 45 0.0936131 0.5407694 22 0.0146934 0.9482548 0.0789197 0.7745449 0.9911425
rho…1448 FumG6m3 Gemcitabine/Cisplatin (nM) 67 -0.1909105 0.1217348 45 -0.1656345 0.2768710 22 -0.2411067 0.2784220 0.0754722 0.7757067 0.9911425
rho…1449 FumG6m3 Gefitinib (EGFR) (uM) 72 0.2565373 0.0296123 47 0.2445061 0.0976490 25 0.3128729 0.1278085 -0.0683667 0.7763852 0.9911425
rho…1450 CitQ24m4 Docetaxel (nM) 67 0.0525770 0.6726204 45 0.0450831 0.7687078 22 -0.0333333 0.8829258 0.0784164 0.7765793 0.9911425
rho…1451 CitQ24m3 Gemcitabine/Cisplatin (nM) 65 0.0736515 0.5598469 44 0.1082643 0.4842206 21 0.0285714 0.9034428 0.0796929 0.7769227 0.9911425
rho…1452 SerG24m2 AZD6244 (MEK) (uM) 66 0.0229228 0.8550403 43 -0.0080800 0.9589877 23 0.0691700 0.7535161 -0.0772500 0.7775741 0.9911425
rho…1453 FumG6m1 Etoposide (uM) 71 -0.0175327 0.8846147 47 -0.0469265 0.7541123 24 0.0278321 0.8972826 -0.0747586 0.7779267 0.9911425
rho…1454 CitG6m5 Gefitinib (EGFR) (uM) 70 0.2546158 0.0334114 46 0.2964654 0.0454337 24 0.2266696 0.2868256 0.0697958 0.7782632 0.9911425
rho…1455 LacG24m2 8-Cl-adenosine (uM) 71 -0.0498897 0.6794790 47 -0.0602047 0.6876887 24 0.0143509 0.9469360 -0.0745557 0.7784205 0.9911425
rho…1456 GlyG6m2 Sorafenib (multi-kinase) (uM) 66 -0.1617705 0.1943952 42 -0.2533134 0.1055250 24 -0.1809089 0.3975699 -0.0724045 0.7787929 0.9911425
rho…1457 MalG24m2 SCH772984 (ERK) (uM) 78 -0.0348031 0.7622696 51 -0.0128471 0.9287038 27 -0.0827088 0.6817065 0.0698617 0.7793229 0.9911425
rho…1458 MalG6m1 Erlotinib (EGFR) (uM) 73 -0.1613055 0.1727709 48 -0.1378318 0.3501881 25 -0.2085016 0.3172214 0.0706698 0.7793350 0.9911425
rho…1459 MalQ24m2 SCH772984 (ERK) (uM) 78 0.1484317 0.1946498 51 0.1939770 0.1725909 27 0.1259430 0.5313458 0.0680341 0.7799343 0.9911425
rho…1460 MalQ24m2 Paclitaxel (nM) 73 0.0004012 0.9973123 48 0.0213904 0.8852582 25 -0.0511735 0.8080619 0.0725639 0.7801542 0.9911425
rho…1461 SerG24m2 Gemcitabine/Cisplatin (nM) 62 0.0784748 0.5443339 41 0.0429517 0.7897440 21 0.1220779 0.5968655 -0.0791262 0.7805642 0.9911425
rho…1462 LacQ6m1 Carboplatin (uM) 69 -0.0005482 0.9964334 46 0.0346678 0.8190816 23 -0.0405339 0.8543054 0.0752017 0.7810270 0.9911425
rho…1463 CitG6m5 Gemcitabine/Cisplatin (nM) 65 -0.0654989 0.6041932 44 -0.0938822 0.5444104 21 -0.0155844 0.9482679 -0.0782977 0.7810934 0.9911425
rho…1464 MalG24m2 Sorafenib (multi-kinase) (uM) 73 -0.1083208 0.3616595 48 -0.1235815 0.4026807 25 -0.0519331 0.8052662 -0.0716484 0.7812615 0.9911425
rho…1465 CitQ24m5 Cisplatin (uM) 68 0.1121631 0.3624794 45 0.1211662 0.4278578 23 0.0464771 0.8332152 0.0746891 0.7817838 0.9911425
rho…1466 CitQ24m3 Vinorelbine (nM) 70 0.0532284 0.6616524 46 0.0236230 0.8761659 24 0.0970621 0.6518534 -0.0734391 0.7817878 0.9911425
rho…1467 MalG6m1 MK-2206 (AKT) (uM) 71 0.0992076 0.4104321 47 0.0599803 0.6887937 24 0.1322602 0.5378505 -0.0722799 0.7831736 0.9911425
rho…1468 CitG24m4 EGFR-pY1173 57 -0.1729323 0.1977645 36 -0.1956242 0.2518400 21 -0.2714286 0.2330433 0.0758044 0.7842411 0.9911425
rho…1469 CitQ24m5 SCH772984 (ERK) (uM) 76 0.1747803 0.1310188 50 0.1765861 0.2199211 26 0.1085947 0.5974581 0.0679914 0.7849684 0.9911425
rho…1470 FumG6m2 Paclitaxel/Carboplatin (nM) 70 0.0503325 0.6790264 46 0.1091851 0.4701017 24 0.0369968 0.8637292 0.0721884 0.7850567 0.9911425
rho…1471 CitG24m2 Gefitinib (EGFR) (uM) 70 0.0014875 0.9902488 46 -0.0072790 0.9617078 24 0.0648249 0.7634610 -0.0721039 0.7862508 0.9911425
rho…1472 CitQ6m4 Paclitaxel/Carboplatin (nM) 68 -0.1282206 0.2973933 45 -0.1753427 0.2492852 23 -0.1033887 0.6387515 -0.0719540 0.7869882 0.9911425
rho…1473 MalG6m4 Vinorelbine (nM) 72 0.0871740 0.4665291 47 0.0701440 0.6394187 25 0.1397498 0.5052467 -0.0696058 0.7874267 0.9911425
rho…1474 MalQ24m1 Etoposide (uM) 71 -0.0810793 0.5014771 47 -0.0531383 0.7227853 24 -0.1239400 0.5639407 0.0708017 0.7877974 0.9911425
rho…1475 CitQ24m3 CDH1 64 -0.3338715 0.0070142 42 -0.3181174 0.0400635 22 -0.3840503 0.0776312 0.0659330 0.7879510 0.9911425
rho…1476 CitQ6m4 CDH1 64 0.1213329 0.3395440 42 0.1749635 0.2677541 22 0.1012445 0.6539265 0.0737191 0.7881193 0.9911425
rho…1477 FumG24m4 E-cadherin 59 -0.1587960 0.2289953 37 -0.1661925 0.3242785 22 -0.0909091 0.6867120 -0.0752834 0.7891727 0.9911425
rho…1478 GlyG24m1 SCH772984 (ERK) (uM) 73 0.1257727 0.2890208 46 0.0906454 0.5491042 27 0.1575854 0.4324449 -0.0669400 0.7895193 0.9911425
rho…1479 GlyG6m1 Gemcitabine/Cisplatin (nM) 61 -0.0538925 0.6799683 40 -0.0249578 0.8785046 21 -0.1012987 0.6613610 0.0763409 0.7895868 0.9911425
rho…1480 LacQ24m2 Sorafenib (multi-kinase) (uM) 73 0.0895035 0.4514302 48 0.1000434 0.4986907 25 0.1681093 0.4218278 -0.0680658 0.7898194 0.9911425
rho…1481 LacG24m1 Beta-catenin 59 0.0467019 0.7254077 37 0.0275044 0.8716278 22 0.1033315 0.6462494 -0.0758270 0.7902412 0.9911425
rho…1482 LacG24m2 Doxorubicin (nM) 73 -0.0002160 0.9985529 48 0.0181334 0.9026372 25 -0.0507692 0.8095091 0.0689027 0.7909821 0.9911425
rho…1483 MalQ24m2 Etoposide (uM) 71 -0.1198759 0.3193669 47 -0.1285958 0.3889883 24 -0.0591433 0.7836893 -0.0694525 0.7915505 0.9911425
rho…1484 FumQ6m4 AZD6244 (MEK) (uM) 71 -0.0209275 0.8624730 47 0.0223777 0.8813159 24 -0.0469565 0.8277062 0.0693342 0.7936628 0.9911425
rho…1485 LacQ24m2 Vinorelbine (nM) 72 0.1264345 0.2899141 47 0.1568843 0.2922855 25 0.0897017 0.6698107 0.0671826 0.7938093 0.9911425
rho…1486 FumG6m2 Paclitaxel (nM) 73 0.0828422 0.4859366 48 0.1469638 0.3188706 25 0.0800308 0.7037387 0.0669330 0.7942853 0.9911425
rho…1487 FumQ24m1 Pemetrexed/Cisplatin (uM) 67 -0.0224896 0.8566470 45 -0.0331368 0.8289157 22 0.0384289 0.8651765 -0.0715657 0.7956672 0.9911425
rho…1488 FumQ24m2 Pemetrexed/Cisplatin (uM) 67 -0.1818862 0.1407231 45 -0.2094272 0.1673671 22 -0.1401922 0.5337696 -0.0692350 0.7960755 0.9911425
rho…1489 LacG6m2 Pemetrexed (uM) 70 -0.0329460 0.7865786 47 -0.0065498 0.9651482 23 -0.0759881 0.7303934 0.0694384 0.7963851 0.9911425
rho…1490 CitG6m5 MK-2206 (AKT) (uM) 69 0.1771456 0.1453530 46 0.2007465 0.1809867 23 0.1334982 0.5436788 0.0672483 0.7981735 0.9911425
rho…1491 GlyG24m1 Gefitinib (EGFR) (uM) 67 -0.2128558 0.0837393 43 -0.2425604 0.1170650 24 -0.1775071 0.4066514 -0.0650533 0.8005347 0.9911425
rho…1492 CitG6m6 Paclitaxel/Carboplatin (nM) 68 0.1335675 0.2775320 45 0.1538664 0.3129039 23 0.0865694 0.6944978 0.0672970 0.8014723 0.9911425
rho…1493 CitG24m2 E-cadherin 57 0.0848457 0.5293099 36 0.0453024 0.7925615 21 0.1181818 0.6087519 -0.0728794 0.8021938 0.9911425
rho…1494 MalG6m1 Paclitaxel (nM) 73 0.1046460 0.3782712 48 0.0812227 0.5831413 25 0.1454406 0.4878860 -0.0642179 0.8024673 0.9911425
rho…1495 FumQ6m3 E-cadherin 59 0.2046786 0.1199362 37 0.1808914 0.2828276 22 0.2490822 0.2636372 -0.0681908 0.8027982 0.9911425
rho…1496 FumQ24m3 Gemcitabine/Cisplatin (nM) 67 0.1853249 0.1332414 45 0.1809856 0.2341329 22 0.2467532 0.2670422 -0.0657676 0.8030598 0.9911425
rho…1497 MalG6m4 EGFR-pY1173 59 -0.0185856 0.8887082 37 -0.0424372 0.8026159 22 0.0287973 0.8998354 -0.0712345 0.8035057 0.9911425
rho…1498 SerG24m3 Paclitaxel/Carboplatin (nM) 63 -0.0855401 0.5050401 41 -0.1194563 0.4569316 22 -0.0503109 0.8240453 -0.0691454 0.8041510 0.9911425
rho…1499 CitG24m3 Pemetrexed (uM) 68 -0.1066582 0.3866587 46 -0.0940769 0.5340192 22 -0.0260847 0.9082663 -0.0679922 0.8042831 0.9911425
rho…1500 MalQ24m3 Pemetrexed (uM) 70 -0.1352027 0.2644424 47 -0.1150333 0.4413272 23 -0.1803301 0.4102883 0.0652968 0.8044258 0.9911425
rho…1501 MalQ24m3 Sorafenib (multi-kinase) (uM) 73 0.0163794 0.8906044 48 0.0235923 0.8735381 25 -0.0407849 0.8465169 0.0643773 0.8044685 0.9911425
rho…1502 FumQ6m1 Paclitaxel (nM) 73 -0.0692794 0.5602921 48 -0.0309455 0.8346083 25 -0.0950366 0.6513551 0.0640911 0.8045738 0.9911425
rho…1503 FumQ6m3 Pemetrexed (uM) 70 -0.0596688 0.6236574 47 -0.0284212 0.8495931 23 0.0380034 0.8633149 -0.0664247 0.8053683 0.9911425
rho…1504 CitQ24m5 Beta-catenin 57 0.3939590 0.0026029 36 0.3997426 0.0163343 21 0.4584416 0.0380271 -0.0586990 0.8059152 0.9911425
rho…1505 LacQ24m3 Gemcitabine/Cisplatin (nM) 67 0.0736358 0.5537187 45 0.0838714 0.5838562 22 0.0163749 0.9438117 0.0674965 0.8065826 0.9911425
rho…1506 FumG24m1 Beta-catenin 59 0.0217718 0.8699878 37 0.0257277 0.8798583 22 0.0954263 0.6718927 -0.0696986 0.8069745 0.9911425
rho…1507 FumQ24m4 EGFR-pY1173 59 0.0743144 0.5759021 37 0.0331911 0.8451392 22 0.1027958 0.6489510 -0.0696047 0.8070483 0.9911425
rho…1508 MalG24m4 SCH772984 (ERK) (uM) 78 0.0083629 0.9420707 51 0.0393250 0.7840999 27 -0.0216171 0.9147709 0.0609420 0.8073371 0.9911425
rho…1509 MalQ24m4 Pemetrexed (uM) 70 -0.0762207 0.5305681 47 -0.0660238 0.6592638 23 -0.1311168 0.5509542 0.0650929 0.8073628 0.9911425
rho…1510 FumG6m4 Pemetrexed/Cisplatin (uM) 67 -0.0526022 0.6724723 45 -0.0571165 0.7093927 22 0.0101724 0.9641643 -0.0672889 0.8075379 0.9911425
rho…1511 LacQ6m3 Pemetrexed (uM) 70 0.1169805 0.3348342 47 0.1527495 0.3053489 23 0.0881779 0.6890943 0.0645716 0.8079632 0.9911425
rho…1512 CitQ6m1 MK-2206 (AKT) (uM) 69 -0.0228581 0.8521083 46 -0.0178907 0.9060590 23 -0.0830655 0.7063185 0.0651748 0.8091654 0.9911425
rho…1513 CitQ24m1 Erlotinib (EGFR) (uM) 71 0.0589922 0.6250683 47 0.0704291 0.6380546 24 0.0065232 0.9758668 0.0639059 0.8092557 0.9911425
rho…1514 CitG24m6 Gefitinib (EGFR) (uM) 70 0.0424830 0.7269421 46 0.0204799 0.8925383 24 0.0844029 0.6949729 -0.0639230 0.8096670 0.9911425
rho…1515 CitG6m5 Etoposide (uM) 69 -0.0583727 0.6337692 46 -0.0848675 0.5749528 23 -0.0202619 0.9268865 -0.0646056 0.8107612 0.9911425
rho…1516 CitQ6m4 MK-2206 (AKT) (uM) 69 0.1051646 0.3897935 46 0.1521947 0.3126273 23 0.0885044 0.6879995 0.0636904 0.8112127 0.9911425
rho…1517 MalG6m4 Sorafenib (multi-kinase) (uM) 73 -0.1197537 0.3129009 48 -0.0679245 0.6464348 25 -0.1292556 0.5380377 0.0613311 0.8117668 0.9911425
rho…1518 LacG24m1 SCH772984 (ERK) (uM) 78 -0.2555300 0.0239474 51 -0.2731359 0.0524680 27 -0.2174239 0.2759745 -0.0557119 0.8125055 0.9911425
rho…1519 CitG24m5 8-Cl-adenosine (uM) 69 -0.2252734 0.0627335 46 -0.2261975 0.1306373 23 -0.1645664 0.4530389 -0.0616311 0.8127838 0.9911425
rho…1520 SerG6m3 Paclitaxel (nM) 62 -0.1949954 0.1288207 42 -0.1874544 0.2345364 20 -0.1203460 0.6132832 -0.0671084 0.8129593 0.9911425
rho…1521 FumG6m2 Crizotinib (ALK) (uM) 75 0.1279448 0.2739869 49 0.1717147 0.2380956 26 0.1125556 0.5840753 0.0591591 0.8130396 0.9911425
rho…1522 FumQ24m3 MK-2206 (AKT) (uM) 71 -0.0998189 0.4075398 47 -0.0989011 0.5083568 24 -0.1605395 0.4536308 0.0616384 0.8130788 0.9911425
rho…1523 FumG6m3 Pemetrexed (uM) 70 0.1656833 0.1704556 47 0.1511706 0.3104347 23 0.2125681 0.3301659 -0.0613975 0.8137872 0.9911425
rho…1524 LacQ24m1 CDH1 66 0.1687757 0.1755185 43 0.1166138 0.4564525 23 0.1796586 0.4120626 -0.0630448 0.8138523 0.9911425
rho…1525 MalQ24m4 Pemetrexed/Cisplatin (uM) 67 -0.0836327 0.5010362 45 -0.0810303 0.5967060 22 -0.1452388 0.5189925 0.0642085 0.8139504 0.9911425
rho…1526 CitG6m4 Paclitaxel/Carboplatin (nM) 68 0.1157536 0.3472193 45 0.0976542 0.5233577 23 0.1602771 0.4650602 -0.0626230 0.8146083 0.9911425
rho…1527 FumQ6m1 Pemetrexed/Cisplatin (uM) 67 -0.0683868 0.5824015 45 -0.0584341 0.7029931 22 -0.1226336 0.5866576 0.0641995 0.8148251 0.9911425
rho…1528 LacQ24m1 EGFR-pY1173 59 0.0496201 0.7083101 37 -0.0595069 0.7256623 22 0.0073405 0.9759039 -0.0668474 0.8152756 0.9911425
rho…1529 CitQ24m3 E-cadherin 57 0.2157765 0.1068971 36 0.2404118 0.1574348 21 0.1753247 0.4454273 0.0650872 0.8163355 0.9911425
rho…1530 CitG24m6 SCH772984 (ERK) (uM) 76 -0.0379600 0.7447570 50 -0.0259000 0.8583003 26 -0.0845013 0.6814991 0.0586013 0.8172690 0.9911425
rho…1531 FumQ6m4 Gefitinib (EGFR) (uM) 72 -0.2943778 0.0120714 47 -0.3165626 0.0301665 25 -0.2613046 0.2070592 -0.0552579 0.8173262 0.9911425
rho…1532 FumQ6m4 Paclitaxel/Carboplatin (nM) 70 -0.1141757 0.3466306 46 -0.1363889 0.3660959 24 -0.0757345 0.7250474 -0.0606543 0.8177038 0.9911425
rho…1533 MalG6m4 Paclitaxel (nM) 73 -0.0710847 0.5500921 48 -0.0744863 0.6148568 25 -0.0150058 0.9432454 -0.0594805 0.8187381 0.9911425
rho…1534 MalQ24m2 Pemetrexed/Cisplatin (uM) 67 -0.1751477 0.1562928 45 -0.1522448 0.3180926 22 -0.0898559 0.6908763 -0.0623889 0.8187990 0.9911425
rho…1535 CitG6m3 Sorafenib (multi-kinase) (uM) 71 -0.0982574 0.4149514 47 -0.0549482 0.7137386 24 -0.1152424 0.5918040 0.0602942 0.8188229 0.9911425
rho…1536 MalQ24m3 8-Cl-adenosine (uM) 71 0.0268654 0.8240070 47 0.0256788 0.8639620 24 0.0861244 0.6890513 -0.0604456 0.8191139 0.9911425
rho…1537 GlyG6m2 SCH772984 (ERK) (uM) 70 0.0434963 0.7206929 44 -0.0265755 0.8640370 26 0.0328228 0.8735306 -0.0593984 0.8195901 0.9911425
rho…1538 LacG6m1 Vinorelbine (nM) 72 0.1354158 0.2567257 47 0.1165312 0.4353623 25 0.1747835 0.4033592 -0.0582523 0.8196489 0.9911425
rho…1539 CitQ6m5 E-cadherin 57 0.4025149 0.0020619 36 0.4141570 0.0126158 21 0.4675325 0.0340221 -0.0533755 0.8210219 0.9911425
rho…1540 SerG6m2 E-cadherin 50 -0.0324137 0.8231765 32 -0.0148474 0.9357185 18 0.0567595 0.8241966 -0.0716069 0.8217099 0.9911425
rho…1541 CitQ24m1 SCH772984 (ERK) (uM) 76 -0.0678166 0.5605102 50 -0.0355866 0.8061868 26 -0.0925324 0.6530086 0.0569458 0.8221609 0.9911425
rho…1542 CitQ24m3 Pemetrexed/Cisplatin (uM) 65 -0.1635869 0.1928889 44 -0.1911340 0.2139281 21 -0.2515438 0.2713584 0.0604099 0.8221765 0.9911425
rho…1543 CitQ6m5 Doxorubicin (nM) 71 -0.0457152 0.7050115 47 -0.0416980 0.7807895 24 -0.1008696 0.6379630 0.0591716 0.8225216 0.9911425
rho…1544 LacQ24m3 Carboplatin (uM) 69 -0.1209048 0.3223699 46 -0.0905530 0.5495130 23 -0.1497776 0.4951669 0.0592246 0.8242418 0.9911425
rho…1545 CitQ24m1 EGFR-pY1173 57 -0.0101115 0.9404875 36 -0.0545689 0.7512544 21 0.0103896 0.9662489 -0.0649585 0.8244109 0.9911425
rho…1546 MalQ6m3 Gemcitabine (nM) 70 0.0366577 0.7632013 46 0.0437047 0.7730409 24 -0.0152207 0.9437248 0.0589254 0.8247443 0.9911425
rho…1547 GlyG24m2 Doxorubicin (nM) 68 -0.1849575 0.1310477 44 -0.2452677 0.1085589 24 -0.1886957 0.3755141 -0.0565721 0.8248524 0.9911425
rho…1548 FumG6m2 Pemetrexed/Cisplatin (uM) 67 -0.0246049 0.8433272 45 0.0356402 0.8162060 22 -0.0254309 0.9105565 0.0610711 0.8251216 0.9911425
rho…1549 LacG24m2 Sorafenib (multi-kinase) (uM) 73 -0.0842026 0.4787781 48 -0.0589114 0.6908241 25 -0.0019234 0.9927195 -0.0569879 0.8263989 0.9911425
rho…1550 FumQ6m3 SCH772984 (ERK) (uM) 78 0.0050178 0.9652228 51 -0.0235361 0.8697804 27 0.0311772 0.8773156 -0.0547134 0.8267192 0.9911425
rho…1551 FumQ6m3 Beta-catenin 59 0.2635632 0.0436989 37 0.2401612 0.1518538 22 0.2982209 0.1776443 -0.0580596 0.8269442 0.9911425
rho…1552 MalQ24m3 SCH772984 (ERK) (uM) 78 -0.0837635 0.4659296 51 -0.0849282 0.5534860 27 -0.1384957 0.4908712 0.0535676 0.8281824 0.9911425
rho…1553 CitQ24m3 Beta-catenin 57 0.3730231 0.0044963 36 0.4025740 0.0155384 21 0.3480519 0.1224596 0.0545221 0.8284558 0.9911425
rho…1554 MalQ24m2 Erlotinib (EGFR) (uM) 73 0.0576837 0.6278556 48 0.1063402 0.4719130 25 0.0503943 0.8109325 0.0559459 0.8286434 0.9911425
rho…1555 CitQ6m4 8-Cl-adenosine (uM) 69 -0.2215482 0.0673240 46 -0.2276162 0.1281768 23 -0.2821843 0.1920492 0.0545681 0.8292248 0.9911425
rho…1556 CitG24m3 Carboplatin (uM) 67 -0.2076797 0.0917223 45 -0.1751392 0.2498436 22 -0.2322034 0.2984071 0.0570642 0.8294559 0.9911425
rho…1557 CitQ24m4 8-Cl-adenosine (uM) 69 -0.0745978 0.5424016 46 -0.0915400 0.5451521 23 -0.1487522 0.4981579 0.0572122 0.8301254 0.9911425
rho…1558 FumQ24m1 MK-2206 (AKT) (uM) 71 0.1154649 0.3376256 47 0.0973395 0.5151078 24 0.1531434 0.4749633 -0.0558039 0.8306938 0.9911425
rho…1559 GlyG6m2 E-cadherin 53 0.0403161 0.7738600 32 0.0857771 0.6394922 21 0.0220779 0.9258276 0.0636992 0.8313443 0.9911425
rho…1560 CitG24m5 Beta-catenin 57 -0.2417034 0.0702528 36 -0.2512227 0.1391668 21 -0.1922078 0.4021544 -0.0590149 0.8321888 0.9911425
rho…1561 FumG24m3 Carboplatin (uM) 69 -0.2194338 0.0700475 46 -0.2076304 0.1661732 23 -0.1522492 0.4879943 -0.0553812 0.8324759 0.9911425
rho…1562 CitG6m3 Doxorubicin (nM) 71 0.0135923 0.9104248 47 0.0516758 0.7301228 24 -0.0043478 0.9854000 0.0560236 0.8325742 0.9911425
rho…1563 CitQ6m1 AZD6244 (MEK) (uM) 69 0.0179591 0.8835536 46 0.0389194 0.7973355 23 0.0958498 0.6625878 -0.0569304 0.8326075 0.9911425
rho…1564 LacQ6m1 Gemcitabine/Cisplatin (nM) 67 -0.0445003 0.7206627 45 -0.0010542 0.9945164 22 -0.0592885 0.7933723 0.0582343 0.8329812 0.9911425
rho…1565 CitG6m3 8-Cl-adenosine (uM) 69 0.0369430 0.7631338 46 0.0587256 0.6982605 23 0.0019768 0.9928578 0.0567488 0.8337305 0.9911425
rho…1566 LacQ24m2 Etoposide (uM) 71 0.0520182 0.6665958 47 0.0434242 0.7719526 24 0.0987171 0.6462917 -0.0552929 0.8339911 0.9911425
rho…1567 FumG6m3 8-Cl-adenosine (uM) 71 -0.0912940 0.4489384 47 -0.1197155 0.4228329 24 -0.1739509 0.4162671 0.0542354 0.8344106 0.9911425
rho…1568 GlyG24m2 Cisplatin (uM) 66 -0.1649234 0.1857269 43 -0.1291443 0.4091637 23 -0.1849197 0.3982738 0.0557754 0.8345473 0.9911425
rho…1569 MalQ6m3 Crizotinib (ALK) (uM) 74 0.1066106 0.3659606 48 0.0739534 0.6173968 26 0.1269244 0.5366626 -0.0529711 0.8345916 0.9911425
rho…1570 CitQ6m6 E-cadherin 57 -0.2238787 0.0941275 36 -0.2818533 0.0959733 21 -0.2246753 0.3259659 -0.0571780 0.8347702 0.9911425
rho…1571 CitG6m5 E-cadherin 57 -0.2193415 0.1011222 36 -0.2527671 0.1366915 21 -0.1948052 0.3957150 -0.0579619 0.8349838 0.9911425
rho…1572 FumG24m4 Carboplatin (uM) 69 -0.2312626 0.0558861 46 -0.2237301 0.1350004 23 -0.1695502 0.4392776 -0.0541799 0.8350013 0.9911425
rho…1573 SerG6m1 8-Cl-adenosine (uM) 61 -0.0721700 0.5804509 41 -0.0698009 0.6645416 20 -0.1293233 0.5856368 0.0595224 0.8367133 0.9911425
rho…1574 FumG24m3 AZD6244 (MEK) (uM) 71 -0.0692558 0.5660414 47 -0.1003238 0.5022455 24 -0.0460870 0.8308800 -0.0542369 0.8370687 0.9911425
rho…1575 MalG24m1 Paclitaxel (nM) 73 0.0120044 0.9197099 48 0.0486984 0.7423871 25 -0.0046172 0.9825246 0.0533156 0.8375004 0.9911425
rho…1576 LacQ6m2 Gemcitabine (nM) 71 0.0999212 0.4070569 47 0.0984107 0.5104720 24 0.1517721 0.4789739 -0.0533614 0.8380091 0.9911425
rho…1577 GlyG6m1 AZD6244 (MEK) (uM) 64 -0.0648189 0.6108454 41 -0.0700409 0.6634561 23 -0.0138340 0.9514040 -0.0562070 0.8384516 0.9911425
rho…1578 LacQ24m3 Pemetrexed (uM) 70 -0.0812364 0.5037885 47 -0.0780707 0.6019415 23 -0.0238394 0.9140203 -0.0542313 0.8401759 0.9911425
rho…1579 LacQ6m2 MK-2206 (AKT) (uM) 71 -0.1312409 0.2752934 47 -0.1098386 0.4623596 24 -0.1622798 0.4486856 0.0524412 0.8403074 0.9911425
rho…1580 CitQ6m6 Crizotinib (ALK) (uM) 73 -0.1074741 0.3654466 48 -0.0885182 0.5496512 25 -0.1401078 0.5041457 0.0515896 0.8407125 0.9911425
rho…1581 MalQ6m3 Gefitinib (EGFR) (uM) 71 -0.1907222 0.1111175 46 -0.2033804 0.1752109 25 -0.1523956 0.4670837 -0.0509848 0.8407679 0.9911425
rho…1582 GlyG6m1 Gefitinib (EGFR) (uM) 65 -0.1545221 0.2190635 41 -0.1667611 0.2973704 24 -0.2192735 0.3032600 0.0525124 0.8409697 0.9911425
rho…1583 SerG6m2 EGFR-pY1173 50 -0.0209849 0.8849885 32 0.0951334 0.6045129 18 0.1578947 0.5301662 -0.0627614 0.8409963 0.9911425
rho…1584 CitG24m1 Sorafenib (multi-kinase) (uM) 71 -0.0750459 0.5339405 47 -0.0478628 0.7493639 24 0.0052185 0.9806925 -0.0530813 0.8412676 0.9911425
rho…1585 CitG24m1 AZD6244 (MEK) (uM) 69 -0.2014360 0.0969656 46 -0.1655513 0.2715365 23 -0.1126482 0.6075737 -0.0529031 0.8419745 0.9911425
rho…1586 FumQ6m3 MK-2206 (AKT) (uM) 71 0.0468740 0.6978904 47 0.0812608 0.5871337 24 0.0287206 0.8940213 0.0525402 0.8424652 0.9911425
rho…1587 LacQ24m2 AZD6244 (MEK) (uM) 71 0.1619029 0.1773620 47 0.2157974 0.1451654 24 0.1652174 0.4386535 0.0505800 0.8430955 0.9911425
rho…1588 CitG24m6 E-cadherin 57 -0.2849735 0.0316656 36 -0.2978121 0.0780232 21 -0.2441558 0.2848250 -0.0536563 0.8432823 0.9911425
rho…1589 MalG24m4 Gemcitabine/Cisplatin (nM) 67 -0.1059017 0.3936970 45 -0.1061405 0.4877199 22 -0.1597967 0.4757807 0.0536563 0.8433470 0.9911425
rho…1590 FumQ24m3 8-Cl-adenosine (uM) 71 0.1189398 0.3231879 47 0.1565554 0.2933110 24 0.1052403 0.6245516 0.0513152 0.8439097 0.9911425
rho…1591 FumG6m4 Docetaxel (nM) 69 0.0207412 0.8656708 46 0.0141297 0.9257451 23 0.0672269 0.7605382 -0.0530972 0.8441798 0.9911425
rho…1592 SerG24m3 Gefitinib (EGFR) (uM) 66 -0.1535522 0.2183435 43 -0.1776301 0.2544672 23 -0.1250927 0.5695532 -0.0525374 0.8443065 0.9911425
rho…1593 LacG24m1 Sorafenib (multi-kinase) (uM) 73 -0.0578432 0.6269034 48 -0.0470502 0.7508212 25 0.0038469 0.9854396 -0.0508971 0.8447818 0.9911425
rho…1594 MalG6m3 E-cadherin 59 -0.1778492 0.1773447 37 -0.1669037 0.3221890 22 -0.2207792 0.3219281 0.0538755 0.8450079 0.9911425
rho…1595 MalG6m2 EGFR-pY1173 59 -0.1600234 0.2253818 37 -0.2027027 0.2280089 22 -0.1485037 0.5079041 -0.0541990 0.8451601 0.9911425
rho…1596 SerG24m2 Gefitinib (EGFR) (uM) 66 -0.2227698 0.0721965 43 -0.2430330 0.1163312 23 -0.1923363 0.3792804 -0.0506967 0.8458790 0.9911425
rho…1597 LacQ6m1 Docetaxel (nM) 69 0.0878540 0.4728637 46 0.0606855 0.6886913 23 0.0084034 0.9696445 0.0522822 0.8466129 0.9911425
rho…1598 SerG24m3 Erlotinib (EGFR) (uM) 68 -0.1226808 0.3189263 45 -0.1481189 0.3315378 23 -0.0963677 0.6618137 -0.0517512 0.8466280 0.9911425
rho…1599 MalQ6m3 Beta-catenin 58 0.2905349 0.0272919 36 0.3212355 0.0565771 22 0.2704687 0.2225773 0.0507669 0.8467579 0.9911425
rho…1600 MalG6m2 SCH772984 (ERK) (uM) 78 -0.1697594 0.1373119 51 -0.1691660 0.2353408 27 -0.1221835 0.5437687 -0.0469826 0.8477077 0.9911425
rho…1601 CitG6m2 CDH1 64 0.2326322 0.0643358 42 0.2269337 0.1483883 22 0.2771497 0.2117732 -0.0502160 0.8479624 0.9911425
rho…1602 FumG24m2 EGFR-pY1173 59 0.0915839 0.4892633 37 0.0957800 0.5715189 22 0.0412196 0.8561479 0.0545603 0.8481893 0.9911425
rho…1603 FumQ6m3 AZD6244 (MEK) (uM) 71 -0.1580977 0.1879029 47 -0.1233954 0.4086104 24 -0.1726462 0.4198257 0.0492508 0.8493919 0.9915636
rho…1604 MalQ24m4 MK-2206 (AKT) (uM) 71 -0.1520414 0.2056001 47 -0.1079237 0.4702471 24 -0.1570590 0.4636064 0.0491353 0.8504002 0.9915636
rho…1605 CitG6m1 8-Cl-adenosine (uM) 69 -0.1002129 0.4126220 46 -0.1040619 0.4913074 23 -0.0533729 0.8088848 -0.0506891 0.8504925 0.9915636
rho…1606 MalQ24m3 MK-2206 (AKT) (uM) 71 -0.0759968 0.5287560 47 -0.0671217 0.6539526 24 -0.1166232 0.5873417 0.0495015 0.8506683 0.9915636
rho…1607 MalQ6m1 MK-2206 (AKT) (uM) 70 0.0711386 0.5584042 46 0.0692229 0.6475840 24 0.0197998 0.9268335 0.0494231 0.8524039 0.9919839
rho…1608 SerG24m1 Crizotinib (ALK) (uM) 70 -0.0617911 0.6113421 45 -0.1055445 0.4901808 25 -0.1535797 0.4635886 0.0480352 0.8527012 0.9919839
rho…1609 MalG24m3 Erlotinib (EGFR) (uM) 73 0.0624205 0.5998421 48 0.0711649 0.6307591 25 0.0234661 0.9113480 0.0476989 0.8541706 0.9919839
rho…1610 LacQ6m1 Crizotinib (ALK) (uM) 75 -0.0075067 0.9490351 49 -0.0036521 0.9801311 26 0.0431064 0.8343802 -0.0467585 0.8546406 0.9919839
rho…1611 SerG6m3 Etoposide (uM) 61 -0.0859988 0.5098965 41 -0.0834567 0.6039250 20 -0.1361414 0.5671083 0.0526847 0.8549492 0.9919839
rho…1612 FumQ24m2 Sorafenib (multi-kinase) (uM) 73 -0.0496706 0.6764455 48 -0.0642867 0.6642156 25 -0.0169296 0.9359829 -0.0473571 0.8552889 0.9919839
rho…1613 GlyG6m2 Gefitinib (EGFR) (uM) 65 -0.1252528 0.3201508 41 -0.1805271 0.2586869 24 -0.1322602 0.5378505 -0.0482669 0.8555817 0.9919839
rho…1614 CitG6m1 Sorafenib (multi-kinase) (uM) 71 -0.1772426 0.1392209 47 -0.1809769 0.2234564 24 -0.1339422 0.5326457 -0.0470347 0.8556746 0.9919839
rho…1615 CitQ6m1 Vinorelbine (nM) 70 -0.0053202 0.9651351 46 -0.0184414 0.9031810 24 -0.0665942 0.7571917 0.0481527 0.8561820 0.9919839
rho…1616 FumQ6m2 Docetaxel (nM) 69 -0.1252718 0.3050694 46 -0.0793509 0.6001390 23 -0.1275649 0.5618869 0.0482140 0.8570738 0.9919839
rho…1617 MalQ24m3 Gemcitabine/Cisplatin (nM) 67 0.1288626 0.2986760 45 0.1453797 0.3406568 22 0.0971477 0.6671339 0.0482320 0.8594371 0.9919839
rho…1618 CitG24m6 Beta-catenin 57 -0.3025393 0.0221719 36 -0.2960103 0.0799067 21 -0.2480519 0.2770127 -0.0479583 0.8596661 0.9919839
rho…1619 FumG24m2 Carboplatin (uM) 69 0.0647542 0.5970705 46 0.0701354 0.6432486 23 0.0227385 0.9179775 0.0473969 0.8606641 0.9919839
rho…1620 LacG24m1 Crizotinib (ALK) (uM) 75 -0.2166674 0.0618842 49 -0.1876086 0.1967539 26 -0.2302430 0.2578197 0.0426343 0.8613946 0.9919839
rho…1621 LacG6m3 Pemetrexed/Cisplatin (uM) 67 -0.1056045 0.3950335 45 -0.1341283 0.3797164 22 -0.0864651 0.7020148 -0.0476631 0.8614325 0.9919839
rho…1622 CitQ6m4 EGFR-pY1173 57 -0.2078398 0.1208090 36 -0.3132561 0.0632743 21 -0.3584416 0.1111341 0.0451854 0.8619728 0.9919839
rho…1623 CitQ24m2 Paclitaxel (nM) 71 -0.1542035 0.1991511 47 -0.1815764 0.2219008 24 -0.1370161 0.5231951 -0.0445603 0.8631125 0.9919839
rho…1624 LacQ24m1 Beta-catenin 59 0.0282876 0.8312318 37 0.0711238 0.6747348 22 0.0220215 0.9237947 0.0491023 0.8635673 0.9919839
rho…1625 CitQ24m6 MK-2206 (AKT) (uM) 69 -0.0475068 0.6982892 46 -0.0338690 0.8231828 23 -0.0800989 0.7163783 0.0462299 0.8639148 0.9919839
rho…1626 LacG24m2 Gemcitabine (nM) 71 0.0127952 0.9156576 47 0.0467656 0.7549293 24 0.0917591 0.6697945 -0.0449935 0.8646268 0.9919839
rho…1627 MalG6m3 EGFR-pY1173 59 -0.0485096 0.7145580 37 -0.1232812 0.4658183 22 -0.0750988 0.7394498 -0.0481824 0.8650718 0.9919839
rho…1628 LacQ6m2 AZD6244 (MEK) (uM) 71 0.1131756 0.3473554 47 0.1399121 0.3482521 24 0.0956522 0.6555820 0.0442599 0.8655987 0.9919839
rho…1629 FumQ24m3 Gefitinib (EGFR) (uM) 72 -0.3317868 0.0044111 47 -0.3545570 0.0144736 25 -0.3925342 0.0522698 0.0379772 0.8657448 0.9919839
rho…1630 LacQ6m3 EGFR-pY1173 59 0.1660749 0.2087165 37 0.1180654 0.4850206 22 0.1654900 0.4617273 -0.0474245 0.8657956 0.9919839
rho…1631 LacQ6m1 CDH1 66 0.1635240 0.1895393 43 0.2006649 0.1969662 23 0.1558636 0.4775993 0.0448013 0.8658018 0.9919839
rho…1632 MalQ24m1 Cisplatin (uM) 70 -0.0167457 0.8905633 46 -0.0220817 0.8841885 24 0.0226235 0.9164327 -0.0447052 0.8666214 0.9919839
rho…1633 SerG24m1 Doxorubicin (nM) 67 -0.1642286 0.1841755 44 -0.2650874 0.0820290 23 -0.2223320 0.3064245 -0.0427554 0.8676127 0.9919839
rho…1634 CitQ6m1 SCH772984 (ERK) (uM) 76 -0.1087484 0.3497310 50 -0.0478632 0.7413450 26 -0.0055869 0.9783907 -0.0422763 0.8679378 0.9919839
rho…1635 MalQ24m4 CDH1 66 -0.1477120 0.2365733 43 -0.1222332 0.4348895 23 -0.1667493 0.4469838 0.0445162 0.8681204 0.9919839
rho…1636 GlyG6m2 Cisplatin (uM) 64 -0.1580520 0.2122681 41 -0.1232847 0.4425282 23 -0.1681088 0.4432345 0.0448241 0.8683086 0.9919839
rho…1637 FumG6m1 Sorafenib (multi-kinase) (uM) 73 -0.3223134 0.0054201 48 -0.3230072 0.0251383 25 -0.2839008 0.1690310 -0.0391064 0.8684693 0.9919839
rho…1638 MalG6m2 Gemcitabine (nM) 71 -0.2443352 0.0400243 47 -0.1995951 0.1785967 24 -0.2413568 0.2558819 0.0417617 0.8685262 0.9919839
rho…1639 MalQ24m1 Paclitaxel (nM) 73 -0.0034871 0.9766415 48 -0.0097723 0.9474407 25 -0.0527126 0.8023993 0.0429403 0.8687486 0.9919839
rho…1640 MalG6m4 CDH1 66 0.1247847 0.3181365 43 0.1717912 0.2706664 23 0.1276597 0.5615938 0.0441315 0.8690458 0.9919839
rho…1641 LacQ6m3 Beta-catenin 59 0.1251626 0.3448922 37 0.0931721 0.5820859 22 0.1395086 0.5357863 -0.0463365 0.8697136 0.9921412
rho…1642 LacG6m1 Pemetrexed/Cisplatin (uM) 67 0.2253565 0.0667175 45 0.2470681 0.1017931 22 0.2887822 0.1924305 -0.0417141 0.8708514 0.9926502
rho…1643 CitG6m1 Cisplatin (uM) 68 0.1532985 0.2119991 45 0.1435678 0.3467730 23 0.1864030 0.3944333 -0.0428352 0.8712203 0.9926502
rho…1644 MalG6m1 E-cadherin 59 -0.1238457 0.3490812 37 -0.1420104 0.4003542 22 -0.0965556 0.6682064 -0.0454548 0.8720828 0.9927817
rho…1645 LacG6m1 CDH1 66 -0.0737032 0.5564463 43 -0.0394016 0.8019243 23 -0.0831273 0.7061097 0.0437256 0.8726518 0.9927817
rho…1646 CitG24m3 Gefitinib (EGFR) (uM) 70 0.0098004 0.9358224 46 0.0044414 0.9766298 24 0.0469872 0.8274129 -0.0425457 0.8729266 0.9927817
rho…1647 CitG6m4 Docetaxel (nM) 67 0.0372973 0.7644439 45 0.0216188 0.8879027 22 0.0655367 0.7719978 -0.0439180 0.8735311 0.9928659
rho…1648 CitQ6m3 Paclitaxel/Carboplatin (nM) 68 -0.2718196 0.0249403 45 -0.2942805 0.0497352 23 -0.2547615 0.2407396 -0.0395189 0.8749714 0.9929544
rho…1649 CitQ24m4 EGFR-pY1173 57 -0.2269899 0.0895548 36 -0.2548263 0.1334424 21 -0.2974026 0.1899490 0.0425763 0.8749848 0.9929544
rho…1650 GlyG24m2 Docetaxel (nM) 66 -0.2069012 0.0955447 43 -0.2148873 0.1664150 23 -0.1735047 0.4285188 -0.0413826 0.8752002 0.9929544
rho…1651 FumG6m1 Gemcitabine/Cisplatin (nM) 67 -0.1588972 0.1990262 45 -0.1130366 0.4597193 22 -0.1552795 0.4885022 0.0422429 0.8763373 0.9936423
rho…1652 GlyG24m2 Sorafenib (multi-kinase) (uM) 68 -0.1948642 0.1112934 44 -0.2845056 0.0612405 24 -0.2461405 0.2462886 -0.0383651 0.8777499 0.9942614
rho…1653 GlyG24m1 Etoposide (uM) 67 -0.0686225 0.5810994 43 -0.0678145 0.6656804 24 -0.0265275 0.9020744 -0.0412870 0.8779455 0.9942614
rho…1654 CitG24m2 8-Cl-adenosine (uM) 69 0.0491107 0.6886165 46 0.0474355 0.7542463 23 0.0064245 0.9767905 0.0410110 0.8794595 0.9953738
rho…1655 MalG6m1 Carboplatin (uM) 69 0.0268779 0.8264745 46 0.0043490 0.9771159 23 0.0449827 0.8385085 -0.0406337 0.8805743 0.9955681
rho…1656 MalQ6m1 SCH772984 (ERK) (uM) 77 -0.0690268 0.5508329 50 -0.0840208 0.5618356 27 -0.0465308 0.8177305 -0.0374900 0.8806949 0.9955681
rho…1657 SerG24m3 EGFR-pY1173 53 -0.2401226 0.0833994 33 -0.2339572 0.1893869 20 -0.1909774 0.4182105 -0.0429798 0.8821050 0.9955802
rho…1658 CitG24m4 Gefitinib (EGFR) (uM) 70 0.1343694 0.2674255 46 0.1389180 0.3571896 24 0.1000653 0.6417748 0.0388527 0.8822841 0.9955802
rho…1659 LacG6m3 CDH1 66 0.1720174 0.1672500 43 0.1681650 0.2810619 23 0.1286493 0.5585387 0.0395157 0.8826886 0.9955802
rho…1660 MalG24m2 Pemetrexed/Cisplatin (uM) 67 0.0784451 0.5280468 45 0.1082416 0.4790956 22 0.0678158 0.7642822 0.0404259 0.8828328 0.9955802
rho…1661 SerG24m3 Carboplatin (uM) 65 -0.2427077 0.0514102 43 -0.2628300 0.0886079 22 -0.2999153 0.1750750 0.0370853 0.8850509 0.9960116
rho…1662 GlyG6m1 Docetaxel (nM) 63 0.0101310 0.9371887 41 -0.0301512 0.8515558 22 0.0101666 0.9641845 -0.0403178 0.8858748 0.9960116
rho…1663 CitG24m2 Etoposide (uM) 69 0.1427984 0.2417947 46 0.0900484 0.5517490 23 0.1279961 0.5605547 -0.0379476 0.8871514 0.9960116
rho…1664 MalQ24m3 Cisplatin (uM) 70 0.0343407 0.7777714 46 0.0201086 0.8944758 24 0.0576588 0.7889975 -0.0375503 0.8876501 0.9960116
rho…1665 FumQ24m2 Erlotinib (EGFR) (uM) 73 0.0203801 0.8641134 48 0.0230160 0.8766034 25 -0.0134667 0.9490586 0.0364827 0.8884568 0.9960116
rho…1666 MalQ6m3 8-Cl-adenosine (uM) 70 0.0028698 0.9811891 46 -0.0036396 0.9808480 24 0.0330507 0.8781520 -0.0366903 0.8903487 0.9960116
rho…1667 CitG24m4 SCH772984 (ERK) (uM) 76 -0.0718752 0.5372295 50 -0.0648536 0.6545454 26 -0.0300294 0.8842196 -0.0348242 0.8908943 0.9960116
rho…1668 CitQ6m6 AZD6244 (MEK) (uM) 69 0.0123138 0.9200102 46 0.0202924 0.8935168 23 0.0573123 0.7950804 -0.0370199 0.8910313 0.9960116
rho…1669 MalQ6m4 Beta-catenin 58 0.1230121 0.3566295 36 0.1052767 0.5397695 22 0.1439864 0.5210474 -0.0387097 0.8913820 0.9960116
rho…1670 FumQ24m4 CDH1 66 -0.1290771 0.3016414 43 -0.1577397 0.3123847 23 -0.1212572 0.5815378 -0.0364825 0.8919196 0.9960116
rho…1671 LacQ6m2 Carboplatin (uM) 69 0.2083193 0.0858482 46 0.2077666 0.1658893 23 0.1725161 0.4311951 0.0352505 0.8924997 0.9960116
rho…1672 CitQ6m2 Gemcitabine (nM) 69 -0.3091515 0.0097451 46 -0.2917035 0.0491839 23 -0.3246850 0.1306368 0.0329814 0.8928770 0.9960116
rho…1673 CitQ24m3 Paclitaxel (nM) 71 0.0954074 0.4286783 47 0.1043805 0.4850281 24 0.0691605 0.7481244 0.0352200 0.8935506 0.9960116
rho…1674 FumG24m2 CDH1 66 0.2634134 0.0325987 43 0.2668279 0.0836905 23 0.2325584 0.2855920 0.0342695 0.8938197 0.9960116
rho…1675 CitQ24m4 Beta-catenin 57 -0.1147265 0.3944128 36 -0.1371943 0.4234527 21 -0.0987013 0.6696047 -0.0384930 0.8940042 0.9960116
rho…1676 FumG24m1 Gemcitabine/Cisplatin (nM) 67 0.0992696 0.4241499 45 0.0987052 0.5188751 22 0.1349520 0.5478204 -0.0362468 0.8942482 0.9960116
rho…1677 CitQ6m6 SCH772984 (ERK) (uM) 76 0.0716018 0.5387830 50 0.0554778 0.7019719 26 0.0890406 0.6653405 -0.0335629 0.8945110 0.9960116
rho…1678 CitG24m1 Gemcitabine (nM) 69 -0.0365067 0.7658510 46 0.0540444 0.7213013 23 0.0182852 0.9340036 0.0357592 0.8947416 0.9960116
rho…1679 CitQ24m5 MK-2206 (AKT) (uM) 69 -0.2352318 0.0516930 46 -0.2170332 0.1473894 23 -0.2506799 0.2486175 0.0336467 0.8953620 0.9960116
rho…1680 CitG24m2 Gemcitabine (nM) 69 0.0832907 0.4962457 46 0.1241188 0.4111725 23 0.0889548 0.6864898 0.0351640 0.8954382 0.9960116
rho…1681 SerG24m3 Docetaxel (nM) 65 -0.1144631 0.3639236 43 -0.1224505 0.4340669 22 -0.0864407 0.7020953 -0.0360098 0.8960270 0.9960116
rho…1682 FumQ24m4 Beta-catenin 59 0.1066643 0.4213554 37 0.1111901 0.5109530 22 0.0745552 0.7415950 0.0366349 0.8973349 0.9960116
rho…1683 CitG6m2 Paclitaxel/Carboplatin (nM) 68 -0.0566639 0.6462565 45 -0.0477728 0.7553220 23 -0.0826120 0.7078535 0.0348392 0.8975181 0.9960116
rho…1684 FumG24m4 MK-2206 (AKT) (uM) 71 0.1668665 0.1642684 47 0.1550607 0.2980014 24 0.1879487 0.3791418 -0.0328880 0.8983313 0.9960116
rho…1685 CitG24m5 E-cadherin 57 -0.2250454 0.0923918 36 -0.2365508 0.1643668 21 -0.2012987 0.3798754 -0.0352521 0.8994306 0.9960116
rho…1686 SerG6m3 Docetaxel (nM) 60 -0.2901097 0.0245440 41 -0.2530609 0.1104048 19 -0.2177349 0.3705391 -0.0353259 0.9001228 0.9960116
rho…1687 CitG6m5 8-Cl-adenosine (uM) 69 -0.2039519 0.0927785 46 -0.1923943 0.2002018 23 -0.2248579 0.3022929 0.0324636 0.9001950 0.9960116
rho…1688 CitQ6m5 Paclitaxel/Carboplatin (nM) 68 -0.1846542 0.1316921 45 -0.1966263 0.1954678 23 -0.1637399 0.4553424 -0.0328863 0.9004258 0.9960116
rho…1689 LacG6m2 8-Cl-adenosine (uM) 71 0.1085836 0.3673916 47 0.1356197 0.3633846 24 0.1678626 0.4330151 -0.0322429 0.9009642 0.9960116
rho…1690 MalG6m4 Crizotinib (ALK) (uM) 75 -0.0662137 0.5724711 49 -0.0565913 0.6993320 26 -0.0249743 0.9036116 -0.0316169 0.9012982 0.9960116
rho…1691 MalQ6m4 E-cadherin 58 -0.1077548 0.4197198 36 -0.1173745 0.4939417 22 -0.1518916 0.4981557 0.0345171 0.9028328 0.9960116
rho…1692 FumG6m4 AZD6244 (MEK) (uM) 71 0.0470533 0.6967905 47 0.0834972 0.5768516 24 0.0513043 0.8118785 0.0321928 0.9029448 0.9960116
rho…1693 MalG24m1 Docetaxel (nM) 69 0.0564769 0.6448489 46 0.0351700 0.8165057 23 0.0677212 0.7588279 -0.0325512 0.9040103 0.9960116
rho…1694 SerG24m3 Gemcitabine/Cisplatin (nM) 62 -0.1841237 0.1519816 41 -0.2494337 0.1157798 21 -0.2168831 0.3433893 -0.0325506 0.9042340 0.9960116
rho…1695 CitQ6m2 Erlotinib (EGFR) (uM) 71 0.0438672 0.7164213 47 0.0148900 0.9208705 24 0.0465319 0.8290611 -0.0316419 0.9049403 0.9960116
rho…1696 GlyG6m1 SCH772984 (ERK) (uM) 70 0.0453740 0.7091613 44 0.0380717 0.8061794 26 0.0069836 0.9729901 0.0310881 0.9049559 0.9960116
rho…1697 CitG6m6 Paclitaxel (nM) 71 0.1352720 0.2606867 47 0.1102790 0.4605559 24 0.1413658 0.5099606 -0.0310868 0.9051936 0.9960116
rho…1698 MalG6m3 Gemcitabine/Cisplatin (nM) 67 -0.1140035 0.3583062 45 -0.1122019 0.4630617 22 -0.0796160 0.7242511 -0.0325858 0.9053031 0.9960116
rho…1699 MalQ24m4 Gemcitabine (nM) 71 0.1142000 0.3429804 47 0.1051936 0.4816149 24 0.0743640 0.7298401 0.0308296 0.9067080 0.9960116
rho…1700 CitQ24m5 AZD6244 (MEK) (uM) 69 0.0487435 0.6908266 46 0.0484796 0.7490107 23 0.0800395 0.7159982 -0.0315599 0.9067826 0.9960116
rho…1701 FumQ24m4 MK-2206 (AKT) (uM) 71 -0.1979272 0.0980109 47 -0.1705032 0.2518575 24 -0.1999565 0.3488627 0.0294533 0.9084420 0.9960116
rho…1702 CitQ24m2 Gemcitabine/Cisplatin (nM) 65 -0.2734912 0.0274972 44 -0.2464759 0.1067746 21 -0.2766234 0.2239441 0.0301475 0.9088691 0.9960116
rho…1703 CitQ24m1 Etoposide (uM) 69 -0.1723045 0.1568534 46 -0.1658494 0.2706620 23 -0.1359031 0.5363768 -0.0299463 0.9098488 0.9960116
rho…1704 FumG24m4 AZD6244 (MEK) (uM) 71 -0.0870134 0.4705749 47 -0.1069735 0.4741871 24 -0.1365217 0.5230993 0.0295482 0.9099580 0.9960116
rho…1705 MalG6m1 Etoposide (uM) 71 0.1257546 0.2960349 47 0.1069188 0.4744146 24 0.1352468 0.5286249 -0.0283280 0.9136761 0.9960116
rho…1706 LacQ6m1 SCH772984 (ERK) (uM) 78 -0.1999953 0.0791607 51 -0.1368100 0.3384114 27 -0.1102784 0.5839779 -0.0265316 0.9141717 0.9960116
rho…1707 MalQ6m4 Paclitaxel (nM) 72 -0.1425010 0.2324370 47 -0.1784692 0.2300457 25 -0.1512120 0.4705911 -0.0272572 0.9145428 0.9960116
rho…1708 FumQ24m4 Erlotinib (EGFR) (uM) 73 -0.1355786 0.2527562 48 -0.1348388 0.3608493 25 -0.1073490 0.6095292 -0.0274898 0.9145908 0.9960116
rho…1709 SerG24m3 CDH1 60 0.0263483 0.8416099 38 0.0272563 0.8709621 22 0.0576924 0.7987093 -0.0304361 0.9147818 0.9960116
rho…1710 CitQ6m4 Vinorelbine (nM) 70 -0.2479415 0.0384982 46 -0.2186450 0.1443338 24 -0.2454844 0.2475903 0.0268394 0.9151364 0.9960116
rho…1711 MalQ24m4 Sorafenib (multi-kinase) (uM) 73 0.1691304 0.1525916 48 0.1830867 0.2129163 25 0.1561839 0.4559497 0.0269029 0.9151973 0.9960116
rho…1712 CitQ24m4 E-cadherin 57 -0.2365180 0.0766328 36 -0.2370656 0.1634299 21 -0.2662338 0.2423856 0.0291681 0.9153565 0.9960116
rho…1713 GlyG6m2 Paclitaxel (nM) 66 -0.1190016 0.3412545 42 -0.1457979 0.3568942 24 -0.1178773 0.5833010 -0.0279205 0.9163861 0.9960116
rho…1714 CitQ6m6 Gemcitabine/Cisplatin (nM) 65 -0.0853212 0.4991878 44 -0.0918382 0.5532459 21 -0.0623377 0.7885725 -0.0295005 0.9164020 0.9960116
rho…1715 FumQ6m1 Gemcitabine (nM) 71 -0.2596492 0.0287673 47 -0.2185682 0.1399462 24 -0.2448358 0.2488814 0.0262676 0.9166425 0.9960116
rho…1716 LacQ6m2 SCH772984 (ERK) (uM) 78 0.0915054 0.4255791 51 0.1352899 0.3438567 27 0.1099651 0.5850533 0.0253248 0.9180808 0.9960116
rho…1717 SerG24m3 Etoposide (uM) 66 -0.1836345 0.1399620 43 -0.1924035 0.2164271 23 -0.2193676 0.3130537 0.0269641 0.9181021 0.9960116
rho…1718 MalG6m3 Paclitaxel/Carboplatin (nM) 70 0.0036927 0.9757967 46 0.0230091 0.8793602 24 -0.0043526 0.9838959 0.0273616 0.9181278 0.9960116
rho…1719 CitG6m5 Erlotinib (EGFR) (uM) 71 0.1311143 0.2757609 47 0.1587834 0.2864088 24 0.1322027 0.5380290 0.0265807 0.9184454 0.9960116
rho…1720 LacQ6m2 Pemetrexed/Cisplatin (uM) 67 0.0621420 0.6173811 45 0.0761604 0.6190158 22 0.0480362 0.8318887 0.0281242 0.9186591 0.9960116
rho…1721 MalQ6m4 MK-2206 (AKT) (uM) 70 -0.0746367 0.5391699 46 -0.0697144 0.6452476 24 -0.0426365 0.8431903 -0.0270778 0.9187254 0.9960116
rho…1722 CitG6m4 Etoposide (uM) 69 -0.0986590 0.4199422 46 -0.0980047 0.5170041 23 -0.1250309 0.5697455 0.0270261 0.9194573 0.9960116
rho…1723 FumG6m2 Gemcitabine (nM) 71 -0.1175583 0.3288801 47 -0.0902820 0.5461695 24 -0.0639269 0.7666484 -0.0263550 0.9203702 0.9960116
rho…1724 SerG6m1 Paclitaxel/Carboplatin (nM) 59 -0.1728926 0.1903701 40 -0.1519189 0.3493765 19 -0.1807811 0.4589086 0.0288621 0.9209683 0.9960116
rho…1725 SerG24m1 Paclitaxel/Carboplatin (nM) 63 -0.1445994 0.2581840 41 -0.1624118 0.3103260 22 -0.1893726 0.3986331 0.0269609 0.9211186 0.9960116
rho…1726 MalG24m4 Cisplatin (uM) 70 -0.1434846 0.2360151 46 -0.1146029 0.4482189 24 -0.1405265 0.5125017 0.0259235 0.9211447 0.9960116
rho…1727 MalQ6m1 Docetaxel (nM) 68 0.0743279 0.5469115 45 0.1046926 0.4937096 23 0.0781211 0.7231105 0.0265714 0.9214285 0.9960116
rho…1728 LacQ24m2 E-cadherin 59 -0.0943892 0.4760072 37 -0.0848743 0.6162812 22 -0.0570299 0.8011587 -0.0278444 0.9221629 0.9960116
rho…1729 MalG24m3 E-cadherin 59 -0.2237029 0.0885329 37 -0.2088668 0.2139447 22 -0.2354602 0.2901084 0.0265934 0.9221932 0.9960116
rho…1730 LacG6m1 Beta-catenin 59 0.1729524 0.1902143 37 0.1522229 0.3684330 22 0.1247883 0.5786862 0.0274346 0.9222017 0.9960116
rho…1731 SerG24m1 8-Cl-adenosine (uM) 66 -0.1212159 0.3322816 43 -0.1084633 0.4887301 23 -0.0820361 0.7098041 -0.0264272 0.9224182 0.9960116
rho…1732 LacQ24m3 8-Cl-adenosine (uM) 71 -0.1062376 0.3778939 47 -0.0669713 0.6546792 24 -0.0926288 0.6668396 0.0256576 0.9224381 0.9960116
rho…1733 MalG6m2 Pemetrexed/Cisplatin (uM) 67 0.0100176 0.9358745 45 0.0492770 0.7478668 22 0.0226053 0.9204624 0.0266717 0.9230445 0.9960116
rho…1734 CitG6m5 Beta-catenin 57 -0.3365310 0.0108043 36 -0.3637066 0.0298644 21 -0.3389610 0.1330440 -0.0247455 0.9232411 0.9960116
rho…1735 CitQ24m6 AZD6244 (MEK) (uM) 69 0.1287647 0.2916738 46 0.1437118 0.3406736 23 0.1689723 0.4391075 -0.0252605 0.9237795 0.9960116
rho…1736 FumG6m4 Gefitinib (EGFR) (uM) 72 0.2044322 0.0849702 47 0.2447953 0.0972407 25 0.2212815 0.2877764 0.0235137 0.9241340 0.9960116
rho…1737 LacG24m2 Crizotinib (ALK) (uM) 75 -0.1203600 0.3036741 49 -0.0881557 0.5469516 26 -0.1122135 0.5852260 0.0240578 0.9241838 0.9960116
rho…1738 MalG24m3 MK-2206 (AKT) (uM) 71 0.1417443 0.2383491 47 0.1263736 0.3973042 24 0.1505330 0.4826127 -0.0241594 0.9260037 0.9969965
rho…1739 SerG6m3 Gemcitabine/Cisplatin (nM) 59 -0.0651440 0.6239954 40 -0.2016231 0.2121773 19 -0.2280702 0.3461250 0.0264471 0.9261629 0.9969965
rho…1740 MalQ6m3 E-cadherin 58 0.2130795 0.1082213 36 0.2167310 0.2034658 22 0.1914173 0.3917312 0.0253137 0.9269160 0.9971557
rho…1741 LacG24m2 E-cadherin 59 -0.0713033 0.5905944 37 -0.1043148 0.5375686 22 -0.0784867 0.7280414 -0.0258281 0.9275428 0.9971557
rho…1742 SerG24m2 E-cadherin 53 0.0951459 0.4968631 33 0.1026070 0.5685151 20 0.1293233 0.5856368 -0.0267164 0.9289138 0.9971557
rho…1743 GlyG6m2 Gemcitabine (nM) 64 -0.2335850 0.0632204 41 -0.3358338 0.0318200 23 -0.3138127 0.1447861 -0.0220211 0.9289850 0.9971557
rho…1744 MalQ6m3 AZD6244 (MEK) (uM) 70 -0.1595290 0.1871194 46 -0.1553075 0.3027153 24 -0.1321739 0.5365488 -0.0231336 0.9292942 0.9971557
rho…1745 SerG6m3 Sorafenib (multi-kinase) (uM) 62 -0.0928944 0.4726831 42 -0.2029667 0.1973476 20 -0.2270677 0.3341229 0.0241010 0.9307094 0.9971557
rho…1746 MalQ24m4 EGFR-pY1173 59 0.1363530 0.3022604 37 0.0844002 0.6182608 22 0.1089780 0.6281709 -0.0245778 0.9309728 0.9971557
rho…1747 FumQ24m3 Sorafenib (multi-kinase) (uM) 73 0.0332215 0.7802278 48 0.0127596 0.9314073 25 -0.0092325 0.9650637 0.0219921 0.9326264 0.9971557
rho…1748 CitQ24m2 Doxorubicin (nM) 71 -0.2204595 0.0646815 47 -0.2346307 0.1124033 24 -0.2556522 0.2269647 0.0210214 0.9327946 0.9971557
rho…1749 CitQ6m3 Gemcitabine/Cisplatin (nM) 65 -0.1081825 0.3910065 44 -0.1202425 0.4368852 21 -0.0974026 0.6737407 -0.0228399 0.9348453 0.9971557
rho…1750 SerG6m2 Etoposide (uM) 61 -0.1188993 0.3614186 41 -0.1149976 0.4740205 20 -0.1383979 0.5606385 0.0234003 0.9350371 0.9971557
rho…1751 SerG6m1 Paclitaxel (nM) 62 -0.2150692 0.0932105 42 -0.1925602 0.2218041 20 -0.2151185 0.3623890 0.0225583 0.9354512 0.9971557
rho…1752 MalQ6m4 Paclitaxel/Carboplatin (nM) 69 -0.1150662 0.3464577 45 -0.1246046 0.4147649 24 -0.1458108 0.4966070 0.0212061 0.9355797 0.9971557
rho…1753 MalG6m4 Beta-catenin 59 -0.2482174 0.0582397 37 -0.2593646 0.1210024 22 -0.2377188 0.2853971 -0.0216458 0.9357996 0.9971557
rho…1754 CitG6m6 Docetaxel (nM) 67 0.1916482 0.1202735 45 0.1779653 0.2421628 22 0.1994351 0.3735642 -0.0214698 0.9358198 0.9971557
rho…1755 FumQ6m4 Paclitaxel (nM) 73 -0.1201358 0.3113484 48 -0.1377345 0.3505318 25 -0.1173528 0.5763935 -0.0203816 0.9365196 0.9971557
rho…1756 CitQ6m6 Pemetrexed (uM) 68 -0.1752021 0.1529904 46 -0.1385246 0.3585662 22 -0.1599107 0.4771705 0.0213861 0.9367110 0.9971557
rho…1757 GlyG24m2 Paclitaxel/Carboplatin (nM) 64 -0.1532666 0.2266144 41 -0.1707763 0.2857227 23 -0.1918893 0.3804102 0.0211130 0.9370103 0.9971557
rho…1758 CitQ6m2 Docetaxel (nM) 67 -0.0999950 0.4207550 45 -0.1349570 0.3767520 22 -0.1135593 0.6148363 -0.0213977 0.9373427 0.9971557
rho…1759 GlyG6m2 Beta-catenin 53 -0.0910337 0.5157165 32 -0.0311584 0.8655523 21 -0.0545455 0.8147885 0.0233871 0.9377585 0.9971557
rho…1760 MalQ24m2 Docetaxel (nM) 69 -0.0555170 0.6504886 46 -0.0452274 0.7653537 23 -0.0242215 0.9126475 -0.0210059 0.9380610 0.9971557
rho…1761 CitQ24m5 Etoposide (uM) 69 0.0399565 0.7444467 46 0.0404601 0.7894914 23 0.0197677 0.9286653 0.0206924 0.9390020 0.9971557
rho…1762 MalG24m2 Pemetrexed (uM) 70 -0.1044005 0.3897321 47 -0.0761430 0.6109671 23 -0.0963510 0.6618690 0.0202079 0.9398192 0.9971557
rho…1763 FumG6m4 SCH772984 (ERK) (uM) 78 -0.0707832 0.5380127 51 -0.0507008 0.7238433 27 -0.0319557 0.8742759 -0.0187451 0.9401265 0.9971557
rho…1764 CitG24m3 CDH1 64 0.0118629 0.9258749 42 -0.0254581 0.8728543 22 -0.0045249 0.9840555 -0.0209332 0.9403406 0.9971557
rho…1765 CitG24m2 Beta-catenin 57 0.1158284 0.3898633 36 0.0797941 0.6425371 21 0.1012987 0.6613610 -0.0215046 0.9410103 0.9971557
rho…1766 MalG24m1 Pemetrexed (uM) 70 -0.0985210 0.4171241 47 -0.0966673 0.5180277 23 -0.0769814 0.7269990 -0.0196859 0.9413652 0.9971557
rho…1767 MalQ6m2 CDH1 66 0.2460639 0.0464178 43 0.2474975 0.1095692 23 0.2662051 0.2195284 -0.0187077 0.9416958 0.9971557
rho…1768 CitQ24m4 Paclitaxel (nM) 71 -0.0655218 0.5872119 47 -0.0973226 0.5151811 24 -0.0782949 0.7161208 -0.0190277 0.9423628 0.9971557
rho…1769 FumG24m1 Gemcitabine (nM) 71 0.0054574 0.9639725 47 -0.0026982 0.9856387 24 -0.0217439 0.9196714 0.0190456 0.9427443 0.9971557
rho…1770 LacQ24m2 Carboplatin (uM) 69 0.0514709 0.6744732 46 0.0618697 0.6829331 23 0.0425111 0.8472775 0.0193585 0.9428235 0.9971557
rho…1771 CitQ6m6 MK-2206 (AKT) (uM) 69 0.0228033 0.8524590 46 0.0405318 0.7891270 23 0.0217553 0.9215135 0.0187765 0.9446370 0.9985096
rho…1772 FumQ24m4 Sorafenib (multi-kinase) (uM) 73 0.1805732 0.1263173 48 0.1998100 0.1733211 25 0.1827626 0.3818854 0.0170474 0.9457694 0.9985961
rho…1773 MalQ6m2 Paclitaxel (nM) 72 -0.1462356 0.2202984 47 -0.1474509 0.3226279 25 -0.1304348 0.5343042 -0.0170161 0.9470185 0.9985961
rho…1774 CitG6m5 Paclitaxel/Carboplatin (nM) 68 -0.0077321 0.9501014 45 -0.0179230 0.9069731 23 0.0000000 1.0000000 -0.0179230 0.9473950 0.9985961
rho…1775 FumQ6m4 CDH1 66 -0.0719349 0.5659809 43 -0.0611921 0.6966806 23 -0.0791688 0.7195418 0.0179767 0.9474030 0.9985961
rho…1776 GlyG24m2 SCH772984 (ERK) (uM) 73 -0.0125225 0.9162571 46 -0.0516738 0.7330649 27 -0.0350886 0.8620608 -0.0165852 0.9480025 0.9985961
rho…1777 CitQ24m6 SCH772984 (ERK) (uM) 76 0.1807531 0.1181575 50 0.1733227 0.2287002 26 0.1892550 0.3544664 -0.0159323 0.9483818 0.9985961
rho…1778 MalQ6m3 Pemetrexed (uM) 69 -0.0003870 0.9974822 46 0.0212573 0.8884847 23 0.0387390 0.8606941 -0.0174818 0.9484529 0.9985961
rho…1779 CitQ6m5 Gemcitabine/Cisplatin (nM) 65 0.0041087 0.9740870 44 -0.0066253 0.9659545 21 -0.0246753 0.9168661 0.0180500 0.9490854 0.9987003
rho…1780 FumG24m1 Pemetrexed/Cisplatin (uM) 67 -0.0381756 0.7590624 45 -0.0755699 0.6217445 22 -0.0926816 0.6816410 0.0171117 0.9502969 0.9994134
rho…1781 CitQ6m3 AZD6244 (MEK) (uM) 69 -0.0933863 0.4453301 46 -0.0706223 0.6409398 23 -0.0543478 0.8055630 -0.0162745 0.9518638 0.9997154
rho…1782 FumQ24m4 Pemetrexed (uM) 70 -0.0781017 0.5204428 47 -0.0595910 0.6907123 23 -0.0437164 0.8429990 -0.0158746 0.9529334 0.9997154
rho…1783 FumG24m3 Etoposide (uM) 71 -0.0621976 0.6063550 47 -0.0287953 0.8476369 24 -0.0443575 0.8369420 0.0155622 0.9531478 0.9997154
rho…1784 LacQ24m1 Vinorelbine (nM) 72 -0.1692777 0.1551680 47 -0.2041696 0.1686437 25 -0.2187140 0.2935491 0.0145444 0.9535026 0.9997154
rho…1785 MalG6m4 E-cadherin 59 -0.1088252 0.4109430 37 -0.1095306 0.5173159 22 -0.1259176 0.5752188 0.0163870 0.9537358 0.9997154
rho…1786 LacG6m2 Gemcitabine (nM) 71 0.0469830 0.6972215 47 0.0743840 0.6192536 24 0.0895847 0.6772025 -0.0152007 0.9539871 0.9997154
rho…1787 GlyG24m2 Gefitinib (EGFR) (uM) 67 -0.1460292 0.2383426 43 -0.1699267 0.2759793 24 -0.1844682 0.3881908 0.0145414 0.9555716 0.9997154
rho…1788 GlyG24m1 Pemetrexed (uM) 66 -0.0915413 0.4647715 43 -0.1279110 0.4136894 23 -0.1425398 0.5164670 0.0146288 0.9566063 0.9997154
rho…1789 GlyG24m1 EGFR-pY1173 53 -0.1035359 0.4606571 32 -0.0344606 0.8514737 21 -0.0181818 0.9392862 -0.0162788 0.9567041 0.9997154
rho…1790 FumG24m4 8-Cl-adenosine (uM) 71 -0.1859923 0.1204313 47 -0.1739055 0.2423770 24 -0.1600348 0.4550704 -0.0138707 0.9570961 0.9997154
rho…1791 LacQ6m1 Etoposide (uM) 71 0.0373793 0.7569558 47 0.0245757 0.8697544 24 0.0104371 0.9613955 0.0141387 0.9574733 0.9997154
rho…1792 CitQ24m1 Paclitaxel/Carboplatin (nM) 68 -0.0072357 0.9533011 45 -0.0282683 0.8537544 23 -0.0138511 0.9499848 -0.0144172 0.9576590 0.9997154
rho…1793 MalQ6m2 SCH772984 (ERK) (uM) 77 0.0443146 0.7019520 50 0.0531552 0.7139052 27 0.0404145 0.8413675 0.0127406 0.9594093 0.9997154
rho…1794 GlyG24m2 Gemcitabine/Cisplatin (nM) 63 -0.0569131 0.6577316 41 -0.1038508 0.5181782 22 -0.0897798 0.6904349 -0.0140711 0.9596809 0.9997154
rho…1795 CitQ24m6 Paclitaxel (nM) 71 -0.1356555 0.2593251 47 -0.1217834 0.4148064 24 -0.1348412 0.5298733 0.0130579 0.9600767 0.9997154
rho…1796 SerG6m1 Carboplatin (uM) 60 -0.1576943 0.2288424 41 -0.2233162 0.1604687 19 -0.2098333 0.3885742 -0.0134829 0.9621393 0.9997154
rho…1797 LacG24m1 CDH1 66 -0.0488029 0.6971775 43 -0.0523970 0.7386100 23 -0.0395844 0.8576839 -0.0128126 0.9626051 0.9997154
rho…1798 FumQ24m4 Pemetrexed/Cisplatin (uM) 67 -0.1046965 0.3991327 45 -0.1048783 0.4929391 22 -0.1175806 0.6022810 0.0127023 0.9628965 0.9997154
rho…1799 MalG24m4 Carboplatin (uM) 69 -0.1569158 0.1978778 46 -0.1226290 0.4168535 23 -0.1102323 0.6165788 -0.0123967 0.9629660 0.9997154
rho…1800 FumQ24m4 8-Cl-adenosine (uM) 71 0.1174221 0.3294445 47 0.1174021 0.4319151 24 0.1052632 0.6244759 0.0121390 0.9630369 0.9997154
rho…1801 FumG24m2 SCH772984 (ERK) (uM) 78 0.0105840 0.9267226 51 0.0048053 0.9733029 27 -0.0062658 0.9752554 0.0110711 0.9646773 0.9997154
rho…1802 CitQ6m5 MK-2206 (AKT) (uM) 69 -0.1528988 0.2097474 46 -0.1684198 0.2632010 23 -0.1799753 0.4112252 0.0115556 0.9648797 0.9997154
rho…1803 FumQ24m4 Paclitaxel/Carboplatin (nM) 70 -0.0109731 0.9281620 46 -0.0258466 0.8646134 24 -0.0374402 0.8621111 0.0115935 0.9652295 0.9997154
rho…1804 MalQ6m2 Paclitaxel/Carboplatin (nM) 69 -0.1760105 0.1479910 45 -0.1727455 0.2564762 24 -0.1836780 0.3902621 0.0109325 0.9663012 0.9997154
rho…1805 MalG6m2 Crizotinib (ALK) (uM) 75 -0.0841723 0.4727659 49 -0.0601155 0.6815738 26 -0.0708177 0.7310167 0.0107022 0.9664283 0.9997154
rho…1806 MalG6m4 Pemetrexed (uM) 70 0.1257809 0.2994853 47 0.1285973 0.3889826 23 0.1395599 0.5253626 -0.0109625 0.9669811 0.9997154
rho…1807 MalG24m4 Erlotinib (EGFR) (uM) 73 -0.0735895 0.5360896 48 -0.0896211 0.5446694 25 -0.0792460 0.7065173 -0.0103751 0.9679589 0.9997154
rho…1808 CitQ6m6 Vinorelbine (nM) 70 -0.0440489 0.7172924 46 -0.0214019 0.8877307 24 -0.0317737 0.8828275 0.0103718 0.9689009 0.9997154
rho…1809 CitQ24m5 Gemcitabine/Cisplatin (nM) 65 0.1248129 0.3218667 44 0.0909219 0.5572285 21 0.0805195 0.7283173 0.0104024 0.9704345 0.9997154
rho…1810 SerG6m1 Pemetrexed (uM) 60 -0.1431580 0.2751838 41 -0.1723046 0.2813685 19 -0.1827855 0.4538583 0.0104809 0.9710324 0.9997154
rho…1811 LacQ6m1 E-cadherin 59 -0.1111079 0.4021577 37 -0.0999407 0.5561786 22 -0.0897798 0.6904349 -0.0101609 0.9714445 0.9997154
rho…1812 CitQ24m2 Sorafenib (multi-kinase) (uM) 71 -0.1354477 0.2600624 47 -0.1299054 0.3841356 24 -0.1391607 0.5166496 0.0092552 0.9716501 0.9997154
rho…1813 LacQ6m3 CDH1 66 -0.2198789 0.0760708 43 -0.2434842 0.1156338 23 -0.2519180 0.2462104 0.0084338 0.9738267 0.9997154
rho…1814 GlyG24m2 Gemcitabine (nM) 66 -0.2111925 0.0887155 43 -0.2872560 0.0617987 23 -0.2954545 0.1707183 0.0081985 0.9739026 0.9997154
rho…1815 CitG24m1 SCH772984 (ERK) (uM) 76 -0.2557495 0.0257576 50 -0.2159075 0.1320912 26 -0.2234745 0.2724617 0.0075671 0.9750743 0.9997154
rho…1816 FumQ24m3 Docetaxel (nM) 69 0.0667379 0.5858585 46 0.0431912 0.7756378 23 0.0514088 0.8157983 -0.0082176 0.9757243 0.9997154
rho…1817 FumG6m3 EGFR-pY1173 59 -0.1374050 0.2985183 37 -0.1578947 0.3492854 22 -0.1496330 0.5046442 -0.0082618 0.9764320 0.9997154
rho…1818 CitG24m1 Doxorubicin (nM) 71 0.0252394 0.8345034 47 0.0407160 0.7858288 24 0.0330435 0.8787738 0.0076725 0.9768905 0.9997154
rho…1819 FumQ24m4 AZD6244 (MEK) (uM) 71 0.0715867 0.5530104 47 0.0922863 0.5372575 24 0.0995869 0.6433763 -0.0073005 0.9778367 0.9997154
rho…1820 LacQ6m1 8-Cl-adenosine (uM) 71 -0.2632881 0.0265258 47 -0.2448814 0.0971193 24 -0.2517939 0.2352573 0.0069124 0.9778414 0.9997154
rho…1821 CitQ24m1 Carboplatin (uM) 67 -0.1222409 0.3243999 45 -0.1153757 0.4504229 22 -0.1079096 0.6326528 -0.0074661 0.9781844 0.9997154
rho…1822 FumQ24m1 Paclitaxel (nM) 73 -0.0231137 0.8460968 48 -0.0288824 0.8454953 25 -0.0227010 0.9142276 -0.0061814 0.9810305 0.9997154
rho…1823 SerG24m3 Cisplatin (uM) 65 -0.1923548 0.1247599 43 -0.1670569 0.2842901 22 -0.1734464 0.4401580 0.0063895 0.9811582 0.9997154
rho…1824 CitG6m2 Pemetrexed/Cisplatin (uM) 65 -0.0774106 0.5399322 44 -0.1104338 0.4754538 21 -0.1039974 0.6537103 -0.0064363 0.9816277 0.9997154
rho…1825 MalQ24m4 8-Cl-adenosine (uM) 71 0.1413515 0.2396659 47 0.1372969 0.3574252 24 0.1313329 0.5407302 0.0059640 0.9817306 0.9997154
rho…1826 CitG6m5 SCH772984 (ERK) (uM) 76 -0.2210948 0.0549412 50 -0.2060603 0.1510957 26 -0.2007779 0.3253697 -0.0052824 0.9827236 0.9997154
rho…1827 SerG24m1 Carboplatin (uM) 65 -0.2306642 0.0645149 43 -0.2681168 0.0821514 22 -0.2733691 0.2183289 0.0052523 0.9837704 0.9997154
rho…1828 CitG24m5 AZD6244 (MEK) (uM) 69 -0.0413808 0.7356647 46 -0.0488497 0.7471578 23 -0.0434783 0.8442705 -0.0053714 0.9841325 0.9997154
rho…1829 LacG24m2 Gemcitabine/Cisplatin (nM) 67 0.0539187 0.6647581 45 0.0679931 0.6571937 22 0.0626765 0.7817293 0.0053167 0.9845919 0.9997154
rho…1830 CitQ24m1 Cisplatin (uM) 68 -0.0985531 0.4239589 45 -0.0967221 0.5273489 23 -0.1018542 0.6437653 0.0051320 0.9847787 0.9997154
rho…1831 CitQ24m6 CDH1 64 -0.0196036 0.8778050 42 -0.0035674 0.9821117 22 0.0016968 0.9940205 -0.0052642 0.9849878 0.9997154
rho…1832 LacG24m1 AZD6244 (MEK) (uM) 71 -0.1873690 0.1176608 47 -0.1535592 0.3027617 24 -0.1582609 0.4584126 0.0047016 0.9855046 0.9997154
rho…1833 CitG24m4 CDH1 64 0.2681064 0.0321966 42 0.2724988 0.0808268 22 0.2771497 0.2117732 -0.0046509 0.9856532 0.9997154
rho…1834 MalG24m1 Doxorubicin (nM) 73 0.0517485 0.6637080 48 0.0584722 0.6930148 25 0.0538462 0.7981088 0.0046261 0.9857674 0.9997154
rho…1835 CitQ24m6 E-cadherin 57 -0.1506352 0.2625845 36 -0.1711712 0.3169014 21 -0.1662338 0.4697217 -0.0049374 0.9861622 0.9997154
rho…1836 CitG24m5 Gefitinib (EGFR) (uM) 70 0.0703348 0.5628695 46 0.0581704 0.7009796 24 0.0626496 0.7711889 -0.0044792 0.9865271 0.9997154
rho…1837 GlyG24m1 AZD6244 (MEK) (uM) 67 0.2019976 0.1011607 43 0.2068874 0.1831465 24 0.2026087 0.3407618 0.0042787 0.9867776 0.9997154
rho…1838 CitG6m1 Erlotinib (EGFR) (uM) 71 -0.1289847 0.2837028 47 -0.1170348 0.4333672 24 -0.1213307 0.5722377 0.0042959 0.9868910 0.9997154
rho…1839 MalQ6m1 8-Cl-adenosine (uM) 70 -0.0566974 0.6410735 46 -0.0347933 0.8184375 24 -0.0391475 0.8558859 0.0043541 0.9869332 0.9997154
rho…1840 GlyG6m2 Paclitaxel/Carboplatin (nM) 63 -0.1503481 0.2395332 40 -0.1734072 0.2845838 23 -0.1775910 0.4175524 0.0041839 0.9875901 0.9997154
rho…1841 CitG24m3 EGFR-pY1173 57 0.0764531 0.5719043 36 -0.0043758 0.9802816 21 0.0000000 1.0000000 -0.0043758 0.9880850 0.9997154
rho…1842 CitQ6m6 Doxorubicin (nM) 71 -0.0362234 0.7642501 47 -0.0587011 0.6951056 24 -0.0547826 0.7992685 -0.0039185 0.9881745 0.9997154
rho…1843 GlyG6m1 Paclitaxel/Carboplatin (nM) 63 0.1469628 0.2504010 40 0.1627100 0.3157926 23 0.1587931 0.4692575 0.0039169 0.9884412 0.9997154
rho…1844 MalG6m3 Paclitaxel (nM) 73 -0.0948002 0.4249911 48 -0.0802411 0.5877167 25 -0.0765679 0.7160265 -0.0036731 0.9886650 0.9997154
rho…1845 LacG6m1 Erlotinib (EGFR) (uM) 73 -0.0778203 0.5128449 48 -0.0542331 0.7142883 25 -0.0577034 0.7841045 0.0034703 0.9893231 0.9997154
rho…1846 CitG24m5 Etoposide (uM) 69 -0.1353808 0.2673748 46 -0.1244642 0.4098616 23 -0.1279961 0.5605547 0.0035319 0.9894200 0.9997154
rho…1847 MalG6m3 CDH1 66 0.1805369 0.1468872 43 0.1995921 0.1994211 23 0.2028701 0.3532113 -0.0032780 0.9900468 0.9997154
rho…1848 MalQ24m4 Cisplatin (uM) 70 0.0635182 0.6013986 46 0.0468774 0.7570489 24 0.0500326 0.8164067 -0.0031552 0.9905216 0.9997154
rho…1849 LacQ6m3 8-Cl-adenosine (uM) 71 -0.0842179 0.4850027 47 -0.0429703 0.7742734 24 -0.0461070 0.8305997 0.0031367 0.9905455 0.9997154
rho…1850 LacQ6m2 8-Cl-adenosine (uM) 71 0.1799514 0.1331821 47 0.1976287 0.1830025 24 0.2004784 0.3475801 -0.0028497 0.9910738 0.9997154
rho…1851 MalQ24m4 AZD6244 (MEK) (uM) 71 0.1350561 0.2614557 47 0.1484330 0.3193797 24 0.1513043 0.4786358 -0.0028714 0.9911638 0.9997154
rho…1852 SerG6m1 Pemetrexed/Cisplatin (uM) 59 -0.2060934 0.1173424 40 -0.2981378 0.0616866 19 -0.3011415 0.2102553 0.0030037 0.9912005 0.9997154
rho…1853 FumG6m2 SCH772984 (ERK) (uM) 78 -0.0449052 0.6962511 51 -0.0349119 0.8078394 27 -0.0375949 0.8523109 0.0026830 0.9914261 0.9997154
rho…1854 CitG6m6 Pemetrexed (uM) 68 0.1841420 0.1327853 46 0.2145668 0.1521574 22 0.2120802 0.3433749 0.0024867 0.9924544 0.9997154
rho…1855 SerG24m1 Gemcitabine (nM) 65 -0.1876960 0.1343325 43 -0.2858148 0.0631756 22 -0.2840203 0.1995537 -0.0017945 0.9944072 0.9997154
rho…1856 MalQ24m4 Beta-catenin 59 0.1454705 0.2708394 37 0.1263632 0.4546667 22 0.1281762 0.5683122 -0.0018130 0.9948667 0.9997154
rho…1857 LacG6m2 Carboplatin (uM) 69 0.1672026 0.1696887 46 0.1637109 0.2769752 23 0.1621355 0.4598319 0.0015755 0.9952289 0.9997154
rho…1858 MalQ24m2 Pemetrexed (uM) 70 -0.2547929 0.0332845 47 -0.2100599 0.1564282 23 -0.2115748 0.3324839 0.0015149 0.9953095 0.9997154
rho…1859 FumQ24m2 Carboplatin (uM) 69 -0.0049517 0.9677898 46 0.0082657 0.9565217 23 0.0066749 0.9758862 0.0015908 0.9953101 0.9997154
rho…1860 LacQ24m2 MK-2206 (AKT) (uM) 71 -0.1877961 0.1168113 47 -0.1832851 0.2175076 24 -0.1818578 0.3950572 -0.0014274 0.9955580 0.9997154
rho…1861 MalQ24m2 Sorafenib (multi-kinase) (uM) 73 -0.0908228 0.4447609 48 -0.0643410 0.6639488 25 -0.0657819 0.7547297 0.0014409 0.9955619 0.9997154
rho…1862 MalQ6m1 AZD6244 (MEK) (uM) 70 0.0438423 0.7185632 46 0.0459522 0.7617024 24 0.0474016 0.8259132 -0.0014494 0.9956466 0.9997154
rho…1863 CitG24m4 Etoposide (uM) 69 -0.0949493 0.4377167 46 -0.0956610 0.5271242 23 -0.0943909 0.6683620 -0.0012701 0.9962217 0.9997154
rho…1864 MalQ24m4 Carboplatin (uM) 69 0.1304769 0.2852507 46 0.1316966 0.3829699 23 0.1304993 0.5528478 0.0011974 0.9964085 0.9997154
rho…1865 CitQ6m2 EGFR-pY1173 57 -0.1405908 0.2968957 36 -0.1919042 0.2621814 21 -0.1909091 0.4053961 -0.0009952 0.9971872 0.9997154
rho…1866 FumG24m1 Paclitaxel (nM) 73 0.0244258 0.8374762 48 0.0295906 0.8417547 25 0.0303963 0.8853160 -0.0008057 0.9975267 0.9997154
rho…1867 FumQ6m2 EGFR-pY1173 59 -0.1060522 0.4240404 37 -0.1138048 0.5024297 22 -0.1146569 0.6113989 0.0008521 0.9975949 0.9997154
rho…1868 CitG6m6 AZD6244 (MEK) (uM) 69 -0.1025404 0.4017964 46 -0.0983192 0.5156538 23 -0.0978261 0.6560180 -0.0004931 0.9985322 0.9997154
rho…1869 CitQ6m2 Paclitaxel/Carboplatin (nM) 68 -0.1151427 0.3497872 45 -0.1382492 0.3651128 23 -0.1385111 0.5285105 0.0002620 0.9992156 0.9997154
rho…1870 LacG24m3 Beta-catenin 59 -0.1221508 0.3557561 37 -0.1261261 0.4555193 22 -0.1259176 0.5752188 -0.0002086 0.9994096 0.9997154
rho…1871 LacQ24m2 Crizotinib (ALK) (uM) 75 -0.3124218 0.0063550 49 -0.2875605 0.0451240 26 -0.2877182 0.1540785 0.0001577 0.9994629 0.9997154
rho…1872 MalQ24m2 Paclitaxel/Carboplatin (nM) 70 -0.0132307 0.9134347 46 -0.0192462 0.8989773 24 -0.0191513 0.9292242 -0.0000949 0.9997154 0.9997154

The pearson correlation results are also derived.

all.out2 = NULL 
for (idx1 in 1:length(all.metID))
  {
    metID = all.metID[idx1]
    
   for (idx2 in 1:length(all.IC50_ID))
    {
      IC50_ID = all.IC50_ID[idx2]
      #cat("metabolite=",metID, "Drug=",IC50_ID,"\n")
      cor.res=CorDiff(met_Dat=TableS1_convolute, IC50_Dat=TableS4,  metID=metID,IC50_ID=IC50_ID, plot=TRUE,method0="pearson")
      out= data.frame(metabolite=metID, drug=IC50_ID, cor.res)
      #print(out)
      all.out2 = bind_rows(all.out2,out)
      
    }
  }

all.out2$FDR.P= with(all.out2, p.adjust(CorDiff.pvalue,method="fdr"))
all.out2 = all.out2 %>% arrange(CorDiff.pvalue)

write.csv(all.out2,file="Metabolite_DrugIC50_PearsonCorSexDiff.csv",row.names=F)
options(width = 300)
#print(data.frame(all.out2),digits=4)

#print table in nice html format
kbl(all.out2) %>%
  kable_paper(full_width = F) %>%
  scroll_box(width = "1000px", height = "500px")
metabolite drug allN allCor allCor.P maleN maleCor maleCor.P femaleN femaleCor femaleCor.P M2FcorDifference CorDiff.pvalue FDR.P
cor…1 LacG24m1 Etoposide (uM) 71 -0.1313522 0.2748828 47 0.1563447 0.2939694 24 -0.5353213 0.0070249 0.6916660 0.0044078 0.9989514
cor…2 SerG24m3 Pemetrexed (uM) 65 -0.2711364 0.0289139 43 -0.4887513 0.0008826 22 0.2112950 0.3452063 -0.7000463 0.0071880 0.9989514
cor…3 MalG24m2 Etoposide (uM) 71 -0.1058936 0.3794487 47 0.0746966 0.6177777 24 -0.5600452 0.0044265 0.6347417 0.0076215 0.9989514
cor…4 FumG24m3 Paclitaxel (nM) 73 -0.0774378 0.5149253 48 -0.3273929 0.0231194 25 0.3289292 0.1083865 -0.6563221 0.0087984 0.9989514
cor…5 CitG24m1 Paclitaxel/Carboplatin (nM) 68 0.2477944 0.0416124 45 0.4613815 0.0014227 23 -0.2083475 0.3400820 0.6697290 0.0089163 0.9989514
cor…6 FumG24m1 Vinorelbine (nM) 72 -0.1195599 0.3171469 47 0.1647837 0.2683511 25 -0.4659756 0.0188898 0.6307593 0.0101532 0.9989514
cor…7 LacG24m3 Etoposide (uM) 71 0.1949019 0.1033588 47 -0.0795028 0.5952741 24 0.5366425 0.0068596 -0.6161453 0.0104544 0.9989514
cor…8 SerG6m3 Pemetrexed (uM) 60 -0.3532843 0.0056253 41 -0.5842841 0.0000605 19 0.0917469 0.7087353 -0.6760310 0.0106693 0.9989514
cor…9 CitG6m4 Sorafenib (multi-kinase) (uM) 71 -0.0955806 0.4278370 47 -0.3371928 0.0204621 24 0.3109757 0.1391149 -0.6481685 0.0112215 0.9989514
cor…10 MalG24m2 Doxorubicin (nM) 73 -0.0297902 0.8024405 48 0.1307397 0.3757658 25 -0.4716713 0.0172980 0.6024110 0.0133459 0.9989514
cor…11 LacG6m1 Crizotinib (ALK) (uM) 75 -0.1195230 0.3070740 49 0.1215565 0.4053968 26 -0.4693175 0.0155723 0.5908741 0.0134266 0.9989514
cor…12 LacQ6m1 CDH1 66 0.0125368 0.9204176 43 0.2072217 0.1824243 23 -0.4244676 0.0435116 0.6316893 0.0154193 0.9989514
cor…13 CitG24m6 Crizotinib (ALK) (uM) 73 -0.0433902 0.7154854 48 -0.2435537 0.0952889 25 0.3581219 0.0787863 -0.6016756 0.0165812 0.9989514
cor…14 CitG6m2 Cisplatin (uM) 68 -0.0809958 0.5114345 45 -0.2817491 0.0607888 23 0.3463264 0.1054786 -0.6280755 0.0165915 0.9989514
cor…15 SerG24m3 AZD6244 (MEK) (uM) 66 0.0881414 0.4815861 43 0.1959891 0.2078233 23 -0.4240281 0.0437527 0.6200172 0.0174225 0.9989514
cor…16 CitG6m1 CDH1 64 0.0029965 0.9812518 42 0.2109050 0.1800149 22 -0.4213306 0.0508340 0.6322356 0.0177252 0.9989514
cor…17 LacG6m3 Carboplatin (uM) 69 0.0062819 0.9591433 46 -0.2053551 0.1709685 23 0.4080857 0.0532257 -0.6134409 0.0177579 0.9989514
cor…18 FumG24m3 Crizotinib (ALK) (uM) 75 -0.1337054 0.2527822 49 -0.3685376 0.0091717 26 0.2101366 0.3028432 -0.5786742 0.0187915 0.9989514
cor…19 CitQ6m1 Beta-catenin 57 -0.2216756 0.0974739 36 -0.4423271 0.0069086 21 0.2084321 0.3645739 -0.6507593 0.0191093 0.9989514
cor…20 FumG24m2 Vinorelbine (nM) 72 -0.1089405 0.3623335 47 0.1090965 0.4654077 25 -0.4589308 0.0210218 0.5680273 0.0204035 0.9989514
cor…21 CitQ6m1 Sorafenib (multi-kinase) (uM) 71 -0.2081849 0.0814727 47 -0.3937377 0.0061773 24 0.1929212 0.3664253 -0.5866590 0.0211174 0.9989514
cor…22 LacG6m1 Etoposide (uM) 71 -0.0170294 0.8879052 47 0.2032835 0.1705395 24 -0.3841332 0.0638490 0.5874166 0.0212296 0.9989514
cor…23 LacG6m3 Docetaxel (nM) 69 -0.0909471 0.4573583 46 -0.3552136 0.0154159 23 0.2456968 0.2584596 -0.6009104 0.0215086 0.9989514
cor…24 CitG6m2 Pemetrexed (uM) 68 -0.0731736 0.5531718 46 -0.2659509 0.0740260 22 0.3406815 0.1207823 -0.6066325 0.0227636 0.9989514
cor…25 FumG24m1 Cisplatin (uM) 70 0.2258073 0.0601657 46 0.0025141 0.9867697 24 0.5428022 0.0061309 -0.5402881 0.0229177 0.9989514
cor…26 FumG24m4 Crizotinib (ALK) (uM) 75 -0.1144639 0.3281456 49 -0.3242989 0.0230073 26 0.2381256 0.2414234 -0.5624245 0.0233208 0.9989514
cor…27 LacG6m3 Paclitaxel (nM) 73 -0.1326462 0.2632594 48 -0.3572601 0.0126741 25 0.2124276 0.3079866 -0.5696877 0.0234609 0.9989514
cor…28 CitQ6m5 Sorafenib (multi-kinase) (uM) 71 0.0890975 0.4599709 47 0.2351701 0.1115560 24 -0.3459071 0.0977836 0.5810772 0.0235824 0.9989514
cor…29 SerG24m3 Pemetrexed/Cisplatin (uM) 62 -0.1689350 0.1893241 41 -0.3991787 0.0097263 21 0.2173880 0.3438508 -0.6165667 0.0244960 0.9989514
cor…30 CitQ6m2 Beta-catenin 57 -0.3246818 0.0137340 36 -0.4904804 0.0023899 21 0.1212764 0.6005102 -0.6117568 0.0246049 0.9989514
cor…31 LacG6m1 Pemetrexed (uM) 70 0.0116745 0.9235840 47 0.2668352 0.0698162 23 -0.3205639 0.1358779 0.5873991 0.0246974 0.9989514
cor…32 CitG24m2 Vinorelbine (nM) 70 -0.0913755 0.4518632 46 0.1400296 0.3533172 24 -0.4266624 0.0375980 0.5666920 0.0249876 0.9989514
cor…33 LacG6m3 Etoposide (uM) 71 0.1496142 0.2130150 47 -0.0668964 0.6550411 24 0.4811866 0.0172888 -0.5480830 0.0257316 0.9989514
cor…34 SerG24m3 MK-2206 (AKT) (uM) 66 0.0742964 0.5532650 43 -0.0519947 0.7405470 23 0.5065079 0.0136507 -0.5585026 0.0259048 0.9989514
cor…35 CitQ6m1 E-cadherin 57 -0.2327044 0.0815157 36 -0.4460133 0.0064027 21 0.1670200 0.4692977 -0.6130333 0.0269290 0.9989514
cor…36 MalG24m2 Docetaxel (nM) 69 0.0924078 0.4501339 46 0.2764817 0.0628821 23 -0.3040944 0.1583256 0.5805760 0.0271721 0.9989514
cor…37 CitG24m5 Vinorelbine (nM) 70 0.0286912 0.8136077 46 -0.1956079 0.1926454 24 0.3711518 0.0741634 -0.5667596 0.0272185 0.9989514
cor…38 CitG24m5 Crizotinib (ALK) (uM) 73 -0.1291583 0.2761311 48 -0.3236768 0.0248209 25 0.2300689 0.2685640 -0.5537457 0.0284441 0.9989514
cor…39 LacG6m2 Paclitaxel (nM) 73 0.1218435 0.3044697 48 0.2555181 0.0796287 25 -0.2977381 0.1483185 0.5532563 0.0289111 0.9989514
cor…40 CitQ24m1 E-cadherin 57 -0.2049724 0.1261371 36 -0.3957025 0.0169014 21 0.2177948 0.3429262 -0.6134973 0.0289784 0.9989514
cor…41 GlyG6m2 Erlotinib (EGFR) (uM) 67 -0.2782952 0.0225884 43 -0.4816505 0.0010750 24 0.0619585 0.7736484 -0.5436091 0.0293389 0.9989514
cor…42 CitG24m2 Pemetrexed/Cisplatin (uM) 65 0.2194129 0.0790700 44 0.4230594 0.0042208 21 -0.1618427 0.4833752 0.5849020 0.0297054 0.9989514
cor…43 LacG24m3 Cisplatin (uM) 70 0.1378620 0.2550738 46 -0.1194224 0.4292319 24 0.4259388 0.0379583 -0.5453612 0.0308083 0.9989514
cor…44 CitG24m5 Paclitaxel (nM) 71 -0.1597149 0.1833692 47 -0.3446392 0.0176782 24 0.2098461 0.3250332 -0.5544854 0.0309295 0.9989514
cor…45 CitQ6m2 Doxorubicin (nM) 71 -0.1768205 0.1401800 47 -0.3300716 0.0234612 24 0.2226765 0.2956275 -0.5527481 0.0318134 0.9989514
cor…46 LacG24m2 Gefitinib (EGFR) (uM) 72 0.0854486 0.4754298 47 0.3026315 0.0386748 25 -0.2360748 0.2559177 0.5387063 0.0341808 0.9989514
cor…47 GlyG24m2 Pemetrexed (uM) 66 -0.2413200 0.0509396 43 -0.4527050 0.0023026 23 0.0911238 0.6792360 -0.5438288 0.0343497 0.9989514
cor…48 LacG6m2 Erlotinib (EGFR) (uM) 73 -0.0285429 0.8105550 48 0.1404638 0.3409743 25 -0.3875981 0.0555723 0.5280619 0.0343786 0.9989514
cor…49 FumG24m4 Paclitaxel (nM) 73 -0.1195196 0.3138549 48 -0.3009143 0.0376835 25 0.2342622 0.2596931 -0.5351765 0.0347566 0.9989514
cor…50 CitG24m3 MK-2206 (AKT) (uM) 69 -0.0711888 0.5610560 46 -0.2547831 0.0874890 23 0.3008284 0.1630687 -0.5556114 0.0349020 0.9989514
cor…51 GlyG24m2 Pemetrexed/Cisplatin (uM) 63 -0.2224842 0.0796724 41 -0.4644325 0.0022211 22 0.0892878 0.6927385 -0.5537202 0.0349764 0.9989514
cor…52 MalQ24m3 CDH1 66 -0.1922865 0.1219190 43 -0.3561532 0.0190742 23 0.2019126 0.3555366 -0.5580658 0.0350628 0.9989514
cor…53 SerG24m2 MK-2206 (AKT) (uM) 66 -0.0421079 0.7370976 43 -0.2577582 0.0951653 23 0.3011258 0.1626327 -0.5588840 0.0359368 0.9989514
cor…54 GlyG24m1 Beta-catenin 53 -0.3334206 0.0146988 32 -0.5082115 0.0029810 21 0.0643891 0.7815592 -0.5726006 0.0373239 0.9989514
cor…55 CitG24m2 Paclitaxel (nM) 71 0.0961739 0.4249612 47 0.2830243 0.0538941 24 -0.2544621 0.2301657 0.5374863 0.0377096 0.9989514
cor…56 FumG6m1 Vinorelbine (nM) 72 -0.0291009 0.8082694 47 0.1548233 0.2987510 25 -0.3683465 0.0700245 0.5231698 0.0377139 0.9989514
cor…57 CitQ24m5 Crizotinib (ALK) (uM) 73 -0.0001803 0.9987921 48 0.1367281 0.3540969 25 -0.3816452 0.0597681 0.5183733 0.0380694 0.9989514
cor…58 LacG24m3 Carboplatin (uM) 69 0.1205581 0.3237698 46 -0.0798534 0.5978248 23 0.4466752 0.0326216 -0.5265287 0.0383485 0.9989514
cor…59 CitG24m6 Vinorelbine (nM) 70 -0.0102419 0.9329375 46 -0.2112659 0.1587147 24 0.3223243 0.1245150 -0.5335902 0.0392857 0.9989514
cor…60 FumG6m3 Paclitaxel (nM) 73 -0.0299969 0.8010979 48 -0.2309395 0.1142783 25 0.2911725 0.1579080 -0.5221120 0.0397214 0.9989514
cor…61 SerG24m1 MK-2206 (AKT) (uM) 66 0.0014009 0.9910932 43 -0.2216826 0.1530960 23 0.3250510 0.1301783 -0.5467336 0.0399056 0.9989514
cor…62 GlyG6m2 Pemetrexed/Cisplatin (uM) 61 -0.2866878 0.0250891 40 -0.5403740 0.0003190 21 -0.0187196 0.9358094 -0.5216543 0.0414463 0.9989514
cor…63 GlyG24m2 MK-2206 (AKT) (uM) 67 -0.0544181 0.6618407 43 -0.2215631 0.1533234 24 0.3131145 0.1362738 -0.5346775 0.0415146 0.9989514
cor…64 CitG24m4 Crizotinib (ALK) (uM) 73 0.0602699 0.6124920 48 -0.0953839 0.5189970 25 0.4070360 0.0434467 -0.5024199 0.0425018 0.9989514
cor…65 MalG24m1 Vinorelbine (nM) 72 0.0970767 0.4172361 47 0.2321049 0.1164366 25 -0.2847551 0.1676965 0.5168600 0.0426706 0.9989514
cor…66 CitG6m4 CDH1 64 0.3589499 0.0035826 42 0.5464476 0.0001812 22 0.0462305 0.8381257 0.5002171 0.0426843 0.9989514
cor…67 CitG24m3 Pemetrexed/Cisplatin (uM) 65 -0.1662874 0.1855439 44 -0.3217620 0.0331810 21 0.2340161 0.3072559 -0.5557781 0.0430555 0.9989514
cor…68 FumQ24m2 Vinorelbine (nM) 72 -0.1906725 0.1086368 47 0.0266056 0.8591011 25 -0.4632714 0.0196863 0.4898769 0.0431356 0.9989514
cor…69 MalQ24m4 Doxorubicin (nM) 73 -0.1056064 0.3738860 48 0.0982031 0.5066619 25 -0.3969526 0.0494454 0.4951557 0.0462308 0.9989514
cor…70 MalG24m3 Paclitaxel (nM) 73 -0.1719328 0.1458091 48 -0.3479079 0.0153900 25 0.1504134 0.4729652 -0.4983213 0.0479057 0.9989514
cor…71 SerG6m3 MK-2206 (AKT) (uM) 61 -0.1775025 0.1711388 41 -0.3239731 0.0387920 20 0.2340332 0.3206523 -0.5580062 0.0489514 0.9989514
cor…72 MalG24m2 MK-2206 (AKT) (uM) 71 -0.0893927 0.4584796 47 -0.2314689 0.1174693 24 0.2788819 0.1869469 -0.5103507 0.0489641 0.9989514
cor…73 GlyG6m1 Cisplatin (uM) 64 -0.0566460 0.6566135 41 0.1737502 0.2772898 23 -0.3454068 0.1064691 0.5191569 0.0524595 0.9989514
cor…74 MalG24m1 8-Cl-adenosine (uM) 71 0.1997293 0.0949295 47 0.2816725 0.0551000 24 -0.2195053 0.3027363 0.5011777 0.0532609 0.9989514
cor…75 CitG24m2 Crizotinib (ALK) (uM) 73 0.0841833 0.4788789 48 0.2606613 0.0735526 25 -0.2312566 0.2660321 0.4919179 0.0534881 0.9989514
cor…76 CitG6m2 Etoposide (uM) 69 -0.0190304 0.8766600 46 -0.1811606 0.2282508 23 0.3268208 0.1279783 -0.5079814 0.0535716 0.9989514
cor…77 SerG6m2 Crizotinib (ALK) (uM) 65 -0.1458715 0.2462733 43 -0.3505751 0.0211767 22 0.1699771 0.4494967 -0.5205522 0.0536081 0.9989514
cor…78 CitG24m2 Doxorubicin (nM) 71 0.0416136 0.7304195 47 0.2097891 0.1569750 24 -0.2896196 0.1698364 0.4994087 0.0539769 0.9989514
cor…79 GlyG6m1 MK-2206 (AKT) (uM) 64 0.0081353 0.9491289 41 -0.2544664 0.1083738 23 0.2649555 0.2217821 -0.5194218 0.0543082 0.9989514
cor…80 CitQ6m4 Pemetrexed (uM) 68 -0.1810060 0.1396294 46 -0.3524798 0.0162829 22 0.1599816 0.4769727 -0.5124614 0.0545262 0.9989514
cor…81 CitG6m6 Cisplatin (uM) 68 -0.1080307 0.3805420 45 0.1042313 0.4956254 23 -0.3947504 0.0623064 0.4989818 0.0546711 0.9989514
cor…82 LacQ24m3 Etoposide (uM) 71 -0.1285837 0.2852147 47 0.0639924 0.6691355 24 -0.4181671 0.0420026 0.4821595 0.0547108 0.9989514
cor…83 CitG24m6 Paclitaxel (nM) 71 -0.1636062 0.1727860 47 -0.3208374 0.0278912 24 0.1743726 0.4151202 -0.4952100 0.0550898 0.9989514
cor…84 SerG24m1 Pemetrexed/Cisplatin (uM) 62 -0.1375967 0.2862106 41 -0.4122982 0.0073915 21 0.1096314 0.6361696 -0.5219296 0.0552662 0.9989514
cor…85 FumG6m2 Sorafenib (multi-kinase) (uM) 73 -0.0461713 0.6981001 48 -0.2414119 0.0983282 25 0.2433513 0.2411216 -0.4847631 0.0572690 0.9989514
cor…86 CitG6m1 Pemetrexed (uM) 68 -0.0530163 0.6676465 46 0.1209161 0.4234403 22 -0.3813352 0.0799319 0.5022514 0.0575637 0.9989514
cor…87 LacG6m1 Paclitaxel (nM) 73 0.0133599 0.9106793 48 0.1851812 0.2076384 25 -0.2968951 0.1495260 0.4820763 0.0578514 0.9989514
cor…88 CitG24m4 Sorafenib (multi-kinase) (uM) 71 -0.2222456 0.0624897 47 -0.3823306 0.0079983 24 0.0984341 0.6472416 -0.4807646 0.0586281 0.9989514
cor…89 LacG24m2 Vinorelbine (nM) 72 0.1213482 0.3099097 47 -0.0389757 0.7947806 25 0.4252276 0.0340862 -0.4642033 0.0589931 0.9989514
cor…90 MalG24m4 Paclitaxel (nM) 73 -0.1854692 0.1161915 48 -0.3554572 0.0131631 25 0.1133543 0.5895426 -0.4688115 0.0619959 0.9989514
cor…91 LacG24m2 Erlotinib (EGFR) (uM) 73 0.1174268 0.3224643 48 0.2944390 0.0422105 25 -0.1787985 0.3924707 0.4732375 0.0627299 0.9989514
cor…92 FumG6m4 Cisplatin (uM) 70 -0.0189215 0.8764490 46 0.1835770 0.2220007 24 -0.2986862 0.1562643 0.4822632 0.0636423 0.9989514
cor…93 CitQ6m1 CDH1 64 0.3401119 0.0059639 42 0.4691897 0.0017219 22 -0.0084384 0.9702701 0.4776280 0.0643700 0.9989514
cor…94 CitG6m2 Carboplatin (uM) 67 -0.0554159 0.6560274 45 -0.1846140 0.2247298 22 0.3131926 0.1558245 -0.4978066 0.0646537 0.9989514
cor…95 FumG6m3 Vinorelbine (nM) 72 0.2366779 0.0453204 47 0.0384453 0.7975146 25 0.4759497 0.0161759 -0.4375045 0.0664367 0.9989514
cor…96 GlyG24m2 Erlotinib (EGFR) (uM) 69 -0.2379931 0.0489304 45 -0.3970123 0.0069284 24 0.0656470 0.7605461 -0.4626593 0.0690883 0.9989514
cor…97 LacQ6m2 Etoposide (uM) 71 0.0959330 0.4261276 47 -0.0435475 0.7713225 24 0.4122085 0.0453270 -0.4557560 0.0692615 0.9989514
cor…98 FumG6m2 Beta-catenin 59 -0.2873219 0.0273494 37 -0.4289723 0.0080674 22 0.0595874 0.7922354 -0.4885597 0.0703757 0.9989514
cor…99 CitG24m6 Pemetrexed/Cisplatin (uM) 65 -0.1834531 0.1435237 44 -0.3205410 0.0338926 21 0.1771079 0.4424785 -0.4976488 0.0705851 0.9989514
cor…100 CitQ24m5 Sorafenib (multi-kinase) (uM) 71 0.2176148 0.0683000 47 0.3373360 0.0204053 24 -0.1259775 0.5574994 0.4633136 0.0716692 0.9989514
cor…101 FumG6m1 Beta-catenin 59 -0.1170261 0.3773983 37 -0.2787530 0.0947827 22 0.2256034 0.3127361 -0.5043563 0.0716933 0.9989514
cor…102 FumQ24m2 8-Cl-adenosine (uM) 71 0.0532834 0.6589828 47 0.2039302 0.1691543 24 -0.2638388 0.2128533 0.4677690 0.0720705 0.9989514
cor…103 SerG6m3 Erlotinib (EGFR) (uM) 63 -0.1639870 0.1990525 43 -0.2821148 0.0668225 20 0.2235556 0.3434030 -0.5056704 0.0739395 0.9989514
cor…104 GlyG6m2 Pemetrexed (uM) 63 -0.1167207 0.3622906 41 -0.3222333 0.0399123 22 0.1662274 0.4597057 -0.4884607 0.0740423 0.9989514
cor…105 MalG24m4 Doxorubicin (nM) 73 -0.0992546 0.4034583 48 -0.2571645 0.0776423 25 0.1986942 0.3410216 -0.4558586 0.0742121 0.9989514
cor…106 MalG24m2 Gemcitabine (nM) 71 0.0166537 0.8903630 47 0.1233608 0.4087428 24 -0.3351752 0.1093617 0.4585360 0.0747482 0.9989514
cor…107 CitQ24m6 EGFR-pY1173 57 0.1462239 0.2777647 36 -0.2342754 0.1690472 21 0.2752223 0.2272438 -0.5094977 0.0752746 0.9989514
cor…108 MalG6m2 CDH1 66 0.3301495 0.0067840 43 0.4925349 0.0007932 23 0.0537116 0.8076938 0.4388233 0.0761790 0.9989514
cor…109 FumG6m2 E-cadherin 59 -0.1457701 0.2706264 37 -0.2904214 0.0812051 22 0.2053040 0.3593691 -0.4957253 0.0765498 0.9989514
cor…110 SerG24m3 Doxorubicin (nM) 67 -0.1763081 0.1535244 44 -0.2971507 0.0501330 23 0.1735486 0.4284003 -0.4706993 0.0773678 0.9989514
cor…111 CitQ6m6 EGFR-pY1173 57 0.3463568 0.0083091 36 0.0840886 0.6258398 21 0.5380917 0.0118624 -0.4540032 0.0775613 0.9989514
cor…112 LacG24m3 Vinorelbine (nM) 72 -0.1721006 0.1482965 47 0.0546108 0.7154225 25 -0.3834310 0.0584845 0.4380418 0.0789444 0.9989514
cor…113 CitG6m6 Sorafenib (multi-kinase) (uM) 71 0.0026979 0.9821854 47 -0.1672558 0.2611363 24 0.2884875 0.1715870 -0.4557433 0.0790781 0.9989514
cor…114 GlyG6m2 Doxorubicin (nM) 66 -0.2169532 0.0801586 42 -0.3743512 0.0145901 24 0.0814176 0.7052825 -0.4557688 0.0792256 0.9989514
cor…115 SerG24m2 CDH1 60 0.1880455 0.1502003 38 0.0149641 0.9289479 22 0.4738784 0.0258853 -0.4589143 0.0792668 0.9989514
cor…116 CitQ24m1 Beta-catenin 57 -0.2497692 0.0609639 36 -0.4017482 0.0151518 21 0.0852133 0.7134294 -0.4869615 0.0810807 0.9989514
cor…117 CitG6m2 Gemcitabine/Cisplatin (nM) 65 0.0567009 0.6536996 44 -0.0474972 0.7594800 21 0.4182545 0.0591771 -0.4657518 0.0811609 0.9989514
cor…118 FumQ24m4 Paclitaxel (nM) 73 0.0266323 0.8230230 48 0.2110352 0.1499162 25 -0.2308455 0.2669067 0.4418807 0.0841248 0.9989514
cor…119 CitG6m4 E-cadherin 57 -0.2844225 0.0320111 36 -0.4708678 0.0037505 21 -0.0053601 0.9816031 -0.4655077 0.0842993 0.9989514
cor…120 LacG24m1 Cisplatin (uM) 70 -0.1305457 0.2814021 46 0.0638906 0.6731467 24 -0.3758389 0.0703028 0.4397295 0.0845629 0.9989514
cor…121 FumG6m4 Vinorelbine (nM) 72 0.2761403 0.0188759 47 0.0884722 0.5542766 25 0.4915517 0.0125771 -0.4030795 0.0852378 0.9989514
cor…122 MalQ24m2 Vinorelbine (nM) 72 -0.0523754 0.6621532 47 0.1102518 0.4606673 25 -0.3262720 0.1114401 0.4365238 0.0852712 0.9989514
cor…123 MalG6m2 Sorafenib (multi-kinase) (uM) 73 -0.1344785 0.2566624 48 -0.3110544 0.0314021 25 0.1247738 0.5523387 -0.4358282 0.0856522 0.9989514
cor…124 CitQ24m4 Gemcitabine/Cisplatin (nM) 65 0.0839634 0.5060663 44 -0.0234506 0.8799000 21 0.4307594 0.0512464 -0.4542100 0.0867528 0.9989514
cor…125 CitQ24m2 Beta-catenin 57 -0.3417741 0.0092671 36 -0.4918119 0.0023157 21 -0.0366444 0.8746969 -0.4551676 0.0868069 0.9989514
cor…126 CitG6m5 Vinorelbine (nM) 70 0.1849187 0.1253908 46 0.0036354 0.9808702 24 0.4292786 0.0363178 -0.4256432 0.0871724 0.9989514
cor…127 FumG24m3 Vinorelbine (nM) 72 0.1182172 0.3226513 47 -0.0730809 0.6254224 25 0.3554489 0.0812085 -0.4285298 0.0884270 0.9989514
cor…128 MalG24m4 Crizotinib (ALK) (uM) 75 -0.0726354 0.5357226 49 -0.2385414 0.0988186 26 0.1894714 0.3539062 -0.4280128 0.0884883 0.9989514
cor…129 MalG24m2 Vinorelbine (nM) 72 -0.0256152 0.8308721 47 0.1216689 0.4152484 25 -0.3116493 0.1293857 0.4333182 0.0885936 0.9989514
cor…130 FumQ24m1 8-Cl-adenosine (uM) 71 -0.0737788 0.5408882 47 0.0499803 0.7386590 24 -0.3807655 0.0664121 0.4307458 0.0890687 0.9989514
cor…131 SerG6m1 MK-2206 (AKT) (uM) 61 -0.2152644 0.0956969 41 -0.3843042 0.0131111 20 0.0905410 0.7042269 -0.4748451 0.0892260 0.9989514
cor…132 LacQ6m1 Pemetrexed (uM) 70 0.0014599 0.9904301 47 -0.1193529 0.4242492 23 0.3249702 0.1302795 -0.4443230 0.0900676 0.9989514
cor…133 FumG24m3 Docetaxel (nM) 69 0.0741865 0.5446361 46 -0.1209064 0.4234778 23 0.3243554 0.1310504 -0.4452618 0.0906078 0.9989514
cor…134 CitG24m5 Docetaxel (nM) 67 -0.0508519 0.6827801 45 -0.2153018 0.1555013 22 0.2431321 0.2755863 -0.4584339 0.0913234 0.9989514
cor…135 FumG6m4 Paclitaxel (nM) 73 0.0631790 0.5954079 48 -0.1171952 0.4276098 25 0.3102284 0.1312349 -0.4274235 0.0918510 0.9989514
cor…136 MalG24m2 Paclitaxel (nM) 73 -0.0568640 0.6327588 48 0.0604222 0.6833064 25 -0.3600680 0.0770576 0.4204902 0.0926496 0.9989514
cor…137 LacG24m3 Docetaxel (nM) 69 -0.0199192 0.8709481 46 -0.2408490 0.1068754 23 0.2048815 0.3483559 -0.4457305 0.0938288 0.9989514
cor…138 FumG24m4 Vinorelbine (nM) 72 0.0395958 0.7412254 47 -0.1355132 0.3637651 25 0.2922510 0.1563035 -0.4277641 0.0939286 0.9989514
cor…139 LacG6m2 SCH772984 (ERK) (uM) 78 -0.0013383 0.9907221 51 -0.1014746 0.4786100 27 0.3062475 0.1202776 -0.4077221 0.0943475 0.9989514
cor…140 LacG6m1 Paclitaxel/Carboplatin (nM) 70 0.1001469 0.4094405 46 0.2665814 0.0733177 24 -0.1647046 0.4418428 0.4312860 0.0988429 0.9989514
cor…141 FumQ6m1 CDH1 66 0.3699606 0.0022325 43 0.5078215 0.0005087 23 0.1081045 0.6234392 0.3997169 0.0993993 0.9989514
cor…142 LacQ24m2 Paclitaxel (nM) 73 0.1204854 0.3099318 48 0.2813458 0.0527246 25 -0.1383580 0.5095385 0.4197038 0.0996125 0.9989514
cor…143 GlyG6m1 8-Cl-adenosine (uM) 64 -0.1216522 0.3382649 41 0.0249668 0.8768641 23 -0.4037057 0.0560875 0.4286725 0.1010163 0.9989514
cor…144 CitQ6m4 Cisplatin (uM) 68 -0.2308977 0.0581698 45 -0.3784660 0.0103615 23 0.0460857 0.8346010 -0.4245517 0.1019017 0.9989514
cor…145 SerG6m3 Crizotinib (ALK) (uM) 65 -0.2396122 0.0545505 43 -0.4141623 0.0057624 22 0.0139915 0.9507237 -0.4281538 0.1027534 0.9989514
cor…146 MalG24m1 Docetaxel (nM) 69 0.2845585 0.0177999 46 0.4062288 0.0050903 23 -0.0102834 0.9628574 0.4165122 0.1029474 0.9989514
cor…147 LacQ6m1 Pemetrexed/Cisplatin (uM) 67 -0.0346676 0.7806207 45 -0.1211354 0.4279763 22 0.3176009 0.1497743 -0.4387363 0.1030651 0.9989514
cor…148 CitG24m1 8-Cl-adenosine (uM) 69 0.0535920 0.6618571 46 -0.0363010 0.8107114 23 0.3836231 0.0707540 -0.4199240 0.1035354 0.9989514
cor…149 MalQ24m2 Gefitinib (EGFR) (uM) 72 -0.2639337 0.0250752 47 -0.1080594 0.4696856 25 -0.4880908 0.0133121 0.3800313 0.1035490 0.9989514
cor…150 FumG6m1 Pemetrexed (uM) 70 -0.1120954 0.3555450 47 0.0186631 0.9009091 23 -0.3970827 0.0606382 0.4157457 0.1036767 0.9989514
cor…151 SerG6m2 MK-2206 (AKT) (uM) 61 -0.2104016 0.1036163 41 -0.3612358 0.0203152 20 0.0931815 0.6959894 -0.4544173 0.1059224 0.9989514
cor…152 LacG6m1 Docetaxel (nM) 69 -0.0270782 0.8252016 46 0.1405652 0.3514605 23 -0.2850325 0.1874095 0.4255977 0.1082932 0.9989514
cor…153 SerG6m1 CDH1 56 0.3057413 0.0219329 37 0.1903399 0.2591477 19 0.5909365 0.0077141 -0.4005966 0.1086195 0.9989514
cor…154 MalQ6m4 Cisplatin (uM) 69 -0.1854701 0.1270707 45 -0.3530545 0.0173651 24 0.0587204 0.7852007 -0.4117749 0.1095165 0.9989514
cor…155 CitQ24m5 Pemetrexed (uM) 68 0.0447332 0.7171862 46 0.1048250 0.4881179 22 -0.3222447 0.1435819 0.4270697 0.1107317 0.9989514
cor…156 FumQ6m2 Beta-catenin 59 -0.2771782 0.0335592 37 -0.4315650 0.0076528 22 -0.0050516 0.9821999 -0.4265134 0.1107845 0.9989514
cor…157 MalQ6m3 Carboplatin (uM) 68 -0.1013077 0.4110574 45 -0.2247688 0.1376939 23 0.2016542 0.3561656 -0.4264230 0.1108760 0.9989514
cor…158 SerG24m1 Pemetrexed (uM) 65 -0.1419356 0.2593878 43 -0.3467997 0.0227073 22 0.0821856 0.7161574 -0.4289853 0.1108995 0.9989514
cor…159 CitG24m1 Vinorelbine (nM) 70 0.0879659 0.4689862 46 0.2436148 0.1027871 24 -0.1735516 0.4173544 0.4171664 0.1112902 0.9989514
cor…160 CitQ24m3 Paclitaxel/Carboplatin (nM) 68 0.0752370 0.5420057 45 0.2284741 0.1311537 23 -0.1970457 0.3674929 0.4255198 0.1116141 0.9989514
cor…161 LacQ24m1 Paclitaxel/Carboplatin (nM) 70 0.0435375 0.7204391 46 0.1532502 0.3092433 24 -0.2619051 0.2163498 0.4151553 0.1124077 0.9989514
cor…162 MalQ6m2 Beta-catenin 58 -0.2640187 0.0452176 36 -0.4129051 0.0123216 22 0.0177742 0.9374240 -0.4306793 0.1126273 0.9989514
cor…163 CitG24m6 Paclitaxel/Carboplatin (nM) 68 -0.2023941 0.0978797 45 -0.3496048 0.0185703 23 0.0654863 0.7665691 -0.4150911 0.1129979 0.9989514
cor…164 CitQ6m2 E-cadherin 57 -0.2123754 0.1127329 36 -0.3386127 0.0433740 21 0.1102951 0.6341151 -0.4489078 0.1138691 0.9989514
cor…165 GlyG6m2 Cisplatin (uM) 64 -0.2695583 0.0312395 41 -0.2212906 0.1643955 23 -0.5788427 0.0038051 0.3575521 0.1147484 0.9989514
cor…166 CitQ6m3 Carboplatin (uM) 67 -0.1097394 0.3766824 45 -0.2149051 0.1562827 22 0.2131984 0.3407766 -0.4281034 0.1157815 0.9989514
cor…167 CitG24m5 Pemetrexed/Cisplatin (uM) 65 -0.1702356 0.1751717 44 -0.2928443 0.0537166 21 0.1414712 0.5407401 -0.4343155 0.1162601 0.9989514
cor…168 FumG24m3 Gemcitabine (nM) 71 -0.0746257 0.5362398 47 -0.1994968 0.1788152 24 0.2110983 0.3220882 -0.4105950 0.1163101 0.9989514
cor…169 CitQ6m2 AZD6244 (MEK) (uM) 69 -0.0223805 0.8551644 46 0.0866474 0.5669311 23 -0.3255850 0.1295117 0.4122324 0.1165753 0.9989514
cor…170 CitQ6m3 Sorafenib (multi-kinase) (uM) 71 -0.1172895 0.3299948 47 0.0147435 0.9216465 24 -0.3810073 0.0662255 0.3957508 0.1167902 0.9989514
cor…171 LacG6m2 Docetaxel (nM) 69 0.1678135 0.1681125 46 0.2844711 0.0553557 23 -0.1311498 0.5508529 0.4156209 0.1168313 0.9989514
cor…172 CitQ6m1 Doxorubicin (nM) 71 -0.0425888 0.7243512 47 -0.1623835 0.2754817 24 0.2455682 0.2474237 -0.4079517 0.1180772 0.9989514
cor…173 GlyG6m2 EGFR-pY1173 53 -0.0289923 0.8367306 32 0.3427565 0.0548062 21 -0.1112401 0.6311945 0.4539966 0.1181191 0.9989514
cor…174 GlyG6m2 Crizotinib (ALK) (uM) 68 -0.0871285 0.4798744 43 -0.2452466 0.1129400 25 0.1619084 0.4393927 -0.4071550 0.1190989 0.9989514
cor…175 CitQ6m4 Gemcitabine/Cisplatin (nM) 65 -0.0978163 0.4382333 44 -0.1916420 0.2126902 21 0.2413492 0.2919017 -0.4329912 0.1194616 0.9989514
cor…176 CitG24m1 Docetaxel (nM) 67 0.0490873 0.6932317 45 0.1678504 0.2704045 22 -0.2550982 0.2518963 0.4229486 0.1196138 0.9989514
cor…177 MalQ24m1 E-cadherin 59 -0.2283557 0.0819346 37 -0.3839183 0.0189850 22 0.0410207 0.8561723 -0.4249390 0.1197059 0.9989514
cor…178 MalG24m1 EGFR-pY1173 59 -0.0823835 0.5350499 37 -0.2310198 0.1689146 22 0.2063004 0.3569906 -0.4373202 0.1206388 0.9989514
cor…179 SerG24m2 Crizotinib (ALK) (uM) 70 0.0019994 0.9868939 45 -0.1513289 0.3210472 25 0.2504882 0.2271665 -0.4018170 0.1206828 0.9989514
cor…180 CitG24m4 Pemetrexed/Cisplatin (uM) 65 -0.1173261 0.3519677 44 -0.2071764 0.1772137 21 0.2240001 0.3290047 -0.4311765 0.1212900 0.9989514
cor…181 MalG24m3 Crizotinib (ALK) (uM) 75 -0.1585179 0.1743514 49 -0.3050647 0.0330543 26 0.0795477 0.6992894 -0.3846124 0.1221065 0.9989514
cor…182 CitQ6m2 Etoposide (uM) 69 -0.1730819 0.1549626 46 -0.2849493 0.0549292 23 0.1240723 0.5727311 -0.4090216 0.1226964 0.9989514
cor…183 MalQ24m2 Beta-catenin 59 -0.3039623 0.0192580 37 -0.4617217 0.0040192 22 -0.0580363 0.7975334 -0.4036854 0.1233135 0.9989514
cor…184 MalQ24m1 CDH1 66 0.4527333 0.0001352 43 0.5767449 0.0000516 23 0.2326754 0.2853429 0.3440696 0.1246240 0.9989514
cor…185 SerG24m3 8-Cl-adenosine (uM) 66 -0.1922683 0.1219549 43 -0.1483408 0.3424486 23 -0.5147032 0.0119707 0.3663624 0.1254250 0.9989514
cor…186 LacQ6m3 AZD6244 (MEK) (uM) 71 -0.3468579 0.0030427 47 -0.2148739 0.1469364 24 -0.5539999 0.0049717 0.3391260 0.1259622 0.9989514
cor…187 MalQ24m2 EGFR-pY1173 59 0.1516066 0.2516973 37 -0.1794337 0.2879428 22 0.2503899 0.2610560 -0.4298235 0.1268962 0.9989514
cor…188 FumG6m3 Docetaxel (nM) 69 0.0549654 0.6537379 46 -0.1171984 0.4379371 23 0.2862769 0.1854067 -0.4034752 0.1277281 0.9989514
cor…189 FumQ24m2 CDH1 66 0.2134007 0.0853544 43 0.3708684 0.0143532 23 -0.0269362 0.9028996 0.3978046 0.1284163 0.9989514
cor…190 CitQ6m6 Gefitinib (EGFR) (uM) 70 -0.3243810 0.0061513 46 -0.1781660 0.2361629 24 -0.5261333 0.0082692 0.3479673 0.1284771 0.9989514
cor…191 LacQ6m3 Paclitaxel (nM) 73 0.0458983 0.6998006 48 -0.1678277 0.2542012 25 0.2218641 0.2864765 -0.3896918 0.1288765 0.9989514
cor…192 CitQ6m4 Carboplatin (uM) 67 -0.1682705 0.1734627 45 -0.2983468 0.0465199 22 0.1113159 0.6218867 -0.4096627 0.1292091 0.9989514
cor…193 FumG6m1 Cisplatin (uM) 70 0.2038619 0.0905037 46 0.0979786 0.5171164 24 0.4631859 0.0226415 -0.3652073 0.1300223 0.9989514
cor…194 CitG24m2 Erlotinib (EGFR) (uM) 71 0.2182152 0.0675231 47 0.3608663 0.0127042 24 -0.0231050 0.9146602 0.3839713 0.1305677 0.9989514
cor…195 CitG6m4 Pemetrexed/Cisplatin (uM) 65 0.0269540 0.8312237 44 -0.0211673 0.8915199 21 0.3847186 0.0850607 -0.4058859 0.1312159 0.9989514
cor…196 MalQ6m1 CDH1 66 0.3522516 0.0037243 43 0.4812131 0.0010880 23 0.1115382 0.6123837 0.3696749 0.1319524 0.9989514
cor…197 FumQ24m2 AZD6244 (MEK) (uM) 71 0.0133048 0.9123117 47 0.1526924 0.3055320 24 -0.2408311 0.2569507 0.3935235 0.1319534 0.9989514
cor…198 MalQ6m4 SCH772984 (ERK) (uM) 77 0.1426463 0.2158709 50 0.3121160 0.0273406 27 -0.0549279 0.7855346 0.3670439 0.1320277 0.9989514
cor…199 FumQ24m2 Beta-catenin 59 -0.3730796 0.0036116 37 -0.5238203 0.0008769 22 -0.1490951 0.5078339 -0.3747252 0.1320593 0.9989514
cor…200 MalG24m1 AZD6244 (MEK) (uM) 71 -0.2888043 0.0145816 47 -0.3705425 0.0103506 24 0.0100252 0.9629177 -0.3805677 0.1324133 0.9989514
cor…201 LacG6m3 Doxorubicin (nM) 73 -0.0048382 0.9675956 48 -0.1594678 0.2789642 25 0.2263744 0.2765389 -0.3858422 0.1326375 0.9989514
cor…202 LacQ24m2 8-Cl-adenosine (uM) 71 0.1703686 0.1554684 47 0.0570831 0.7031176 24 0.4265741 0.0376418 -0.3694909 0.1329198 0.9989514
cor…203 FumQ6m2 CDH1 66 0.3202647 0.0087525 43 0.4496581 0.0024854 23 0.0731212 0.7402175 0.3765369 0.1333991 0.9989514
cor…204 SerG6m1 Erlotinib (EGFR) (uM) 63 -0.2480823 0.0499460 43 -0.3822028 0.0114304 20 0.0313579 0.8955866 -0.4135607 0.1338647 0.9989514
cor…205 LacG6m1 Carboplatin (uM) 69 0.0267269 0.8274343 46 0.1590699 0.2910069 23 -0.2404410 0.2691074 0.3995109 0.1339140 0.9989514
cor…206 FumG24m1 Paclitaxel/Carboplatin (nM) 70 -0.0814433 0.5026989 46 0.0882479 0.5597626 24 -0.3007626 0.1532669 0.3890105 0.1341007 0.9989514
cor…207 CitG24m5 Paclitaxel/Carboplatin (nM) 68 -0.1675774 0.1719577 45 -0.3124021 0.0366813 23 0.0834100 0.7051534 -0.3958121 0.1342920 0.9989514
cor…208 MalG24m2 Carboplatin (uM) 69 -0.1289367 0.2910243 46 -0.0439593 0.7717539 23 -0.4208498 0.0455272 0.3768905 0.1348154 0.9989514
cor…209 FumG6m1 EGFR-pY1173 59 0.0338113 0.7993213 37 -0.2577941 0.1234512 22 0.1629645 0.4686855 -0.4207586 0.1349521 0.9989514
cor…210 CitG6m5 Crizotinib (ALK) (uM) 73 -0.0734827 0.5366832 48 -0.2167027 0.1390258 25 0.1668481 0.4253687 -0.3835508 0.1352199 0.9989514
cor…211 CitQ6m2 Cisplatin (uM) 68 -0.1582429 0.1974502 45 -0.2622372 0.0818173 23 0.1358493 0.5365399 -0.3980865 0.1358358 0.9989514
cor…212 CitG24m1 Pemetrexed (uM) 68 -0.0195039 0.8745619 46 0.1277465 0.3975257 22 -0.2751105 0.2152928 0.4028569 0.1358691 0.9989514
cor…213 FumQ6m2 MK-2206 (AKT) (uM) 71 -0.0752681 0.5327271 47 -0.2134603 0.1496783 24 0.1765871 0.4091270 -0.3900474 0.1361639 0.9989514
cor…214 CitQ24m1 Sorafenib (multi-kinase) (uM) 71 -0.1825445 0.1275889 47 -0.3092451 0.0344180 24 0.0750839 0.7273215 -0.3843289 0.1364773 0.9989514
cor…215 GlyG24m2 AZD6244 (MEK) (uM) 67 -0.0437140 0.7254016 43 0.0336792 0.8302332 24 -0.3516585 0.0919667 0.3853377 0.1367099 0.9989514
cor…216 CitQ24m6 Etoposide (uM) 69 -0.1151457 0.3461224 46 -0.2122837 0.1566713 23 0.1840437 0.4005518 -0.3963273 0.1377405 0.9989514
cor…217 LacQ6m1 Vinorelbine (nM) 72 0.0752594 0.5297992 47 -0.0527992 0.7244842 25 0.3226954 0.1156495 -0.3754946 0.1378045 0.9989514
cor…218 CitQ6m5 Pemetrexed (uM) 68 -0.0254979 0.8364814 46 0.0424514 0.7793841 22 -0.3506015 0.1096575 0.3930529 0.1380026 0.9989514
cor…219 LacG24m3 Gefitinib (EGFR) (uM) 72 0.0786271 0.5114934 47 -0.1587827 0.2864108 25 0.2229300 0.2841081 -0.3817127 0.1384419 0.9989514
cor…220 CitG6m2 Vinorelbine (nM) 70 -0.2225256 0.0640905 46 -0.0837831 0.5798656 24 -0.4449378 0.0293598 0.3611547 0.1384926 0.9989514
cor…221 LacQ6m3 Vinorelbine (nM) 72 0.1303407 0.2751475 47 -0.0875882 0.5582572 25 0.2903268 0.1591742 -0.3779151 0.1385832 0.9989514
cor…222 FumQ6m2 8-Cl-adenosine (uM) 71 -0.1130513 0.3478885 47 -0.0052651 0.9719811 24 -0.3779080 0.0686481 0.3726430 0.1390614 0.9989514
cor…223 CitG24m5 Doxorubicin (nM) 71 -0.0954991 0.4282328 47 -0.2217625 0.1341041 24 0.1652793 0.4402293 -0.3870418 0.1390949 0.9989514
cor…224 SerG24m1 Sorafenib (multi-kinase) (uM) 67 -0.1946614 0.1144444 44 -0.3897944 0.0089090 23 -0.0089846 0.9675458 -0.3808098 0.1399439 0.9989514
cor…225 MalG24m4 Pemetrexed/Cisplatin (uM) 67 -0.0299825 0.8096693 45 -0.1449839 0.3419869 22 0.2560097 0.2501473 -0.4009936 0.1401751 0.9989514
cor…226 MalG24m2 Beta-catenin 59 -0.2354057 0.0726835 37 -0.3585808 0.0293056 22 0.0455581 0.8404506 -0.4041389 0.1417597 0.9989514
cor…227 FumG6m3 Crizotinib (ALK) (uM) 75 -0.0937053 0.4239174 49 -0.2458685 0.0885868 26 0.1235166 0.5477414 -0.3693852 0.1418194 0.9989514
cor…228 FumG6m2 Gemcitabine/Cisplatin (nM) 67 -0.0608551 0.6246999 45 0.0334334 0.8274078 22 -0.3562717 0.1036447 0.3897050 0.1419251 0.9989514
cor…229 LacG6m2 Gefitinib (EGFR) (uM) 72 -0.0117986 0.9216419 47 0.1219200 0.4142793 25 -0.2544882 0.2195849 0.3764082 0.1427122 0.9989514
cor…230 LacQ24m3 Erlotinib (EGFR) (uM) 73 -0.2297208 0.0505723 48 -0.3911644 0.0059757 25 -0.0322409 0.8784056 -0.3589235 0.1431248 0.9989514
cor…231 FumQ6m2 Doxorubicin (nM) 73 -0.2327877 0.0474872 48 -0.3593311 0.0121316 25 0.0043721 0.9834520 -0.3637033 0.1435790 0.9989514
cor…232 FumQ24m2 MK-2206 (AKT) (uM) 71 -0.1111069 0.3562958 47 -0.2538997 0.0850472 24 0.1261355 0.5570014 -0.3800352 0.1451691 0.9989514
cor…233 CitQ24m2 MK-2206 (AKT) (uM) 69 -0.0377844 0.7579022 46 -0.1690346 0.2614369 23 0.2199410 0.3132650 -0.3889755 0.1452002 0.9989514
cor…234 FumQ24m2 Gemcitabine (nM) 71 -0.1871808 0.1180365 47 -0.0838584 0.5751985 24 -0.4382544 0.0321860 0.3543960 0.1455603 0.9989514
cor…235 FumG24m3 Doxorubicin (nM) 73 -0.0350715 0.7683226 48 -0.1700736 0.2478089 25 0.2039116 0.3282308 -0.3739851 0.1456287 0.9989514
cor…236 FumQ24m4 Doxorubicin (nM) 73 -0.1055101 0.3743241 48 0.0460573 0.7559163 25 -0.3206552 0.1181023 0.3667125 0.1457200 0.9989514
cor…237 CitQ6m3 Etoposide (uM) 69 -0.1571521 0.1971947 46 -0.2700753 0.0694891 23 0.1159794 0.5982050 -0.3860547 0.1460366 0.9989514
cor…238 FumQ24m1 CDH1 66 0.4583205 0.0001089 43 0.5694600 0.0000674 23 0.2445520 0.2607553 0.3249079 0.1470438 0.9989514
cor…239 CitG24m6 Docetaxel (nM) 67 -0.0742621 0.5503422 45 -0.2115504 0.1630052 22 0.1827513 0.4156256 -0.3943017 0.1483482 0.9989514
cor…240 CitQ6m4 Etoposide (uM) 69 -0.0695475 0.5701439 46 -0.2090576 0.1632154 23 0.1764547 0.4205864 -0.3855124 0.1490755 0.9989514
cor…241 LacG6m3 Crizotinib (ALK) (uM) 75 0.0968777 0.4083270 49 -0.0649450 0.6575141 26 0.2934191 0.1457209 -0.3583641 0.1503143 0.9989514
cor…242 SerG6m2 Pemetrexed (uM) 60 -0.1866910 0.1532131 41 -0.3498032 0.0249665 19 0.0627871 0.7984497 -0.4125902 0.1508756 0.9989514
cor…243 CitQ6m1 Crizotinib (ALK) (uM) 73 -0.0174358 0.8835968 48 0.1098365 0.4573827 25 -0.2569469 0.2150097 0.3667834 0.1514994 0.9989514
cor…244 MalG24m4 Vinorelbine (nM) 72 0.0367492 0.7592445 47 -0.1208108 0.4185705 25 0.2473233 0.2332871 -0.3681341 0.1520949 0.9989514
cor…245 MalQ24m4 Paclitaxel (nM) 73 0.0132178 0.9116254 48 0.1640771 0.2651216 25 -0.2031416 0.3301000 0.3672186 0.1531922 0.9989514
cor…246 LacQ6m2 E-cadherin 59 -0.1522852 0.2495561 37 -0.2852000 0.0870810 22 0.1148383 0.6108316 -0.4000382 0.1536384 0.9989514
cor…247 CitG6m4 8-Cl-adenosine (uM) 69 -0.2367796 0.0501292 46 -0.1394517 0.3553272 23 -0.4812509 0.0200772 0.3417992 0.1557045 0.9989514
cor…248 SerG6m3 Pemetrexed/Cisplatin (uM) 59 -0.2597336 0.0469664 40 -0.4745962 0.0019738 19 -0.0911841 0.7104483 -0.3834121 0.1559301 0.9989514
cor…249 CitQ6m2 Vinorelbine (nM) 70 -0.0521327 0.6682061 46 0.0743064 0.6235818 24 -0.2942739 0.1627703 0.3685803 0.1559958 0.9989514
cor…250 CitQ24m3 Sorafenib (multi-kinase) (uM) 71 0.1590547 0.1852104 47 0.2845564 0.0525531 24 -0.0831814 0.6991849 0.3677378 0.1562870 0.9989514
cor…251 MalQ24m2 Paclitaxel (nM) 73 -0.0173747 0.8840019 48 0.0851232 0.5651215 25 -0.2744787 0.1842431 0.3596020 0.1582871 0.9989514
cor…252 MalQ24m1 EGFR-pY1173 59 -0.1322759 0.3179456 37 -0.4464580 0.0056078 22 -0.0760124 0.7367159 -0.3704456 0.1582933 0.9989514
cor…253 FumG6m1 E-cadherin 59 -0.0848921 0.5226456 37 -0.2161810 0.1987560 22 0.1822139 0.4170217 -0.3983950 0.1584893 0.9989514
cor…254 LacQ24m1 Paclitaxel (nM) 73 -0.1224770 0.3019432 48 -0.0421454 0.7760874 25 -0.3875724 0.0555898 0.3454270 0.1585831 0.9989514
cor…255 FumQ6m2 AZD6244 (MEK) (uM) 71 -0.0668538 0.5796191 47 0.0494578 0.7412959 24 -0.3129879 0.1364408 0.3624457 0.1592311 0.9989514
cor…256 FumG6m1 8-Cl-adenosine (uM) 71 0.0873693 0.4687548 47 0.1743020 0.2412881 24 -0.1946474 0.3620694 0.3689495 0.1593310 0.9989514
cor…257 MalQ6m4 Gemcitabine/Cisplatin (nM) 66 -0.0373344 0.7659974 44 -0.1384439 0.3701342 22 0.2453498 0.2710936 -0.3837937 0.1601601 0.9989514
cor…258 GlyG6m2 Carboplatin (uM) 63 -0.3316715 0.0079199 41 -0.4524653 0.0029762 22 -0.0952778 0.6731941 -0.3571875 0.1627295 0.9989514
cor…259 LacQ6m2 EGFR-pY1173 59 0.0378016 0.7762201 37 -0.2060136 0.2212182 22 0.1879322 0.4022966 -0.3939458 0.1634114 0.9989514
cor…260 LacG6m3 Gemcitabine (nM) 71 -0.0043766 0.9711042 47 -0.1603937 0.2814867 24 0.2037978 0.3394872 -0.3641915 0.1647414 0.9989514
cor…261 SerG6m1 Gemcitabine (nM) 60 -0.2588577 0.0458137 41 -0.3114972 0.0474227 19 -0.6267922 0.0040802 0.3152950 0.1648706 0.9989514
cor…262 FumG6m1 Erlotinib (EGFR) (uM) 73 -0.0551446 0.6430948 48 0.0765599 0.6050159 25 -0.2771081 0.1799060 0.3536680 0.1649357 0.9989514
cor…263 SerG6m3 Doxorubicin (nM) 62 -0.2244926 0.0794051 42 -0.3243005 0.0361460 20 0.0650515 0.7852565 -0.3893520 0.1670336 0.9989514
cor…264 FumQ24m4 Crizotinib (ALK) (uM) 75 0.0012697 0.9913740 49 0.1699206 0.2431092 26 -0.1792490 0.3809376 0.3491696 0.1671393 0.9989514
cor…265 CitG24m6 Pemetrexed (uM) 68 -0.0085125 0.9450728 46 -0.1244389 0.4099576 22 0.2495157 0.2627797 -0.3739546 0.1677815 0.9989514
cor…266 LacQ6m3 E-cadherin 59 0.1537515 0.2449724 37 0.2877461 0.0841761 22 -0.0980258 0.6642947 0.3857720 0.1684779 0.9989514
cor…267 CitG6m6 Gemcitabine/Cisplatin (nM) 65 -0.1107596 0.3797524 44 0.0178947 0.9082137 21 -0.3552667 0.1140132 0.3731614 0.1684985 0.9989514
cor…268 MalQ24m4 Crizotinib (ALK) (uM) 75 0.0060743 0.9587505 49 0.1750393 0.2289925 26 -0.1722557 0.4000938 0.3472950 0.1694866 0.9989514
cor…269 GlyG6m1 CDH1 60 0.2213995 0.0891223 38 0.0494655 0.7680546 22 0.4140567 0.0553991 -0.3645912 0.1700367 0.9989514
cor…270 LacQ24m1 E-cadherin 59 -0.1500237 0.2567396 37 -0.2701350 0.1058800 22 0.1148956 0.6106524 -0.3850305 0.1706840 0.9989514
cor…271 MalQ24m3 Pemetrexed/Cisplatin (uM) 67 -0.1043817 0.4005597 45 0.0106796 0.9444908 22 -0.3522816 0.1078500 0.3629612 0.1707446 0.9989514
cor…272 LacG24m2 EGFR-pY1173 59 0.0262593 0.8434989 37 -0.2640765 0.1142525 22 0.1198812 0.5951461 -0.3839578 0.1722901 0.9989514
cor…273 MalG24m4 Docetaxel (nM) 69 -0.0676897 0.5805131 46 -0.2208645 0.1402030 23 0.1431584 0.5146296 -0.3640228 0.1731082 0.9989514
cor…274 LacQ24m1 Docetaxel (nM) 69 -0.1002839 0.4122892 46 -0.0105158 0.9447025 23 -0.3619976 0.0896235 0.3514818 0.1731625 0.9989514
cor…275 MalQ6m2 Vinorelbine (nM) 71 -0.1247312 0.3000143 46 0.0085085 0.9552459 25 -0.3342496 0.1024587 0.3427582 0.1742875 0.9989514
cor…276 GlyG24m1 Vinorelbine (nM) 67 -0.0482196 0.6983920 43 0.0568743 0.7171629 24 -0.2995551 0.1550049 0.3564294 0.1744475 0.9989514
cor…277 CitG24m5 Gemcitabine (nM) 69 -0.1210688 0.3217090 46 -0.2130832 0.1550796 23 0.1488592 0.4978452 -0.3619424 0.1758525 0.9989514
cor…278 LacQ24m3 E-cadherin 59 0.1050084 0.4286411 37 0.2562175 0.1258441 22 -0.1246143 0.5805809 0.3808318 0.1763026 0.9989514
cor…279 CitG6m4 Beta-catenin 57 -0.3445376 0.0086786 36 -0.4889702 0.0024767 21 -0.1384815 0.5494135 -0.3504887 0.1772822 0.9989514
cor…280 FumQ24m1 Vinorelbine (nM) 72 -0.0507006 0.6723304 47 0.0911925 0.5421124 25 -0.2548271 0.2189503 0.3460196 0.1776215 0.9989514
cor…281 CitG6m4 MK-2206 (AKT) (uM) 69 0.1933688 0.1113930 46 0.0799020 0.5976012 23 0.4165031 0.0480445 -0.3366010 0.1794071 0.9989514
cor…282 LacG24m1 Pemetrexed (uM) 70 -0.0889053 0.4642341 47 0.0820333 0.5835727 23 -0.2727540 0.2079670 0.3547874 0.1794224 0.9989514
cor…283 CitQ24m2 Erlotinib (EGFR) (uM) 71 0.0425754 0.7244340 47 -0.0807463 0.5895110 24 0.2676519 0.2060702 -0.3483982 0.1804309 0.9989514
cor…284 CitQ24m2 CDH1 64 0.0707355 0.5786022 42 0.2146393 0.1722489 22 -0.1553220 0.4900645 0.3699613 0.1805662 0.9989514
cor…285 LacQ6m3 Pemetrexed/Cisplatin (uM) 67 0.0998080 0.4216286 45 -0.0229679 0.8809560 22 0.3327704 0.1302209 -0.3557383 0.1820993 0.9989514
cor…286 LacG24m3 Gemcitabine (nM) 71 0.0320020 0.7910596 47 -0.1493684 0.3163053 24 0.1996562 0.3496020 -0.3490246 0.1833761 0.9989514
cor…287 MalG6m2 Beta-catenin 59 -0.2690871 0.0393169 37 -0.3840169 0.0189517 22 -0.0240275 0.9154750 -0.3599894 0.1837759 0.9989514
cor…288 CitG24m6 Doxorubicin (nM) 71 -0.0753218 0.5324339 47 -0.1823010 0.2200304 24 0.1659072 0.4384700 -0.3482082 0.1846857 0.9989514
cor…289 FumG6m1 Etoposide (uM) 71 0.0084545 0.9442133 47 -0.0905631 0.5449151 24 0.2548540 0.2294240 -0.3454171 0.1851950 0.9989514
cor…290 CitQ24m4 Etoposide (uM) 69 0.0083257 0.9458682 46 -0.1322463 0.3809700 23 0.2216236 0.3094833 -0.3538698 0.1854577 0.9989514
cor…291 LacG6m3 Pemetrexed (uM) 70 0.0564761 0.6423787 47 -0.1077495 0.4709681 23 0.2435764 0.2627221 -0.3513259 0.1858904 0.9989514
cor…292 SerG6m1 Crizotinib (ALK) (uM) 65 -0.0775679 0.5391068 43 -0.2456627 0.1123111 22 0.1168054 0.6046929 -0.3624681 0.1864179 0.9989514
cor…293 LacG6m3 E-cadherin 59 -0.1592229 0.2283773 37 -0.2810712 0.0919554 22 0.0889855 0.6937298 -0.3700567 0.1868631 0.9989514
cor…294 FumQ6m1 Sorafenib (multi-kinase) (uM) 73 -0.2096143 0.0750981 48 -0.3491742 0.0149955 25 -0.0219268 0.9171429 -0.3272474 0.1878924 0.9989514
cor…295 FumQ6m3 CDH1 66 -0.2014883 0.1047371 43 -0.3226758 0.0348246 23 0.0256125 0.9076511 -0.3482883 0.1883608 0.9989514
cor…296 LacQ6m3 Crizotinib (ALK) (uM) 75 -0.1770210 0.1286809 49 -0.3698608 0.0089054 26 -0.0529578 0.7972309 -0.3169030 0.1892562 0.9989514
cor…297 CitG24m4 Pemetrexed (uM) 68 -0.0563478 0.6480991 46 -0.1470848 0.3293408 22 0.2084530 0.3518833 -0.3555379 0.1916260 0.9989514
cor…298 CitG24m1 Gemcitabine/Cisplatin (nM) 65 0.1571105 0.2113483 44 0.2745005 0.0713527 21 -0.0872288 0.7069363 0.3617293 0.1916629 0.9989514
cor…299 FumQ6m4 Cisplatin (uM) 70 -0.1671528 0.1666429 46 -0.2954647 0.0462018 24 0.0428322 0.8424792 -0.3382970 0.1919182 0.9989514
cor…300 FumG6m2 8-Cl-adenosine (uM) 71 -0.0302104 0.8025134 47 0.0670246 0.6544217 24 -0.2717246 0.1989882 0.3387492 0.1922441 0.9989514
cor…301 FumQ24m1 E-cadherin 59 -0.2822254 0.0303367 37 -0.4082570 0.0121254 22 -0.0603094 0.7897721 -0.3479476 0.1926771 0.9989514
cor…302 MalG24m3 Doxorubicin (nM) 73 -0.0487543 0.6820913 48 -0.1612985 0.2734106 25 0.1735619 0.4067052 -0.3348604 0.1937794 0.9989514
cor…303 CitG6m2 Sorafenib (multi-kinase) (uM) 71 -0.0565825 0.6392941 47 -0.2059046 0.1649758 24 0.1348453 0.5298607 -0.3407499 0.1939048 0.9989514
cor…304 CitQ24m6 Carboplatin (uM) 67 0.1163787 0.3483135 45 0.0504068 0.7422818 22 0.3877688 0.0745615 -0.3373620 0.1944728 0.9989514
cor…305 FumQ24m3 CDH1 66 -0.2493618 0.0434730 43 -0.3550444 0.0194775 23 -0.0162148 0.9414628 -0.3388296 0.1948955 0.9989514
cor…306 MalG24m1 Paclitaxel (nM) 73 0.0477920 0.6880398 48 0.1196404 0.4179638 25 -0.2131937 0.3062040 0.3328341 0.1955327 0.9989514
cor…307 LacG6m2 EGFR-pY1173 59 0.1603333 0.2251070 37 -0.0896756 0.5976254 22 0.2736527 0.2178326 -0.3633282 0.1955667 0.9989514
cor…308 MalG6m2 Gemcitabine/Cisplatin (nM) 67 -0.0907354 0.4652480 45 -0.0108533 0.9435892 22 -0.3508979 0.1093371 0.3400446 0.1983666 0.9989514
cor…309 LacG6m2 AZD6244 (MEK) (uM) 71 0.0791252 0.5118783 47 0.0131214 0.9302444 24 0.3392379 0.1048659 -0.3261165 0.1997295 0.9989514
cor…310 MalG24m1 Doxorubicin (nM) 73 0.3352236 0.0037423 48 0.3989147 0.0049768 25 0.0888380 0.6728164 0.3100767 0.2001455 0.9989514
cor…311 LacG6m2 MK-2206 (AKT) (uM) 71 -0.0518739 0.6674662 47 0.0276832 0.8534556 24 -0.3022331 0.1511690 0.3299163 0.2003161 0.9989514
cor…312 GlyG6m2 MK-2206 (AKT) (uM) 64 -0.1620664 0.2007368 41 -0.3090254 0.0493042 23 0.0342967 0.8765423 -0.3433222 0.2003240 0.9989514
cor…313 CitG24m4 E-cadherin 57 -0.2588534 0.0518613 36 -0.3689885 0.0267873 21 -0.0125915 0.9567997 -0.3563970 0.2010273 0.9989514
cor…314 LacG24m2 Pemetrexed/Cisplatin (uM) 67 0.0732141 0.5559978 45 0.0131049 0.9319117 22 0.3508186 0.1094228 -0.3377137 0.2013386 0.9989514
cor…315 MalQ6m2 Pemetrexed/Cisplatin (uM) 66 -0.1816123 0.1444546 44 -0.2936680 0.0530157 22 0.0515822 0.8196692 -0.3452502 0.2018563 0.9989514
cor…316 FumG6m3 E-cadherin 59 -0.0486884 0.7142169 37 -0.1885807 0.2636583 22 0.1728906 0.4416471 -0.3614713 0.2019276 0.9989514
cor…317 LacG6m2 Crizotinib (ALK) (uM) 75 -0.1239399 0.2894110 49 -0.0390686 0.7898371 26 -0.3487128 0.0808239 0.3096442 0.2033041 0.9989514
cor…318 FumG24m3 Pemetrexed/Cisplatin (uM) 67 -0.0470893 0.7051345 45 -0.1492467 0.3278279 22 0.1986181 0.3755653 -0.3478647 0.2033976 0.9989514
cor…319 SerG6m1 Beta-catenin 50 -0.2460238 0.0850275 32 -0.3444822 0.0535182 18 0.0447879 0.8599287 -0.3892701 0.2039990 0.9989514
cor…320 CitG6m3 Cisplatin (uM) 68 -0.0872562 0.4792286 45 0.0322948 0.8332003 23 -0.3025710 0.1605258 0.3348658 0.2045821 0.9989514
cor…321 GlyG6m1 Beta-catenin 53 -0.2787224 0.0432810 32 -0.4900987 0.0044075 21 -0.1554390 0.5010735 -0.3346597 0.2059907 0.9989514
cor…322 CitG6m2 AZD6244 (MEK) (uM) 69 0.2163333 0.0742001 46 0.1185538 0.4326203 23 0.4311117 0.0399923 -0.3125579 0.2061828 0.9989514
cor…323 GlyG6m2 Etoposide (uM) 64 -0.2449089 0.0511200 41 -0.3637217 0.0194064 23 -0.0320625 0.8845308 -0.3316593 0.2063457 0.9989514
cor…324 MalG24m4 Gemcitabine (nM) 71 -0.1445065 0.2292306 47 -0.2436135 0.0989177 24 0.0858968 0.6898331 -0.3295104 0.2069456 0.9989514
cor…325 SerG6m3 CDH1 56 0.1961945 0.1472823 37 0.1088422 0.5213623 19 0.4555750 0.0499748 -0.3467329 0.2071410 0.9989514
cor…326 CitG6m5 Gemcitabine (nM) 69 -0.0754309 0.5378891 46 -0.1571788 0.2968545 23 0.1806123 0.4095438 -0.3377911 0.2075640 0.9989514
cor…327 FumQ6m2 Vinorelbine (nM) 72 -0.1967529 0.0976165 47 -0.0690073 0.6448694 25 -0.3777842 0.0626178 0.3087769 0.2085709 0.9989514
cor…328 LacG24m1 Gefitinib (EGFR) (uM) 72 0.0622539 0.6034115 47 0.2599459 0.0776334 25 -0.0609785 0.7721587 0.3209244 0.2103093 0.9989514
cor…329 CitG6m6 Vinorelbine (nM) 70 0.2390265 0.0462812 46 0.0983291 0.5156111 24 0.4069220 0.0484459 -0.3085928 0.2106283 0.9989514
cor…330 FumG6m3 Paclitaxel/Carboplatin (nM) 70 -0.0238218 0.8448083 46 -0.1644437 0.2748012 24 0.1643605 0.4428106 -0.3288041 0.2126249 0.9989514
cor…331 MalG24m3 Docetaxel (nM) 69 -0.0072405 0.9529152 46 -0.1437319 0.3406055 23 0.1901229 0.3848939 -0.3338548 0.2128203 0.9989514
cor…332 LacQ6m1 Paclitaxel/Carboplatin (nM) 70 0.2116134 0.0786488 46 0.3092562 0.0364990 24 -0.0119299 0.9558787 0.3211861 0.2128487 0.9989514
cor…333 SerG6m1 AZD6244 (MEK) (uM) 61 -0.2653894 0.0387244 41 -0.4182971 0.0064963 20 -0.0820382 0.7309647 -0.3362590 0.2129691 0.9989514
cor…334 MalQ6m3 CDH1 66 -0.1853635 0.1362048 43 -0.3018805 0.0491372 23 0.0293417 0.8942735 -0.3312222 0.2131584 0.9989514
cor…335 LacG6m1 Gemcitabine (nM) 71 -0.0634962 0.5988444 47 0.0747136 0.6176973 24 -0.2498235 0.2390645 0.3245371 0.2133151 0.9989514
cor…336 MalQ6m2 E-cadherin 58 -0.1244624 0.3519210 36 -0.2480128 0.1447143 22 0.1046902 0.6428948 -0.3527030 0.2133491 0.9989514
cor…337 CitG24m3 Beta-catenin 57 -0.0208315 0.8777623 36 -0.1452688 0.3979157 21 0.2143671 0.3507623 -0.3596359 0.2140832 0.9989514
cor…338 LacG6m3 Paclitaxel/Carboplatin (nM) 70 -0.1205337 0.3202574 46 -0.2543493 0.0880480 24 0.0702380 0.7443271 -0.3245873 0.2145666 0.9989514
cor…339 MalQ6m3 Cisplatin (uM) 69 -0.1356897 0.2662744 45 -0.2426574 0.1082526 24 0.0830698 0.6995703 -0.3257272 0.2157325 0.9989514
cor…340 LacQ24m3 Vinorelbine (nM) 72 -0.0019991 0.9867031 47 -0.1507344 0.3118492 25 0.1691512 0.4189146 -0.3198856 0.2165375 0.9989514
cor…341 CitQ24m5 Pemetrexed/Cisplatin (uM) 65 -0.0259289 0.8375536 44 -0.0563063 0.7165826 21 -0.3843736 0.0853646 0.3280673 0.2173271 0.9989514
cor…342 CitG24m1 Crizotinib (ALK) (uM) 73 -0.0129639 0.9133167 48 0.1117572 0.4495048 25 -0.2055505 0.3242735 0.3173077 0.2175971 0.9989514
cor…343 MalG6m1 Vinorelbine (nM) 72 -0.0166030 0.8899048 47 0.1127362 0.4505620 25 -0.2050759 0.3254165 0.3178120 0.2185971 0.9989514
cor…344 SerG24m1 E-cadherin 53 -0.0903693 0.5198804 33 0.0697319 0.6997905 20 -0.2945396 0.2074538 0.3642715 0.2187221 0.9989514
cor…345 GlyG24m2 CDH1 61 0.0711252 0.5859572 38 -0.0413001 0.8055344 23 0.2927974 0.1751516 -0.3340975 0.2211510 0.9989514
cor…346 CitG24m3 Crizotinib (ALK) (uM) 73 -0.1146285 0.3342094 48 -0.2206339 0.1318254 25 0.0935227 0.6565726 -0.3141566 0.2213898 0.9989514
cor…347 GlyG24m2 E-cadherin 53 -0.0294540 0.8341665 32 0.1076360 0.5576309 21 -0.2530998 0.2683051 0.3607359 0.2215833 0.9989514
cor…348 SerG24m3 SCH772984 (ERK) (uM) 72 -0.0379836 0.7514140 46 -0.0087546 0.9539526 26 -0.3134127 0.1189774 0.3046581 0.2218657 0.9989514
cor…349 SerG24m1 Gemcitabine (nM) 65 -0.1347409 0.2845623 43 -0.2982073 0.0521007 22 0.0324936 0.8858563 -0.3307009 0.2222827 0.9989514
cor…350 MalQ24m1 Beta-catenin 59 -0.3564918 0.0055821 37 -0.4729163 0.0031176 22 -0.1629097 0.4688371 -0.3100066 0.2224667 0.9989514
cor…351 LacG6m1 SCH772984 (ERK) (uM) 78 -0.3848694 0.0005028 51 -0.4797697 0.0003674 27 -0.2148729 0.2817864 -0.2648968 0.2233601 0.9989514
cor…352 MalQ6m2 Doxorubicin (nM) 72 -0.1886419 0.1125240 47 -0.2842579 0.0528123 25 0.0256074 0.9032936 -0.3098653 0.2233967 0.9989514
cor…353 MalQ24m3 Etoposide (uM) 71 0.1339500 0.2654182 47 0.0356899 0.8117532 24 0.3438063 0.0999750 -0.3081164 0.2237274 0.9989514
cor…354 FumQ24m2 EGFR-pY1173 59 0.0374554 0.7782170 37 -0.2248474 0.1809105 22 0.1185723 0.5992010 -0.3434197 0.2245346 0.9989514
cor…355 MalQ6m1 EGFR-pY1173 58 -0.2015871 0.1291539 36 -0.4278072 0.0092489 22 -0.1070444 0.6353989 -0.3207628 0.2245605 0.9989514
cor…356 CitG24m4 Paclitaxel (nM) 71 -0.1456483 0.2255331 47 -0.2466948 0.0945913 24 0.0700416 0.7450187 -0.3167364 0.2246627 0.9989514
cor…357 FumG24m4 Docetaxel (nM) 69 0.0317342 0.7957481 46 -0.0936722 0.5357878 23 0.2298872 0.2913184 -0.3235594 0.2255401 0.9989514
cor…358 CitQ24m3 Crizotinib (ALK) (uM) 73 -0.0169243 0.8869885 48 0.0833287 0.5733799 25 -0.2274024 0.2743048 0.3107311 0.2259954 0.9989514
cor…359 FumG6m4 E-cadherin 59 0.0149888 0.9102892 37 -0.1269930 0.4538599 22 0.2151805 0.3361994 -0.3421735 0.2266856 0.9989514
cor…360 MalQ6m1 E-cadherin 58 -0.2179260 0.1003077 36 -0.3291412 0.0499778 22 0.0061416 0.9783598 -0.3352828 0.2268841 0.9989514
cor…361 MalG24m4 AZD6244 (MEK) (uM) 71 -0.0688146 0.5685240 47 0.0373215 0.8033144 24 -0.2756509 0.1923191 0.3129724 0.2271755 0.9989514
cor…362 CitQ24m2 Pemetrexed/Cisplatin (uM) 65 -0.0609005 0.6298656 44 -0.1376936 0.3727587 21 0.1996060 0.3856808 -0.3372996 0.2279495 0.9989514
cor…363 GlyG6m1 Pemetrexed (uM) 63 0.1072431 0.4028249 41 -0.0716689 0.6561128 22 0.2607112 0.2412502 -0.3323801 0.2280831 0.9989514
cor…364 MalQ24m2 8-Cl-adenosine (uM) 71 0.0597748 0.6204772 47 0.1428644 0.3380721 24 -0.1738667 0.4164961 0.3167312 0.2283504 0.9989514
cor…365 FumG24m2 8-Cl-adenosine (uM) 71 -0.1411819 0.2402359 47 -0.0615296 0.6811774 24 -0.3629246 0.0813266 0.3013949 0.2296010 0.9989514
cor…366 FumG24m2 Etoposide (uM) 71 0.0423400 0.7258973 47 0.1457250 0.3283867 24 -0.1699516 0.4272281 0.3156766 0.2299752 0.9989514
cor…367 GlyG6m1 Sorafenib (multi-kinase) (uM) 66 0.1502535 0.2285152 42 -0.0148192 0.9257877 24 0.3003642 0.1538388 -0.3151834 0.2302240 0.9989514
cor…368 CitQ6m3 Paclitaxel/Carboplatin (nM) 68 -0.2407334 0.0479828 45 -0.1369739 0.3695954 23 -0.4330630 0.0390023 0.2960891 0.2304176 0.9989514
cor…369 FumG6m3 Gemcitabine (nM) 71 -0.0543715 0.6524624 47 -0.1540754 0.3011198 24 0.1608808 0.4526587 -0.3149562 0.2311241 0.9989514
cor…370 SerG6m2 Carboplatin (uM) 60 -0.3104639 0.0157680 41 -0.4018300 0.0092093 19 -0.0689246 0.7791919 -0.3329054 0.2312206 0.9989514
cor…371 CitG24m4 Beta-catenin 57 -0.3984349 0.0021429 36 -0.4930538 0.0022483 21 -0.1874020 0.4159644 -0.3056518 0.2317017 0.9989514
cor…372 MalQ24m1 Crizotinib (ALK) (uM) 75 0.0501385 0.6692425 49 -0.0562918 0.7008487 26 0.2438889 0.2298801 -0.3001807 0.2319636 0.9989514
cor…373 MalQ6m2 MK-2206 (AKT) (uM) 70 -0.1340559 0.2685534 46 -0.2345026 0.1167257 24 0.0790943 0.7133413 -0.3135969 0.2319817 0.9989514
cor…374 SerG24m1 AZD6244 (MEK) (uM) 66 -0.1211370 0.3325988 43 -0.0309210 0.8439571 23 -0.3436230 0.1084097 0.3127020 0.2320874 0.9989514
cor…375 CitG6m1 Gemcitabine (nM) 69 -0.0019419 0.9873653 46 0.1014287 0.5023965 23 -0.2172345 0.3194067 0.3186632 0.2333975 0.9989514
cor…376 CitQ6m3 Beta-catenin 57 0.0477816 0.7241236 36 -0.0528089 0.7596924 21 0.2871604 0.2068975 -0.3399693 0.2345333 0.9989514
cor…377 LacQ24m3 Docetaxel (nM) 69 -0.2187992 0.0708819 46 -0.0909206 0.5478870 23 -0.3907407 0.0652563 0.2998201 0.2348920 0.9989514
cor…378 SerG6m1 Cisplatin (uM) 60 -0.1361063 0.2997675 41 -0.1131747 0.4811031 19 -0.4361040 0.0619594 0.3229293 0.2352296 0.9989514
cor…379 FumG24m2 Paclitaxel (nM) 73 -0.0304725 0.7980106 48 0.0678586 0.6467553 25 -0.2358706 0.2563413 0.3037292 0.2358882 0.9989514
cor…380 MalG6m3 Pemetrexed/Cisplatin (uM) 67 -0.0514568 0.6792109 45 -0.1366179 0.3708527 22 0.1877798 0.4026851 -0.3243977 0.2361837 0.9989514
cor…381 CitQ24m3 EGFR-pY1173 57 0.1718691 0.2011179 36 0.0496057 0.7738773 21 0.3768652 0.0921793 -0.3272596 0.2366521 0.9989514
cor…382 LacG24m3 EGFR-pY1173 59 -0.1403416 0.2890639 37 0.1703874 0.3133343 22 -0.1652230 0.4624603 0.3356104 0.2368534 0.9989514
cor…383 SerG6m2 Doxorubicin (nM) 62 -0.2639533 0.0381729 42 -0.3665278 0.0169665 20 -0.0406891 0.8647582 -0.3258387 0.2369704 0.9989514
cor…384 FumG6m1 Paclitaxel/Carboplatin (nM) 70 -0.0494188 0.6845434 46 0.0434617 0.7742692 24 -0.2647076 0.2112948 0.3081694 0.2372397 0.9989514
cor…385 CitQ6m4 CDH1 64 0.1497241 0.2376600 42 0.2874851 0.0648811 22 -0.0346105 0.8784718 0.3220956 0.2375520 0.9989514
cor…386 FumG24m1 Docetaxel (nM) 69 -0.0560699 0.6472378 46 0.0931141 0.5382310 23 -0.2222717 0.3080341 0.3153859 0.2379228 0.9989514
cor…387 FumG24m2 Gemcitabine (nM) 71 -0.0369266 0.7598100 47 0.0414854 0.7818799 24 -0.2647785 0.2111679 0.3062639 0.2383311 0.9989514
cor…388 FumQ24m2 Paclitaxel (nM) 73 -0.0979000 0.4099381 48 0.0124687 0.9329678 25 -0.2855467 0.1664667 0.2980153 0.2392164 0.9989514
cor…389 MalG6m1 Gefitinib (EGFR) (uM) 72 -0.1744433 0.1427689 47 -0.0612298 0.6826491 25 -0.3526928 0.0837645 0.2914630 0.2393864 0.9989514
cor…390 FumG24m3 Paclitaxel/Carboplatin (nM) 70 -0.1578056 0.1919896 46 -0.2886906 0.0516835 24 0.0160206 0.9407724 -0.3047111 0.2394741 0.9989514
cor…391 CitG24m3 Gemcitabine/Cisplatin (nM) 65 -0.0467818 0.7113441 44 0.0524126 0.7354463 21 -0.2730286 0.2311201 0.3254412 0.2394764 0.9989514
cor…392 LacG24m1 Vinorelbine (nM) 72 0.1587735 0.1828184 47 0.0172066 0.9086078 25 0.3132361 0.1273431 -0.2960294 0.2398273 0.9989514
cor…393 MalQ6m4 Carboplatin (uM) 68 -0.2058856 0.0921048 45 -0.3232556 0.0303138 23 -0.0162018 0.9415097 -0.3070538 0.2402125 0.9989514
cor…394 GlyG6m2 CDH1 60 0.1039807 0.4291575 38 0.0164789 0.9217766 22 0.3372324 0.1248346 -0.3207535 0.2404774 0.9989514
cor…395 LacG24m1 Docetaxel (nM) 69 -0.0635661 0.6038312 46 0.0710388 0.6389679 23 -0.2415817 0.2667730 0.3126205 0.2406035 0.9989514
cor…396 FumG24m2 Sorafenib (multi-kinase) (uM) 73 -0.0876240 0.4610265 48 -0.2045369 0.1631629 25 0.0974288 0.6431429 -0.3019657 0.2407207 0.9989514
cor…397 CitQ24m1 Gemcitabine/Cisplatin (nM) 65 -0.1748002 0.1637142 44 -0.1044980 0.4996387 21 -0.4104273 0.0645965 0.3059293 0.2413892 0.9989514
cor…398 CitG6m4 Erlotinib (EGFR) (uM) 71 0.0950805 0.4302691 47 0.2288205 0.1218443 24 -0.0774463 0.7190754 0.3062668 0.2416546 0.9989514
cor…399 FumG24m3 Beta-catenin 59 -0.1530430 0.2471800 37 -0.2780490 0.0956543 22 0.0492082 0.8278456 -0.3272572 0.2424384 0.9989514
cor…400 CitG6m3 Carboplatin (uM) 67 -0.0166470 0.8936347 45 0.0730764 0.6333224 22 -0.2447418 0.2723206 0.3178183 0.2426749 0.9989514
cor…401 CitQ6m6 CDH1 64 0.1005363 0.4292685 42 0.2191384 0.1632167 22 -0.1036722 0.6461466 0.3228105 0.2427741 0.9989514
cor…402 CitG6m3 Vinorelbine (nM) 70 0.3172486 0.0074505 46 0.2088624 0.1636176 24 0.4793788 0.0177747 -0.2705163 0.2439496 0.9989514
cor…403 LacG24m1 Carboplatin (uM) 69 -0.1575153 0.1961483 46 -0.0605826 0.6891928 23 -0.3590669 0.0924443 0.2984843 0.2442573 0.9989514
cor…404 LacQ6m2 Erlotinib (EGFR) (uM) 73 0.1148685 0.3331916 48 0.2236271 0.1265331 25 -0.0749260 0.7218769 0.2985532 0.2448513 0.9989514
cor…405 CitQ24m2 E-cadherin 57 -0.1879686 0.1614511 36 -0.3039748 0.0714821 21 0.0260515 0.9107512 -0.3300263 0.2459770 0.9989514
cor…406 CitG6m1 Crizotinib (ALK) (uM) 73 -0.0724357 0.5425180 48 0.0418996 0.7773601 25 -0.2535803 0.2212906 0.2954798 0.2470074 0.9989514
cor…407 LacG24m3 MK-2206 (AKT) (uM) 71 -0.0424841 0.7250015 47 0.0877802 0.5573914 24 -0.2149823 0.3130564 0.3027625 0.2480029 0.9989514
cor…408 FumQ6m1 Beta-catenin 59 -0.2519604 0.0542143 37 -0.3545681 0.0313004 22 -0.0402218 0.8589459 -0.3143462 0.2486821 0.9989514
cor…409 CitG24m3 Vinorelbine (nM) 70 -0.0203352 0.8672992 46 -0.1456277 0.3342072 24 0.1583736 0.4598253 -0.3040013 0.2497857 0.9989514
cor…410 CitQ6m3 Erlotinib (EGFR) (uM) 71 -0.2541201 0.0324772 47 -0.3534874 0.0147935 24 -0.0645646 0.7643844 -0.2889228 0.2505232 0.9989514
cor…411 FumQ24m1 Sorafenib (multi-kinase) (uM) 73 -0.2295963 0.0507010 48 -0.3462200 0.0159295 25 -0.0627602 0.7656809 -0.2834598 0.2515239 0.9989514
cor…412 MalG24m4 Gefitinib (EGFR) (uM) 72 -0.0171514 0.8862920 47 0.1160528 0.4372627 25 -0.1802175 0.3886626 0.2962703 0.2525152 0.9989514
cor…413 MalQ24m2 Carboplatin (uM) 69 0.0948796 0.4380544 46 0.1741954 0.2469396 23 -0.1321941 0.5476573 0.3063895 0.2536523 0.9989514
cor…414 LacQ6m3 SCH772984 (ERK) (uM) 78 -0.2597025 0.0216673 51 -0.1086223 0.4480101 27 -0.3749846 0.0539460 0.2663623 0.2540228 0.9989514
cor…415 SerG6m1 Sorafenib (multi-kinase) (uM) 62 -0.1210128 0.3488032 42 -0.3044715 0.0499400 20 0.0168705 0.9437211 -0.3213419 0.2542907 0.9989514
cor…416 SerG24m2 Pemetrexed (uM) 65 -0.1455096 0.2474598 43 -0.2921277 0.0573206 22 0.0165449 0.9417446 -0.3086726 0.2545773 0.9989514
cor…417 MalQ24m1 Vinorelbine (nM) 72 -0.0166095 0.8898619 47 0.1053206 0.4810828 25 -0.1892486 0.3649229 0.2945692 0.2549290 0.9989514
cor…418 MalG24m3 Vinorelbine (nM) 72 0.1051105 0.3795528 47 -0.0159687 0.9151581 25 0.2736891 0.1855594 -0.2896579 0.2556536 0.9989514
cor…419 CitG6m4 Gemcitabine (nM) 69 -0.1697196 0.1632635 46 -0.2256645 0.1315706 23 0.0775825 0.7249475 -0.3032470 0.2561302 0.9989514
cor…420 MalG24m3 Pemetrexed/Cisplatin (uM) 67 0.0278523 0.8229644 45 -0.0469967 0.7591772 22 0.2607219 0.2412301 -0.3077187 0.2562093 0.9989514
cor…421 MalG24m2 Cisplatin (uM) 70 -0.0303073 0.8033138 46 0.0513127 0.7348621 24 -0.2456137 0.2473334 0.2969264 0.2564795 0.9989514
cor…422 LacG24m2 Paclitaxel (nM) 73 0.0573582 0.6298006 48 0.1375091 0.3513282 25 -0.1552978 0.4585414 0.2928069 0.2568863 0.9989514
cor…423 CitQ6m4 SCH772984 (ERK) (uM) 76 0.1229437 0.2900301 50 0.2718216 0.0561871 26 -0.0095727 0.9629823 0.2813943 0.2570683 0.9989514
cor…424 LacQ24m1 SCH772984 (ERK) (uM) 78 -0.0820518 0.4751236 51 -0.1464927 0.3049961 27 0.1349442 0.5021625 -0.2814369 0.2570855 0.9989514
cor…425 CitQ6m3 Pemetrexed (uM) 68 -0.1667697 0.1740635 46 -0.0785991 0.6036081 22 -0.3720660 0.0881724 0.2934669 0.2573023 0.9989514
cor…426 CitQ6m1 Gemcitabine/Cisplatin (nM) 65 -0.2492727 0.0452377 44 -0.1764875 0.2517924 21 -0.4609156 0.0354754 0.2844281 0.2575619 0.9989514
cor…427 CitG6m1 Vinorelbine (nM) 70 0.0171526 0.8879211 46 0.1318315 0.3824788 24 -0.1669525 0.4355492 0.2987840 0.2580000 0.9989514
cor…428 LacG24m2 Beta-catenin 59 0.0565928 0.6702986 37 -0.0492944 0.7720221 22 0.2679039 0.2280413 -0.3171983 0.2580786 0.9989514
cor…429 FumG24m4 Pemetrexed/Cisplatin (uM) 67 -0.0675269 0.5871641 45 -0.1623055 0.2867751 22 0.1468621 0.5142810 -0.3091676 0.2596006 0.9989514
cor…430 FumG24m4 Doxorubicin (nM) 73 -0.0078666 0.9473356 48 -0.1036241 0.4833687 25 0.1866321 0.3717121 -0.2902562 0.2603012 0.9989514
cor…431 FumQ24m3 Crizotinib (ALK) (uM) 75 0.0802053 0.4939532 49 0.1894385 0.1923434 26 -0.0949266 0.6446041 0.2843651 0.2611388 0.9989514
cor…432 MalQ6m1 Sorafenib (multi-kinase) (uM) 72 -0.1522817 0.2016017 47 -0.2698328 0.0666161 25 0.0167217 0.9367674 -0.2865545 0.2611564 0.9989514
cor…433 CitG24m6 Carboplatin (uM) 67 -0.3826763 0.0013935 45 -0.4514641 0.0018529 22 -0.1746131 0.4370407 -0.2768510 0.2620064 0.9989514
cor…434 CitG6m2 Docetaxel (nM) 67 -0.0038869 0.9750964 45 -0.1135080 0.4578375 22 0.1931528 0.3891079 -0.3066609 0.2627877 0.9989514
cor…435 FumG24m1 Etoposide (uM) 71 0.0050400 0.9667262 47 -0.1020351 0.4949447 24 0.1916478 0.3696581 -0.2936829 0.2637074 0.9989514
cor…436 CitG24m6 Sorafenib (multi-kinase) (uM) 71 -0.1977824 0.0982617 47 -0.3062503 0.0362950 24 -0.0206084 0.9238539 -0.2856419 0.2647521 0.9989514
cor…437 FumQ24m3 Pemetrexed (uM) 70 0.0258491 0.8317866 47 0.1312984 0.3790137 23 -0.1669299 0.4464849 0.2982283 0.2650499 0.9989514
cor…438 SerG24m1 Cisplatin (uM) 65 -0.1628905 0.1948163 43 -0.1092263 0.4856591 22 -0.3970740 0.0672807 0.2878477 0.2650960 0.9989514
cor…439 CitQ6m3 Pemetrexed/Cisplatin (uM) 65 -0.2771611 0.0254060 44 -0.3715686 0.0130143 21 -0.0750258 0.7465326 -0.2965427 0.2651357 0.9989514
cor…440 MalG6m2 E-cadherin 59 -0.2240560 0.0880179 37 -0.3246771 0.0499223 22 -0.0177757 0.9374189 -0.3069014 0.2652738 0.9989514
cor…441 CitG24m4 MK-2206 (AKT) (uM) 69 0.0855126 0.4847860 46 0.0026479 0.9860659 23 0.2937459 0.1736932 -0.2910980 0.2676641 0.9989514
cor…442 MalG6m4 CDH1 66 0.1688306 0.1753760 43 0.2909187 0.0584070 23 -0.0026934 0.9902688 0.2936120 0.2697197 0.9989514
cor…443 MalG24m1 SCH772984 (ERK) (uM) 78 -0.1943959 0.0881106 51 -0.2780915 0.0481659 27 -0.0097977 0.9613159 -0.2682938 0.2699154 0.9989514
cor…444 CitG24m1 Carboplatin (uM) 67 0.1771892 0.1514468 45 0.2546297 0.0914129 22 -0.0445290 0.8440113 0.2991587 0.2700923 0.9989514
cor…445 FumG24m2 Docetaxel (nM) 69 0.0183746 0.8808791 46 0.1271632 0.3997020 23 -0.1686317 0.4417969 0.2957949 0.2707058 0.9989514
cor…446 MalG24m3 Gemcitabine (nM) 71 -0.0861773 0.4748658 47 -0.1682955 0.2581412 24 0.1213859 0.5720619 -0.2896813 0.2710897 0.9989514
cor…447 LacG24m3 Pemetrexed (uM) 70 0.0379487 0.7551189 47 -0.1213989 0.4162922 23 0.1724393 0.4314034 -0.2938382 0.2720885 0.9989514
cor…448 CitG6m6 Erlotinib (EGFR) (uM) 71 0.0986838 0.4129200 47 0.2399057 0.1043244 24 -0.0465546 0.8289789 0.2864603 0.2721369 0.9989514
cor…449 MalG24m2 EGFR-pY1173 59 -0.0366839 0.7826723 37 -0.2273011 0.1760713 22 0.0826421 0.7146444 -0.3099433 0.2727074 0.9989514
cor…450 MalG24m4 Erlotinib (EGFR) (uM) 73 -0.0931865 0.4329505 48 0.0263344 0.8589810 25 -0.2528993 0.2225759 0.2792337 0.2735391 0.9989514
cor…451 MalQ6m4 Pemetrexed/Cisplatin (uM) 66 -0.1985664 0.1099765 44 -0.3029265 0.0456324 22 -0.0089682 0.9684041 -0.2939582 0.2737110 0.9989514
cor…452 FumQ6m2 Pemetrexed/Cisplatin (uM) 67 -0.1660830 0.1792026 45 -0.2893661 0.0538584 22 0.0044892 0.9841813 -0.2938553 0.2741223 0.9989514
cor…453 LacG24m2 Docetaxel (nM) 69 0.1504964 0.2170827 46 0.2423376 0.1046598 23 -0.0486480 0.8255386 0.2909857 0.2742101 0.9989514
cor…454 CitG24m1 Erlotinib (EGFR) (uM) 71 0.0222588 0.8538174 47 -0.0600321 0.6885385 24 0.2252581 0.2899179 -0.2852902 0.2753920 0.9989514
cor…455 MalQ6m3 Gefitinib (EGFR) (uM) 71 -0.2734392 0.0210379 46 -0.1584804 0.2928219 25 -0.4182706 0.0374547 0.2597902 0.2756316 0.9989514
cor…456 CitQ24m1 Vinorelbine (nM) 70 0.0516743 0.6709548 46 0.1570651 0.2972087 24 -0.1307499 0.5425442 0.2878150 0.2762174 0.9989514
cor…457 CitQ6m4 Erlotinib (EGFR) (uM) 71 0.0833087 0.4897456 47 -0.0201347 0.8931393 24 0.2618277 0.2164906 -0.2819624 0.2771980 0.9989514
cor…458 SerG24m3 Paclitaxel/Carboplatin (nM) 63 -0.1194482 0.3511043 41 -0.1939059 0.2244512 22 0.1072810 0.6346476 -0.3011869 0.2791383 0.9989514
cor…459 FumQ6m1 E-cadherin 59 -0.1394487 0.2921736 37 -0.2390941 0.1540988 22 0.0656847 0.7714962 -0.3047788 0.2797602 0.9989514
cor…460 CitQ6m5 CDH1 64 -0.3668634 0.0028658 42 -0.4500610 0.0027848 22 -0.1808026 0.4207007 -0.2692584 0.2804442 0.9989514
cor…461 MalG24m1 Paclitaxel/Carboplatin (nM) 70 0.1701050 0.1591729 46 0.2482776 0.0961678 24 -0.0323055 0.8808800 0.2805831 0.2828744 0.9989514
cor…462 CitQ24m5 E-cadherin 57 0.3709791 0.0044983 36 0.4599680 0.0047648 21 0.1810227 0.4322924 0.2789453 0.2835402 0.9989514
cor…463 MalG24m3 Gefitinib (EGFR) (uM) 72 0.1321597 0.2684458 47 0.2549086 0.0837730 25 -0.0190060 0.9281501 0.2739146 0.2841555 0.9989514
cor…464 CitG6m3 E-cadherin 57 -0.0884009 0.5131713 36 -0.1862602 0.2767392 21 0.1236754 0.5932683 -0.3099356 0.2857815 0.9989514
cor…465 MalG24m1 MK-2206 (AKT) (uM) 71 -0.0712121 0.5550948 47 -0.1311221 0.3796596 24 0.1497001 0.4850663 -0.2808223 0.2864557 0.9989514
cor…466 FumQ6m4 Gemcitabine/Cisplatin (nM) 67 0.0038494 0.9753365 45 -0.0600040 0.6953943 22 0.2301401 0.3028424 -0.2901441 0.2869373 0.9989514
cor…467 SerG6m1 Vinorelbine (nM) 61 -0.2157657 0.0949082 41 -0.1706650 0.2860417 20 -0.4485484 0.0472943 0.2778834 0.2872211 0.9989514
cor…468 LacG24m3 Doxorubicin (nM) 73 0.1205736 0.3095753 48 -0.0000741 0.9996010 25 0.2692942 0.1930050 -0.2693683 0.2884101 0.9989514
cor…469 CitG24m3 Paclitaxel/Carboplatin (nM) 68 -0.0006024 0.9961097 45 0.1037948 0.4974424 23 -0.1819281 0.4060827 0.2857228 0.2888665 0.9989514
cor…470 MalG24m4 Paclitaxel/Carboplatin (nM) 70 -0.1571983 0.1937276 46 -0.2681965 0.0715277 24 0.0066825 0.9752774 -0.2748790 0.2901619 0.9989514
cor…471 LacG6m3 Cisplatin (uM) 70 -0.0610345 0.6157203 46 -0.1841102 0.2206376 24 0.0947286 0.6597257 -0.2788388 0.2907701 0.9989514
cor…472 CitQ24m3 Pemetrexed (uM) 68 -0.1424549 0.2465150 46 -0.0688513 0.6493532 22 -0.3449422 0.1159086 0.2760909 0.2912541 0.9989514
cor…473 SerG6m1 Doxorubicin (nM) 62 -0.3035785 0.0164561 42 -0.4066018 0.0075379 20 -0.1245840 0.6007459 -0.2820178 0.2919195 0.9989514
cor…474 MalQ24m1 8-Cl-adenosine (uM) 71 -0.0780882 0.5174424 47 -0.0006050 0.9967795 24 -0.2728649 0.1970353 0.2722599 0.2922276 0.9989514
cor…475 MalG6m1 Erlotinib (EGFR) (uM) 73 -0.2092786 0.0755767 48 -0.1158604 0.4329276 25 -0.3710588 0.0678305 0.2551983 0.2935196 0.9989514
cor…476 MalG6m4 Doxorubicin (nM) 73 0.0275437 0.8170699 48 -0.0667675 0.6520693 25 0.2034942 0.3292431 -0.2702617 0.2935643 0.9989514
cor…477 CitG6m6 8-Cl-adenosine (uM) 69 -0.0097362 0.9367147 46 0.0840906 0.5784705 23 -0.1970948 0.3673711 0.2811855 0.2940464 0.9989514
cor…478 CitG6m4 Docetaxel (nM) 67 0.0804524 0.5175096 45 -0.0519877 0.7344893 22 0.2334897 0.2956625 -0.2854774 0.2943704 0.9989514
cor…479 CitG24m5 Carboplatin (uM) 67 -0.3039916 0.0123862 45 -0.3756574 0.0109915 22 -0.1052709 0.6410426 -0.2703865 0.2953380 0.9989514
cor…480 MalQ6m4 Erlotinib (EGFR) (uM) 72 -0.1374392 0.2496198 47 -0.2527810 0.0864777 25 0.0147505 0.9442094 -0.2675315 0.2955520 0.9989514
cor…481 MalQ24m2 Doxorubicin (nM) 73 -0.0167767 0.8879680 48 0.0665218 0.6532685 25 -0.2025997 0.3314191 0.2691215 0.2956535 0.9989514
cor…482 FumG24m3 Pemetrexed (uM) 70 0.0674619 0.5789652 47 -0.0356479 0.8119705 23 0.2412672 0.2674153 -0.2769151 0.2960800 0.9989514
cor…483 SerG24m3 Sorafenib (multi-kinase) (uM) 67 -0.2295461 0.0616796 44 -0.3548428 0.0181040 23 -0.0862417 0.6956007 -0.2686011 0.2968751 0.9989514
cor…484 FumG24m2 AZD6244 (MEK) (uM) 71 0.0369443 0.7596985 47 0.1184422 0.4278183 24 -0.1563795 0.4655670 0.2748217 0.2968777 0.9989514
cor…485 MalG6m4 Erlotinib (EGFR) (uM) 73 -0.0236482 0.8425829 48 0.0934481 0.5275528 25 -0.1754497 0.4015411 0.2688977 0.2975335 0.9989514
cor…486 MalG24m1 CDH1 66 0.1010241 0.4196028 43 0.0439129 0.7797801 23 0.3173873 0.1400192 -0.2734745 0.2983701 0.9989514
cor…487 FumG6m3 Doxorubicin (nM) 73 -0.0485662 0.6832525 48 -0.1478827 0.3158209 25 0.1205932 0.5658333 -0.2684759 0.2990467 0.9989514
cor…488 LacG24m3 Paclitaxel (nM) 73 -0.0048768 0.9673367 48 -0.1224914 0.4068751 25 0.1450600 0.4890374 -0.2675515 0.3007633 0.9989514
cor…489 LacQ24m1 Gemcitabine/Cisplatin (nM) 67 -0.0578615 0.6418642 45 -0.0927376 0.5445782 22 0.1906236 0.3954667 -0.2833612 0.3009521 0.9989514
cor…490 FumQ24m2 SCH772984 (ERK) (uM) 78 -0.0822205 0.4742132 51 0.0154386 0.9143711 27 -0.2380561 0.2318026 0.2534947 0.3017868 0.9989514
cor…491 MalG24m2 Gemcitabine/Cisplatin (nM) 67 0.1235428 0.3192343 45 0.1780727 0.2418741 22 -0.1048233 0.6424701 0.2828960 0.3022854 0.9989514
cor…492 LacG6m1 Doxorubicin (nM) 73 0.0607892 0.6094268 48 0.1674646 0.2552448 25 -0.0987208 0.6387244 0.2661855 0.3027423 0.9989514
cor…493 CitG6m5 Erlotinib (EGFR) (uM) 71 0.1224838 0.3088752 47 0.2278930 0.1234052 24 -0.0412993 0.8480516 0.2691923 0.3028277 0.9989514
cor…494 FumG6m2 Erlotinib (EGFR) (uM) 73 0.0085217 0.9429566 48 0.1145205 0.4383031 25 -0.1517677 0.4689427 0.2662882 0.3029695 0.9989514
cor…495 FumQ6m2 Erlotinib (EGFR) (uM) 73 -0.1001503 0.3992074 48 -0.2132198 0.1456464 25 0.0508396 0.8092918 -0.2640593 0.3039611 0.9989514
cor…496 SerG24m1 EGFR-pY1173 53 -0.0066793 0.9621410 33 0.3106227 0.0785090 20 0.0095735 0.9680468 0.3010491 0.3045902 0.9989514
cor…497 FumG24m1 AZD6244 (MEK) (uM) 71 -0.1137920 0.3447185 47 -0.0273930 0.8549749 24 -0.2906839 0.1682021 0.2632908 0.3052677 0.9989514
cor…498 LacQ24m1 Crizotinib (ALK) (uM) 75 -0.2512933 0.0296497 49 -0.1787100 0.2192236 26 -0.4150858 0.0349761 0.2363758 0.3066046 0.9989514
cor…499 SerG6m3 Beta-catenin 50 -0.3282910 0.0199348 32 -0.3950619 0.0252336 18 -0.0924331 0.7152689 -0.3026288 0.3067073 0.9989514
cor…500 CitQ24m6 Doxorubicin (nM) 71 0.0034215 0.9774085 47 0.0715121 0.6328828 24 -0.1967241 0.3568692 0.2682362 0.3069718 0.9989514
cor…501 LacQ24m2 Etoposide (uM) 71 0.0944440 0.4333763 47 -0.0098929 0.9473798 24 0.2547840 0.2295564 -0.2646769 0.3079393 0.9989514
cor…502 CitQ6m6 Beta-catenin 57 -0.0475054 0.7256558 36 -0.1546704 0.3677436 21 0.1402979 0.5441366 -0.2949683 0.3105296 0.9989514
cor…503 CitQ24m2 8-Cl-adenosine (uM) 69 -0.1169895 0.3384024 46 -0.0419403 0.7819750 23 -0.3060241 0.1555690 0.2640838 0.3110404 0.9989514
cor…504 SerG24m2 Beta-catenin 53 -0.0799539 0.5692845 33 -0.1725503 0.3369372 20 0.1322663 0.5782946 -0.3048166 0.3113436 0.9989514
cor…505 LacG24m3 Gemcitabine/Cisplatin (nM) 67 -0.0305572 0.8060912 45 -0.1392465 0.3616301 22 0.1385364 0.5386604 -0.2777829 0.3118971 0.9989514
cor…506 LacQ6m2 Gefitinib (EGFR) (uM) 72 0.1067306 0.3722096 47 0.2146178 0.1474304 25 -0.0459278 0.8274314 0.2605456 0.3120558 0.9989514
cor…507 CitG24m2 Docetaxel (nM) 67 0.1021004 0.4109905 45 0.2068554 0.1727633 22 -0.0694001 0.7589312 0.2762555 0.3122334 0.9989514
cor…508 CitQ6m3 Cisplatin (uM) 68 -0.1145125 0.3524482 45 -0.1963286 0.1961586 23 0.0752229 0.7330116 -0.2715515 0.3127060 0.9989514
cor…509 CitQ24m4 Pemetrexed (uM) 68 -0.0473972 0.7011140 46 -0.1472536 0.3287800 22 0.1290112 0.5671905 -0.2762647 0.3127829 0.9989514
cor…510 CitQ24m3 AZD6244 (MEK) (uM) 69 -0.0568591 0.6426086 46 0.0175184 0.9080055 23 -0.2497823 0.2503722 0.2673007 0.3136719 0.9989514
cor…511 FumG24m1 Gefitinib (EGFR) (uM) 72 -0.0494697 0.6798481 47 -0.1820893 0.2205756 25 0.0787751 0.7081862 -0.2608645 0.3136823 0.9989514
cor…512 LacQ6m2 Paclitaxel (nM) 73 0.1623779 0.1698953 48 0.2375904 0.1039363 25 -0.0198082 0.9251254 0.2573986 0.3138222 0.9989514
cor…513 FumQ6m3 EGFR-pY1173 59 0.3071304 0.0179748 37 0.2521905 0.1321126 22 0.4974363 0.0184954 -0.2452457 0.3144286 0.9989514
cor…514 MalG24m2 8-Cl-adenosine (uM) 71 -0.0039890 0.9736624 47 0.0573664 0.7017124 24 -0.2062006 0.3336999 0.2635671 0.3147616 0.9989514
cor…515 FumG6m4 Gemcitabine/Cisplatin (nM) 67 -0.1495112 0.2272116 45 -0.0696860 0.6492048 22 -0.3342231 0.1284494 0.2645370 0.3150476 0.9989514
cor…516 MalG24m4 Sorafenib (multi-kinase) (uM) 73 -0.2465111 0.0355181 48 -0.3485479 0.0151895 25 -0.1023737 0.6262971 -0.2461742 0.3156230 0.9989514
cor…517 CitQ24m5 Paclitaxel/Carboplatin (nM) 68 0.0396500 0.7481899 45 0.1321932 0.3866915 23 -0.1386429 0.5281144 0.2708362 0.3158272 0.9989514
cor…518 LacG24m2 Carboplatin (uM) 69 0.1053259 0.3890625 46 0.1702490 0.2579753 23 -0.0992300 0.6523741 0.2694791 0.3158418 0.9989514
cor…519 FumQ6m1 8-Cl-adenosine (uM) 71 -0.0665729 0.5812162 47 0.0052430 0.9720986 24 -0.2548700 0.2293936 0.2601130 0.3161650 0.9989514
cor…520 CitQ6m2 MK-2206 (AKT) (uM) 69 -0.1042215 0.3940826 46 -0.1762601 0.2412951 23 0.0928362 0.6735289 -0.2690963 0.3162989 0.9989514
cor…521 CitG6m5 Doxorubicin (nM) 71 -0.0062987 0.9584231 47 -0.0988533 0.5085628 24 0.1648710 0.4413753 -0.2637243 0.3166940 0.9989514
cor…522 MalQ24m2 Paclitaxel/Carboplatin (nM) 70 0.0842156 0.4882189 46 0.1608507 0.2855694 24 -0.1038783 0.6290666 0.2647290 0.3167820 0.9989514
cor…523 FumQ6m3 Carboplatin (uM) 69 -0.1398031 0.2519138 46 -0.2174890 0.1465207 23 0.0490547 0.8241022 -0.2665437 0.3182862 0.9989514
cor…524 CitQ24m1 CDH1 64 0.4373012 0.0003024 42 0.5128559 0.0005151 22 0.2799162 0.2070600 0.2329397 0.3186379 0.9989514
cor…525 FumQ6m2 SCH772984 (ERK) (uM) 78 -0.1375675 0.2297250 51 -0.0572124 0.6900580 27 -0.2971067 0.1323287 0.2398943 0.3191176 0.9989514
cor…526 CitQ6m3 Paclitaxel (nM) 71 -0.1849248 0.1226137 47 -0.2671512 0.0694732 24 -0.0095657 0.9646165 -0.2575855 0.3191409 0.9989514
cor…527 CitG6m1 Docetaxel (nM) 67 0.1793534 0.1464325 45 0.2645075 0.0791120 22 -0.0044862 0.9841919 0.2689937 0.3191428 0.9989514
cor…528 CitG24m4 Paclitaxel/Carboplatin (nM) 68 -0.1059397 0.3898839 45 -0.2034476 0.1801052 23 0.0642111 0.7709955 -0.2676587 0.3191900 0.9989514
cor…529 MalG24m2 Paclitaxel/Carboplatin (nM) 70 0.0770066 0.5263256 46 0.1572798 0.2965405 24 -0.1060972 0.6217178 0.2633769 0.3193674 0.9989514
cor…530 FumG24m1 E-cadherin 59 0.0419960 0.7521428 37 0.1628367 0.3355735 22 -0.1202605 0.5939734 0.2830972 0.3194906 0.9989514
cor…531 CitQ6m6 Pemetrexed (uM) 68 -0.1028840 0.4037780 46 0.0069110 0.9636424 22 -0.2600288 0.2425287 0.2669398 0.3215917 0.9989514
cor…532 CitG6m5 Cisplatin (uM) 68 -0.1371437 0.2647527 45 -0.0481846 0.7532791 23 -0.3063971 0.1550401 0.2582125 0.3232906 0.9989514
cor…533 LacG24m1 Gemcitabine (nM) 71 -0.0921577 0.4446411 47 0.0354418 0.8130386 24 -0.2225722 0.2958597 0.2580139 0.3235752 0.9989514
cor…534 CitQ24m2 Cisplatin (uM) 68 -0.1756629 0.1518962 45 -0.2540116 0.0922292 23 0.0083538 0.9698235 -0.2623654 0.3238173 0.9989514
cor…535 FumQ24m3 Pemetrexed/Cisplatin (uM) 67 -0.0386379 0.7562345 45 0.0472127 0.7581039 22 -0.2217818 0.3212205 0.2689945 0.3238351 0.9989514
cor…536 CitQ6m2 CDH1 64 0.3705702 0.0025763 42 0.4435891 0.0032567 22 0.1980710 0.3769087 0.2455181 0.3239389 0.9989514
cor…537 CitQ6m3 CDH1 64 -0.1717038 0.1748901 42 -0.2522312 0.1070729 22 0.0160623 0.9434413 -0.2682934 0.3276496 0.9989514
cor…538 SerG24m2 Doxorubicin (nM) 67 -0.0958963 0.4401410 44 -0.2023740 0.1876940 23 0.0613905 0.7808111 -0.2637645 0.3282028 0.9989514
cor…539 MalG24m4 SCH772984 (ERK) (uM) 78 -0.0048987 0.9660476 51 0.0851127 0.5526214 27 -0.1575687 0.4324940 0.2426814 0.3286451 0.9989514
cor…540 LacQ6m2 Gemcitabine/Cisplatin (nM) 67 0.0045235 0.9710193 45 -0.0514898 0.7369408 22 0.2148821 0.3368861 -0.2663719 0.3291088 0.9989514
cor…541 FumG24m2 MK-2206 (AKT) (uM) 71 0.0418148 0.7291659 47 -0.0403795 0.7875579 24 0.2147281 0.3136425 -0.2551076 0.3296984 0.9989514
cor…542 FumQ24m2 Crizotinib (ALK) (uM) 75 0.1214793 0.2991663 49 0.2198275 0.1290899 26 -0.0248056 0.9042598 0.2446331 0.3309354 0.9989514
cor…543 SerG24m2 Pemetrexed/Cisplatin (uM) 62 -0.1888876 0.1414789 41 -0.3499660 0.0248946 21 -0.0871285 0.7072593 -0.2628375 0.3311636 0.9989514
cor…544 CitQ24m4 Vinorelbine (nM) 70 -0.1669305 0.1672155 46 -0.0455726 0.7636139 24 -0.2948607 0.1618942 0.2492881 0.3319704 0.9989514
cor…545 LacG6m2 Doxorubicin (nM) 73 0.0462897 0.6973635 48 0.1103576 0.4552381 25 -0.1406188 0.5025762 0.2509764 0.3320033 0.9989514
cor…546 FumQ24m3 EGFR-pY1173 59 0.1544290 0.2428741 37 0.0572347 0.7365151 22 0.3227953 0.1428597 -0.2655607 0.3326942 0.9989514
cor…547 MalG6m3 Gemcitabine (nM) 71 -0.0981746 0.4153469 47 -0.1623664 0.2755330 24 0.0923237 0.6678758 -0.2546900 0.3336812 0.9989514
cor…548 MalQ24m2 E-cadherin 59 -0.1815630 0.1687469 37 -0.2933671 0.0780287 22 -0.0255858 0.9100140 -0.2677813 0.3341111 0.9989514
cor…549 LacQ24m2 Gemcitabine/Cisplatin (nM) 67 -0.0272843 0.8265183 45 -0.0945407 0.5367483 22 0.1704457 0.4482291 -0.2649864 0.3342795 0.9989514
cor…550 GlyG24m2 Crizotinib (ALK) (uM) 71 -0.1218933 0.3112310 45 -0.2103562 0.1654482 26 0.0365808 0.8591849 -0.2469371 0.3348900 0.9989514
cor…551 CitQ6m3 Docetaxel (nM) 67 -0.2666599 0.0291618 45 -0.3568947 0.0161019 22 -0.1065241 0.6370527 -0.2503706 0.3352883 0.9989514
cor…552 CitQ24m3 8-Cl-adenosine (uM) 69 0.0209054 0.8646176 46 -0.0433519 0.7748248 23 0.2138291 0.3272373 -0.2571810 0.3357037 0.9989514
cor…553 MalQ24m2 Pemetrexed/Cisplatin (uM) 67 -0.0804603 0.5174688 45 -0.1193146 0.4350034 22 0.1449193 0.5199222 -0.2642339 0.3363060 0.9989514
cor…554 CitG6m3 Etoposide (uM) 69 -0.0897857 0.4631472 46 -0.0067861 0.9642990 23 -0.2602608 0.2303856 0.2534747 0.3374829 0.9989514
cor…555 CitG24m4 Doxorubicin (nM) 71 -0.0914399 0.4482107 47 -0.1647073 0.2685762 24 0.0873632 0.6848011 -0.2520705 0.3385978 0.9989514
cor…556 MalQ24m3 EGFR-pY1173 59 0.1156324 0.3831451 37 -0.0019874 0.9906856 22 0.2652859 0.2327928 -0.2672733 0.3391704 0.9989514
cor…557 CitG24m4 8-Cl-adenosine (uM) 69 -0.2250361 0.0630182 46 -0.1684317 0.2631667 23 -0.4038375 0.0559997 0.2354058 0.3401476 0.9989514
cor…558 MalG6m1 EGFR-pY1173 59 0.0778114 0.5580219 37 -0.0178537 0.9164706 22 0.2496538 0.2625069 -0.2675075 0.3407150 0.9989514
cor…559 MalG6m2 Etoposide (uM) 71 -0.0930190 0.4403782 47 -0.0077398 0.9588210 24 -0.2546154 0.2298753 0.2468756 0.3408976 0.9989514
cor…560 LacQ24m2 Pemetrexed (uM) 70 -0.0740421 0.5424161 47 -0.1663950 0.2636337 23 0.0885788 0.6877497 -0.2549739 0.3410349 0.9989514
cor…561 MalQ24m4 Paclitaxel/Carboplatin (nM) 70 0.0576373 0.6355427 46 0.1661091 0.2699021 24 -0.0855904 0.6908863 0.2516995 0.3410620 0.9989514
cor…562 MalQ6m2 8-Cl-adenosine (uM) 70 -0.1499246 0.2154237 46 -0.0848722 0.5749317 24 -0.3260300 0.1199976 0.2411578 0.3413673 0.9989514
cor…563 LacQ24m1 Carboplatin (uM) 69 -0.1577985 0.1953351 46 -0.2116342 0.1579731 23 0.0418937 0.8494708 -0.2535279 0.3427234 0.9989514
cor…564 SerG24m1 Doxorubicin (nM) 67 -0.1471326 0.2347756 44 -0.2652686 0.0818124 23 -0.0130312 0.9529420 -0.2522373 0.3428078 0.9989514
cor…565 MalQ6m2 CDH1 66 0.3137509 0.0103070 43 0.3896208 0.0098065 23 0.1504410 0.4932364 0.2391798 0.3428678 0.9989514
cor…566 LacG24m3 Crizotinib (ALK) (uM) 75 0.1272317 0.2766923 49 0.0055817 0.9696370 26 0.2428561 0.2319213 -0.2372744 0.3428747 0.9989514
cor…567 MalQ24m3 Doxorubicin (nM) 73 0.0072360 0.9515521 48 -0.0653982 0.6587628 25 0.1792972 0.3911300 -0.2446954 0.3428786 0.9989514
cor…568 FumQ24m1 AZD6244 (MEK) (uM) 71 -0.0728478 0.5460207 47 0.0057779 0.9692530 24 -0.2409399 0.2567294 0.2467178 0.3429131 0.9989514
cor…569 CitG24m1 Pemetrexed/Cisplatin (uM) 65 -0.0411729 0.7446937 44 0.1058654 0.4940121 21 -0.1604017 0.4873304 0.2662671 0.3430962 0.9989514
cor…570 CitG6m4 Doxorubicin (nM) 71 -0.0566625 0.6388200 47 -0.1453028 0.3298052 24 0.1047156 0.6262894 -0.2500183 0.3431247 0.9989514
cor…571 FumQ6m4 Carboplatin (uM) 69 -0.2187777 0.0709102 46 -0.3102661 0.0358600 23 -0.0643948 0.7703574 -0.2458713 0.3435588 0.9989514
cor…572 FumQ24m3 Etoposide (uM) 71 0.1287783 0.2844802 47 0.0440141 0.7689393 24 0.2868310 0.1741710 -0.2428169 0.3438396 0.9989514
cor…573 SerG24m2 Gemcitabine (nM) 65 -0.0663935 0.5992524 43 -0.1877315 0.2280041 22 0.0721831 0.7495578 -0.2599146 0.3465063 0.9989514
cor…574 MalG24m3 Paclitaxel/Carboplatin (nM) 70 -0.1335574 0.2703537 46 -0.2309139 0.1225924 24 0.0154194 0.9429914 -0.2463332 0.3465913 0.9989514
cor…575 FumG24m4 Beta-catenin 59 -0.1857596 0.1589501 37 -0.2774568 0.0963922 22 -0.0156537 0.9448776 -0.2618031 0.3471756 0.9989514
cor…576 FumQ6m1 Vinorelbine (nM) 72 0.0649243 0.5879343 47 0.1625700 0.2749230 25 -0.0812530 0.6994189 0.2438230 0.3472011 0.9989514
cor…577 MalQ6m2 Cisplatin (uM) 69 -0.0339711 0.7816956 45 -0.1117180 0.4650050 24 0.1379581 0.5203151 -0.2496762 0.3475934 0.9989514
cor…578 FumG6m4 Carboplatin (uM) 69 0.0416494 0.7340127 46 0.1294084 0.3913627 23 -0.1229535 0.5762240 0.2523619 0.3485490 0.9989514
cor…579 CitG24m1 Gemcitabine (nM) 69 -0.0010662 0.9930624 46 0.1062948 0.4820048 23 -0.1449089 0.5094468 0.2512037 0.3506101 0.9989514
cor…580 FumG6m2 MK-2206 (AKT) (uM) 71 0.0220214 0.8553595 47 -0.0630655 0.6736583 24 0.1823097 0.3938635 -0.2453752 0.3507000 0.9989514
cor…581 MalG6m4 AZD6244 (MEK) (uM) 71 -0.0217297 0.8572556 47 0.0702187 0.6390613 24 -0.1752113 0.4128447 0.2454300 0.3509874 0.9989514
cor…582 LacQ24m2 Gemcitabine (nM) 71 -0.0530293 0.6605091 47 -0.1120672 0.4532711 24 0.1339989 0.5324705 -0.2460661 0.3510320 0.9989514
cor…583 LacG6m2 Etoposide (uM) 71 0.0675895 0.5754444 47 0.0095467 0.9492188 24 0.2512484 0.2363072 -0.2417017 0.3513274 0.9989514
cor…584 CitG24m1 Paclitaxel (nM) 71 0.0551543 0.6477878 47 0.1116977 0.4547710 24 -0.1339445 0.5326384 0.2456423 0.3518690 0.9989514
cor…585 LacQ6m2 Pemetrexed (uM) 70 0.0987111 0.4162214 47 0.0250320 0.8673575 23 0.2691909 0.2142055 -0.2441589 0.3520799 0.9989514
cor…586 CitQ24m2 AZD6244 (MEK) (uM) 69 0.0110549 0.9281646 46 0.0971511 0.5206787 23 -0.1525399 0.4871541 0.2496910 0.3533547 0.9989514
cor…587 FumG24m2 Beta-catenin 59 -0.1789906 0.1749657 37 -0.2680444 0.1087147 22 -0.0091037 0.9679271 -0.2589407 0.3536925 0.9989514
cor…588 LacG24m2 Cisplatin (uM) 70 0.0712194 0.5579562 46 0.1481226 0.3259021 24 -0.0973671 0.6508271 0.2454897 0.3537162 0.9989514
cor…589 FumQ6m2 Gemcitabine (nM) 71 -0.3153967 0.0073807 47 -0.2761695 0.0602353 24 -0.4843386 0.0164677 0.2081691 0.3554174 0.9989514
cor…590 SerG6m2 AZD6244 (MEK) (uM) 61 -0.2404073 0.0620037 41 -0.3551750 0.0226812 20 -0.1013604 0.6706851 -0.2538146 0.3554272 0.9989514
cor…591 FumG6m4 CDH1 66 0.1572405 0.2073517 43 0.2653204 0.0855190 23 0.0191861 0.9307591 0.2461343 0.3562724 0.9989514
cor…592 MalG24m2 E-cadherin 59 -0.1498850 0.2571846 37 -0.2298154 0.1712093 22 0.0300381 0.8944334 -0.2598535 0.3566172 0.9989514
cor…593 LacQ24m2 Doxorubicin (nM) 73 0.2201412 0.0612824 48 0.3185614 0.0273334 25 0.0901017 0.6684203 0.2284597 0.3568446 0.9989514
cor…594 FumQ6m2 E-cadherin 59 -0.1225569 0.3551075 37 -0.2178872 0.1951490 22 0.0422478 0.8519149 -0.2601350 0.3572219 0.9989514
cor…595 CitG6m6 Paclitaxel (nM) 71 0.1465784 0.2225523 47 0.0343677 0.8186075 24 0.2713177 0.1996883 -0.2369500 0.3577819 0.9989514
cor…596 CitQ24m5 Erlotinib (EGFR) (uM) 71 -0.2116244 0.0764522 47 -0.2905346 0.0475762 24 -0.0554485 0.7969180 -0.2350861 0.3582942 0.9989514
cor…597 MalG24m4 Pemetrexed (uM) 70 0.0360492 0.7670199 47 -0.0517674 0.7296623 23 0.1931161 0.3773139 -0.2448835 0.3589694 0.9989514
cor…598 CitG24m2 AZD6244 (MEK) (uM) 69 0.2106814 0.0822740 46 0.1415881 0.3479314 23 0.3719529 0.0805197 -0.2303648 0.3592426 0.9989514
cor…599 FumG6m4 Beta-catenin 59 0.0107309 0.9357092 37 -0.0978495 0.5645125 22 0.1626498 0.4695565 -0.2604992 0.3598518 0.9989514
cor…600 SerG24m2 Etoposide (uM) 66 -0.0076062 0.9516673 43 -0.0997913 0.5243299 23 0.1494242 0.4961967 -0.2492155 0.3600136 0.9989514
cor…601 CitQ6m4 Docetaxel (nM) 67 -0.1474148 0.2338691 45 -0.2716696 0.0710351 22 -0.0258023 0.9092555 -0.2458674 0.3604223 0.9989514
cor…602 CitQ24m6 Crizotinib (ALK) (uM) 73 -0.0845408 0.4770070 48 -0.0133273 0.9283632 25 -0.2459238 0.2360281 0.2325964 0.3607845 0.9989514
cor…603 LacG24m1 EGFR-pY1173 59 0.0291239 0.8266772 37 -0.2312805 0.1684208 22 0.0260621 0.9083454 -0.2573426 0.3610636 0.9989514
cor…604 SerG6m1 Etoposide (uM) 61 -0.2098923 0.1044742 41 -0.1643158 0.3046110 20 -0.4071016 0.0748345 0.2427858 0.3614011 0.9989514
cor…605 GlyG24m2 Cisplatin (uM) 66 -0.1815508 0.1445927 43 -0.1602773 0.3045642 23 -0.3897588 0.0659947 0.2294815 0.3616095 0.9989514
cor…606 MalG6m3 SCH772984 (ERK) (uM) 78 -0.0817473 0.4767693 51 -0.1545010 0.2790213 27 0.0718624 0.7216907 -0.2263635 0.3623274 0.9989514
cor…607 CitQ6m1 SCH772984 (ERK) (uM) 76 -0.1844714 0.1106551 50 -0.2392297 0.0942845 26 -0.0122856 0.9525016 -0.2269441 0.3626086 0.9989514
cor…608 CitQ24m2 Gemcitabine (nM) 69 -0.3055989 0.0106639 46 -0.2464287 0.0987520 23 -0.4605241 0.0270091 0.2140955 0.3626853 0.9989514
cor…609 CitG24m6 Gemcitabine (nM) 69 -0.0928851 0.4477873 46 -0.1513804 0.3152539 23 0.0929798 0.6730508 -0.2443603 0.3637913 0.9989514
cor…610 SerG6m3 Gemcitabine/Cisplatin (nM) 59 -0.1309958 0.3226931 40 -0.2539847 0.1137727 19 0.0114554 0.9628765 -0.2654401 0.3648673 0.9989514
cor…611 LacQ24m1 Sorafenib (multi-kinase) (uM) 73 0.0274537 0.8176574 48 -0.0136867 0.9264369 25 0.2184413 0.2941663 -0.2321280 0.3649103 0.9989514
cor…612 FumQ24m2 Pemetrexed/Cisplatin (uM) 67 -0.1266764 0.3070176 45 -0.2292698 0.1297799 22 0.0170428 0.9399946 -0.2463126 0.3649888 0.9989514
cor…613 SerG24m1 Vinorelbine (nM) 66 0.0369591 0.7682834 43 -0.0886168 0.5720127 23 0.1571732 0.4738610 -0.2457900 0.3664482 0.9989514
cor…614 MalG24m1 Erlotinib (EGFR) (uM) 73 -0.0477935 0.6880306 48 -0.0080193 0.9568588 25 -0.2380384 0.2518683 0.2300190 0.3670140 0.9989514
cor…615 MalQ24m4 Gefitinib (EGFR) (uM) 72 -0.3095725 0.0081406 47 -0.4080992 0.0044053 25 -0.1954946 0.3490108 -0.2126046 0.3675503 0.9989514
cor…616 GlyG6m1 Etoposide (uM) 64 -0.0003038 0.9980992 41 -0.1213863 0.4496388 23 0.1262479 0.5659652 -0.2476343 0.3675711 0.9989514
cor…617 MalG6m4 Pemetrexed/Cisplatin (uM) 67 -0.0730259 0.5570165 45 -0.1430116 0.3486639 22 0.1046898 0.6428961 -0.2477014 0.3676553 0.9989514
cor…618 FumG24m4 Paclitaxel/Carboplatin (nM) 70 -0.1448860 0.2314222 46 -0.2324995 0.1199734 24 0.0027497 0.9898259 -0.2352492 0.3681623 0.9989514
cor…619 SerG6m3 AZD6244 (MEK) (uM) 61 0.0612784 0.6389699 41 0.0753749 0.6395155 20 -0.1849027 0.4351370 0.2602776 0.3681849 0.9989514
cor…620 LacQ6m3 Gefitinib (EGFR) (uM) 72 -0.0961779 0.4215824 47 0.0693970 0.6429988 25 -0.1638551 0.4338366 0.2332520 0.3684272 0.9989514
cor…621 FumQ24m2 Doxorubicin (nM) 73 -0.1704378 0.1493985 48 -0.0940074 0.5250735 25 -0.3165320 0.1231752 0.2225246 0.3694112 0.9989514
cor…622 CitQ6m2 Carboplatin (uM) 67 -0.1339782 0.2797403 45 -0.1904205 0.2102291 22 0.0552304 0.8071394 -0.2456510 0.3696075 0.9989514
cor…623 CitG24m3 Gemcitabine (nM) 69 -0.1437704 0.2385718 46 -0.1914687 0.2024164 23 0.0488489 0.8248290 -0.2403176 0.3697804 0.9989514
cor…624 LacQ6m1 Sorafenib (multi-kinase) (uM) 73 -0.1346408 0.2560835 48 -0.0383745 0.7956710 25 -0.2650448 0.2003962 0.2266703 0.3701685 0.9989514
cor…625 GlyG6m2 Vinorelbine (nM) 65 0.0060150 0.9620719 41 -0.1043584 0.5161243 24 0.1379976 0.5201945 -0.2423560 0.3702676 0.9989514
cor…626 LacQ24m1 AZD6244 (MEK) (uM) 71 0.0182095 0.8801926 47 -0.0284233 0.8495821 24 0.2058216 0.3346088 -0.2342450 0.3710786 0.9989514
cor…627 CitG24m2 MK-2206 (AKT) (uM) 69 -0.0043283 0.9718433 46 0.0758053 0.6165761 23 -0.1646190 0.4528923 0.2404244 0.3710978 0.9989514
cor…628 FumG24m1 MK-2206 (AKT) (uM) 71 -0.0232281 0.8475267 47 -0.1085291 0.4677455 24 0.1274266 0.5529388 -0.2359558 0.3713888 0.9989514
cor…629 FumQ6m4 SCH772984 (ERK) (uM) 78 0.1176538 0.3049472 51 0.2246363 0.1130158 27 0.0050653 0.9799952 0.2195710 0.3713901 0.9989514
cor…630 CitG24m4 Carboplatin (uM) 67 -0.2892558 0.0175919 45 -0.3420450 0.0214601 22 -0.1088864 0.6295579 -0.2331585 0.3714888 0.9989514
cor…631 MalQ24m4 SCH772984 (ERK) (uM) 78 0.1249526 0.2757073 51 0.2313174 0.1024231 27 0.0121744 0.9519414 0.2191429 0.3715235 0.9989514
cor…632 GlyG6m1 Gemcitabine (nM) 64 -0.0761152 0.5499809 41 -0.0129194 0.9361023 23 -0.2540677 0.2420671 0.2411483 0.3715815 0.9989514
cor…633 CitQ24m2 Carboplatin (uM) 67 -0.1472611 0.2343625 45 -0.2171125 0.1519712 22 0.0263309 0.9074041 -0.2434434 0.3717327 0.9989514
cor…634 MalG6m2 Gefitinib (EGFR) (uM) 72 0.1798271 0.1306535 47 0.2743853 0.0619802 25 0.0490838 0.8157658 0.2253016 0.3732949 0.9989514
cor…635 CitQ24m5 CDH1 64 -0.3325053 0.0072647 42 -0.4052321 0.0077624 22 -0.1789189 0.4256380 -0.2263131 0.3734081 0.9989514
cor…636 LacQ24m2 Docetaxel (nM) 69 0.0450533 0.7131785 46 0.1437586 0.3405149 23 -0.0954000 0.6650163 0.2391586 0.3743261 0.9989514
cor…637 CitG24m5 Sorafenib (multi-kinase) (uM) 71 -0.1542567 0.1989941 47 -0.2495808 0.0906734 24 -0.0197118 0.9271581 -0.2298690 0.3750923 0.9989514
cor…638 CitG6m3 Gemcitabine/Cisplatin (nM) 65 -0.1541060 0.2203220 44 -0.0950555 0.5393690 21 -0.3322050 0.1412102 0.2371495 0.3766712 0.9989514
cor…639 FumQ24m1 Beta-catenin 59 -0.3477075 0.0069672 37 -0.4309226 0.0077538 22 -0.2049404 0.3602392 -0.2259822 0.3768112 0.9989514
cor…640 MalQ24m3 Gemcitabine (nM) 71 0.0753055 0.5325230 47 0.1381564 0.3543944 24 -0.0947576 0.6596276 0.2329140 0.3774578 0.9989514
cor…641 FumQ24m4 Paclitaxel/Carboplatin (nM) 70 0.0704648 0.5621462 46 0.1716957 0.2538921 24 -0.0614496 0.7754610 0.2331453 0.3775098 0.9989514
cor…642 CitQ24m6 8-Cl-adenosine (uM) 69 0.0548127 0.6546387 46 0.1030366 0.4956099 23 -0.1342472 0.5413998 0.2372838 0.3782852 0.9989514
cor…643 FumG24m2 Erlotinib (EGFR) (uM) 73 0.0101447 0.9321166 48 0.0990625 0.5029313 25 -0.1289467 0.5390179 0.2280092 0.3785945 0.9989514
cor…644 FumG6m2 Doxorubicin (nM) 73 -0.0316271 0.7905283 48 -0.1084076 0.4632916 25 0.1194655 0.5694988 -0.2278731 0.3789756 0.9989514
cor…645 GlyG24m2 EGFR-pY1173 53 -0.1357358 0.3324937 32 0.1215096 0.5076660 21 -0.1407115 0.5429381 0.2622211 0.3793864 0.9989514
cor…646 MalG24m1 Cisplatin (uM) 70 0.1917007 0.1118828 46 0.1509865 0.3165296 24 0.3680125 0.0768378 -0.2170261 0.3794781 0.9989514
cor…647 FumQ24m2 Paclitaxel/Carboplatin (nM) 70 -0.0160141 0.8953172 46 0.0793604 0.6000950 24 -0.1527696 0.4760549 0.2321300 0.3804360 0.9989514
cor…648 FumG6m1 MK-2206 (AKT) (uM) 71 0.1544357 0.1984671 47 0.2221531 0.1334025 24 -0.0061210 0.9773544 0.2282741 0.3816443 0.9989514
cor…649 CitG24m3 8-Cl-adenosine (uM) 69 -0.1135652 0.3528268 46 -0.1811227 0.2283498 23 0.0534524 0.8086053 -0.2345751 0.3819344 0.9989514
cor…650 MalG24m1 Pemetrexed (uM) 70 0.0349276 0.7740730 47 0.0774643 0.6047744 23 -0.1565972 0.4755035 0.2340615 0.3824901 0.9989514
cor…651 CitG6m2 CDH1 64 0.1528300 0.2279562 42 0.2314186 0.1403190 22 -0.0084349 0.9702823 0.2398535 0.3828938 0.9989514
cor…652 CitQ6m6 Pemetrexed/Cisplatin (uM) 65 -0.0928190 0.4620957 44 0.0223083 0.8857104 21 -0.2205704 0.3366569 0.2428787 0.3831846 0.9989514
cor…653 LacG6m1 Pemetrexed/Cisplatin (uM) 67 0.1381702 0.2648305 45 0.2903017 0.0530530 22 0.0579015 0.7979943 0.2324002 0.3835263 0.9989514
cor…654 CitQ6m2 Sorafenib (multi-kinase) (uM) 71 -0.1187797 0.3238442 47 -0.1873723 0.2072460 24 0.0410344 0.8490155 -0.2284067 0.3844636 0.9989514
cor…655 CitG6m4 Paclitaxel/Carboplatin (nM) 68 0.1625864 0.1852710 45 0.0511781 0.7384768 23 0.2798069 0.1959814 -0.2286289 0.3845238 0.9989514
cor…656 MalQ6m1 Vinorelbine (nM) 71 0.0753775 0.5321300 46 0.1671817 0.2667775 25 -0.0590229 0.7792858 0.2262046 0.3847023 0.9989514
cor…657 CitQ24m1 Gemcitabine (nM) 69 -0.1929590 0.1121678 46 -0.1429351 0.3433171 23 -0.3618787 0.0897367 0.2189436 0.3850018 0.9989514
cor…658 CitG6m3 CDH1 64 0.1565768 0.2166207 42 0.2357396 0.1328561 22 -0.0020221 0.9928742 0.2377617 0.3864953 0.9989514
cor…659 CitQ6m1 8-Cl-adenosine (uM) 69 0.0814701 0.5057398 46 0.0265224 0.8611079 23 0.2548891 0.2404960 -0.2283667 0.3870656 0.9989514
cor…660 MalQ24m1 Sorafenib (multi-kinase) (uM) 73 -0.2065535 0.0795514 48 -0.2759468 0.0576349 25 -0.0582593 0.7820734 -0.2176875 0.3871728 0.9989514
cor…661 MalG6m2 MK-2206 (AKT) (uM) 71 0.0394125 0.7441764 47 -0.0384682 0.7973964 24 0.1885266 0.3776510 -0.2269948 0.3873010 0.9989514
cor…662 CitG24m5 Pemetrexed (uM) 68 0.0247495 0.8412172 46 -0.0544724 0.7191839 22 0.1811861 0.4196994 -0.2356585 0.3881399 0.9989514
cor…663 MalQ6m1 Cisplatin (uM) 69 0.1253870 0.3046216 45 0.1998991 0.1879851 24 -0.0275870 0.8981828 0.2274861 0.3890123 0.9989514
cor…664 FumQ24m2 E-cadherin 59 -0.2654051 0.0421952 37 -0.3629694 0.0272449 22 -0.1328311 0.5556689 -0.2301382 0.3891173 0.9989514
cor…665 SerG24m3 Gemcitabine (nM) 65 -0.2795918 0.0240961 43 -0.3974123 0.0083180 22 -0.1789619 0.4255252 -0.2184504 0.3896999 0.9989514
cor…666 MalQ24m2 Cisplatin (uM) 70 0.1268107 0.2955143 46 0.2053241 0.1710346 24 -0.0204554 0.9244176 0.2257795 0.3902221 0.9989514
cor…667 LacG24m1 Crizotinib (ALK) (uM) 75 -0.2540990 0.0278180 49 -0.1611935 0.2685185 26 -0.3634413 0.0679956 0.2022478 0.3927980 0.9989514
cor…668 GlyG6m1 Crizotinib (ALK) (uM) 68 0.1266227 0.3035042 43 -0.0000717 0.9996357 25 0.2228090 0.2843762 -0.2228808 0.3931006 0.9989514
cor…669 MalG6m2 Cisplatin (uM) 70 -0.0139343 0.9088501 46 0.0608279 0.6879980 24 -0.1647132 0.4418186 0.2255411 0.3935715 0.9989514
cor…670 CitG6m5 Pemetrexed/Cisplatin (uM) 65 0.0677218 0.5919499 44 0.0232940 0.8806959 21 0.2583731 0.2581192 -0.2350791 0.3938888 0.9989514
cor…671 CitQ24m2 Pemetrexed (uM) 68 -0.2451064 0.0439497 46 -0.3116355 0.0350082 22 -0.0874366 0.6988173 -0.2241989 0.3942358 0.9989514
cor…672 FumQ6m1 MK-2206 (AKT) (uM) 71 0.0652592 0.5887140 47 -0.0112553 0.9401457 24 0.2113995 0.3213822 -0.2226547 0.3943886 0.9989514
cor…673 SerG24m2 Carboplatin (uM) 65 -0.1408505 0.2630851 43 -0.2228944 0.1508054 22 0.0105842 0.9627144 -0.2334786 0.3944206 0.9989514
cor…674 FumQ24m3 Carboplatin (uM) 69 0.1131676 0.3545259 46 0.0497325 0.7427431 23 0.2730448 0.2074634 -0.2233123 0.3946722 0.9989514
cor…675 MalG24m1 Gefitinib (EGFR) (uM) 72 0.0255166 0.8315134 47 0.0739633 0.6212422 25 -0.1468844 0.4835297 0.2208477 0.3951032 0.9989514
cor…676 CitG24m4 Docetaxel (nM) 67 -0.0210641 0.8656461 45 -0.1061610 0.4876354 22 0.1276441 0.5713392 -0.2338051 0.3955286 0.9989514
cor…677 FumQ6m3 Sorafenib (multi-kinase) (uM) 73 -0.0484997 0.6836635 48 0.0429146 0.7721091 25 -0.1759970 0.4000507 0.2189116 0.3960431 0.9989514
cor…678 MalG6m4 Carboplatin (uM) 69 -0.0405335 0.7408853 46 0.0304103 0.8409937 23 -0.1966256 0.3685356 0.2270359 0.3961877 0.9989514
cor…679 GlyG6m1 Gemcitabine/Cisplatin (nM) 61 0.0779028 0.5506668 40 0.1556270 0.3375990 21 -0.0866203 0.7088949 0.2422473 0.3963438 0.9989514
cor…680 CitG6m5 Paclitaxel (nM) 71 -0.0611842 0.6122448 47 -0.1470207 0.3240575 24 0.0764907 0.7224074 -0.2235114 0.3968154 0.9989514
cor…681 FumQ24m2 Docetaxel (nM) 69 -0.1229634 0.3141380 46 -0.0283258 0.8517662 23 -0.2519707 0.2461084 0.2236448 0.3971287 0.9989514
cor…682 GlyG24m1 Doxorubicin (nM) 68 -0.0955478 0.4382949 44 -0.0384456 0.8043128 24 -0.2592868 0.2211452 0.2208411 0.3978465 0.9989514
cor…683 MalG6m2 Erlotinib (EGFR) (uM) 73 0.0398984 0.7375180 48 0.1297585 0.3793901 25 -0.0891568 0.6717063 0.2189153 0.3979742 0.9989514
cor…684 FumQ6m3 Pemetrexed (uM) 70 0.0067525 0.9557572 47 0.0932364 0.5330581 23 -0.1336190 0.5433108 0.2268554 0.3980046 0.9989514
cor…685 CitQ6m2 Pemetrexed/Cisplatin (uM) 65 -0.1683831 0.1799843 44 -0.2068961 0.1778138 21 0.0290254 0.9006090 -0.2359214 0.3980342 0.9989514
cor…686 CitG6m3 AZD6244 (MEK) (uM) 69 -0.2336823 0.0532982 46 -0.1665996 0.2684700 23 -0.3771742 0.0760325 0.2105745 0.3983425 0.9989514
cor…687 CitG24m3 Paclitaxel (nM) 71 -0.1112428 0.3557044 47 -0.1958078 0.1871512 24 0.0251900 0.9069904 -0.2209978 0.3992772 0.9989514
cor…688 CitG6m2 SCH772984 (ERK) (uM) 76 0.2093879 0.0694734 50 0.1387413 0.3366059 26 0.3397423 0.0894913 -0.2010010 0.4000173 0.9989514
cor…689 CitG6m4 Paclitaxel (nM) 71 -0.0002191 0.9985530 47 -0.0964958 0.5187741 24 0.1256839 0.5584255 -0.2221797 0.4001546 0.9989514
cor…690 CitQ24m2 Etoposide (uM) 69 -0.2794618 0.0200443 46 -0.3534787 0.0159615 23 -0.1409347 0.5212495 -0.2125440 0.4005322 0.9989514
cor…691 MalG24m1 Beta-catenin 59 -0.1766421 0.1807874 37 -0.2160334 0.1990702 22 0.0206049 0.9274819 -0.2366383 0.4018948 0.9989514
cor…692 MalQ24m1 AZD6244 (MEK) (uM) 71 -0.0151128 0.9004529 47 0.0623513 0.6771510 24 -0.1584394 0.4596365 0.2207907 0.4021238 0.9989514
cor…693 MalQ24m3 Carboplatin (uM) 69 0.1030288 0.3995462 46 0.0457213 0.7628650 23 0.2657158 0.2204090 -0.2199945 0.4026871 0.9989514
cor…694 MalQ6m3 Sorafenib (multi-kinase) (uM) 72 0.0122414 0.9187109 47 0.1073643 0.4725644 25 -0.1102304 0.5999042 0.2175948 0.4027962 0.9989514
cor…695 FumG24m1 Paclitaxel (nM) 73 -0.0283383 0.8118877 48 0.0565628 0.7025690 25 -0.1595644 0.4461329 0.2161272 0.4029829 0.9989514
cor…696 MalG6m2 Vinorelbine (nM) 72 0.0898125 0.4530954 47 0.1777497 0.2319606 25 -0.0385562 0.8548145 0.2163059 0.4032843 0.9989514
cor…697 CitQ6m2 Pemetrexed (uM) 68 -0.2245024 0.0656886 46 -0.2828402 0.0568300 22 -0.0606469 0.7886213 -0.2221933 0.4036726 0.9989514
cor…698 CitQ6m3 Doxorubicin (nM) 71 -0.2376074 0.0460154 47 -0.3018404 0.0392117 24 -0.0898900 0.6761605 -0.2119504 0.4038368 0.9989514
cor…699 CitG6m3 MK-2206 (AKT) (uM) 69 0.0481824 0.6942089 46 -0.0224170 0.8824423 23 0.2007307 0.3584189 -0.2231477 0.4038944 0.9989514
cor…700 FumG6m3 SCH772984 (ERK) (uM) 78 -0.0068817 0.9523171 51 -0.0848831 0.5536971 27 0.1228836 0.5414451 -0.2077667 0.4040654 0.9989514
cor…701 LacQ24m2 Cisplatin (uM) 70 0.1247461 0.3035108 46 0.0542072 0.7204957 24 0.2695458 0.2027561 -0.2153386 0.4041047 0.9989514
cor…702 MalG6m4 EGFR-pY1173 59 -0.0160597 0.9039084 37 -0.1693743 0.3162630 22 0.0676439 0.7648634 -0.2370182 0.4045065 0.9989514
cor…703 FumG24m1 8-Cl-adenosine (uM) 71 0.1269384 0.2914751 47 0.1961857 0.1862846 24 -0.0219660 0.9188534 0.2181517 0.4052778 0.9989514
cor…704 MalQ24m2 Erlotinib (EGFR) (uM) 73 -0.1003939 0.3980557 48 -0.0131934 0.9290810 25 -0.2256454 0.2781301 0.2124519 0.4054970 0.9989514
cor…705 FumG6m4 Sorafenib (multi-kinase) (uM) 73 -0.0380691 0.7491466 48 -0.1130853 0.4441017 25 0.1022402 0.6267494 -0.2153255 0.4060016 0.9989514
cor…706 CitG6m1 Etoposide (uM) 69 0.0492815 0.6875892 46 0.1175666 0.4364890 23 -0.1063005 0.6292796 0.2238671 0.4061834 0.9989514
cor…707 MalG6m1 Cisplatin (uM) 70 0.1460030 0.2278063 46 0.0745763 0.6223180 24 0.2874735 0.1731655 -0.2128972 0.4062635 0.9989514
cor…708 LacQ24m1 Cisplatin (uM) 70 0.0019418 0.9872711 46 -0.0424031 0.7796289 24 0.1765293 0.4092829 -0.2189324 0.4068336 0.9989514
cor…709 MalG24m1 Crizotinib (ALK) (uM) 75 -0.0215234 0.8545716 49 -0.0732441 0.6169726 26 0.1374883 0.5030052 -0.2107324 0.4070322 0.9989514
cor…710 FumQ24m4 EGFR-pY1173 59 0.2252307 0.0863217 37 0.0436508 0.7975443 22 0.2739750 0.2172693 -0.2303242 0.4070537 0.9989514
cor…711 CitG6m3 Pemetrexed (uM) 68 0.0371569 0.7635467 46 0.1235456 0.4133529 22 -0.1035853 0.6464244 0.2271309 0.4075810 0.9989514
cor…712 SerG6m2 Gefitinib (EGFR) (uM) 61 -0.1240906 0.3406826 41 -0.0828882 0.6064007 20 -0.3136818 0.1780485 0.2307936 0.4077756 0.9989514
cor…713 FumQ6m4 EGFR-pY1173 59 0.2705093 0.0382496 37 0.1358083 0.4228658 22 0.3569576 0.1029341 -0.2211493 0.4085083 0.9989514
cor…714 FumQ6m4 Crizotinib (ALK) (uM) 75 0.0050260 0.9658643 49 0.1016914 0.4868868 26 -0.1085488 0.5976138 0.2102402 0.4086244 0.9989514
cor…715 FumG6m4 Gemcitabine (nM) 71 -0.0428306 0.7228487 47 -0.0969711 0.5167070 24 0.1212260 0.5725720 -0.2181971 0.4087551 0.9989514
cor…716 CitQ24m4 MK-2206 (AKT) (uM) 69 0.0639264 0.6017779 46 0.1575926 0.2955685 23 -0.0644528 0.7701560 0.2220454 0.4090227 0.9989514
cor…717 LacG6m3 Sorafenib (multi-kinase) (uM) 73 0.1353903 0.2534217 48 0.0203691 0.8907023 25 0.2308510 0.2668949 -0.2104819 0.4091653 0.9989514
cor…718 LacG6m2 Beta-catenin 59 0.0940131 0.4787909 37 0.0215408 0.8993004 22 0.2523089 0.2572974 -0.2307681 0.4093191 0.9989514
cor…719 LacQ6m1 Gefitinib (EGFR) (uM) 72 0.2323716 0.0495061 47 0.3372635 0.0204340 25 0.1349796 0.5200295 0.2022839 0.4098674 0.9989514
cor…720 CitQ24m5 Gefitinib (EGFR) (uM) 70 -0.2379258 0.0473262 46 -0.3230629 0.0285306 24 -0.1152078 0.5919161 -0.2078550 0.4099962 0.9989514
cor…721 CitQ6m1 Pemetrexed/Cisplatin (uM) 65 -0.1931162 0.1232460 44 -0.0986307 0.5241485 21 -0.3200147 0.1573016 0.2213840 0.4104872 0.9989514
cor…722 MalQ6m2 Erlotinib (EGFR) (uM) 72 -0.0402664 0.7370002 47 -0.1215206 0.4158216 25 0.0924783 0.6601811 -0.2139989 0.4105764 0.9989514
cor…723 FumQ6m2 Cisplatin (uM) 70 -0.0641113 0.5980005 46 -0.1426692 0.3442250 24 0.0752749 0.7266535 -0.2179441 0.4105829 0.9989514
cor…724 LacQ6m3 Doxorubicin (nM) 73 0.1147660 0.3336258 48 0.0323295 0.8273213 25 0.2414083 0.2450163 -0.2090788 0.4108868 0.9989514
cor…725 LacQ24m3 AZD6244 (MEK) (uM) 71 -0.2618530 0.0273915 47 -0.1885613 0.2043255 24 -0.3875318 0.0613399 0.1989705 0.4110140 0.9989514
cor…726 FumG24m1 Pemetrexed (uM) 70 -0.2281573 0.0574767 47 -0.1563028 0.2941004 23 -0.3620761 0.0895488 0.2057733 0.4110734 0.9989514
cor…727 CitG6m4 AZD6244 (MEK) (uM) 69 -0.1496806 0.2196140 46 -0.0717947 0.6353949 23 -0.2860362 0.1857929 0.2142415 0.4114040 0.9989514
cor…728 MalQ24m3 E-cadherin 59 0.2063259 0.1169203 37 0.2743163 0.1003787 22 0.0462416 0.8380873 0.2280747 0.4114671 0.9989514
cor…729 GlyG6m1 EGFR-pY1173 53 -0.1075600 0.4433169 32 0.0627960 0.7327782 21 -0.1814090 0.4312939 0.2442051 0.4117115 0.9989514
cor…730 MalG24m1 E-cadherin 59 -0.1336779 0.3127977 37 -0.1694948 0.3159136 22 0.0634659 0.7790265 -0.2329607 0.4125675 0.9989514
cor…731 MalQ6m3 EGFR-pY1173 58 0.3087942 0.0183505 36 0.2670542 0.1153661 22 0.4696762 0.0274215 -0.2026220 0.4125743 0.9989514
cor…732 MalG24m4 EGFR-pY1173 59 -0.0278700 0.8340315 37 -0.1698642 0.3148447 22 0.0627848 0.7813420 -0.2326490 0.4131722 0.9989514
cor…733 CitG6m3 Pemetrexed/Cisplatin (uM) 65 0.0895104 0.4782755 44 0.0408298 0.7924371 21 0.2656763 0.2444244 -0.2248465 0.4132228 0.9989514
cor…734 CitQ6m5 Vinorelbine (nM) 70 -0.0801511 0.5095235 46 -0.1546905 0.3046636 24 0.0617174 0.7745071 -0.2164079 0.4134265 0.9989514
cor…735 FumG24m3 Sorafenib (multi-kinase) (uM) 73 -0.1413786 0.2328324 48 -0.2272725 0.1203057 25 -0.0186299 0.9295684 -0.2086426 0.4136233 0.9989514
cor…736 CitQ24m5 Docetaxel (nM) 67 -0.0781664 0.5295183 45 -0.0123599 0.9357741 22 -0.2338073 0.2949872 0.2214474 0.4139933 0.9989514
cor…737 CitG24m2 Gemcitabine (nM) 69 0.0753840 0.5381429 46 0.1406804 0.3510620 23 -0.0792969 0.7191057 0.2199773 0.4140219 0.9989514
cor…738 CitQ24m3 Erlotinib (EGFR) (uM) 71 -0.2563324 0.0309474 47 -0.3267742 0.0249700 24 -0.1222452 0.5693239 -0.2045291 0.4146592 0.9989514
cor…739 LacQ24m2 Erlotinib (EGFR) (uM) 73 0.0623959 0.5999860 48 0.1757846 0.2320474 25 -0.0342228 0.8709904 0.2100073 0.4154127 0.9989514
cor…740 CitQ6m4 Pemetrexed/Cisplatin (uM) 65 -0.2144965 0.0861978 44 -0.2523110 0.0984703 21 -0.0276530 0.9052877 -0.2246581 0.4155164 0.9989514
cor…741 SerG24m2 Erlotinib (EGFR) (uM) 68 -0.3240205 0.0070274 45 -0.3994050 0.0065670 23 -0.1995002 0.3614342 -0.1999048 0.4165268 0.9989514
cor…742 CitQ24m1 Crizotinib (ALK) (uM) 73 0.0987982 0.4056349 48 0.0354474 0.8109597 25 0.2418378 0.2441518 -0.2063904 0.4167407 0.9989514
cor…743 CitG6m1 Carboplatin (uM) 67 0.1124439 0.3649626 45 0.1711250 0.2610330 22 -0.0516542 0.8194215 0.2227791 0.4167420 0.9989514
cor…744 FumQ6m4 Doxorubicin (nM) 73 -0.1907686 0.1059473 48 -0.1148447 0.4369991 25 -0.3154698 0.1245075 0.2006251 0.4167593 0.9989514
cor…745 MalG24m3 Erlotinib (EGFR) (uM) 73 0.0266433 0.8229508 48 0.1177330 0.4254773 25 -0.0926597 0.6595538 0.2103927 0.4168622 0.9989514
cor…746 FumQ24m3 Gemcitabine (nM) 71 0.0987805 0.4124597 47 0.1587215 0.2865991 24 -0.0547813 0.7993129 0.2135028 0.4177760 0.9989514
cor…747 CitG24m2 SCH772984 (ERK) (uM) 76 0.1446739 0.2124317 50 0.0815929 0.5732326 26 0.2798300 0.1661970 -0.1982370 0.4188389 0.9989514
cor…748 FumG6m4 Docetaxel (nM) 69 0.0821492 0.5021877 46 -0.0210579 0.8895242 23 0.1950541 0.3724517 -0.2161120 0.4191860 0.9989514
cor…749 FumG6m2 CDH1 66 0.3712843 0.0021462 43 0.4379697 0.0033109 23 0.2435107 0.2628549 0.1944590 0.4192311 0.9989514
cor…750 MalG6m2 Carboplatin (uM) 69 -0.0007675 0.9950059 46 0.0590899 0.6964783 23 -0.1580290 0.4714259 0.2171189 0.4194488 0.9989514
cor…751 GlyG24m1 MK-2206 (AKT) (uM) 67 0.1187890 0.3383518 43 0.0250657 0.8732371 24 0.2379751 0.2628074 -0.2129094 0.4194828 0.9989514
cor…752 MalG6m3 Crizotinib (ALK) (uM) 75 -0.1546400 0.1852664 49 -0.2279848 0.1151357 26 -0.0260375 0.8995284 -0.2019474 0.4198239 0.9989514
cor…753 CitG6m1 Beta-catenin 57 -0.1990159 0.1377718 36 -0.2921398 0.0838233 21 -0.0646584 0.7806673 -0.2274814 0.4202739 0.9989514
cor…754 SerG6m3 Gefitinib (EGFR) (uM) 61 -0.0272332 0.8349660 41 -0.1108107 0.4903698 20 0.1231604 0.6049457 -0.2339711 0.4204868 0.9989514
cor…755 FumQ6m4 Pemetrexed/Cisplatin (uM) 67 -0.1702441 0.1684003 45 -0.2289082 0.1304029 22 -0.0103715 0.9634633 -0.2185367 0.4206134 0.9989514
cor…756 MalQ6m2 AZD6244 (MEK) (uM) 70 -0.0016656 0.9890816 46 0.0642357 0.6714807 24 -0.1489330 0.4873318 0.2131687 0.4206819 0.9989514
cor…757 LacG6m2 Sorafenib (multi-kinase) (uM) 73 -0.0382947 0.7477098 48 -0.0816550 0.5811315 25 0.1266033 0.5464801 -0.2082583 0.4214751 0.9989514
cor…758 CitQ24m6 Cisplatin (uM) 68 0.0316614 0.7977115 45 -0.0164488 0.9145952 23 0.1988510 0.3630310 -0.2152998 0.4223408 0.9989514
cor…759 CitQ6m5 EGFR-pY1173 57 0.3529867 0.0070760 36 0.5960164 0.0001253 21 0.7268141 0.0001900 -0.1307977 0.4225620 0.9989514
cor…760 MalG24m1 Gemcitabine (nM) 71 0.0910973 0.4499205 47 0.1133416 0.4481179 24 -0.0982223 0.6479526 0.2115639 0.4233010 0.9989514
cor…761 CitQ6m1 Carboplatin (uM) 67 -0.0301919 0.8083652 45 -0.0818149 0.5931450 22 0.1383790 0.5391264 -0.2201939 0.4235288 0.9989514
cor…762 MalG6m3 Vinorelbine (nM) 72 0.1733204 0.1453988 47 0.0918838 0.5390418 25 0.2921396 0.1564687 -0.2002558 0.4240058 0.9989514
cor…763 GlyG24m1 Carboplatin (uM) 66 0.0118204 0.9249517 43 0.0582741 0.7105004 23 -0.1587374 0.4694154 0.2170115 0.4251035 0.9989514
cor…764 FumG24m2 Doxorubicin (nM) 73 -0.0933802 0.4319908 48 -0.0327129 0.8253055 25 -0.2356767 0.2567438 0.2029638 0.4251622 0.9989514
cor…765 FumG6m3 Beta-catenin 59 -0.0461904 0.7282988 37 -0.1348045 0.4263340 22 0.0923853 0.6826072 -0.2271898 0.4254648 0.9989514
cor…766 MalQ6m2 EGFR-pY1173 58 -0.1420839 0.2873593 36 -0.3414683 0.0415274 22 -0.1257192 0.5772032 -0.2157491 0.4257681 0.9989514
cor…767 CitQ6m4 Vinorelbine (nM) 70 -0.2747421 0.0213490 46 -0.1874157 0.2123169 24 -0.3813350 0.0659733 0.1939193 0.4259237 0.9989514
cor…768 LacQ24m1 Erlotinib (EGFR) (uM) 73 0.0866569 0.4660074 48 0.0464626 0.7538349 25 0.2483186 0.2313506 -0.2018560 0.4259281 0.9989514
cor…769 MalG6m2 8-Cl-adenosine (uM) 71 -0.1321231 0.2720511 47 -0.0766635 0.6085244 24 -0.2802261 0.1847425 0.2035626 0.4260517 0.9989514
cor…770 LacQ24m2 Carboplatin (uM) 69 0.1226428 0.3154114 46 0.0611865 0.6862530 23 0.2687351 0.2150124 -0.2075486 0.4286284 0.9989514
cor…771 FumG6m1 Docetaxel (nM) 69 -0.0689063 0.5737131 46 -0.0021934 0.9884572 23 -0.2130497 0.3290455 0.2108563 0.4287718 0.9989514
cor…772 CitQ24m2 Vinorelbine (nM) 70 -0.1197555 0.3234149 46 -0.0322498 0.8315105 24 -0.2382359 0.2622690 0.2059861 0.4288139 0.9989514
cor…773 CitG6m6 Paclitaxel/Carboplatin (nM) 68 0.2339484 0.0548376 45 0.1202364 0.4314378 23 0.3233412 0.1323295 -0.2031048 0.4296856 0.9989514
cor…774 LacQ6m2 CDH1 66 -0.0344798 0.7834352 43 0.0213539 0.8918875 23 -0.1924167 0.3790773 0.2137706 0.4298427 0.9989514
cor…775 SerG6m1 SCH772984 (ERK) (uM) 67 -0.1305066 0.2925017 44 -0.2503542 0.1011978 23 -0.0411032 0.8522805 -0.2092510 0.4312532 0.9989514
cor…776 FumQ6m4 Erlotinib (EGFR) (uM) 73 -0.1793522 0.1289445 48 -0.2569332 0.0779189 25 -0.0581569 0.7824475 -0.1987763 0.4315895 0.9989514
cor…777 GlyG6m1 SCH772984 (ERK) (uM) 70 -0.0462590 0.7037483 44 0.0311850 0.8407364 26 -0.1718602 0.4011930 0.2030452 0.4318394 0.9989514
cor…778 FumG6m2 Vinorelbine (nM) 72 0.0460767 0.7007299 47 0.1300049 0.3837684 25 -0.0742801 0.7241828 0.2042850 0.4320370 0.9989514
cor…779 MalQ6m3 Pemetrexed (uM) 69 0.0312834 0.7985885 46 0.1157255 0.4437558 23 -0.0958557 0.6635075 0.2115812 0.4326040 0.9989514
cor…780 GlyG24m1 E-cadherin 53 -0.1176240 0.4015736 32 -0.1755414 0.3365552 21 0.0578129 0.8034248 -0.2333543 0.4330285 0.9989514
cor…781 MalG6m1 Paclitaxel (nM) 73 0.0252563 0.8320295 48 0.0982523 0.5064479 25 -0.1047054 0.6184157 0.2029576 0.4337055 0.9989514
cor…782 CitQ24m1 Doxorubicin (nM) 71 -0.0352166 0.7706203 47 -0.0947770 0.5262825 24 0.1120539 0.6021638 -0.2068309 0.4338162 0.9989514
cor…783 CitQ6m1 Cisplatin (uM) 68 -0.0275287 0.8236591 45 -0.0768424 0.6158701 23 0.1347051 0.5400085 -0.2115476 0.4340630 0.9989514
cor…784 FumG24m4 Gemcitabine (nM) 71 -0.0718726 0.5514219 47 -0.1339680 0.3693119 24 0.0721767 0.7375092 -0.2061447 0.4349424 0.9989514
cor…785 FumQ6m2 Crizotinib (ALK) (uM) 75 -0.0426429 0.7164097 49 0.0294755 0.8406629 26 -0.1682787 0.4112246 0.1977542 0.4349653 0.9989514
cor…786 SerG24m2 Vinorelbine (nM) 66 -0.0691901 0.5809311 43 -0.1774746 0.2548899 23 0.0342678 0.8766456 -0.2117424 0.4352976 0.9989514
cor…787 MalG6m3 Carboplatin (uM) 69 -0.1070939 0.3811063 46 -0.0497959 0.7424264 23 -0.2545548 0.2411346 0.2047589 0.4368565 0.9989514
cor…788 CitG6m2 Crizotinib (ALK) (uM) 73 0.0542450 0.6485293 48 -0.0196226 0.8946852 25 0.1800002 0.3892445 -0.1996228 0.4383542 0.9989514
cor…789 CitQ6m3 Vinorelbine (nM) 70 -0.2355924 0.0496058 46 -0.3125474 0.0344503 24 -0.1165933 0.5874381 -0.1959542 0.4385236 0.9989514
cor…790 MalG24m3 Sorafenib (multi-kinase) (uM) 73 -0.1929332 0.1019704 48 -0.2709335 0.0625174 25 -0.0764426 0.7164727 -0.1944909 0.4391018 0.9989514
cor…791 CitG24m6 SCH772984 (ERK) (uM) 76 -0.0343756 0.7681470 50 0.0267666 0.8536100 26 -0.1683933 0.4109016 0.1951599 0.4393353 0.9989514
cor…792 CitQ24m4 Carboplatin (uM) 67 0.1122764 0.3656816 45 0.0509404 0.7396490 22 0.2584986 0.2454113 -0.2075582 0.4399604 0.9989514
cor…793 GlyG24m1 Paclitaxel (nM) 68 -0.0081245 0.9475728 44 0.0798249 0.6064983 24 -0.1261642 0.5569108 0.2059891 0.4408376 0.9989514
cor…794 FumG6m3 Pemetrexed/Cisplatin (uM) 67 -0.0628349 0.6134562 45 -0.1356517 0.3742776 22 0.0764367 0.7352972 -0.2120885 0.4408929 0.9989514
cor…795 FumQ24m4 Vinorelbine (nM) 72 -0.1393596 0.2430015 47 -0.0405749 0.7865537 25 -0.2371182 0.2537607 0.1965433 0.4411600 0.9989514
cor…796 CitQ6m4 AZD6244 (MEK) (uM) 69 0.0931426 0.4465239 46 0.1774689 0.2380315 23 -0.0288927 0.8958829 0.2063615 0.4416024 0.9989514
cor…797 CitG6m6 Gefitinib (EGFR) (uM) 70 0.2373669 0.0478642 46 0.3520170 0.0164337 24 0.1615284 0.4508173 0.1904887 0.4417531 0.9989514
cor…798 LacG6m3 Gefitinib (EGFR) (uM) 72 0.0633393 0.5970989 47 -0.0531106 0.7229237 25 0.1465323 0.4845902 -0.1996429 0.4419914 0.9989514
cor…799 SerG6m2 Docetaxel (nM) 60 -0.1721457 0.1884335 41 -0.2146679 0.1777192 19 0.0108670 0.9647822 -0.2255349 0.4423918 0.9989514
cor…800 MalQ24m4 Docetaxel (nM) 69 -0.0852933 0.4859111 46 0.0004091 0.9978468 23 -0.2045011 0.3492712 0.2049102 0.4425545 0.9989514
cor…801 CitQ6m1 Paclitaxel/Carboplatin (nM) 68 0.1507993 0.2196338 45 0.0691542 0.6517102 23 0.2707638 0.2114363 -0.2016096 0.4429825 0.9989514
cor…802 MalQ24m2 Docetaxel (nM) 69 -0.0321390 0.7932001 46 0.0249429 0.8693056 23 -0.1805864 0.4096122 0.2055292 0.4432089 0.9989514
cor…803 LacQ24m3 MK-2206 (AKT) (uM) 71 0.0603383 0.6171801 47 -0.0142148 0.9244481 24 0.1865076 0.3828737 -0.2007224 0.4441993 0.9989514
cor…804 FumG6m4 Etoposide (uM) 71 0.0252628 0.8343519 47 0.1062639 0.4771409 24 -0.0959499 0.6556011 0.2022138 0.4442433 0.9989514
cor…805 SerG24m3 Beta-catenin 53 -0.2826570 0.0402931 33 -0.3308341 0.0600315 20 -0.1115745 0.6395596 -0.2192596 0.4452729 0.9989514
cor…806 SerG6m2 Paclitaxel/Carboplatin (nM) 59 -0.1485546 0.2614803 40 -0.2057912 0.2026799 19 0.0195570 0.9366612 -0.2253483 0.4453952 0.9989514
cor…807 CitQ24m5 Gemcitabine/Cisplatin (nM) 65 0.1536324 0.2217606 44 0.1484497 0.3362011 21 -0.0660671 0.7760045 0.2145168 0.4455004 0.9989514
cor…808 LacG6m1 Gefitinib (EGFR) (uM) 72 0.0728233 0.5432410 47 0.1927575 0.1942503 25 -0.0039438 0.9850728 0.1967014 0.4456655 0.9989514
cor…809 FumG24m3 E-cadherin 59 -0.1382589 0.2963512 37 -0.2242061 0.1821906 22 -0.0097546 0.9656352 -0.2144515 0.4459260 0.9989514
cor…810 SerG6m2 Paclitaxel (nM) 62 -0.2541539 0.0462235 42 -0.3089746 0.0464844 20 -0.0976920 0.6819943 -0.2112826 0.4461660 0.9989514
cor…811 LacQ6m1 Beta-catenin 59 0.0438546 0.7415476 37 0.0997473 0.5569468 22 -0.1175416 0.6024022 0.2172889 0.4462552 0.9989514
cor…812 SerG6m2 Beta-catenin 50 -0.3193165 0.0238006 32 -0.3788377 0.0325014 18 -0.1551965 0.5386097 -0.2236412 0.4462578 0.9989514
cor…813 LacG24m1 MK-2206 (AKT) (uM) 71 0.1297625 0.2807846 47 0.0592003 0.6926399 24 0.2553660 0.2284574 -0.1961657 0.4465758 0.9989514
cor…814 SerG6m1 Gemcitabine/Cisplatin (nM) 59 -0.0329997 0.8040421 40 -0.0656988 0.6871137 19 -0.2849416 0.2370383 0.2192428 0.4475373 0.9989514
cor…815 CitG24m4 CDH1 64 0.2813810 0.0242969 42 0.3476561 0.0240732 22 0.1493183 0.5071915 0.1983378 0.4478852 0.9989514
cor…816 FumQ24m2 Cisplatin (uM) 70 -0.0321924 0.7913487 46 0.0406092 0.7887335 24 -0.1599413 0.4553374 0.2005505 0.4480898 0.9989514
cor…817 CitG6m5 Pemetrexed (uM) 68 0.1798553 0.1422060 46 0.1133446 0.4532508 22 0.3119744 0.1575262 -0.1986297 0.4482640 0.9989514
cor…818 FumG24m2 Pemetrexed (uM) 70 -0.1096749 0.3660938 47 -0.0442587 0.7676910 23 -0.2436350 0.2626038 0.1993763 0.4486066 0.9989514
cor…819 CitG6m1 Paclitaxel/Carboplatin (nM) 68 0.0735314 0.5512280 45 0.1313884 0.3896148 23 -0.0732196 0.7398797 0.2046080 0.4493979 0.9989514
cor…820 MalQ6m3 Vinorelbine (nM) 71 -0.1627712 0.1750185 46 -0.2416958 0.1056107 25 -0.0485388 0.8177776 -0.1931570 0.4500388 0.9989514
cor…821 CitG24m6 8-Cl-adenosine (uM) 69 -0.1706421 0.1609540 46 -0.1228496 0.4160093 23 -0.3165583 0.1411147 0.1937087 0.4502551 0.9989514
cor…822 LacG24m3 8-Cl-adenosine (uM) 71 -0.0255294 0.8326290 47 0.0493459 0.7418611 24 -0.1492912 0.4862732 0.1986372 0.4512592 0.9989514
cor…823 MalG6m4 MK-2206 (AKT) (uM) 71 0.1303768 0.2784940 47 0.2087268 0.1591341 24 0.0128764 0.9523819 0.1958504 0.4531614 0.9989514
cor…824 GlyG24m2 Doxorubicin (nM) 68 -0.1835949 0.1339606 44 -0.2482590 0.1041821 24 -0.0524828 0.8075762 -0.1957762 0.4537791 0.9989514
cor…825 FumG6m3 Cisplatin (uM) 70 -0.1781533 0.1400697 46 -0.1086252 0.4723955 24 -0.2989792 0.1558388 0.1903540 0.4539897 0.9989514
cor…826 MalQ24m4 Vinorelbine (nM) 72 -0.0887907 0.4582723 47 0.0087236 0.9535921 25 -0.1843896 0.3775886 0.1931132 0.4546180 0.9989514
cor…827 LacQ24m3 Pemetrexed/Cisplatin (uM) 67 -0.0032212 0.9793605 45 -0.0716840 0.6398263 22 0.1339688 0.5522581 -0.2056528 0.4549419 0.9989514
cor…828 MalQ6m1 Erlotinib (EGFR) (uM) 72 0.0534216 0.6558266 47 0.1254219 0.4008974 25 -0.0688433 0.7436814 0.1942652 0.4551002 0.9989514
cor…829 LacQ6m2 Gemcitabine (nM) 71 0.0506408 0.6749225 47 0.0087704 0.9533435 24 0.2039754 0.3390575 -0.1952050 0.4551079 0.9989514
cor…830 CitG6m6 Docetaxel (nM) 67 0.2074490 0.0920916 45 0.1090471 0.4758112 22 0.3048782 0.1676970 -0.1958311 0.4575211 0.9989514
cor…831 CitG6m5 Gefitinib (EGFR) (uM) 70 0.2505582 0.0364321 46 0.3314463 0.0244403 24 0.1457065 0.4969181 0.1857398 0.4577153 0.9989514
cor…832 MalG6m1 Doxorubicin (nM) 73 0.0724853 0.5422408 48 0.0071524 0.9615190 25 0.1973981 0.3442444 -0.1902458 0.4584560 0.9989514
cor…833 SerG6m3 Carboplatin (uM) 60 -0.3768725 0.0029963 41 -0.4496924 0.0031803 19 -0.2582046 0.2858312 -0.1914878 0.4601225 0.9989514
cor…834 GlyG24m2 Gefitinib (EGFR) (uM) 67 -0.1169635 0.3458798 43 -0.2254583 0.1460418 24 -0.0306752 0.8868525 -0.1947831 0.4608779 0.9989514
cor…835 FumQ6m3 Gefitinib (EGFR) (uM) 72 -0.2593321 0.0278227 47 -0.1822533 0.2201533 25 -0.3599361 0.0771739 0.1776828 0.4609890 0.9989514
cor…836 LacG24m1 Doxorubicin (nM) 73 -0.1720578 0.1455118 48 -0.0974029 0.5101476 25 -0.2812955 0.1731462 0.1838926 0.4619483 0.9989514
cor…837 MalQ6m1 Beta-catenin 58 -0.3109606 0.0175070 36 -0.3755292 0.0240096 22 -0.1812230 0.4196030 -0.1943062 0.4624883 0.9989514
cor…838 CitQ24m4 EGFR-pY1173 57 -0.0056470 0.9667458 36 -0.2372963 0.1634605 21 -0.0268776 0.9079322 -0.2104187 0.4630548 0.9989514
cor…839 GlyG24m2 SCH772984 (ERK) (uM) 73 -0.0904258 0.4467623 46 -0.0810594 0.5922876 27 -0.2619607 0.1868456 0.1809013 0.4630626 0.9989514
cor…840 FumQ6m1 Doxorubicin (nM) 73 -0.0409781 0.7306819 48 -0.1049213 0.4778794 25 0.0845189 0.6879199 -0.1894403 0.4651031 0.9989514
cor…841 CitQ24m6 Sorafenib (multi-kinase) (uM) 71 -0.0343566 0.7760735 47 -0.0833324 0.5776063 24 0.1092755 0.6112522 -0.1926080 0.4662601 0.9989514
cor…842 MalG24m3 Beta-catenin 59 -0.1481659 0.2627442 37 -0.2205949 0.1895194 22 -0.0157444 0.9445588 -0.2048504 0.4665857 0.9989514
cor…843 LacG24m1 Gemcitabine/Cisplatin (nM) 67 -0.0548941 0.6590648 45 0.0198615 0.8969635 22 -0.1794579 0.4242222 0.1993193 0.4665932 0.9989514
cor…844 CitG6m6 E-cadherin 57 -0.1506265 0.2633935 36 -0.2711103 0.1097382 21 -0.0650537 0.7793579 -0.2060566 0.4674493 0.9989514
cor…845 LacQ6m2 MK-2206 (AKT) (uM) 71 -0.1126263 0.3497154 47 -0.0555284 0.7108470 24 -0.2433159 0.2519244 0.1877875 0.4674830 0.9989514
cor…846 CitQ6m3 8-Cl-adenosine (uM) 69 0.0269262 0.8261676 46 0.0749615 0.6205159 23 -0.1209092 0.5826307 0.1958707 0.4675938 0.9989514
cor…847 MalG6m3 Beta-catenin 59 -0.0846288 0.5239408 37 -0.1613483 0.3400692 22 0.0448179 0.8430113 -0.2061663 0.4685474 0.9989514
cor…848 CitQ24m6 CDH1 64 -0.0770731 0.5449573 42 -0.0209677 0.8951425 22 -0.2200140 0.3251918 0.1990463 0.4687481 0.9989514
cor…849 CitQ24m6 Beta-catenin 57 0.0152702 0.9102370 36 -0.0663713 0.7005353 21 0.1447522 0.5312948 -0.2111235 0.4688536 0.9989514
cor…850 LacQ24m2 CDH1 66 -0.0281421 0.8225211 43 0.0346573 0.8253786 23 -0.1621722 0.4597288 0.1968295 0.4690379 0.9989514
cor…851 GlyG6m2 Paclitaxel/Carboplatin (nM) 63 -0.0599038 0.6409508 40 -0.1100111 0.4991904 23 0.0896662 0.6841075 -0.1996774 0.4703302 0.9989514
cor…852 GlyG6m2 Sorafenib (multi-kinase) (uM) 66 -0.0939690 0.4529627 42 -0.1946634 0.2167004 24 -0.0019125 0.9929235 -0.1927509 0.4706435 0.9989514
cor…853 LacQ24m1 Beta-catenin 59 0.0011969 0.9928215 37 -0.0651282 0.7017425 22 0.1404545 0.5329968 -0.2055827 0.4707115 0.9989514
cor…854 CitG6m6 Etoposide (uM) 69 0.0592912 0.6284299 46 0.1379405 0.3606162 23 -0.0561294 0.7992052 0.1940699 0.4712063 0.9989514
cor…855 MalQ24m2 AZD6244 (MEK) (uM) 71 0.1253447 0.2976249 47 0.1902368 0.2002596 24 0.0017701 0.9934506 0.1884667 0.4718779 0.9989514
cor…856 CitQ24m5 AZD6244 (MEK) (uM) 69 0.0306739 0.8024320 46 0.0678691 0.6540375 23 -0.1260472 0.5665879 0.1939163 0.4719323 0.9989514
cor…857 CitG24m6 MK-2206 (AKT) (uM) 69 0.0554922 0.6506342 46 -0.0030963 0.9837068 23 0.1891301 0.3874269 -0.1922264 0.4723050 0.9989514
cor…858 FumG6m1 CDH1 66 0.2380287 0.0542835 43 0.1904592 0.2211946 23 0.3706547 0.0816657 -0.1801955 0.4733522 0.9989514
cor…859 CitQ6m2 Erlotinib (EGFR) (uM) 71 0.0284197 0.8140024 47 -0.0270922 0.8565510 24 0.1614620 0.4510060 -0.1885541 0.4737995 0.9989514
cor…860 MalQ24m2 MK-2206 (AKT) (uM) 71 -0.0499499 0.6791136 47 -0.1025086 0.4929342 24 0.0868046 0.6867166 -0.1893132 0.4740153 0.9989514
cor…861 CitG6m5 MK-2206 (AKT) (uM) 69 0.0916873 0.4536895 46 0.1569170 0.2976701 23 -0.0352972 0.8729688 0.1922142 0.4745734 0.9989514
cor…862 CitQ24m5 Vinorelbine (nM) 70 -0.0614559 0.6132803 46 -0.1278824 0.3970195 24 0.0614237 0.7755531 -0.1893061 0.4752176 0.9989514
cor…863 MalQ24m1 Erlotinib (EGFR) (uM) 73 0.0588235 0.6210647 48 0.1432486 0.3313908 25 -0.0411433 0.8451839 0.1843920 0.4760312 0.9989514
cor…864 CitG24m3 Etoposide (uM) 69 -0.1839281 0.1303180 46 -0.1226075 0.4169358 23 -0.3059923 0.1556142 0.1833848 0.4760494 0.9989514
cor…865 FumG24m1 CDH1 66 0.0550728 0.6605178 43 -0.0189795 0.9038494 23 0.1740998 0.4269122 -0.1930793 0.4767269 0.9989514
cor…866 CitQ24m4 Crizotinib (ALK) (uM) 73 0.0500031 0.6744011 48 0.1350144 0.3602185 25 -0.0490818 0.8157730 0.1840962 0.4770838 0.9989514
cor…867 CitG24m2 CDH1 64 -0.1010346 0.4269732 42 -0.0389455 0.8065559 22 -0.2330505 0.2965978 0.1941051 0.4781272 0.9989514
cor…868 CitQ6m2 SCH772984 (ERK) (uM) 76 -0.1430262 0.2177409 50 -0.0825433 0.5687586 26 -0.2571790 0.2046802 0.1746357 0.4784839 0.9989514
cor…869 CitQ24m1 Paclitaxel (nM) 71 -0.0834082 0.4892251 47 -0.1434663 0.3360197 24 0.0434629 0.8401889 -0.1869292 0.4785445 0.9989514
cor…870 CitG6m1 Pemetrexed/Cisplatin (uM) 65 0.0131564 0.9171564 44 0.1249319 0.4190790 21 -0.0746292 0.7478307 0.1995610 0.4785689 0.9989514
cor…871 CitG24m2 Pemetrexed (uM) 68 -0.0093458 0.9397051 46 0.0604672 0.6897547 22 -0.1334419 0.5538367 0.1939091 0.4795177 0.9989514
cor…872 CitG6m6 Gemcitabine (nM) 69 -0.0196249 0.8728383 46 -0.0194344 0.8979947 23 0.1699114 0.4382891 -0.1893458 0.4803545 0.9989514
cor…873 MalG6m3 E-cadherin 59 -0.1436863 0.2776089 37 -0.2205527 0.1896061 22 -0.0221055 0.9222156 -0.1984472 0.4803904 0.9989514
cor…874 LacQ24m3 Doxorubicin (nM) 73 -0.1207209 0.3089803 48 -0.0503713 0.7338568 25 -0.2294930 0.2697973 0.1791217 0.4812022 0.9989514
cor…875 FumG6m1 Sorafenib (multi-kinase) (uM) 73 -0.2607148 0.0258951 48 -0.3127899 0.0304194 25 -0.1395063 0.5059964 -0.1732836 0.4812678 0.9989514
cor…876 CitQ24m4 Doxorubicin (nM) 71 -0.0516890 0.6685819 47 0.0247311 0.8689379 24 -0.1601783 0.4546609 0.1849094 0.4824083 0.9989514
cor…877 MalQ24m3 8-Cl-adenosine (uM) 71 0.0993205 0.4098971 47 0.0525452 0.7257580 24 0.2338155 0.2714892 -0.1812703 0.4840025 0.9989514
cor…878 CitQ24m2 Gefitinib (EGFR) (uM) 70 -0.0397451 0.7439152 46 -0.1106696 0.4640499 24 0.0747728 0.7284094 -0.1854424 0.4846758 0.9989514
cor…879 CitQ6m1 Etoposide (uM) 69 -0.0646635 0.5975856 46 -0.1199741 0.4270875 23 0.0682299 0.7570691 -0.1882040 0.4852430 0.9989514
cor…880 LacG6m3 Gemcitabine/Cisplatin (nM) 67 -0.0235149 0.8501854 45 -0.0810625 0.5965598 22 0.1109910 0.6229103 -0.1920535 0.4858379 0.9989514
cor…881 FumQ24m1 EGFR-pY1173 59 -0.1601396 0.2256751 37 -0.3196462 0.0537889 22 -0.1309596 0.5613005 -0.1886866 0.4860350 0.9989514
cor…882 SerG24m1 Erlotinib (EGFR) (uM) 68 -0.3083259 0.0105266 45 -0.3821540 0.0095815 23 -0.2106789 0.3345828 -0.1714751 0.4873300 0.9989514
cor…883 FumQ24m1 Gemcitabine (nM) 71 -0.2156046 0.0709538 47 -0.1729918 0.2448989 24 -0.3442403 0.0995194 0.1712485 0.4875001 0.9989514
cor…884 FumQ6m3 Docetaxel (nM) 69 -0.1756228 0.1489003 46 -0.2513831 0.0919454 23 -0.0689065 0.7547316 -0.1824766 0.4875986 0.9989514
cor…885 SerG6m2 Pemetrexed/Cisplatin (uM) 59 -0.1981234 0.1325276 40 -0.3447591 0.0293623 19 -0.1508759 0.5375308 -0.1938833 0.4881123 0.9989514
cor…886 SerG24m3 Docetaxel (nM) 65 -0.1158475 0.3581116 43 -0.1573174 0.3136983 22 0.0337782 0.8813741 -0.1910956 0.4897993 0.9989514
cor…887 SerG24m3 Erlotinib (EGFR) (uM) 68 -0.1306600 0.2882198 45 -0.1844334 0.2251915 23 0.0009464 0.9965805 -0.1853798 0.4900641 0.9989514
cor…888 FumQ6m3 Vinorelbine (nM) 72 -0.1412474 0.2366141 47 -0.2131548 0.1502758 25 -0.0363785 0.8629368 -0.1767763 0.4904131 0.9989514
cor…889 FumG6m4 Doxorubicin (nM) 73 0.0679335 0.5679544 48 0.0075467 0.9593991 25 0.1845099 0.3772719 -0.1769632 0.4911643 0.9989514
cor…890 CitG6m3 Crizotinib (ALK) (uM) 73 -0.0517391 0.6637653 48 -0.1132661 0.4433689 25 0.0651783 0.7569137 -0.1784443 0.4913476 0.9989514
cor…891 LacQ24m3 Pemetrexed (uM) 70 -0.1167837 0.3356534 47 -0.0327415 0.8270560 23 -0.2146328 0.3253788 0.1818913 0.4920839 0.9989514
cor…892 MalQ6m4 AZD6244 (MEK) (uM) 70 0.0315989 0.7951108 46 0.1104629 0.4648899 24 -0.0717457 0.7390232 0.1822087 0.4923448 0.9989514
cor…893 GlyG24m2 8-Cl-adenosine (uM) 67 -0.1457727 0.2391773 43 -0.1199299 0.4436584 24 -0.2963529 0.1596815 0.1764230 0.4923764 0.9989514
cor…894 FumQ6m1 EGFR-pY1173 59 -0.2200626 0.0939801 37 -0.3772105 0.0213643 22 -0.1978934 0.3773454 -0.1793171 0.4932156 0.9989514
cor…895 CitQ6m3 EGFR-pY1173 57 0.2660669 0.0454488 36 0.2034324 0.2340421 21 0.3855359 0.0843441 -0.1821034 0.4943803 0.9989514
cor…896 CitQ6m1 EGFR-pY1173 57 -0.1131164 0.4021523 36 -0.3456185 0.0389576 21 -0.1592328 0.4905505 -0.1863857 0.4951899 0.9989514
cor…897 FumG24m2 E-cadherin 59 -0.0819929 0.5369941 37 -0.1493145 0.3777604 22 0.0448513 0.8428958 -0.1941658 0.4952965 0.9989514
cor…898 CitQ6m2 Docetaxel (nM) 67 -0.0965306 0.4371088 45 -0.1687005 0.2679505 22 0.0181011 0.9362753 -0.1868016 0.4955302 0.9989514
cor…899 MalQ6m1 Gemcitabine/Cisplatin (nM) 66 -0.0643823 0.6075429 44 -0.0218329 0.8881301 22 -0.2077691 0.3535014 0.1859361 0.4958587 0.9989514
cor…900 CitG24m3 CDH1 64 0.1130032 0.3739707 42 0.0567329 0.7211945 22 0.2422380 0.2774110 -0.1855051 0.4962530 0.9989514
cor…901 MalQ6m1 Carboplatin (uM) 68 0.0834138 0.4988662 45 0.1353765 0.3752568 23 -0.0485070 0.8260366 0.1838835 0.4964670 0.9989514
cor…902 CitG6m1 Doxorubicin (nM) 71 0.0301824 0.8026923 47 0.0880291 0.5562701 24 -0.0918149 0.6696045 0.1798441 0.4965612 0.9989514
cor…903 MalG6m3 Paclitaxel (nM) 73 -0.1415581 0.2322337 48 -0.2042699 0.1637250 25 -0.0303325 0.8855551 -0.1739373 0.4966454 0.9989514
cor…904 CitQ24m5 Cisplatin (uM) 68 0.1397038 0.2558515 45 0.1625658 0.2859923 23 -0.0205893 0.9257085 0.1831551 0.4968041 0.9989514
cor…905 FumG24m4 Sorafenib (multi-kinase) (uM) 73 -0.2022576 0.0861533 48 -0.2747305 0.0587904 25 -0.1048675 0.6178692 -0.1698630 0.4969462 0.9989514
cor…906 FumQ24m4 Etoposide (uM) 71 -0.0403669 0.7382015 47 -0.1213962 0.4163025 24 0.0581051 0.7874009 -0.1795013 0.4969513 0.9989514
cor…907 MalQ24m1 Pemetrexed (uM) 70 -0.1637761 0.1754990 47 -0.2131601 0.1502655 23 -0.0334463 0.8795818 -0.1797138 0.4973538 0.9989514
cor…908 LacG24m1 8-Cl-adenosine (uM) 71 -0.1401348 0.2437761 47 -0.2124597 0.1516419 24 -0.0361553 0.8668012 -0.1763044 0.4983703 0.9989514
cor…909 CitG6m3 Beta-catenin 57 -0.0671339 0.6197664 36 -0.1297980 0.4505469 21 0.0671289 0.7724951 -0.1969269 0.4997227 0.9989514
cor…910 FumG24m4 Gemcitabine/Cisplatin (nM) 67 -0.1018946 0.4119391 45 -0.0584758 0.7027906 22 -0.2399602 0.2820932 0.1814844 0.5006750 0.9989514
cor…911 MalQ24m1 Gefitinib (EGFR) (uM) 72 0.0988535 0.4087216 47 0.1895429 0.2019366 25 0.0161327 0.9389907 0.1734102 0.5009535 0.9989514
cor…912 CitQ24m2 Docetaxel (nM) 67 -0.1396868 0.2595707 45 -0.2236552 0.1397061 22 -0.0414334 0.8547399 -0.1822217 0.5010109 0.9989514
cor…913 FumQ6m1 Docetaxel (nM) 69 0.0088582 0.9424117 46 0.0842937 0.5775499 23 -0.0972178 0.6590049 0.1815115 0.5012596 0.9989514
cor…914 FumG6m1 Doxorubicin (nM) 73 0.1185012 0.3180256 48 0.0755509 0.6097961 25 0.2450795 0.2376918 -0.1695287 0.5024238 0.9989514
cor…915 FumQ24m4 Docetaxel (nM) 69 -0.0892742 0.4657091 46 -0.0150598 0.9208721 23 -0.1937661 0.3756790 0.1787063 0.5032221 0.9989514
cor…916 LacQ24m3 Carboplatin (uM) 69 -0.1513517 0.2144508 46 -0.0989695 0.5128668 23 -0.2733479 0.2069394 0.1743784 0.5032277 0.9989514
cor…917 CitG6m6 Beta-catenin 57 -0.2157737 0.1069582 36 -0.3244559 0.0535297 21 -0.1395914 0.5461864 -0.1848645 0.5033158 0.9989514
cor…918 FumQ6m4 Paclitaxel (nM) 73 -0.1838329 0.1195037 48 -0.1290402 0.3820565 25 -0.2942646 0.1533387 0.1652244 0.5049031 0.9989514
cor…919 CitQ24m5 Paclitaxel (nM) 71 0.2013134 0.0922841 47 0.2637247 0.0732646 24 0.0930571 0.6653863 0.1706676 0.5050791 0.9989514
cor…920 MalG6m4 E-cadherin 59 -0.0671484 0.6133399 37 -0.1341521 0.4285965 22 0.0558157 0.8051333 -0.1899678 0.5052422 0.9989514
cor…921 CitQ24m6 Gemcitabine (nM) 69 -0.0847388 0.4887609 46 -0.1055355 0.4851577 23 0.0742582 0.7363165 -0.1797938 0.5052532 0.9989514
cor…922 FumQ6m4 Paclitaxel/Carboplatin (nM) 70 -0.0945589 0.4361926 46 -0.0301739 0.8422139 24 -0.2041546 0.3386242 0.1739807 0.5064291 0.9989514
cor…923 MalQ6m3 Docetaxel (nM) 68 -0.1608044 0.1902005 45 -0.2364638 0.1178455 23 -0.0606504 0.7833921 -0.1758135 0.5069133 0.9989514
cor…924 FumQ6m3 Cisplatin (uM) 70 -0.1566610 0.1952744 46 -0.2133528 0.1545456 24 -0.0405664 0.8507186 -0.1727864 0.5083254 0.9989514
cor…925 SerG6m1 EGFR-pY1173 50 -0.0105580 0.9419891 32 0.2716362 0.1326040 18 0.0684011 0.7874044 0.2032352 0.5088198 0.9989514
cor…926 FumQ24m3 AZD6244 (MEK) (uM) 71 -0.0744383 0.5372666 47 -0.0196469 0.8957134 24 -0.1920215 0.3687078 0.1723745 0.5098959 0.9989514
cor…927 FumQ24m1 Doxorubicin (nM) 73 0.0238709 0.8411200 48 -0.0326678 0.8255424 25 0.1377980 0.5112702 -0.1704658 0.5100872 0.9989514
cor…928 CitQ24m6 Erlotinib (EGFR) (uM) 71 -0.1691122 0.1585842 47 -0.1188085 0.4263807 24 -0.2856469 0.1760346 0.1668384 0.5107147 0.9989514
cor…929 CitG6m3 Erlotinib (EGFR) (uM) 71 0.1041615 0.3873372 47 0.1739664 0.2422095 24 0.0013303 0.9950779 0.1726362 0.5107727 0.9989514
cor…930 MalQ6m1 Doxorubicin (nM) 72 0.0722283 0.5465491 47 0.0166335 0.9116397 25 0.1860208 0.3733087 -0.1693873 0.5111228 0.9989514
cor…931 LacQ24m1 8-Cl-adenosine (uM) 71 -0.2336741 0.0498477 47 -0.2709011 0.0655042 24 -0.1034808 0.6303867 -0.1674203 0.5118403 0.9989514
cor…932 SerG24m1 Crizotinib (ALK) (uM) 70 0.0108167 0.9291835 45 -0.0710140 0.6429652 25 0.1010602 0.6307544 -0.1720742 0.5120844 0.9989514
cor…933 CitQ6m4 Doxorubicin (nM) 71 -0.1423685 0.2362670 47 -0.2057687 0.1652611 24 -0.0349050 0.8713695 -0.1708637 0.5122133 0.9989514
cor…934 MalQ6m4 Sorafenib (multi-kinase) (uM) 72 -0.0746834 0.5329624 47 0.0178994 0.9049446 25 -0.1519366 0.4684423 0.1698361 0.5124868 0.9989514
cor…935 MalG24m4 MK-2206 (AKT) (uM) 71 0.1511534 0.2082911 47 0.2136478 0.1493126 24 0.0432742 0.8408739 0.1703736 0.5125543 0.9989514
cor…936 CitQ24m6 Paclitaxel/Carboplatin (nM) 68 -0.0381567 0.7573771 45 0.0053978 0.9719275 23 -0.1707978 0.4358680 0.1761956 0.5126186 0.9989514
cor…937 GlyG6m2 8-Cl-adenosine (uM) 64 -0.1394931 0.2716218 41 -0.1313336 0.4130756 23 -0.3030407 0.1598451 0.1717071 0.5128828 0.9989514
cor…938 SerG24m2 E-cadherin 53 0.1339048 0.3391173 33 0.2332156 0.1914976 20 0.0392174 0.8696090 0.1939982 0.5135094 0.9989514
cor…939 MalQ6m3 Etoposide (uM) 70 0.0873191 0.4722737 46 0.0246508 0.8708228 24 0.1958005 0.3591766 -0.1711497 0.5140900 0.9989514
cor…940 FumG6m1 Paclitaxel (nM) 73 -0.0190898 0.8726426 48 0.0261899 0.8597471 25 -0.1423861 0.4971666 0.1685760 0.5145502 0.9989514
cor…941 CitQ24m4 Sorafenib (multi-kinase) (uM) 71 0.0830760 0.4909631 47 0.0276119 0.8538289 24 0.1977807 0.3542403 -0.1701688 0.5147082 0.9989514
cor…942 CitQ6m4 Paclitaxel (nM) 71 -0.1879758 0.1164552 47 -0.2676663 0.0689170 24 -0.1016718 0.6364085 -0.1659946 0.5158741 0.9989514
cor…943 CitG24m6 Gefitinib (EGFR) (uM) 70 -0.0571759 0.6382552 46 0.0017361 0.9908638 24 -0.1693604 0.4288615 0.1710965 0.5164227 0.9989514
cor…944 SerG24m2 Cisplatin (uM) 65 -0.1124000 0.3726912 43 -0.0822714 0.5999425 22 -0.2572299 0.2478180 0.1749585 0.5166755 0.9989514
cor…945 LacQ6m2 Beta-catenin 59 0.0204204 0.8779946 37 -0.0409183 0.8099784 22 0.1429223 0.5257514 -0.1838405 0.5187011 0.9989514
cor…946 FumG6m3 Sorafenib (multi-kinase) (uM) 73 0.0143801 0.9038899 48 -0.0552484 0.7091727 25 0.1114314 0.5959116 -0.1666798 0.5204090 0.9989514
cor…947 CitG6m4 Pemetrexed (uM) 68 0.0298724 0.8089187 46 -0.0152479 0.9198868 22 0.1603758 0.4758733 -0.1756238 0.5204831 0.9989514
cor…948 FumQ24m1 Etoposide (uM) 71 -0.0357354 0.7673359 47 0.0234879 0.8754733 24 -0.1455961 0.4972479 0.1690839 0.5212321 0.9989514
cor…949 CitG24m6 Gemcitabine/Cisplatin (nM) 65 -0.1868601 0.1361071 44 -0.2244601 0.1429750 21 -0.0470408 0.8395417 -0.1774193 0.5214501 0.9989514
cor…950 LacQ6m1 Crizotinib (ALK) (uM) 75 -0.0743078 0.5263467 49 -0.0172046 0.9065970 26 -0.1788430 0.3820350 0.1616384 0.5218172 0.9989514
cor…951 FumG24m4 Etoposide (uM) 71 -0.0219235 0.8559959 47 0.0367856 0.8060835 24 -0.1321363 0.5382349 0.1689219 0.5222479 0.9989514
cor…952 SerG6m3 SCH772984 (ERK) (uM) 67 0.0302474 0.8080194 44 0.0215835 0.8894002 23 -0.1514914 0.4901878 0.1730749 0.5228973 0.9989514
cor…953 CitQ24m2 Sorafenib (multi-kinase) (uM) 71 -0.2435438 0.0406935 47 -0.1739562 0.2422376 24 -0.3317332 0.1132801 0.1577770 0.5239276 0.9989514
cor…954 CitQ6m1 MK-2206 (AKT) (uM) 69 -0.0653783 0.5935332 46 -0.0124600 0.9344995 23 -0.1826027 0.4043146 0.1701427 0.5245968 0.9989514
cor…955 CitQ24m1 Gefitinib (EGFR) (uM) 70 0.0705517 0.5616626 46 0.1326479 0.3795125 24 -0.0358500 0.8679163 0.1684979 0.5248216 0.9989514
cor…956 CitG24m1 AZD6244 (MEK) (uM) 69 -0.1494887 0.2202124 46 -0.1822927 0.2253078 23 -0.0122465 0.9557729 -0.1700461 0.5248549 0.9989514
cor…957 CitQ6m2 8-Cl-adenosine (uM) 69 -0.1553643 0.2024040 46 -0.1178968 0.4351931 23 -0.2824417 0.1916267 0.1645450 0.5253851 0.9989514
cor…958 FumQ6m2 Pemetrexed (uM) 70 -0.2522335 0.0351584 47 -0.2018036 0.1737400 23 -0.3585496 0.0929490 0.1567459 0.5269733 0.9989514
cor…959 MalQ6m4 8-Cl-adenosine (uM) 70 0.0010746 0.9929557 46 -0.0547759 0.7176839 24 0.1129498 0.5992454 -0.1677257 0.5273587 0.9989514
cor…960 FumG6m2 Etoposide (uM) 71 0.0279936 0.8167426 47 0.0868792 0.5614597 24 -0.0802084 0.7094729 0.1670876 0.5277436 0.9989514
cor…961 CitQ24m3 Gemcitabine/Cisplatin (nM) 65 0.1276818 0.3107806 44 0.1552916 0.3141481 21 -0.0219583 0.9247321 0.1772498 0.5277937 0.9989514
cor…962 CitG24m3 Carboplatin (uM) 67 -0.2175248 0.0770191 45 -0.1750585 0.2500654 22 -0.3375320 0.1244788 0.1624735 0.5281222 0.9989514
cor…963 CitG6m2 Gemcitabine (nM) 69 -0.0120424 0.9217675 46 -0.0712453 0.6379908 23 0.0986482 0.6542889 -0.1698935 0.5291257 0.9989514
cor…964 CitQ6m2 Paclitaxel (nM) 71 -0.1134364 0.3462380 47 -0.1661208 0.2644328 24 -0.0007903 0.9970760 -0.1653305 0.5292121 0.9989514
cor…965 CitG24m3 Erlotinib (EGFR) (uM) 71 -0.0269361 0.8235516 47 -0.0848001 0.5708991 24 0.0816899 0.7043402 -0.1664899 0.5292315 0.9989514
cor…966 MalQ6m1 SCH772984 (ERK) (uM) 77 -0.1334819 0.2471383 50 -0.1957192 0.1731487 27 -0.0411840 0.8383860 -0.1545353 0.5312729 0.9989514
cor…967 FumG6m1 Gefitinib (EGFR) (uM) 72 0.0689279 0.5650739 47 0.1405038 0.3461971 25 -0.0217239 0.9179071 0.1622276 0.5320491 0.9989514
cor…968 LacG24m1 SCH772984 (ERK) (uM) 78 -0.2928540 0.0092689 51 -0.3477274 0.0124098 27 -0.2037614 0.3080030 -0.1439660 0.5320960 0.9989514
cor…969 CitQ24m1 AZD6244 (MEK) (uM) 69 -0.0590191 0.6300095 46 -0.0115975 0.9390246 23 -0.1787618 0.4144390 0.1671643 0.5321070 0.9989514
cor…970 CitG6m3 EGFR-pY1173 57 -0.1675691 0.2127930 36 -0.3224115 0.0551413 21 -0.1505142 0.5148956 -0.1718973 0.5330148 0.9989514
cor…971 CitG24m6 EGFR-pY1173 57 -0.0076055 0.9552229 36 -0.1293446 0.4521439 21 0.0522997 0.8218662 -0.1816443 0.5335727 0.9989514
cor…972 CitG24m1 Gefitinib (EGFR) (uM) 70 -0.0160103 0.8953414 46 -0.0559920 0.7116842 24 0.1091009 0.6118254 -0.1650929 0.5339504 0.9989514
cor…973 MalG6m4 Etoposide (uM) 71 -0.0288493 0.8112428 47 0.0332380 0.8244749 24 -0.1308414 0.5422593 0.1640794 0.5342550 0.9989514
cor…974 LacQ6m2 Carboplatin (uM) 69 0.2365224 0.0503863 46 0.1991319 0.1845940 23 0.3538851 0.0975926 -0.1547532 0.5346702 0.9989514
cor…975 MalQ6m3 Gemcitabine/Cisplatin (nM) 66 -0.0104897 0.9333801 44 -0.0430131 0.7816028 22 0.1285558 0.5685708 -0.1715689 0.5346807 0.9989514
cor…976 CitQ6m5 Crizotinib (ALK) (uM) 73 0.0416623 0.7263607 48 0.0739756 0.6172906 25 -0.0868687 0.6796881 0.1608443 0.5354913 0.9989514
cor…977 LacQ6m1 Gemcitabine (nM) 71 -0.1592260 0.1847313 47 -0.1768715 0.2343127 24 -0.0147930 0.9453038 -0.1620785 0.5364615 0.9989514
cor…978 CitG24m5 Gefitinib (EGFR) (uM) 70 0.0702047 0.5635938 46 0.1300768 0.3889002 24 -0.0333981 0.8768804 0.1634749 0.5373122 0.9989514
cor…979 CitQ24m6 Gemcitabine/Cisplatin (nM) 65 0.0319164 0.8007396 44 0.0155251 0.9203262 21 0.1876051 0.4154503 -0.1720800 0.5375320 0.9989514
cor…980 SerG6m2 Gemcitabine (nM) 60 -0.2820508 0.0290111 41 -0.3507688 0.0245422 19 -0.5003659 0.0291212 0.1495970 0.5381299 0.9989514
cor…981 CitG24m5 Beta-catenin 57 -0.2340281 0.0797478 36 -0.2903108 0.0858691 21 -0.1181318 0.6100576 -0.1721790 0.5385217 0.9989514
cor…982 FumG24m1 Carboplatin (uM) 69 0.0164214 0.8934630 46 -0.0399140 0.7922697 23 0.1256469 0.5678308 -0.1655608 0.5390554 0.9989514
cor…983 CitQ6m6 Carboplatin (uM) 67 -0.1084476 0.3823594 45 -0.1572890 0.3021305 22 0.0107206 0.9622341 -0.1680096 0.5402481 0.9989514
cor…984 MalQ6m1 Etoposide (uM) 70 0.0448541 0.7123475 46 0.1028556 0.4963716 24 -0.0594513 0.7825891 0.1623069 0.5410014 0.9989514
cor…985 FumG6m3 CDH1 66 0.1494806 0.2309453 43 0.2191233 0.1580175 23 0.0558686 0.8001200 0.1632547 0.5424599 0.9989514
cor…986 CitQ6m6 Doxorubicin (nM) 71 -0.1115344 0.3544369 47 -0.0548696 0.7141307 24 -0.2129726 0.3177102 0.1581030 0.5429394 0.9989514
cor…987 CitG24m5 E-cadherin 57 -0.1968060 0.1422870 36 -0.2542709 0.1345224 21 -0.0816125 0.7250769 -0.1726585 0.5431300 0.9989514
cor…988 FumG24m2 CDH1 66 0.3273961 0.0072889 43 0.2829671 0.0659680 23 0.4278247 0.0417043 -0.1448577 0.5436262 0.9989514
cor…989 FumQ24m4 SCH772984 (ERK) (uM) 78 0.1104548 0.3356928 51 0.1843270 0.1953715 27 0.0346794 0.8636545 0.1496475 0.5438115 0.9989514
cor…990 MalG6m1 SCH772984 (ERK) (uM) 78 -0.2131433 0.0609813 51 -0.2742774 0.0514504 27 -0.1293653 0.5201560 -0.1449121 0.5448094 0.9989514
cor…991 CitG6m5 Paclitaxel/Carboplatin (nM) 68 -0.0069423 0.9551927 45 -0.0798921 0.6018887 23 0.0837770 0.7039129 -0.1636691 0.5459846 0.9989514
cor…992 FumG6m2 Crizotinib (ALK) (uM) 75 0.0771615 0.5105403 49 0.1359506 0.3516357 26 -0.0171835 0.9336006 0.1531341 0.5465336 0.9989514
cor…993 LacQ24m2 E-cadherin 59 -0.1164077 0.3799418 37 -0.2038721 0.2261627 22 -0.0341105 0.8802149 -0.1697615 0.5466784 0.9989514
cor…994 FumQ6m1 Crizotinib (ALK) (uM) 75 -0.0525791 0.6541454 49 0.0014271 0.9922354 26 -0.1512558 0.4607667 0.1526829 0.5468729 0.9989514
cor…995 LacQ24m2 MK-2206 (AKT) (uM) 71 -0.2024742 0.0903825 47 -0.1442648 0.3333088 24 -0.2955261 0.1609048 0.1512613 0.5480167 0.9989514
cor…996 FumG24m1 SCH772984 (ERK) (uM) 78 -0.2786645 0.0134920 51 -0.2345715 0.0975491 27 -0.3705453 0.0570843 0.1359738 0.5484173 0.9989514
cor…997 CitQ6m1 Pemetrexed (uM) 68 -0.0651551 0.5975804 46 -0.0999480 0.5086875 22 0.0647429 0.7746902 -0.1646909 0.5489165 0.9989514
cor…998 GlyG24m1 EGFR-pY1173 53 -0.1091414 0.4366026 32 -0.1357273 0.4588872 21 0.0428934 0.8535346 -0.1786207 0.5497251 0.9989514
cor…999 FumQ6m1 Gemcitabine/Cisplatin (nM) 67 -0.1139632 0.3584774 45 -0.0840566 0.5830228 22 -0.2445417 0.2727253 0.1604850 0.5498192 0.9989514
cor…1000 GlyG24m1 Erlotinib (EGFR) (uM) 69 0.1324191 0.2780785 45 0.1760291 0.2474075 24 0.0181949 0.9327506 0.1578342 0.5501828 0.9989514
cor…1001 FumG6m4 Paclitaxel/Carboplatin (nM) 70 0.1255771 0.3002754 46 0.0479318 0.7517561 24 0.2035158 0.3401705 -0.1555839 0.5517781 0.9989514
cor…1002 SerG24m3 Gemcitabine/Cisplatin (nM) 62 -0.2389723 0.0614036 41 -0.3258388 0.0376192 21 -0.1664122 0.4709394 -0.1594266 0.5519769 0.9989514
cor…1003 FumQ24m3 E-cadherin 59 0.2296685 0.0801449 37 0.2827658 0.0899301 22 0.1198187 0.5953395 0.1629471 0.5521668 0.9989514
cor…1004 CitQ6m3 E-cadherin 57 0.0860775 0.5243484 36 0.0310489 0.8573394 21 0.2022388 0.3793143 -0.1711899 0.5526146 0.9989514
cor…1005 FumG6m4 Pemetrexed (uM) 70 0.1123766 0.3543322 47 0.1897737 0.2013775 23 0.0321195 0.8843269 0.1576543 0.5530529 0.9989514
cor…1006 LacQ6m1 Etoposide (uM) 71 0.0164486 0.8917050 47 0.0613659 0.6819807 24 -0.0951669 0.6582442 0.1565329 0.5541447 0.9989514
cor…1007 LacQ24m1 Vinorelbine (nM) 72 -0.1215743 0.3090024 47 -0.0756528 0.6132716 25 -0.2262567 0.2767954 0.1506039 0.5542044 0.9989514
cor…1008 LacG24m1 Sorafenib (multi-kinase) (uM) 73 -0.0800140 0.5009977 48 -0.1229239 0.4052082 25 0.0302836 0.8857384 -0.1532075 0.5542775 0.9989514
cor…1009 MalG6m1 Pemetrexed (uM) 70 0.0123132 0.9194166 47 0.0653455 0.6625537 23 -0.0937443 0.6705092 0.1590898 0.5543260 0.9989514
cor…1010 CitG24m1 Cisplatin (uM) 68 0.2684017 0.0268948 45 0.2551665 0.0907084 23 0.3982457 0.0598192 -0.1430792 0.5543515 0.9989514
cor…1011 LacQ24m2 Beta-catenin 59 -0.0023816 0.9857168 37 -0.0817148 0.6306609 22 0.0867323 0.7011349 -0.1684471 0.5555342 0.9989514
cor…1012 MalQ24m1 Pemetrexed/Cisplatin (uM) 67 -0.0716570 0.5644522 45 -0.0823910 0.5905363 22 0.0801291 0.7229858 -0.1625201 0.5557816 0.9989514
cor…1013 MalQ6m1 Pemetrexed/Cisplatin (uM) 66 -0.0091948 0.9415887 44 0.0447903 0.7728133 22 -0.1175720 0.6023076 0.1623623 0.5571321 0.9989514
cor…1014 CitG6m6 CDH1 64 0.1916337 0.1292789 42 0.2646412 0.0903303 22 0.1068791 0.6359243 0.1577622 0.5582187 0.9989514
cor…1015 CitQ6m1 Gefitinib (EGFR) (uM) 70 0.0631186 0.6036926 46 0.1282684 0.3955841 24 -0.0265572 0.9019652 0.1548256 0.5590486 0.9989514
cor…1016 MalQ6m4 Paclitaxel/Carboplatin (nM) 69 -0.1239770 0.3101352 45 -0.0632362 0.6798429 24 -0.2157605 0.3112654 0.1525244 0.5597135 0.9989514
cor…1017 MalG24m1 Etoposide (uM) 71 0.2172115 0.0688260 47 0.2558713 0.0825712 24 0.1067609 0.6195265 0.1491105 0.5601781 0.9989514
cor…1018 CitG24m4 Gefitinib (EGFR) (uM) 70 0.1153423 0.3416931 46 0.1732931 0.2494344 24 0.0199750 0.9261879 0.1533180 0.5602124 0.9989514
cor…1019 LacG24m1 Paclitaxel (nM) 73 -0.1105994 0.3515878 48 -0.0618173 0.6763910 25 -0.2102318 0.3131309 0.1484145 0.5602774 0.9989514
cor…1020 LacG6m2 Pemetrexed (uM) 70 -0.0072638 0.9524105 47 0.0412333 0.7831731 23 -0.1152566 0.6005032 0.1564899 0.5603817 0.9989514
cor…1021 CitQ6m5 Carboplatin (uM) 67 -0.0890463 0.4736305 45 -0.1230722 0.4205716 22 0.0371519 0.8696191 -0.1602242 0.5606712 0.9989514
cor…1022 CitQ6m1 Docetaxel (nM) 67 0.0373513 0.7641128 45 -0.0285770 0.8521754 22 0.1311034 0.5608670 -0.1596804 0.5616980 0.9989514
cor…1023 MalG24m1 Pemetrexed/Cisplatin (uM) 67 0.1684290 0.1730521 45 0.1992864 0.1893702 22 0.0416572 0.8539636 0.1576292 0.5620372 0.9989514
cor…1024 GlyG24m2 Gemcitabine (nM) 66 -0.2170418 0.0800324 43 -0.3179380 0.0377392 23 -0.1691156 0.4404686 -0.1488224 0.5625159 0.9989514
cor…1025 FumQ6m4 MK-2206 (AKT) (uM) 71 -0.0259970 0.8296094 47 0.0382515 0.7985138 24 -0.1147220 0.5934897 0.1529735 0.5627622 0.9989514
cor…1026 MalQ24m4 EGFR-pY1173 59 0.2662911 0.0414872 37 0.1302029 0.4424347 22 0.2881109 0.1935131 -0.1579080 0.5632619 0.9989514
cor…1027 LacQ6m2 Cisplatin (uM) 70 0.1440165 0.2342645 46 0.1016946 0.5012708 24 0.2504056 0.2379355 -0.1487110 0.5634643 0.9989514
cor…1028 MalQ24m2 Crizotinib (ALK) (uM) 75 0.1682124 0.1491342 49 0.1265474 0.3862407 26 0.2678693 0.1858264 -0.1413219 0.5639792 0.9989514
cor…1029 CitQ24m5 Gemcitabine (nM) 69 0.0840559 0.4922832 46 0.0593289 0.6953100 23 -0.0959291 0.6632644 0.1552580 0.5653032 0.9989514
cor…1030 LacQ24m2 Gefitinib (EGFR) (uM) 72 0.0573791 0.6321154 47 0.1472474 0.3233036 25 -0.0016086 0.9939111 0.1488560 0.5658294 0.9989514
cor…1031 MalQ24m3 Pemetrexed (uM) 70 -0.0516013 0.6713932 47 -0.0009417 0.9949874 23 -0.1543194 0.4820265 0.1533777 0.5664090 0.9989514
cor…1032 MalG6m4 Beta-catenin 59 -0.1110641 0.4023444 37 -0.1685370 0.3186965 22 -0.0059981 0.9788654 -0.1625389 0.5665578 0.9989514
cor…1033 CitG6m1 AZD6244 (MEK) (uM) 69 -0.0847878 0.4885088 46 -0.0340241 0.8223864 23 -0.1868318 0.3933271 0.1528077 0.5668248 0.9989514
cor…1034 CitG6m3 Gefitinib (EGFR) (uM) 70 0.1840511 0.1272049 46 0.2517566 0.0914474 24 0.1048537 0.6258318 0.1469029 0.5679147 0.9989514
cor…1035 MalQ6m4 Etoposide (uM) 70 -0.1241085 0.3060083 46 -0.1937392 0.1970144 24 -0.0443016 0.8371447 -0.1494376 0.5683177 0.9989514
cor…1036 SerG6m2 Erlotinib (EGFR) (uM) 63 -0.2745534 0.0294362 43 -0.3316206 0.0298262 20 -0.1777171 0.4534968 -0.1539034 0.5686882 0.9989514
cor…1037 MalQ6m4 Docetaxel (nM) 68 -0.2494948 0.0401877 45 -0.3283540 0.0276555 23 -0.1841797 0.4001977 -0.1441744 0.5691285 0.9989514
cor…1038 FumG24m2 Pemetrexed/Cisplatin (uM) 67 0.1216075 0.3269321 45 0.1843864 0.2253118 22 0.0291493 0.8975409 0.1552371 0.5692455 0.9989514
cor…1039 GlyG6m2 Docetaxel (nM) 63 -0.3329397 0.0076705 41 -0.3971945 0.0101293 22 -0.2546958 0.2526709 -0.1424986 0.5693314 0.9989514
cor…1040 CitQ24m3 MK-2206 (AKT) (uM) 69 -0.1344077 0.2708607 46 -0.1797534 0.2319458 23 -0.0285025 0.8972817 -0.1512510 0.5713305 0.9989514
cor…1041 GlyG24m1 CDH1 61 0.3493377 0.0057891 38 0.2988007 0.0684119 23 0.4355155 0.0377856 -0.1367148 0.5718114 0.9989514
cor…1042 CitQ6m2 Gemcitabine (nM) 69 -0.3413584 0.0040983 46 -0.3159013 0.0324612 23 -0.4463334 0.0327710 0.1304321 0.5718154 0.9989514
cor…1043 MalG6m3 Sorafenib (multi-kinase) (uM) 73 -0.0489909 0.6806320 48 -0.0996019 0.5005975 25 0.0466656 0.8247010 -0.1462674 0.5729910 0.9989514
cor…1044 CitQ6m4 Crizotinib (ALK) (uM) 73 -0.0962957 0.4176898 48 -0.1393882 0.3447214 25 0.0063245 0.9760643 -0.1457127 0.5730082 0.9989514
cor…1045 LacG6m2 Carboplatin (uM) 69 0.1882106 0.1214515 46 0.1623217 0.2811280 23 0.3058986 0.1557472 -0.1435769 0.5737783 0.9989514
cor…1046 MalQ24m3 Crizotinib (ALK) (uM) 75 0.0434063 0.7115538 49 0.0953183 0.5147309 26 -0.0479502 0.8160661 0.1432684 0.5739196 0.9989514
cor…1047 LacG6m1 Cisplatin (uM) 70 0.1269617 0.2949348 46 0.1998363 0.1830140 24 0.0531396 0.8052129 0.1466967 0.5747435 0.9989514
cor…1048 CitG6m3 Docetaxel (nM) 67 0.0444234 0.7211258 45 0.1010563 0.5089178 22 -0.0530822 0.8145121 0.1541385 0.5762054 0.9989514
cor…1049 LacQ6m3 Erlotinib (EGFR) (uM) 73 -0.1927993 0.1022129 48 -0.2518840 0.0841549 25 -0.1116047 0.5953363 -0.1402792 0.5763472 0.9989514
cor…1050 SerG6m2 SCH772984 (ERK) (uM) 67 -0.0894838 0.4714518 44 -0.1821919 0.2365434 23 -0.0322556 0.8838399 -0.1499363 0.5773704 0.9989514
cor…1051 FumQ6m2 Gefitinib (EGFR) (uM) 72 -0.0719007 0.5483744 47 -0.1422486 0.3401803 25 0.0022109 0.9916316 -0.1444595 0.5775566 0.9989514
cor…1052 CitQ24m1 8-Cl-adenosine (uM) 69 -0.0276512 0.8215631 46 0.0085473 0.9550419 23 -0.1411631 0.5205677 0.1497105 0.5777720 0.9989514
cor…1053 MalQ6m4 CDH1 66 -0.0963067 0.4417503 43 -0.0307392 0.8448632 23 -0.1811563 0.4081108 0.1504172 0.5778059 0.9989514
cor…1054 SerG24m1 Gemcitabine/Cisplatin (nM) 62 -0.0368192 0.7763253 41 -0.1268119 0.4294820 21 0.0316223 0.8917647 -0.1584341 0.5781108 0.9989514
cor…1055 MalQ6m3 MK-2206 (AKT) (uM) 70 0.0247102 0.8390972 46 0.0789500 0.6019881 24 -0.0686549 0.7499085 0.1476048 0.5785769 0.9989514
cor…1056 CitG24m1 Beta-catenin 57 0.0892982 0.5088868 36 0.0213057 0.9018405 21 0.1815615 0.4309002 -0.1602558 0.5796794 0.9989514
cor…1057 LacG24m2 Etoposide (uM) 71 0.0318093 0.7922894 47 0.0741603 0.6203109 24 -0.0721486 0.7376080 0.1463088 0.5805235 0.9989514
cor…1058 MalQ6m4 MK-2206 (AKT) (uM) 70 -0.0836259 0.4912805 46 -0.1397643 0.3542392 24 0.0062905 0.9767275 -0.1460548 0.5808958 0.9989514
cor…1059 SerG24m1 Gefitinib (EGFR) (uM) 66 -0.2968246 0.0155138 43 -0.2810166 0.0679364 23 -0.4135642 0.0498068 0.1325476 0.5810828 0.9989514
cor…1060 GlyG24m2 Beta-catenin 53 -0.1833664 0.1887549 32 -0.2127985 0.2422710 21 -0.0509373 0.8264376 -0.1618611 0.5821271 0.9989514
cor…1061 SerG6m2 CDH1 56 0.1503027 0.2688611 37 0.0796834 0.6392085 19 0.2417412 0.3187256 -0.1620578 0.5822592 0.9989514
cor…1062 LacG24m3 Sorafenib (multi-kinase) (uM) 73 0.0250034 0.8336871 48 -0.0823062 0.5781099 25 0.0602144 0.7749414 -0.1425205 0.5831135 0.9989514
cor…1063 CitQ24m4 Cisplatin (uM) 68 -0.0381449 0.7574499 45 -0.0880471 0.5651992 23 0.0607010 0.7832156 -0.1487481 0.5832591 0.9989514
cor…1064 CitG6m3 SCH772984 (ERK) (uM) 76 -0.3685283 0.0010543 50 -0.3167511 0.0250149 26 -0.4362853 0.0258664 0.1195342 0.5832807 0.9989514
cor…1065 CitQ6m3 MK-2206 (AKT) (uM) 69 -0.0432183 0.7243851 46 -0.0859815 0.5699263 23 0.0620081 0.7786592 -0.1479896 0.5837898 0.9989514
cor…1066 GlyG6m2 Gefitinib (EGFR) (uM) 65 -0.0153976 0.9031064 41 -0.1136394 0.4792925 24 0.0345261 0.8727546 -0.1481655 0.5845363 0.9989514
cor…1067 LacQ24m3 Crizotinib (ALK) (uM) 75 -0.2737275 0.0174867 49 -0.2162454 0.1356043 26 -0.3444843 0.0848264 0.1282389 0.5850068 0.9989514
cor…1068 CitG24m2 Etoposide (uM) 69 0.1079117 0.3774593 46 0.0605219 0.6894884 23 0.2048635 0.3483991 -0.1443417 0.5865178 0.9989514
cor…1069 CitG6m6 Pemetrexed (uM) 68 0.2037039 0.0956810 46 0.1819494 0.2261974 22 0.3216567 0.1443557 -0.1397073 0.5873498 0.9989514
cor…1070 CitG6m1 SCH772984 (ERK) (uM) 76 -0.2514622 0.0284370 50 -0.1875283 0.1922027 26 -0.3165858 0.1150888 0.1290575 0.5874090 0.9989514
cor…1071 CitQ24m6 Gefitinib (EGFR) (uM) 70 -0.1847684 0.1257036 46 -0.1477175 0.3272418 24 -0.2850559 0.1769698 0.1373385 0.5876182 0.9989514
cor…1072 FumQ24m3 Sorafenib (multi-kinase) (uM) 73 0.0910452 0.4436422 48 0.1456608 0.3232273 25 0.0057014 0.9784218 0.1399594 0.5878110 0.9989514
cor…1073 FumQ24m3 Paclitaxel (nM) 73 0.1309253 0.2695585 48 0.1794158 0.2223914 25 0.0404948 0.8475961 0.1389210 0.5881839 0.9989514
cor…1074 CitQ6m6 E-cadherin 57 -0.1143494 0.3970088 36 -0.1809472 0.2909151 21 -0.0244595 0.9161860 -0.1564877 0.5885652 0.9989514
cor…1075 FumQ24m1 Carboplatin (uM) 69 -0.0625181 0.6098228 46 -0.0217890 0.8857136 23 -0.1665932 0.4474154 0.1448042 0.5886550 0.9989514
cor…1076 FumQ24m3 Vinorelbine (nM) 72 -0.0863064 0.4709931 47 -0.1444284 0.3327550 25 -0.0043915 0.9833786 -0.1400369 0.5890624 0.9989514
cor…1077 CitQ24m3 Doxorubicin (nM) 71 -0.0373571 0.7570957 47 0.0051019 0.9728491 24 -0.1371280 0.5228525 0.1422300 0.5895200 0.9989514
cor…1078 FumG6m1 Carboplatin (uM) 69 0.1031001 0.3992187 46 0.0694201 0.6466461 23 0.2122560 0.3308933 -0.1428358 0.5895915 0.9989514
cor…1079 SerG24m2 SCH772984 (ERK) (uM) 72 -0.1138330 0.3410463 46 -0.1881176 0.2105785 26 -0.0513379 0.8033124 -0.1367798 0.5905215 0.9989514
cor…1080 MalG6m3 EGFR-pY1173 59 -0.1176644 0.3747838 37 -0.2943051 0.0770378 22 -0.1482215 0.5103516 -0.1460836 0.5909357 0.9989514
cor…1081 SerG24m3 Gefitinib (EGFR) (uM) 66 -0.0696720 0.5782934 43 -0.1247893 0.4252717 23 0.0216438 0.9219144 -0.1464330 0.5912000 0.9989514
cor…1082 CitG6m4 Gefitinib (EGFR) (uM) 70 0.2591135 0.0303109 46 0.3297070 0.0252459 24 0.1978754 0.3540054 0.1318316 0.5938203 0.9989514
cor…1083 CitQ24m6 Pemetrexed/Cisplatin (uM) 65 -0.1507390 0.2306917 44 -0.1682548 0.2749421 21 -0.0200679 0.9311962 -0.1481869 0.5962503 0.9989514
cor…1084 CitQ24m3 SCH772984 (ERK) (uM) 76 -0.0539312 0.6435751 50 -0.0225832 0.8762945 26 -0.1560690 0.4464515 0.1334858 0.5963872 0.9989514
cor…1085 MalQ24m1 Gemcitabine/Cisplatin (nM) 67 -0.1236814 0.3186873 45 -0.0747587 0.6255014 22 -0.2175584 0.3307568 0.1427996 0.5969675 0.9989514
cor…1086 FumG6m1 SCH772984 (ERK) (uM) 78 -0.2497695 0.0274281 51 -0.2762591 0.0497219 27 -0.1511929 0.4515760 -0.1250662 0.5995374 0.9989514
cor…1087 MalQ24m1 Gemcitabine (nM) 71 -0.2411596 0.0427661 47 -0.1876189 0.2066379 24 -0.3177284 0.1302873 0.1301095 0.5995695 0.9989514
cor…1088 FumQ6m2 Carboplatin (uM) 69 -0.1241465 0.3094689 46 -0.1688045 0.2620960 23 -0.0283631 0.8977816 -0.1404415 0.5996610 0.9989514
cor…1089 FumG6m4 MK-2206 (AKT) (uM) 71 0.1347425 0.2625749 47 0.1964314 0.1857228 24 0.0598832 0.7810470 0.1365482 0.6000603 0.9989514
cor…1090 FumG24m4 Pemetrexed (uM) 70 0.0459112 0.7058735 47 -0.0035294 0.9812155 23 0.1367513 0.5338126 -0.1402807 0.6007155 0.9989514
cor…1091 CitQ24m3 Docetaxel (nM) 67 -0.0955320 0.4418883 45 -0.0421046 0.7836082 22 -0.1846868 0.4106181 0.1425822 0.6007170 0.9989514
cor…1092 CitQ24m4 SCH772984 (ERK) (uM) 76 0.1922389 0.0961762 50 0.2725741 0.0554827 26 0.1454973 0.4782039 0.1270768 0.6009265 0.9989514
cor…1093 FumG6m3 Pemetrexed (uM) 70 0.1287422 0.2881594 47 0.0758070 0.6125465 23 0.2133637 0.3283163 -0.1375567 0.6017550 0.9989514
cor…1094 FumG24m3 Gemcitabine/Cisplatin (nM) 67 -0.2164297 0.0785554 45 -0.1808682 0.2344418 22 -0.3159027 0.1520851 0.1350346 0.6019562 0.9989514
cor…1095 FumQ6m1 Gefitinib (EGFR) (uM) 72 0.1761127 0.1389252 47 0.1159762 0.4375673 25 0.2473109 0.2333113 -0.1313347 0.6023551 0.9989514
cor…1096 CitG6m2 Doxorubicin (nM) 71 -0.0548996 0.6493074 47 -0.1035828 0.4883894 24 0.0342000 0.8739471 -0.1377828 0.6024068 0.9989514
cor…1097 LacQ6m3 Sorafenib (multi-kinase) (uM) 73 -0.1340138 0.2583248 48 -0.0351734 0.8123945 25 -0.1688629 0.4197194 0.1336895 0.6029796 0.9989514
cor…1098 SerG24m3 Crizotinib (ALK) (uM) 70 -0.1625245 0.1788675 45 -0.2233867 0.1401945 25 -0.0900929 0.6684509 -0.1332938 0.6029945 0.9989514
cor…1099 FumQ6m4 Gemcitabine (nM) 71 -0.1107638 0.3577923 47 -0.0490782 0.7432136 24 -0.1845084 0.3880855 0.1354302 0.6040905 0.9989514
cor…1100 FumG24m2 Gemcitabine/Cisplatin (nM) 67 0.0468822 0.7063724 45 0.0855245 0.5764370 22 -0.0574561 0.7995175 0.1429806 0.6043652 0.9989514
cor…1101 CitQ24m2 SCH772984 (ERK) (uM) 76 -0.0023818 0.9837085 50 0.0636721 0.6604528 26 -0.0674837 0.7432513 0.1311557 0.6057493 0.9989514
cor…1102 MalG24m4 CDH1 66 0.2832524 0.0211888 43 0.3277140 0.0319308 23 0.1963506 0.3692193 0.1313634 0.6058067 0.9989514
cor…1103 FumQ24m1 Docetaxel (nM) 69 -0.0189233 0.8773489 46 0.0349604 0.8175807 23 -0.1041389 0.6363057 0.1390993 0.6062857 0.9989514
cor…1104 CitQ6m4 Sorafenib (multi-kinase) (uM) 71 -0.1676844 0.1621813 47 -0.2027439 0.1717015 24 -0.0690135 0.7486431 -0.1337304 0.6068792 0.9989514
cor…1105 LacG24m2 MK-2206 (AKT) (uM) 71 -0.0681967 0.5720098 47 -0.1047681 0.4833996 24 0.0312894 0.8846016 -0.1360575 0.6069199 0.9989514
cor…1106 FumQ24m1 Pemetrexed/Cisplatin (uM) 67 -0.0044788 0.9713059 45 -0.0461495 0.7633925 22 0.0955536 0.6722989 -0.1417031 0.6074601 0.9989514
cor…1107 MalQ24m4 AZD6244 (MEK) (uM) 71 0.1118626 0.3530135 47 0.1815188 0.2220498 24 0.0472837 0.8263398 0.1342351 0.6074992 0.9989514
cor…1108 CitG24m6 AZD6244 (MEK) (uM) 69 -0.1727959 0.1556562 46 -0.1375302 0.3620602 23 -0.2705028 0.2118943 0.1329725 0.6075604 0.9989514
cor…1109 FumQ6m4 Gefitinib (EGFR) (uM) 72 -0.3300928 0.0046294 47 -0.2607354 0.0767041 25 -0.3806446 0.0604968 0.1199092 0.6080499 0.9989514
cor…1110 MalG6m1 8-Cl-adenosine (uM) 71 -0.0634575 0.5990679 47 -0.0264527 0.8599028 24 -0.1609282 0.4525239 0.1344755 0.6084309 0.9989514
cor…1111 FumQ24m3 Doxorubicin (nM) 73 -0.0257615 0.8287203 48 -0.0701001 0.6358929 25 0.0629554 0.7649719 -0.1330555 0.6084936 0.9989514
cor…1112 LacG6m1 Gemcitabine/Cisplatin (nM) 67 -0.0965224 0.4371480 45 -0.0408612 0.7898518 22 -0.1801289 0.4224629 0.1392677 0.6094758 0.9989514
cor…1113 LacQ6m2 Crizotinib (ALK) (uM) 75 -0.1758381 0.1312961 49 -0.2179425 0.1324879 26 -0.0914030 0.6569877 -0.1265395 0.6111660 0.9989514
cor…1114 MalQ24m2 Pemetrexed (uM) 70 -0.1469411 0.2247999 47 -0.0896105 0.5491708 23 -0.2230351 0.3063325 0.1334246 0.6114562 0.9989514
cor…1115 FumQ6m4 Vinorelbine (nM) 72 -0.2736909 0.0200021 47 -0.2165677 0.1437002 25 -0.3385247 0.0978727 0.1219571 0.6121891 0.9989514
cor…1116 CitG6m5 E-cadherin 57 -0.1707895 0.2040056 36 -0.2249403 0.1871729 21 -0.0802605 0.7294653 -0.1446799 0.6124879 0.9989514
cor…1117 MalG24m2 Erlotinib (EGFR) (uM) 73 0.0658500 0.5799121 48 0.0305587 0.8366472 25 0.1606992 0.4428629 -0.1301405 0.6131225 0.9989514
cor…1118 FumQ6m1 Pemetrexed (uM) 70 -0.1175488 0.3324751 47 -0.0778853 0.6028072 23 -0.2109953 0.3338406 0.1331101 0.6136080 0.9989514
cor…1119 CitG6m5 Docetaxel (nM) 67 -0.0434366 0.7270759 45 -0.0989223 0.5179515 22 0.0400377 0.8595854 -0.1389600 0.6143626 0.9989514
cor…1120 MalQ6m4 Doxorubicin (nM) 72 -0.2074107 0.0804291 47 -0.1617453 0.2773985 25 -0.2864507 0.1650699 0.1247055 0.6144918 0.9989514
cor…1121 LacG24m2 CDH1 66 -0.0579400 0.6440086 43 -0.0998849 0.5239391 23 0.0376734 0.8644913 -0.1375583 0.6145585 0.9989514
cor…1122 CitG6m4 Etoposide (uM) 69 -0.0682381 0.5774434 46 -0.1167125 0.4398519 23 0.0190009 0.9314261 -0.1357134 0.6146813 0.9989514
cor…1123 FumQ6m3 MK-2206 (AKT) (uM) 71 0.0458403 0.7042419 47 0.0927990 0.5349895 24 -0.0402749 0.8517796 0.1330739 0.6150880 0.9989514
cor…1124 CitQ24m5 SCH772984 (ERK) (uM) 76 0.0908340 0.4351767 50 0.0954693 0.5095721 26 -0.0320219 0.8765932 0.1274911 0.6155295 0.9989514
cor…1125 MalG24m1 Sorafenib (multi-kinase) (uM) 73 0.0088297 0.9408986 48 0.0242584 0.8699980 25 -0.1057860 0.6147767 0.1300444 0.6160668 0.9989514
cor…1126 MalG24m4 E-cadherin 59 -0.1504968 0.2552253 37 -0.1072611 0.5274671 22 -0.2461271 0.2695299 0.1388660 0.6161054 0.9989514
cor…1127 CitQ24m4 CDH1 64 -0.1112125 0.3816374 42 -0.0529675 0.7390261 22 -0.1908574 0.3948765 0.1378899 0.6162611 0.9989514
cor…1128 CitQ6m6 Cisplatin (uM) 68 -0.1740229 0.1558177 45 -0.2120965 0.1618966 23 -0.0792414 0.7192948 -0.1328552 0.6167687 0.9989514
cor…1129 FumG24m2 Crizotinib (ALK) (uM) 75 0.1599740 0.1703770 49 0.2054457 0.1567310 26 0.0804837 0.6959156 0.1249620 0.6168958 0.9989514
cor…1130 MalG6m3 AZD6244 (MEK) (uM) 71 -0.0452253 0.7080303 47 -0.0864712 0.5633060 24 0.0458107 0.8316730 -0.1322820 0.6172977 0.9989514
cor…1131 CitQ6m2 Crizotinib (ALK) (uM) 73 0.0398315 0.7379425 48 0.0820111 0.5794781 25 -0.0477586 0.8206595 0.1297697 0.6173000 0.9989514
cor…1132 SerG24m2 Docetaxel (nM) 65 -0.0173027 0.8911873 43 -0.0581966 0.7108686 22 0.0804594 0.7218878 -0.1386560 0.6181270 0.9989514
cor…1133 MalQ24m1 Doxorubicin (nM) 73 -0.0023541 0.9842298 48 -0.0394695 0.7899709 25 0.0899373 0.6689915 -0.1294068 0.6181657 0.9989514
cor…1134 FumQ6m3 Etoposide (uM) 71 -0.0224810 0.8523748 47 -0.0687076 0.6463096 24 0.0631476 0.7694177 -0.1318552 0.6185801 0.9989514
cor…1135 LacG24m3 AZD6244 (MEK) (uM) 71 0.1574566 0.1897224 47 0.1035041 0.4887214 24 0.2314263 0.2765577 -0.1279222 0.6191862 0.9989514
cor…1136 MalG6m4 Paclitaxel (nM) 73 -0.0825542 0.4874589 48 -0.1351900 0.3595881 25 -0.0069929 0.9735351 -0.1281971 0.6199039 0.9989514
cor…1137 CitQ24m1 MK-2206 (AKT) (uM) 69 0.0110997 0.9278742 46 -0.0262098 0.8627295 23 0.1075996 0.6250717 -0.1338093 0.6199282 0.9989514
cor…1138 LacG6m2 Paclitaxel/Carboplatin (nM) 70 0.1478845 0.2218049 46 0.1802010 0.2307661 24 0.0504517 0.8148950 0.1297493 0.6208246 0.9989514
cor…1139 FumQ6m4 Sorafenib (multi-kinase) (uM) 73 -0.0991021 0.4041848 48 -0.0227931 0.8777889 25 -0.1502442 0.4734690 0.1274511 0.6210882 0.9989514
cor…1140 CitQ6m5 Paclitaxel/Carboplatin (nM) 68 -0.1747176 0.1541473 45 -0.1321161 0.3869710 23 -0.2603102 0.2302939 0.1281941 0.6230263 0.9989514
cor…1141 LacQ24m3 SCH772984 (ERK) (uM) 78 -0.2526607 0.0256311 51 -0.1976390 0.1644713 27 -0.3123452 0.1126997 0.1147063 0.6230934 0.9989514
cor…1142 FumQ6m2 Sorafenib (multi-kinase) (uM) 73 -0.1633362 0.1673555 48 -0.2239263 0.1260131 25 -0.0999179 0.6346413 -0.1240084 0.6239675 0.9989514
cor…1143 SerG24m3 CDH1 60 0.1296275 0.3235734 38 0.1580331 0.3433271 22 0.0198448 0.9301506 0.1381883 0.6244064 0.9989514
cor…1144 CitG6m1 MK-2206 (AKT) (uM) 69 0.2470937 0.0406703 46 0.2186920 0.1442453 23 0.3404214 0.1119576 -0.1217294 0.6250111 0.9989514
cor…1145 CitG6m6 SCH772984 (ERK) (uM) 76 -0.1599528 0.1675156 50 -0.1775787 0.2172980 26 -0.0554284 0.7879780 -0.1221502 0.6260653 0.9989514
cor…1146 SerG24m2 Sorafenib (multi-kinase) (uM) 67 -0.1829452 0.1383861 44 -0.2715133 0.0746147 23 -0.1446679 0.5101591 -0.1268454 0.6263112 0.9989514
cor…1147 MalQ24m4 Pemetrexed (uM) 70 -0.0783346 0.5191960 47 -0.0093956 0.9500215 23 -0.1391248 0.5266673 0.1297293 0.6280910 0.9989514
cor…1148 CitQ24m3 Gemcitabine (nM) 69 0.0025178 0.9836185 46 0.0162274 0.9147590 23 -0.1142552 0.6036933 0.1304826 0.6284210 0.9989514
cor…1149 MalQ24m4 Beta-catenin 59 0.1101125 0.4064131 37 0.0520951 0.7594417 22 0.1882726 0.4014290 -0.1361775 0.6289552 0.9989514
cor…1150 LacQ24m3 Paclitaxel (nM) 73 -0.1743452 0.1401535 48 -0.1361710 0.3560797 25 -0.2564465 0.2159355 0.1202755 0.6301125 0.9989514
cor…1151 GlyG24m1 Crizotinib (ALK) (uM) 71 0.1026428 0.3943337 45 0.0499658 0.7444602 26 0.1730861 0.3977911 -0.1231203 0.6303303 0.9989514
cor…1152 CitG6m5 Gemcitabine/Cisplatin (nM) 65 -0.1416236 0.2604472 44 -0.1666412 0.2796382 21 -0.0322656 0.8895758 -0.1343757 0.6306876 0.9989514
cor…1153 CitG6m2 E-cadherin 57 -0.4646878 0.0002710 36 -0.5086991 0.0015347 21 -0.3971965 0.0746011 -0.1115026 0.6312047 0.9989514
cor…1154 LacG6m2 CDH1 66 -0.0952847 0.4466329 43 -0.1297369 0.4069994 23 0.0008509 0.9969257 -0.1305878 0.6315658 0.9989514
cor…1155 LacQ24m3 Gemcitabine (nM) 71 -0.0538883 0.6553545 47 0.0041397 0.9779680 24 -0.1222320 0.5693658 0.1263717 0.6320958 0.9989514
cor…1156 MalQ24m3 AZD6244 (MEK) (uM) 71 -0.0652165 0.5889587 47 -0.0278490 0.8525875 24 -0.1535725 0.4737120 0.1257235 0.6322167 0.9989514
cor…1157 MalG24m2 AZD6244 (MEK) (uM) 71 -0.0304948 0.8006919 47 0.0026574 0.9858559 24 -0.1234705 0.5654297 0.1261279 0.6326991 0.9989514
cor…1158 GlyG24m2 Etoposide (uM) 67 -0.1156938 0.3511768 43 -0.0833062 0.5953474 24 -0.2091416 0.3266974 0.1258354 0.6327487 0.9989514
cor…1159 FumG24m1 Pemetrexed/Cisplatin (uM) 67 -0.1014069 0.4141923 45 -0.1747214 0.2509930 22 -0.0445142 0.8440627 -0.1302071 0.6330838 0.9989514
cor…1160 CitQ6m1 Vinorelbine (nM) 70 0.0402028 0.7410689 46 0.0906706 0.5489924 24 -0.0360789 0.8670803 0.1267495 0.6332916 0.9989514
cor…1161 MalG6m4 Gefitinib (EGFR) (uM) 72 0.0461819 0.7000793 47 0.1150197 0.4413815 25 -0.0088553 0.9664906 0.1238750 0.6338150 0.9989514
cor…1162 LacG6m1 8-Cl-adenosine (uM) 71 -0.0418383 0.7290196 47 -0.0018224 0.9902999 24 -0.1273853 0.5530685 0.1255629 0.6340481 0.9989514
cor…1163 MalG6m2 Gemcitabine (nM) 71 -0.2149686 0.0718105 47 -0.1877005 0.2064369 24 -0.3058331 0.1461189 0.1181326 0.6347717 0.9989514
cor…1164 CitQ24m2 EGFR-pY1173 57 -0.0256791 0.8496156 36 -0.2065935 0.2266977 21 -0.0704425 0.7615711 -0.1361511 0.6351074 0.9989514
cor…1165 CitQ24m1 Etoposide (uM) 69 -0.1661359 0.1724670 46 -0.1305348 0.3872182 23 -0.2539911 0.2422140 0.1234563 0.6352398 0.9989514
cor…1166 FumG24m3 MK-2206 (AKT) (uM) 71 0.0434355 0.7190959 47 -0.0018845 0.9899694 24 0.1225154 0.5684639 -0.1244000 0.6373829 0.9989514
cor…1167 LacQ24m1 Etoposide (uM) 71 -0.0051439 0.9660410 47 0.0258058 0.8632958 24 -0.0984907 0.6470514 0.1242965 0.6384492 0.9989514
cor…1168 FumG24m2 Cisplatin (uM) 70 0.0428886 0.7244383 46 0.0836065 0.5806674 24 -0.0411281 0.8486746 0.1247346 0.6388155 0.9989514
cor…1169 FumQ6m2 Gemcitabine/Cisplatin (nM) 67 -0.1444638 0.2434671 45 -0.1243816 0.4156070 22 -0.2493300 0.2631469 0.1249483 0.6390694 0.9989514
cor…1170 MalQ6m2 Sorafenib (multi-kinase) (uM) 72 -0.1981108 0.0952791 47 -0.2434595 0.0991380 25 -0.1255948 0.5497062 -0.1178647 0.6398276 0.9989514
cor…1171 MalQ24m4 Erlotinib (EGFR) (uM) 73 -0.1330496 0.2617971 48 -0.1781372 0.2257592 25 -0.0583210 0.7818479 -0.1198161 0.6399996 0.9989514
cor…1172 MalG6m4 Vinorelbine (nM) 72 0.1665159 0.1621169 47 0.1157088 0.4386318 25 0.2338761 0.2605019 -0.1181673 0.6401844 0.9989514
cor…1173 LacG24m3 CDH1 66 0.0898846 0.4729247 43 0.1531698 0.3267866 23 0.0265222 0.9043855 0.1266476 0.6405961 0.9989514
cor…1174 GlyG6m1 Docetaxel (nM) 63 0.0761790 0.5529087 41 0.0210678 0.8959793 22 0.1504426 0.5039624 -0.1293748 0.6422664 0.9989514
cor…1175 CitG6m2 Paclitaxel (nM) 71 -0.2019577 0.0912248 47 -0.2358344 0.1105191 24 -0.1168906 0.5864791 -0.1189438 0.6430123 0.9989514
cor…1176 CitQ24m3 CDH1 64 -0.2650814 0.0342696 42 -0.3050693 0.0494697 22 -0.1834771 0.4137441 -0.1215923 0.6433989 0.9989514
cor…1177 FumQ6m1 Cisplatin (uM) 70 0.0800731 0.5099368 46 0.1171913 0.4379650 24 -0.0051978 0.9807691 0.1223891 0.6442565 0.9989514
cor…1178 FumG6m2 Cisplatin (uM) 70 0.0609126 0.6164270 46 0.1035367 0.4935091 24 -0.0187318 0.9307708 0.1222685 0.6450302 0.9989514
cor…1179 CitG6m1 8-Cl-adenosine (uM) 69 0.0350796 0.7747573 46 0.0064297 0.9661728 23 0.1299250 0.5546117 -0.1234952 0.6462298 0.9989514
cor…1180 CitG6m4 SCH772984 (ERK) (uM) 76 -0.2040441 0.0770633 50 -0.1340179 0.3534720 26 -0.2464498 0.2248708 0.1124319 0.6462373 0.9989514
cor…1181 FumG24m3 Carboplatin (uM) 69 -0.1791364 0.1408112 46 -0.2229424 0.1364159 23 -0.1022374 0.6425119 -0.1207050 0.6464402 0.9989514
cor…1182 FumQ24m4 Gemcitabine (nM) 71 0.0249114 0.8366246 47 0.0945616 0.5272272 24 -0.0266554 0.9016046 0.1212170 0.6468661 0.9989514
cor…1183 CitQ6m3 Gefitinib (EGFR) (uM) 70 -0.2585459 0.0306883 46 -0.3037858 0.0401251 24 -0.1894588 0.3752536 -0.1143270 0.6470090 0.9989514
cor…1184 MalG24m3 EGFR-pY1173 59 -0.0961203 0.4689454 37 -0.2398703 0.1527260 22 -0.1130168 0.6165383 -0.1268535 0.6470807 0.9989514
cor…1185 LacQ6m1 Erlotinib (EGFR) (uM) 73 0.1949968 0.0982883 48 0.1760311 0.2313829 25 0.2882065 0.1623805 -0.1121754 0.6481190 0.9989514
cor…1186 CitG6m4 Crizotinib (ALK) (uM) 73 0.0070697 0.9526643 48 -0.0285318 0.8473486 25 0.0893582 0.6710054 -0.1178900 0.6497466 0.9989514
cor…1187 LacQ24m2 Pemetrexed/Cisplatin (uM) 67 -0.0997002 0.4221331 45 -0.0266253 0.8621702 22 -0.1509549 0.5024943 0.1243296 0.6499225 0.9989514
cor…1188 CitG24m1 E-cadherin 57 0.1163856 0.3885993 36 0.1377250 0.4231231 21 0.0056616 0.9805687 0.1320635 0.6500380 0.9989514
cor…1189 LacQ6m3 Carboplatin (uM) 69 -0.0373413 0.7606556 46 0.0055545 0.9707755 23 -0.1166730 0.5960032 0.1222275 0.6501413 0.9989514
cor…1190 MalQ6m2 Paclitaxel/Carboplatin (nM) 69 -0.0656966 0.5917325 45 -0.0239102 0.8761093 24 -0.1440602 0.5018453 0.1201500 0.6503191 0.9989514
cor…1191 FumQ6m1 Carboplatin (uM) 69 0.0392228 0.7489836 46 0.0733835 0.6279119 23 -0.0491215 0.8238665 0.1225049 0.6503665 0.9989514
cor…1192 SerG24m2 Paclitaxel/Carboplatin (nM) 63 -0.0968985 0.4499569 41 -0.1472009 0.3584021 22 -0.0209338 0.9263274 -0.1262672 0.6503967 0.9989514
cor…1193 FumG24m3 SCH772984 (ERK) (uM) 78 -0.0749605 0.5142313 51 -0.1113365 0.4366792 27 0.0010024 0.9960410 -0.1123389 0.6518386 0.9989514
cor…1194 CitQ6m5 Gemcitabine (nM) 69 0.0168374 0.8907804 46 -0.0043832 0.9769361 23 -0.1257579 0.5674859 0.1213747 0.6520503 0.9989514
cor…1195 FumQ6m3 Gemcitabine/Cisplatin (nM) 67 -0.0433938 0.7273342 45 -0.0706156 0.6448345 22 0.0537757 0.8121302 -0.1243913 0.6523322 0.9989514
cor…1196 MalQ6m1 Gefitinib (EGFR) (uM) 71 0.1416838 0.2385517 46 0.1898933 0.2062253 25 0.0742683 0.7242250 0.1156251 0.6530838 0.9989514
cor…1197 LacG24m2 Gemcitabine/Cisplatin (nM) 67 0.0409136 0.7423617 45 0.0804345 0.5994167 22 -0.0435907 0.8472605 0.1240252 0.6532033 0.9989514
cor…1198 CitG24m3 Sorafenib (multi-kinase) (uM) 71 -0.1060462 0.3787584 47 -0.0514720 0.7311469 24 -0.1690006 0.4298574 0.1175285 0.6533436 0.9989514
cor…1199 MalG6m3 Erlotinib (EGFR) (uM) 73 0.0621026 0.6017043 48 0.1149888 0.4364200 25 -0.0012796 0.9951566 0.1162684 0.6535065 0.9989514
cor…1200 SerG6m2 E-cadherin 50 -0.0928299 0.5213985 32 -0.0267688 0.8843727 18 -0.1676696 0.5060344 0.1409008 0.6541288 0.9989514
cor…1201 LacQ6m2 Doxorubicin (nM) 73 0.2680953 0.0218350 48 0.3019731 0.0369828 25 0.1927308 0.3560002 0.1092422 0.6542329 0.9989514
cor…1202 MalQ24m2 CDH1 66 0.3377176 0.0055509 43 0.3851351 0.0107629 23 0.2767474 0.2011218 0.1083877 0.6561860 0.9989514
cor…1203 CitQ24m1 Pemetrexed (uM) 68 -0.0825340 0.5034204 46 -0.1117229 0.4597812 22 0.0100859 0.9644687 -0.1218088 0.6571321 0.9989514
cor…1204 FumQ24m4 Sorafenib (multi-kinase) (uM) 73 0.0876011 0.4611440 48 0.1664712 0.2581153 25 0.0529146 0.8016568 0.1135566 0.6582506 0.9989514
cor…1205 CitG24m4 Cisplatin (uM) 68 -0.2419001 0.0468781 45 -0.2667937 0.0764591 23 -0.1522001 0.4881360 -0.1145936 0.6586637 0.9989514
cor…1206 CitQ24m3 Cisplatin (uM) 68 0.1266561 0.3033757 45 0.1546534 0.3104052 23 0.0359642 0.8705877 0.1186892 0.6589087 0.9989514
cor…1207 FumQ6m3 Paclitaxel (nM) 73 -0.0766528 0.5192074 48 -0.1176326 0.4258750 25 -0.0033848 0.9871886 -0.1142479 0.6590185 0.9989514
cor…1208 GlyG24m2 Sorafenib (multi-kinase) (uM) 68 -0.2155472 0.0775119 44 -0.3048871 0.0441814 24 -0.1940138 0.3636649 -0.1108733 0.6590678 0.9989514
cor…1209 FumG24m4 EGFR-pY1173 59 0.0342936 0.7965198 37 -0.0435107 0.7981806 22 0.0825129 0.7150724 -0.1260236 0.6594086 0.9989514
cor…1210 MalQ24m4 Gemcitabine/Cisplatin (nM) 67 0.1775748 0.1505443 45 0.1705495 0.2626639 22 0.2858446 0.1971979 -0.1152950 0.6595404 0.9989514
cor…1211 CitG24m6 Etoposide (uM) 69 -0.1074341 0.3795868 46 -0.0726115 0.6315435 23 -0.1893870 0.3867706 0.1167755 0.6602791 0.9989514
cor…1212 MalG6m3 MK-2206 (AKT) (uM) 71 0.1015949 0.3992042 47 0.1430892 0.3373047 24 0.0276042 0.8981195 0.1154850 0.6605762 0.9989514
cor…1213 MalG6m2 EGFR-pY1173 59 -0.1844250 0.1620191 37 -0.3473833 0.0351498 22 -0.2324349 0.2979121 -0.1149484 0.6607644 0.9989514
cor…1214 CitQ6m6 Paclitaxel (nM) 71 -0.1257751 0.2959555 47 -0.1770908 0.2337238 24 -0.0625689 0.7714758 -0.1145219 0.6609580 0.9989514
cor…1215 MalG6m3 Etoposide (uM) 71 -0.1593936 0.1842637 47 -0.1208257 0.4185129 24 -0.2329146 0.2733934 0.1120889 0.6622611 0.9989514
cor…1216 CitG24m4 Etoposide (uM) 69 -0.1397297 0.2521653 46 -0.1063198 0.4819012 23 -0.2211542 0.3105354 0.1148344 0.6624634 0.9989514
cor…1217 FumG6m3 8-Cl-adenosine (uM) 71 -0.0933148 0.4389198 47 -0.1333344 0.3716007 24 -0.0184718 0.9317294 -0.1148626 0.6627836 0.9989514
cor…1218 MalG6m4 Cisplatin (uM) 70 -0.0209852 0.8630975 46 0.0247017 0.8705587 24 -0.0911308 0.6719318 0.1158325 0.6627885 0.9989514
cor…1219 GlyG6m2 E-cadherin 53 0.0205510 0.8838729 32 0.0834601 0.6497342 21 -0.0471248 0.8392589 0.1305849 0.6628692 0.9989514
cor…1220 SerG24m2 Paclitaxel (nM) 67 0.0022053 0.9858689 44 -0.0364068 0.8145033 23 0.0815467 0.7114631 -0.1179534 0.6648760 0.9989514
cor…1221 LacQ24m3 Sorafenib (multi-kinase) (uM) 73 -0.0046858 0.9686157 48 0.0659566 0.6560302 25 -0.0460781 0.8268752 0.1120346 0.6663578 0.9989514
cor…1222 GlyG24m1 Paclitaxel/Carboplatin (nM) 64 0.1401026 0.2695121 41 0.1838860 0.2497821 23 0.0668063 0.7619944 0.1170798 0.6663874 0.9989514
cor…1223 MalQ24m3 Sorafenib (multi-kinase) (uM) 73 0.1087342 0.3598194 48 0.1517786 0.3030967 25 0.0415222 0.8437754 0.1102564 0.6684519 0.9989514
cor…1224 FumQ24m1 SCH772984 (ERK) (uM) 78 -0.1532801 0.1803074 51 -0.1157504 0.4185989 27 -0.2194741 0.2713597 0.1037237 0.6691405 0.9989514
cor…1225 FumG6m3 Gemcitabine/Cisplatin (nM) 67 -0.2280467 0.0634460 45 -0.2074684 0.1714658 22 -0.3171223 0.1504231 0.1096539 0.6697400 0.9989514
cor…1226 LacG6m1 E-cadherin 59 0.0994832 0.4534607 37 0.1383192 0.4142598 22 0.0174741 0.9384788 0.1208451 0.6708314 0.9989514
cor…1227 CitG6m3 Gemcitabine (nM) 69 -0.0747976 0.5413178 46 -0.0818656 0.5885983 23 0.0326774 0.8823310 -0.1145430 0.6716217 0.9989514
cor…1228 CitQ24m3 Paclitaxel (nM) 71 0.0958341 0.4266071 47 0.1337266 0.3701828 24 0.0223283 0.9175193 0.1113983 0.6722716 0.9989514
cor…1229 MalQ24m3 Gemcitabine/Cisplatin (nM) 67 0.1509067 0.2228540 45 0.1829793 0.2289333 22 0.0684262 0.7622194 0.1145531 0.6734059 0.9989514
cor…1230 FumQ24m2 Etoposide (uM) 71 -0.1552429 0.1961028 47 -0.1154482 0.4396705 24 -0.2232924 0.2942591 0.1078442 0.6751542 0.9989514
cor…1231 GlyG24m2 Vinorelbine (nM) 67 -0.0767430 0.5370643 43 -0.1405556 0.3686528 24 -0.0291344 0.8925030 -0.1114212 0.6767412 0.9989514
cor…1232 FumG6m2 AZD6244 (MEK) (uM) 71 0.0197317 0.8702609 47 0.0531390 0.7227815 24 -0.0573094 0.7902482 0.1104485 0.6767859 0.9989514
cor…1233 LacG6m3 8-Cl-adenosine (uM) 71 -0.1812828 0.1302875 47 -0.1582376 0.2880898 24 -0.2631839 0.2140332 0.1049464 0.6784793 0.9989514
cor…1234 FumQ24m3 Gemcitabine/Cisplatin (nM) 67 0.1650654 0.1819192 45 0.1983043 0.1916055 22 0.0863640 0.7023481 0.1119404 0.6790740 0.9989514
cor…1235 FumG24m4 Gefitinib (EGFR) (uM) 72 -0.0225241 0.8510315 47 0.0195423 0.8962655 25 -0.0878341 0.6763162 0.1073765 0.6802668 0.9989514
cor…1236 LacQ24m1 Gemcitabine (nM) 71 -0.2257383 0.0583773 47 -0.2254717 0.1275511 24 -0.1197895 0.5771639 -0.1056822 0.6809703 0.9989514
cor…1237 GlyG6m1 Doxorubicin (nM) 66 0.0638877 0.6103102 42 0.0090070 0.9548549 24 0.1194958 0.5781046 -0.1104888 0.6815641 0.9989514
cor…1238 MalQ6m2 Gemcitabine/Cisplatin (nM) 66 -0.2226681 0.0723299 44 -0.2011241 0.1904923 22 -0.3073292 0.1641340 0.1062050 0.6820623 0.9989514
cor…1239 MalQ24m3 Gefitinib (EGFR) (uM) 72 -0.2840758 0.0155921 47 -0.2508652 0.0889708 25 -0.3481088 0.0881495 0.0972436 0.6820969 0.9989514
cor…1240 MalG6m1 Gemcitabine (nM) 71 -0.0451600 0.7084329 47 -0.0240663 0.8724316 24 -0.1318610 0.5390893 0.1077947 0.6823079 0.9989514
cor…1241 LacQ24m1 EGFR-pY1173 59 -0.0197655 0.8818790 37 -0.1887569 0.2632044 22 -0.0738403 0.7439924 -0.1149166 0.6827391 0.9989514
cor…1242 MalQ24m1 Etoposide (uM) 71 -0.0888529 0.4612086 47 -0.0539297 0.7188248 24 -0.1609155 0.4525600 0.1069858 0.6829112 0.9989514
cor…1243 FumG6m3 AZD6244 (MEK) (uM) 71 0.0234582 0.8460345 47 -0.0154802 0.9177443 24 0.0922624 0.6680841 -0.1077426 0.6838451 0.9989514
cor…1244 FumQ24m1 Gefitinib (EGFR) (uM) 72 0.0962256 0.4213508 47 0.1409402 0.3446858 25 0.0362186 0.8635337 0.1047216 0.6857644 0.9989514
cor…1245 CitQ24m3 Carboplatin (uM) 67 0.1281742 0.3012864 45 0.1015527 0.5068278 22 0.2102367 0.3476840 -0.1086840 0.6866991 0.9989514
cor…1246 CitG24m3 Gefitinib (EGFR) (uM) 70 0.0122616 0.9197532 46 -0.0267398 0.8599809 24 0.0803281 0.7090579 -0.1070679 0.6870596 0.9989514
cor…1247 CitG24m5 EGFR-pY1173 57 -0.0643958 0.6341451 36 -0.1691527 0.3240208 21 -0.0527300 0.8204235 -0.1164227 0.6871246 0.9989514
cor…1248 CitQ6m5 Erlotinib (EGFR) (uM) 71 -0.2409341 0.0429666 47 -0.2889011 0.0488965 24 -0.1887196 0.3771540 -0.1001815 0.6884175 0.9989514
cor…1249 LacQ24m2 Vinorelbine (nM) 72 0.1041636 0.3838849 47 0.1557640 0.2957885 25 0.0523209 0.8038395 0.1034431 0.6885160 0.9989514
cor…1250 GlyG24m1 Etoposide (uM) 67 -0.0396334 0.7501561 43 0.0056052 0.9715430 24 -0.1019661 0.6354272 0.1075713 0.6887867 0.9989514
cor…1251 SerG6m1 8-Cl-adenosine (uM) 61 -0.0468778 0.7197820 41 -0.0471588 0.7696842 20 -0.1621686 0.4945527 0.1150099 0.6899020 0.9989514
cor…1252 CitQ6m3 Gemcitabine/Cisplatin (nM) 65 -0.1086902 0.3887740 44 -0.1338039 0.3865414 21 -0.0222487 0.9237393 -0.1115552 0.6910852 0.9989514
cor…1253 MalG6m4 SCH772984 (ERK) (uM) 78 -0.0840074 0.4646274 51 -0.0305243 0.8316139 27 -0.1291490 0.5208595 0.0986248 0.6911002 0.9989514
cor…1254 CitQ24m3 Beta-catenin 57 0.3193437 0.0154630 36 0.2928041 0.0830896 21 0.3950460 0.0763312 -0.1022418 0.6918533 0.9989514
cor…1255 MalQ6m2 Gemcitabine (nM) 70 -0.3315441 0.0050516 46 -0.3129488 0.0342071 24 -0.4047270 0.0497889 0.0917782 0.6919565 0.9989514
cor…1256 FumQ6m1 AZD6244 (MEK) (uM) 71 -0.0724875 0.5480129 47 -0.0446426 0.7657327 24 -0.1485667 0.4884154 0.1039242 0.6921840 0.9989514
cor…1257 FumQ24m4 E-cadherin 59 -0.0031290 0.9812354 37 0.0259568 0.8787963 22 -0.0871568 0.6997378 0.1131136 0.6923265 0.9989514
cor…1258 CitG24m3 Doxorubicin (nM) 71 -0.0855907 0.4778886 47 -0.1199361 0.4219724 24 -0.0159031 0.9412058 -0.1040329 0.6932705 0.9989514
cor…1259 MalQ6m3 Crizotinib (ALK) (uM) 74 0.0823304 0.4855772 48 0.0463453 0.7544373 26 0.1462460 0.4759180 -0.0999007 0.6937734 0.9989514
cor…1260 FumQ24m2 Carboplatin (uM) 69 -0.0394601 0.7475150 46 -0.0072540 0.9618392 23 -0.1133104 0.6067093 0.1060564 0.6938382 0.9989514
cor…1261 CitQ24m2 Paclitaxel/Carboplatin (nM) 68 -0.1498548 0.2225690 45 -0.2047528 0.1772672 23 -0.1004038 0.6485181 -0.1043490 0.6938432 0.9989514
cor…1262 CitQ24m2 Crizotinib (ALK) (uM) 73 0.0317128 0.7899738 48 0.0001430 0.9992304 25 0.1016095 0.6288888 -0.1014665 0.6955112 0.9989514
cor…1263 LacG24m2 Crizotinib (ALK) (uM) 75 -0.1123607 0.3371698 49 -0.0772119 0.5979721 26 -0.1754634 0.3912407 0.0982515 0.6955662 0.9989514
cor…1264 FumQ6m3 Beta-catenin 59 0.2336761 0.0748721 37 0.2035018 0.2270251 22 0.3080909 0.1630374 -0.1045891 0.6956506 0.9989514
cor…1265 MalG6m4 Paclitaxel/Carboplatin (nM) 70 0.0402458 0.7408021 46 -0.0068938 0.9637327 24 0.0968296 0.6526361 -0.1037234 0.6959789 0.9989514
cor…1266 CitQ6m1 Erlotinib (EGFR) (uM) 71 0.0365614 0.7621150 47 0.0777497 0.6034402 24 -0.0255881 0.9055266 0.1033379 0.6963652 0.9989514
cor…1267 CitQ6m5 Doxorubicin (nM) 71 -0.0656373 0.5865518 47 -0.0447988 0.7649360 24 -0.1472018 0.4924638 0.1024030 0.6965059 0.9989514
cor…1268 GlyG24m1 Sorafenib (multi-kinase) (uM) 68 -0.0602879 0.6252847 44 -0.1390381 0.3680637 24 -0.0352789 0.8700030 -0.1037592 0.6965467 0.9989514
cor…1269 MalG6m3 CDH1 66 0.2064889 0.0962220 43 0.2479430 0.1089112 23 0.1455052 0.5076873 0.1024378 0.6968912 0.9989514
cor…1270 LacQ24m3 Paclitaxel/Carboplatin (nM) 70 -0.0593807 0.6253369 46 -0.0230626 0.8790816 24 -0.1260576 0.5572469 0.1029950 0.6969866 0.9989514
cor…1271 SerG6m3 8-Cl-adenosine (uM) 61 -0.1738698 0.1802109 41 -0.1942621 0.2235845 20 -0.3003724 0.1981736 0.1061103 0.6981349 0.9989514
cor…1272 MalG24m3 AZD6244 (MEK) (uM) 71 -0.1102997 0.3598228 47 -0.0776690 0.6038175 24 -0.1781789 0.4048490 0.1005099 0.6997839 0.9989514
cor…1273 CitQ24m4 E-cadherin 57 -0.2112678 0.1146658 36 -0.2005998 0.2407588 21 -0.3060546 0.1772463 0.1054549 0.7001925 0.9989514
cor…1274 CitG24m2 Beta-catenin 57 0.0826129 0.5412382 36 0.1177953 0.4938384 21 0.0055316 0.9810146 0.1122637 0.7002330 0.9989514
cor…1275 MalQ6m4 Crizotinib (ALK) (uM) 74 -0.0810030 0.4926626 48 -0.0331184 0.8231745 26 -0.1310526 0.5233850 0.0979342 0.7002474 0.9989514
cor…1276 FumQ24m2 Erlotinib (EGFR) (uM) 73 -0.0485307 0.6834719 48 -0.0918759 0.5345522 25 0.0080077 0.9696965 -0.0998836 0.7002751 0.9989514
cor…1277 CitG6m6 Crizotinib (ALK) (uM) 73 -0.0215799 0.8561968 48 -0.0485132 0.7433334 25 0.0513572 0.8073856 -0.0998704 0.7008159 0.9989514
cor…1278 CitG24m1 CDH1 64 0.0019162 0.9880105 42 0.0435899 0.7840078 22 -0.0633372 0.7794637 0.1069272 0.7020196 0.9989514
cor…1279 CitG24m1 SCH772984 (ERK) (uM) 76 -0.3145981 0.0056436 50 -0.3190331 0.0239322 26 -0.2290950 0.2602664 -0.0899381 0.7020862 0.9989514
cor…1280 CitQ6m2 EGFR-pY1173 57 -0.2265267 0.0901790 36 -0.3251245 0.0530109 21 -0.4214199 0.0570866 0.0962955 0.7021617 0.9989514
cor…1281 MalQ24m2 Sorafenib (multi-kinase) (uM) 73 -0.1264791 0.2862990 48 -0.1413691 0.3378403 25 -0.0430701 0.8380256 -0.0982991 0.7028913 0.9989514
cor…1282 FumQ24m1 Crizotinib (ALK) (uM) 75 0.0778884 0.5065531 49 0.0416562 0.7762656 26 0.1381453 0.5009473 -0.0964891 0.7030425 0.9989514
cor…1283 FumQ24m4 Gefitinib (EGFR) (uM) 72 -0.3350815 0.0040125 47 -0.3711266 0.0102214 25 -0.2823756 0.1714317 -0.0887510 0.7032544 0.9989514
cor…1284 LacQ24m1 Pemetrexed (uM) 70 -0.1863787 0.1223827 47 -0.2019234 0.1734794 23 -0.1017334 0.6441606 -0.1001900 0.7034722 0.9989514
cor…1285 CitG6m1 Cisplatin (uM) 68 0.1619374 0.1870555 45 0.1462263 0.3378220 23 0.2455665 0.2587202 -0.0993402 0.7034832 0.9989514
cor…1286 SerG24m3 Cisplatin (uM) 65 -0.1777341 0.1566467 43 -0.1865571 0.2309798 22 -0.2864040 0.1962839 0.0998469 0.7039467 0.9989514
cor…1287 CitQ6m5 Docetaxel (nM) 67 -0.1973716 0.1093891 45 -0.2219226 0.1428799 22 -0.1200453 0.5946386 -0.1018773 0.7039773 0.9989514
cor…1288 CitQ6m4 MK-2206 (AKT) (uM) 69 0.0684560 0.5762259 46 0.1116853 0.4599334 23 0.0093205 0.9663332 0.1023648 0.7039940 0.9989514
cor…1289 CitQ24m4 AZD6244 (MEK) (uM) 69 0.2165021 0.0739690 46 0.2690301 0.0706174 23 0.1716007 0.4336810 0.0974294 0.7048989 0.9989514
cor…1290 SerG24m1 SCH772984 (ERK) (uM) 72 -0.2148591 0.0699146 46 -0.2223228 0.1375370 26 -0.3129828 0.1195115 0.0906600 0.7051376 0.9989514
cor…1291 GlyG24m1 Gemcitabine/Cisplatin (nM) 63 0.1585004 0.2147069 41 0.1563522 0.3289640 22 0.0513248 0.8205549 0.1050274 0.7052547 0.9989514
cor…1292 CitG24m2 Paclitaxel/Carboplatin (nM) 68 0.1181929 0.3370834 45 0.1548482 0.3097888 23 0.0537156 0.8076797 0.1011326 0.7064100 0.9989514
cor…1293 CitG24m2 Carboplatin (uM) 67 0.3250791 0.0072717 45 0.3563523 0.0162754 22 0.2625682 0.2377933 0.0937841 0.7072392 0.9989514
cor…1294 FumG6m4 EGFR-pY1173 59 -0.0442871 0.7390884 37 -0.1931144 0.2521382 22 -0.0880428 0.6968246 -0.1050716 0.7079544 0.9989514
cor…1295 LacG24m3 Beta-catenin 59 -0.1923777 0.1443619 37 -0.1489713 0.3788699 22 -0.2515344 0.2588101 0.1025630 0.7088296 0.9989514
cor…1296 CitQ6m2 Gemcitabine/Cisplatin (nM) 65 -0.2821453 0.0227821 44 -0.2546514 0.0952829 21 -0.3500494 0.1198049 0.0953980 0.7100569 0.9989514
cor…1297 LacG6m1 Vinorelbine (nM) 72 0.1682913 0.1576239 47 0.2181753 0.1406778 25 0.1240832 0.5545577 0.0940921 0.7102406 0.9989514
cor…1298 FumQ24m1 Cisplatin (uM) 70 0.0085248 0.9441615 46 0.0426551 0.7783522 24 -0.0561686 0.7943355 0.0988237 0.7102461 0.9989514
cor…1299 CitG6m3 Sorafenib (multi-kinase) (uM) 71 -0.1277888 0.2882283 47 -0.1524252 0.3063892 24 -0.0551860 0.7978601 -0.0972392 0.7106927 0.9989514
cor…1300 LacG6m3 MK-2206 (AKT) (uM) 71 -0.0319375 0.7914709 47 0.0002583 0.9986249 24 -0.0976199 0.6499770 0.0978782 0.7112268 0.9989514
cor…1301 CitQ6m4 Beta-catenin 57 -0.3516425 0.0073122 36 -0.4171944 0.0113595 21 -0.3239237 0.1520090 -0.0932707 0.7117645 0.9989514
cor…1302 MalQ24m1 Carboplatin (uM) 69 -0.0520799 0.6708412 46 -0.0243212 0.8725355 23 -0.1235428 0.5743831 0.0992215 0.7121876 0.9989514
cor…1303 FumQ6m4 8-Cl-adenosine (uM) 71 0.0199105 0.8690955 47 -0.0098447 0.9476358 24 0.0877165 0.6835905 -0.0975612 0.7123579 0.9989514
cor…1304 CitG6m4 Gemcitabine/Cisplatin (nM) 65 -0.1299712 0.3021122 44 -0.0776672 0.6162918 21 -0.1800648 0.4347732 0.1023976 0.7124122 0.9989514
cor…1305 SerG6m3 Sorafenib (multi-kinase) (uM) 62 -0.0910000 0.4817976 42 -0.2056928 0.1912678 20 -0.1013190 0.6708122 -0.1043737 0.7127432 0.9989514
cor…1306 MalG24m2 Gefitinib (EGFR) (uM) 72 -0.0260103 0.8283030 47 -0.0616094 0.6807865 25 0.0343870 0.8703763 -0.0959964 0.7128812 0.9989514
cor…1307 CitQ6m5 Beta-catenin 57 0.3640575 0.0053708 36 0.3767596 0.0235148 21 0.4653042 0.0335397 -0.0885446 0.7129946 0.9989514
cor…1308 FumQ24m4 Pemetrexed (uM) 70 -0.0656942 0.5889731 47 -0.0101020 0.9462693 23 -0.1087188 0.6214554 0.0986169 0.7134105 0.9989514
cor…1309 LacQ6m2 Docetaxel (nM) 69 0.0729037 0.5516342 46 0.1076051 0.4765892 23 0.0088261 0.9681180 0.0987789 0.7139900 0.9989514
cor…1310 FumQ6m1 Paclitaxel (nM) 73 -0.0442175 0.7102983 48 -0.0099524 0.9464732 25 -0.1047472 0.6182745 0.0947948 0.7144623 0.9989514
cor…1311 LacG6m1 Sorafenib (multi-kinase) (uM) 73 -0.1614346 0.1724229 48 -0.0938900 0.5255935 25 -0.1870913 0.3705153 0.0932013 0.7145376 0.9989514
cor…1312 MalQ24m3 Beta-catenin 59 0.2238651 0.0882960 37 0.2538328 0.1295288 22 0.1537175 0.4946133 0.1001153 0.7150803 0.9989514
cor…1313 GlyG6m1 Vinorelbine (nM) 65 -0.0331364 0.7932890 41 0.0041502 0.9794548 24 -0.0946183 0.6600986 0.0987685 0.7156457 0.9989514
cor…1314 CitQ6m6 Erlotinib (EGFR) (uM) 71 -0.2661444 0.0248714 47 -0.2277323 0.1236772 24 -0.3169628 0.1312673 0.0892305 0.7160625 0.9989514
cor…1315 MalQ24m3 MK-2206 (AKT) (uM) 71 -0.0711254 0.5555777 47 -0.0410770 0.7839750 24 -0.1366879 0.5242005 0.0956108 0.7161245 0.9989514
cor…1316 FumQ24m1 Erlotinib (EGFR) (uM) 73 0.0549125 0.6444952 48 0.0921682 0.5332476 25 -0.0018445 0.9930185 0.0940126 0.7170604 0.9989514
cor…1317 LacQ24m2 Paclitaxel/Carboplatin (nM) 70 0.1735736 0.1507163 46 0.2061205 0.1693443 24 0.1126171 0.6003284 0.0935034 0.7183441 0.9989514
cor…1318 CitQ24m4 Gefitinib (EGFR) (uM) 70 -0.1249731 0.3026246 46 -0.1634427 0.2777737 24 -0.0688121 0.7493535 -0.0946306 0.7183964 0.9989514
cor…1319 CitQ24m4 Paclitaxel (nM) 71 -0.0910338 0.4502377 47 -0.0613540 0.6820392 24 -0.1557195 0.4674755 0.0943655 0.7186124 0.9989514
cor…1320 SerG24m1 Paclitaxel (nM) 67 -0.0566692 0.6487538 44 -0.0281802 0.8559116 23 -0.1257197 0.5676046 0.0975395 0.7188135 0.9989514
cor…1321 CitG24m5 Gemcitabine/Cisplatin (nM) 65 -0.2460529 0.0481842 44 -0.2699085 0.0764149 21 -0.1738020 0.4511774 -0.0961065 0.7204564 0.9989514
cor…1322 CitQ6m2 Gefitinib (EGFR) (uM) 70 -0.0125958 0.9175739 46 -0.0414920 0.7842495 24 0.0536846 0.8032531 -0.0951766 0.7205004 0.9989514
cor…1323 CitG6m6 AZD6244 (MEK) (uM) 69 -0.1735438 0.1538472 46 -0.2038228 0.1742540 23 -0.1094988 0.6189404 -0.0943240 0.7206679 0.9989514
cor…1324 MalQ6m1 Paclitaxel (nM) 72 0.0552845 0.6446212 47 0.0880725 0.5560746 25 -0.0050447 0.9809068 0.0931172 0.7207264 0.9989514
cor…1325 MalG24m3 Cisplatin (uM) 70 -0.1240854 0.3060991 46 -0.0909913 0.5475743 24 -0.1841779 0.3889511 0.0931865 0.7210401 0.9989514
cor…1326 FumG6m4 8-Cl-adenosine (uM) 71 -0.0149488 0.9015277 47 -0.0465659 0.7559434 24 0.0477868 0.8245198 -0.0943528 0.7218365 0.9989514
cor…1327 MalQ24m3 Vinorelbine (nM) 72 -0.0933481 0.4354334 47 -0.1287421 0.3884443 25 -0.0366901 0.8617737 -0.0920520 0.7224243 0.9989514
cor…1328 MalG6m1 MK-2206 (AKT) (uM) 71 0.0886317 0.4623298 47 0.1187252 0.4267072 24 0.0256430 0.9053250 0.0930823 0.7240504 0.9989514
cor…1329 CitQ24m1 Docetaxel (nM) 67 -0.0532968 0.6683977 45 -0.0941191 0.5385740 22 0.0031808 0.9887914 -0.0972999 0.7241375 0.9989514
cor…1330 SerG6m1 Gefitinib (EGFR) (uM) 61 -0.0911341 0.4848578 41 -0.0915048 0.5693608 20 -0.1922961 0.4166635 0.1007913 0.7241958 0.9989514
cor…1331 MalG24m2 Pemetrexed/Cisplatin (uM) 67 0.0850662 0.4937005 45 0.0648804 0.6719815 22 0.1608254 0.4746209 -0.0959450 0.7249974 0.9989514
cor…1332 GlyG6m2 Gemcitabine/Cisplatin (nM) 61 -0.1400317 0.2817616 40 -0.2125419 0.1879358 21 -0.1143780 0.6215348 -0.0981638 0.7253699 0.9989514
cor…1333 FumQ24m4 Gemcitabine/Cisplatin (nM) 67 0.1965349 0.1109310 45 0.1989946 0.1900324 22 0.2898223 0.1907616 -0.0908277 0.7265591 0.9989514
cor…1334 FumQ6m2 Paclitaxel/Carboplatin (nM) 70 -0.0853616 0.4822983 46 -0.0459001 0.7619644 24 -0.1380920 0.5199063 0.0921919 0.7267069 0.9989514
cor…1335 CitQ24m4 Beta-catenin 57 -0.2079208 0.1206609 36 -0.1943259 0.2560931 21 -0.2902744 0.2017968 0.0959486 0.7276677 0.9989514
cor…1336 LacG24m1 Beta-catenin 59 0.1527976 0.2479479 37 0.1087395 0.5217578 22 0.2055337 0.3588199 -0.0967942 0.7287474 0.9989514
cor…1337 LacG6m1 MK-2206 (AKT) (uM) 71 0.1513550 0.2076781 47 0.1974450 0.1834181 24 0.1078210 0.6160328 0.0896240 0.7291682 0.9989514
cor…1338 CitQ6m3 Crizotinib (ALK) (uM) 73 0.0151684 0.8986481 48 0.0438376 0.7673431 25 -0.0461510 0.8266052 0.0899886 0.7292317 0.9989514
cor…1339 FumQ6m4 CDH1 66 -0.0481607 0.7009737 43 -0.0061500 0.9687788 23 -0.1002823 0.6489168 0.0941323 0.7301264 0.9989514
cor…1340 FumG24m4 E-cadherin 59 -0.0866157 0.5142074 37 -0.1220676 0.4716964 22 -0.0239299 0.9158171 -0.0981377 0.7302891 0.9989514
cor…1341 LacG6m2 Gemcitabine/Cisplatin (nM) 67 0.0532261 0.6688119 45 0.0509959 0.7393752 22 0.1451999 0.5191056 -0.0942041 0.7306171 0.9989514
cor…1342 MalQ6m4 E-cadherin 58 -0.0851633 0.5250229 36 -0.0620140 0.7193718 22 -0.1597595 0.4775927 0.0977455 0.7308989 0.9989514
cor…1343 FumG24m1 EGFR-pY1173 59 -0.0595781 0.6539835 37 -0.1144896 0.4998444 22 -0.0166117 0.9415098 -0.0978779 0.7312455 0.9989514
cor…1344 SerG6m3 Cisplatin (uM) 60 -0.2201479 0.0909913 41 -0.2538879 0.1092062 19 -0.3468192 0.1457458 0.0929314 0.7315012 0.9989514
cor…1345 MalQ24m2 Gemcitabine (nM) 71 -0.1080919 0.3695779 47 -0.0589310 0.6939697 24 -0.1488383 0.4876119 0.0899073 0.7316570 0.9989514
cor…1346 FumG6m4 SCH772984 (ERK) (uM) 78 -0.0400229 0.7279115 51 -0.0548869 0.7020593 27 0.0305770 0.8796604 -0.0854639 0.7322646 0.9989514
cor…1347 MalG6m1 Pemetrexed/Cisplatin (uM) 67 0.0561179 0.6519488 45 0.0992638 0.5165005 22 0.0050057 0.9823617 0.0942582 0.7322693 0.9989514
cor…1348 FumQ24m2 Pemetrexed (uM) 70 -0.2376827 0.0475596 47 -0.2054366 0.1659594 23 -0.2918167 0.1766684 0.0863801 0.7325790 0.9989514
cor…1349 GlyG6m1 Gefitinib (EGFR) (uM) 65 -0.0434580 0.7310467 41 -0.1099820 0.4936399 24 -0.0175350 0.9351847 -0.0924471 0.7326308 0.9989514
cor…1350 FumG6m2 Gemcitabine (nM) 71 -0.0733986 0.5429809 47 -0.0499299 0.7389134 24 -0.1396523 0.5151547 0.0897224 0.7326595 0.9989514
cor…1351 CitQ6m6 Gemcitabine (nM) 69 -0.1403141 0.2501674 46 -0.0981128 0.5165398 23 -0.1884517 0.3891633 0.0903389 0.7330827 0.9989514
cor…1352 LacG6m3 Erlotinib (EGFR) (uM) 73 -0.1000095 0.3998737 48 -0.0801637 0.5880778 25 -0.1674547 0.4236634 0.0872910 0.7331025 0.9989514
cor…1353 SerG24m1 Beta-catenin 53 -0.1940502 0.1638331 33 -0.2189691 0.2208374 20 -0.1189311 0.6174923 -0.1000380 0.7342004 0.9989514
cor…1354 CitQ24m4 Pemetrexed/Cisplatin (uM) 65 -0.0610109 0.6292437 44 0.0089372 0.9540855 21 -0.0865581 0.7090951 0.0954953 0.7349788 0.9989514
cor…1355 CitG24m5 MK-2206 (AKT) (uM) 69 0.0911600 0.4563014 46 0.0612296 0.6860435 23 0.1516497 0.4897292 -0.0904201 0.7352523 0.9989514
cor…1356 MalG6m3 Gefitinib (EGFR) (uM) 72 0.1642089 0.1680955 47 0.2093408 0.1578835 25 0.1236117 0.5560751 0.0857291 0.7354285 0.9989514
cor…1357 FumG24m3 8-Cl-adenosine (uM) 71 -0.2036984 0.0884108 47 -0.2381007 0.1070370 24 -0.1519916 0.4783309 -0.0861092 0.7355510 0.9989514
cor…1358 GlyG6m1 Erlotinib (EGFR) (uM) 67 0.0621442 0.6173687 43 0.0080466 0.9591572 24 0.0987328 0.6462392 -0.0906862 0.7355737 0.9989514
cor…1359 LacG24m2 Pemetrexed (uM) 70 0.0328697 0.7870610 47 0.0180105 0.9043576 23 0.1084412 0.6223515 -0.0904308 0.7361874 0.9989514
cor…1360 SerG24m3 Etoposide (uM) 66 -0.1953282 0.1160166 43 -0.2427111 0.1168307 23 -0.1541754 0.4824406 -0.0885357 0.7362628 0.9989514
cor…1361 MalQ6m3 SCH772984 (ERK) (uM) 77 -0.0190633 0.8692917 50 -0.0471523 0.7450564 27 0.0371779 0.8539317 -0.0843302 0.7366155 0.9989514
cor…1362 MalG6m4 Gemcitabine (nM) 71 -0.0664539 0.5818937 47 -0.0870152 0.5608447 24 0.0015991 0.9940830 -0.0886143 0.7376726 0.9989514
cor…1363 FumQ6m4 Beta-catenin 59 0.0306191 0.8179276 37 -0.0084396 0.9604611 22 0.0872714 0.6993609 -0.0957110 0.7376804 0.9989514
cor…1364 GlyG6m1 E-cadherin 53 0.0021585 0.9877614 32 -0.0524019 0.7757729 21 0.0475070 0.8379716 -0.0999090 0.7389543 0.9989514
cor…1365 MalG24m2 Crizotinib (ALK) (uM) 75 0.0376049 0.7487321 49 0.0129792 0.9294690 26 0.0974521 0.6357840 -0.0844729 0.7398973 0.9989514
cor…1366 MalG6m3 Cisplatin (uM) 70 -0.1174049 0.3330713 46 -0.0854418 0.5723592 24 -0.1721419 0.4212058 0.0867001 0.7403534 0.9989514
cor…1367 FumQ24m3 Erlotinib (EGFR) (uM) 73 -0.2627991 0.0246885 48 -0.2344162 0.1087785 25 -0.3138504 0.1265586 0.0794342 0.7410958 0.9989514
cor…1368 GlyG6m2 AZD6244 (MEK) (uM) 64 -0.1177877 0.3539462 41 -0.1229664 0.4437160 23 -0.2114693 0.3327306 0.0885029 0.7415271 0.9989514
cor…1369 MalQ6m2 Paclitaxel (nM) 72 -0.2033925 0.0866023 47 -0.2304318 0.1191681 25 -0.1476629 0.4811887 -0.0827688 0.7421915 0.9989514
cor…1370 LacQ6m3 Etoposide (uM) 71 0.0627716 0.6030304 47 0.1164976 0.4354959 24 0.0299636 0.8894617 0.0865340 0.7427368 0.9989514
cor…1371 CitG6m5 EGFR-pY1173 57 -0.1023832 0.4485431 36 -0.2112191 0.2162365 21 -0.1178893 0.6107964 -0.0933298 0.7431759 0.9989514
cor…1372 CitG6m4 Vinorelbine (nM) 70 0.1145569 0.3450122 46 0.1570708 0.2971910 24 0.0712015 0.7409364 0.0858693 0.7436544 0.9989514
cor…1373 LacQ6m1 E-cadherin 59 -0.1874702 0.1550795 37 -0.2249149 0.1807760 22 -0.1345494 0.5505212 -0.0903656 0.7442134 0.9989514
cor…1374 MalG6m3 Doxorubicin (nM) 73 -0.0470242 0.6927991 48 -0.0734142 0.6199711 25 0.0109676 0.9585032 -0.0843818 0.7452782 0.9989514
cor…1375 FumQ24m4 AZD6244 (MEK) (uM) 71 0.0957651 0.4269417 47 0.1444100 0.3328171 24 0.0592712 0.7832324 0.0851388 0.7455049 0.9989514
cor…1376 CitG6m5 Sorafenib (multi-kinase) (uM) 71 0.0049435 0.9673635 47 -0.0230182 0.8779443 24 0.0629004 0.7702966 -0.0859186 0.7457334 0.9989514
cor…1377 GlyG24m2 Carboplatin (uM) 66 -0.2795952 0.0229905 43 -0.3232156 0.0345046 23 -0.2416035 0.2667284 -0.0816120 0.7458656 0.9989514
cor…1378 FumG24m3 Etoposide (uM) 71 -0.0481794 0.6898986 47 -0.0819480 0.5839658 24 0.0036981 0.9863173 -0.0856460 0.7462347 0.9989514
cor…1379 MalG6m2 Crizotinib (ALK) (uM) 75 -0.0875328 0.4552091 49 -0.0565625 0.6994777 26 -0.1381649 0.5008858 0.0816024 0.7468596 0.9989514
cor…1380 CitQ6m1 Paclitaxel (nM) 71 0.0169326 0.8885385 47 -0.0184473 0.9020493 24 0.0670290 0.7556530 -0.0854763 0.7469518 0.9989514
cor…1381 CitG6m2 Paclitaxel/Carboplatin (nM) 68 -0.0975712 0.4286130 45 -0.1196946 0.4335316 23 -0.0329329 0.8814173 -0.0867617 0.7478830 0.9989514
cor…1382 GlyG6m1 AZD6244 (MEK) (uM) 64 -0.1422240 0.2622549 41 -0.1212445 0.4501726 23 -0.2075702 0.3419272 0.0863257 0.7479096 0.9989514
cor…1383 MalG6m2 Pemetrexed (uM) 70 -0.0608196 0.6169663 47 -0.0331009 0.8251874 23 -0.1188947 0.5889736 0.0857938 0.7488300 0.9989514
cor…1384 MalQ6m2 Docetaxel (nM) 68 -0.1605182 0.1910010 45 -0.1956179 0.1978150 23 -0.1107338 0.6149667 -0.0848842 0.7488427 0.9989514
cor…1385 MalQ24m4 8-Cl-adenosine (uM) 71 0.1426542 0.2353182 47 0.1251942 0.4017597 24 0.2073643 0.3309184 -0.0821701 0.7498604 0.9989514
cor…1386 CitQ6m1 AZD6244 (MEK) (uM) 69 -0.0293446 0.8108320 46 -0.0467751 0.7575629 23 0.0394411 0.8581940 -0.0862163 0.7499200 0.9989514
cor…1387 FumQ6m1 Paclitaxel/Carboplatin (nM) 70 0.0627207 0.6059813 46 0.0986221 0.5143547 24 0.0144487 0.9465748 0.0841734 0.7509552 0.9989514
cor…1388 SerG24m3 E-cadherin 53 -0.2344070 0.0911342 33 -0.1953072 0.2760544 20 -0.2855536 0.2223065 0.0902464 0.7521521 0.9989514
cor…1389 LacQ6m3 CDH1 66 -0.2355736 0.0568926 43 -0.2987120 0.0516852 23 -0.2181828 0.3172465 -0.0805292 0.7525088 0.9989514
cor…1390 LacQ24m3 8-Cl-adenosine (uM) 71 -0.0424903 0.7249628 47 -0.0723187 0.6290424 24 0.0111703 0.9586856 -0.0834890 0.7525645 0.9989514
cor…1391 SerG6m1 Pemetrexed (uM) 60 -0.1199763 0.3611969 41 -0.2022051 0.2048521 19 -0.1108402 0.6514581 -0.0913649 0.7531263 0.9989514
cor…1392 LacQ6m3 Pemetrexed (uM) 70 0.0033452 0.9780735 47 0.0516462 0.7302716 23 -0.0330348 0.8810529 0.0846810 0.7533535 0.9989514
cor…1393 MalQ6m2 Crizotinib (ALK) (uM) 74 -0.0312068 0.7918220 48 -0.0592141 0.6893154 26 0.0209935 0.9189212 -0.0802076 0.7541278 0.9989514
cor…1394 MalQ24m3 Paclitaxel (nM) 73 0.1624892 0.1695989 48 0.1869543 0.2032426 25 0.1075771 0.6087647 0.0793771 0.7549875 0.9989514
cor…1395 MalG6m3 Paclitaxel/Carboplatin (nM) 70 -0.0439601 0.7178384 46 -0.0801837 0.5963062 24 0.0024274 0.9910184 -0.0826111 0.7558345 0.9989514
cor…1396 MalQ6m3 Pemetrexed/Cisplatin (uM) 66 -0.0521970 0.6772401 44 -0.0601336 0.6982015 22 0.0260396 0.9084243 -0.0861732 0.7559635 0.9989514
cor…1397 FumG6m1 Gemcitabine/Cisplatin (nM) 67 -0.1360942 0.2721460 45 -0.1416234 0.3534110 22 -0.0567603 0.8018983 -0.0848631 0.7564189 0.9989514
cor…1398 CitG24m2 Gemcitabine/Cisplatin (nM) 65 0.1754375 0.1621594 44 0.1675347 0.2770315 21 0.2512510 0.2719356 -0.0837163 0.7566496 0.9989514
cor…1399 MalG6m4 Docetaxel (nM) 69 -0.0730751 0.5506964 46 -0.1123922 0.4570799 23 -0.0291435 0.8949839 -0.0832487 0.7570855 0.9989514
cor…1400 LacG24m3 Pemetrexed/Cisplatin (uM) 67 -0.0344690 0.7818464 45 -0.0308900 0.8403597 22 -0.1158874 0.6075546 0.0849974 0.7571062 0.9989514
cor…1401 CitG24m4 SCH772984 (ERK) (uM) 76 -0.0687411 0.5551650 50 -0.0874839 0.5457650 26 -0.0091211 0.9647275 -0.0783628 0.7574542 0.9989514
cor…1402 FumG6m1 Crizotinib (ALK) (uM) 75 -0.0133150 0.9097294 49 0.0162582 0.9117143 26 -0.0624486 0.7618426 0.0787068 0.7576846 0.9989514
cor…1403 LacG24m2 Gemcitabine (nM) 71 0.0914238 0.4482913 47 0.0975297 0.5142832 24 0.1776613 0.4062372 -0.0801316 0.7579803 0.9989514
cor…1404 MalG6m4 Sorafenib (multi-kinase) (uM) 73 -0.0638070 0.5917478 48 -0.0866848 0.5579807 25 -0.0069185 0.9738168 -0.0797663 0.7584952 0.9989514
cor…1405 MalG24m4 Beta-catenin 59 -0.2382563 0.0691878 37 -0.2648607 0.1131417 22 -0.1813965 0.4191504 -0.0834642 0.7589294 0.9989514
cor…1406 FumQ24m3 MK-2206 (AKT) (uM) 71 -0.0856640 0.4775100 47 -0.0587277 0.6949737 24 -0.1390620 0.5169500 0.0803342 0.7595659 0.9989514
cor…1407 LacQ24m3 Cisplatin (uM) 70 -0.1125403 0.3536269 46 -0.0783524 0.6047488 24 -0.1584805 0.4595187 0.0801281 0.7600337 0.9989514
cor…1408 MalQ6m3 AZD6244 (MEK) (uM) 70 -0.1688370 0.1623503 46 -0.1920373 0.2010539 24 -0.1128117 0.5996948 -0.0792256 0.7604818 0.9989514
cor…1409 MalG24m3 Pemetrexed (uM) 70 0.0912091 0.4526904 47 0.0651163 0.6636671 23 0.1462424 0.5055160 -0.0811261 0.7608249 0.9989514
cor…1410 FumG6m3 Carboplatin (uM) 69 -0.0813590 0.5063221 46 -0.0583956 0.6998761 23 -0.1398184 0.5245880 0.0814228 0.7611330 0.9989514
cor…1411 GlyG6m1 Paclitaxel (nM) 66 0.1207266 0.3342514 42 0.1627897 0.3029862 24 0.0820373 0.7031384 0.0807524 0.7618415 0.9989514
cor…1412 CitQ24m5 8-Cl-adenosine (uM) 69 0.2145443 0.0766843 46 0.1997281 0.1832562 23 0.2769590 0.2007634 -0.0772309 0.7620963 0.9989514
cor…1413 CitQ24m1 Erlotinib (EGFR) (uM) 71 0.0739720 0.5398256 47 0.1027320 0.4919872 24 0.0234117 0.9135315 0.0793203 0.7638577 0.9989514
cor…1414 MalG6m2 Docetaxel (nM) 69 0.0435153 0.7225673 46 0.0740510 0.6247788 23 -0.0069402 0.9749279 0.0809913 0.7643752 0.9989514
cor…1415 CitG24m1 Sorafenib (multi-kinase) (uM) 71 -0.0196508 0.8707886 47 0.0480079 0.7486289 24 -0.0310351 0.8855334 0.0790430 0.7655542 0.9989514
cor…1416 MalQ6m1 Crizotinib (ALK) (uM) 74 -0.0009934 0.9932980 48 -0.0313650 0.8323979 26 0.0448564 0.8277532 -0.0762215 0.7660659 0.9989514
cor…1417 LacQ24m3 CDH1 66 -0.2875476 0.0192275 43 -0.3238914 0.0341074 23 -0.2491668 0.2515800 -0.0747246 0.7661112 0.9989514
cor…1418 CitQ24m6 Docetaxel (nM) 67 -0.1084729 0.3822481 45 -0.1406509 0.3567599 22 -0.0597618 0.7916400 -0.0808890 0.7674556 0.9989514
cor…1419 CitQ24m3 Etoposide (uM) 69 0.0397089 0.7459771 46 0.0158212 0.9168855 23 0.0954731 0.6647742 -0.0796519 0.7677169 0.9989514
cor…1420 SerG24m2 8-Cl-adenosine (uM) 66 -0.1009237 0.4200675 43 -0.1229546 0.4321628 23 -0.0426907 0.8466397 -0.0802638 0.7677872 0.9989514
cor…1421 LacQ6m1 SCH772984 (ERK) (uM) 78 -0.1763232 0.1225330 51 -0.1822777 0.2004720 27 -0.1100756 0.5846741 -0.0722021 0.7677976 0.9989514
cor…1422 GlyG6m2 Paclitaxel (nM) 66 -0.1231849 0.3244289 42 -0.1561847 0.3232874 24 -0.0775291 0.7187869 -0.0786556 0.7681573 0.9989514
cor…1423 MalQ6m1 8-Cl-adenosine (uM) 70 -0.0347251 0.7753483 46 -0.0138393 0.9272669 24 -0.0920003 0.6689744 0.0781610 0.7683236 0.9989514
cor…1424 FumG6m3 EGFR-pY1173 59 -0.1562305 0.2373544 37 -0.2588243 0.1219060 22 -0.1787235 0.4261520 -0.0801008 0.7688297 0.9989514
cor…1425 FumQ6m3 AZD6244 (MEK) (uM) 71 -0.1752763 0.1437318 47 -0.1977892 0.1826401 24 -0.1221475 0.5696347 -0.0756416 0.7696429 0.9989514
cor…1426 MalQ24m4 Etoposide (uM) 71 -0.0819093 0.4970923 47 -0.1200052 0.4217032 24 -0.0429411 0.8420839 -0.0770641 0.7697910 0.9989514
cor…1427 FumQ24m4 8-Cl-adenosine (uM) 71 0.1343940 0.2638226 47 0.1184964 0.4276053 24 0.1941601 0.3632960 -0.0756637 0.7698425 0.9989514
cor…1428 CitQ6m5 Etoposide (uM) 69 -0.0068883 0.9552032 46 0.0110166 0.9420733 23 -0.0680201 0.7577942 0.0790368 0.7699752 0.9989514
cor…1429 LacQ24m2 Sorafenib (multi-kinase) (uM) 73 0.0940489 0.4286863 48 0.0861161 0.5605762 25 0.1609193 0.4422302 -0.0748032 0.7701772 0.9989514
cor…1430 CitG6m4 Cisplatin (uM) 68 -0.0506830 0.6814702 45 -0.0097572 0.9492783 23 -0.0884601 0.6881478 0.0787029 0.7714010 0.9989514
cor…1431 LacQ24m2 EGFR-pY1173 59 0.0316460 0.8119305 37 -0.0950967 0.5755695 22 -0.0124522 0.9561395 -0.0826444 0.7721723 0.9989514
cor…1432 MalQ24m3 Erlotinib (EGFR) (uM) 73 -0.2246231 0.0560627 48 -0.1979676 0.1774016 25 -0.2691214 0.1933018 0.0711538 0.7722362 0.9989514
cor…1433 SerG24m2 Gemcitabine/Cisplatin (nM) 62 0.0309529 0.8112446 41 -0.0220170 0.8913200 21 0.0602948 0.7951553 -0.0823118 0.7733933 0.9989514
cor…1434 LacQ6m3 8-Cl-adenosine (uM) 71 -0.0562359 0.6413513 47 -0.0292553 0.8452321 24 -0.1052062 0.6246643 0.0759509 0.7734985 0.9989514
cor…1435 MalQ6m1 AZD6244 (MEK) (uM) 70 -0.0194722 0.8728827 46 -0.0461997 0.7604566 24 0.0302110 0.8885543 -0.0764108 0.7739778 0.9989514
cor…1436 CitQ24m5 Etoposide (uM) 69 0.1320270 0.2795167 46 0.1523509 0.3121249 23 0.0757337 0.7312636 0.0766172 0.7741449 0.9989514
cor…1437 SerG6m3 EGFR-pY1173 50 -0.2616211 0.0664672 32 -0.1968676 0.2801618 18 -0.1081235 0.6693414 -0.0887441 0.7749635 0.9989514
cor…1438 SerG24m1 Docetaxel (nM) 65 -0.1638436 0.1921817 43 -0.1352359 0.3872301 22 -0.2122797 0.3429103 0.0770439 0.7754241 0.9989514
cor…1439 MalQ24m4 Carboplatin (uM) 69 0.0825612 0.5000388 46 0.1183688 0.4333438 23 0.0420032 0.8490818 0.0763656 0.7763212 0.9989514
cor…1440 FumG6m1 AZD6244 (MEK) (uM) 71 -0.1684574 0.1602264 47 -0.1446668 0.3319489 24 -0.2173098 0.3077190 0.0726430 0.7769393 0.9989514
cor…1441 LacQ6m1 Paclitaxel (nM) 73 0.0061088 0.9590918 48 0.0215112 0.8846143 25 -0.0519702 0.8051295 0.0734814 0.7774425 0.9989514
cor…1442 MalQ24m1 Docetaxel (nM) 69 0.0361934 0.7678038 46 0.0540440 0.7213032 23 -0.0223968 0.9192062 0.0764408 0.7774572 0.9989514
cor…1443 CitQ24m6 Vinorelbine (nM) 70 -0.0722396 0.5523150 46 -0.0513262 0.7347946 24 -0.1258518 0.5578961 0.0745255 0.7777240 0.9989514
cor…1444 CitQ24m2 Paclitaxel (nM) 71 -0.2195643 0.0658031 47 -0.2520360 0.0874406 24 -0.1807782 0.3979165 -0.0712578 0.7779316 0.9989514
cor…1445 CitG6m1 E-cadherin 57 -0.1598756 0.2348523 36 -0.1554698 0.3652425 21 -0.2347267 0.3057470 0.0792568 0.7784294 0.9989514
cor…1446 LacG6m3 EGFR-pY1173 59 -0.0939611 0.4790352 37 -0.0035675 0.9832814 22 -0.0838038 0.7107990 0.0802363 0.7788553 0.9989514
cor…1447 LacG6m2 Vinorelbine (nM) 72 0.0585733 0.6250309 47 0.0856704 0.5669389 25 0.0126055 0.9523126 0.0730649 0.7790012 0.9989514
cor…1448 LacG6m1 EGFR-pY1173 59 0.0328405 0.8049689 37 -0.1091964 0.5199994 22 -0.0294862 0.8963628 -0.0797102 0.7796442 0.9989514
cor…1449 LacG24m2 AZD6244 (MEK) (uM) 71 0.0229322 0.8494461 47 0.0484447 0.7464175 24 -0.0257143 0.9050630 0.0741589 0.7796554 0.9989514
cor…1450 CitQ6m6 Etoposide (uM) 69 -0.0893889 0.4651340 46 -0.0634745 0.6751575 23 -0.1383465 0.5290055 0.0748720 0.7797746 0.9989514
cor…1451 GlyG24m2 Paclitaxel (nM) 68 -0.1413488 0.2502403 44 -0.1169838 0.4495020 24 -0.1898171 0.3743343 0.0728334 0.7809392 0.9989514
cor…1452 MalG24m4 8-Cl-adenosine (uM) 71 -0.2994910 0.0111714 47 -0.3270479 0.0248418 24 -0.2598385 0.2201289 -0.0672094 0.7814459 0.9989514
cor…1453 CitQ24m4 Erlotinib (EGFR) (uM) 71 0.0318411 0.7920865 47 0.0693412 0.6432663 24 -0.0041268 0.9847313 0.0734680 0.7814585 0.9989514
cor…1454 FumQ24m1 MK-2206 (AKT) (uM) 71 0.0783194 0.5161992 47 0.0532791 0.7220801 24 0.1261720 0.5568864 -0.0728929 0.7816353 0.9989514
cor…1455 MalG6m3 Docetaxel (nM) 69 -0.0141557 0.9080935 46 -0.0476252 0.7532942 23 0.0269356 0.9029019 -0.0745608 0.7828270 0.9989514
cor…1456 LacG24m2 SCH772984 (ERK) (uM) 78 -0.0650544 0.5714827 51 -0.0737842 0.6068578 27 -0.0050909 0.9798942 -0.0686933 0.7830778 0.9989514
cor…1457 FumQ6m3 Erlotinib (EGFR) (uM) 73 -0.2381904 0.0424295 48 -0.2630264 0.0708845 25 -0.1953629 0.3493420 -0.0676635 0.7835834 0.9989514
cor…1458 FumG24m3 Gefitinib (EGFR) (uM) 72 0.1127906 0.3455147 47 0.1505014 0.3126063 25 0.0798171 0.7044950 0.0706843 0.7837307 0.9989514
cor…1459 FumQ24m2 Sorafenib (multi-kinase) (uM) 73 -0.1095540 0.3561867 48 -0.1431024 0.3318899 25 -0.0725705 0.7302967 -0.0705319 0.7837519 0.9989514
cor…1460 GlyG24m1 Pemetrexed (uM) 66 -0.1490014 0.2324609 43 -0.2216900 0.1530819 23 -0.1492761 0.4966286 -0.0724140 0.7840990 0.9989514
cor…1461 LacQ24m3 Gemcitabine/Cisplatin (nM) 67 0.0480985 0.6991129 45 0.0773279 0.6136353 22 0.0018046 0.9936407 0.0755233 0.7843001 0.9989514
cor…1462 CitQ24m1 EGFR-pY1173 57 -0.0936347 0.4884418 36 -0.1928726 0.2597354 21 -0.1150817 0.6193768 -0.0777909 0.7855569 0.9989514
cor…1463 FumG6m4 Erlotinib (EGFR) (uM) 73 0.0160868 0.8925468 48 0.0626701 0.6721768 25 -0.0076779 0.9709439 0.0703480 0.7865969 0.9989514
cor…1464 CitG6m1 Paclitaxel (nM) 71 -0.0110381 0.9272063 47 -0.0000574 0.9996943 24 -0.0717167 0.7391253 0.0716592 0.7866649 0.9989514
cor…1465 FumQ24m3 Gefitinib (EGFR) (uM) 72 -0.3123664 0.0075552 47 -0.2907963 0.0473674 25 -0.3539676 0.0825747 0.0631713 0.7870570 0.9989514
cor…1466 FumQ6m2 Docetaxel (nM) 69 -0.1464857 0.2297265 46 -0.1148703 0.4471537 23 -0.1858844 0.3957737 0.0710141 0.7882587 0.9989514
cor…1467 CitG24m2 Sorafenib (multi-kinase) (uM) 71 0.1518419 0.2062024 47 0.1861334 0.2103201 24 0.1167388 0.5869687 0.0693946 0.7887749 0.9989514
cor…1468 LacG6m3 AZD6244 (MEK) (uM) 71 0.1244377 0.3011622 47 0.0930427 0.5339128 24 0.1629018 0.4469249 -0.0698591 0.7887798 0.9989514
cor…1469 FumQ24m3 Beta-catenin 59 0.2873662 0.0273245 37 0.3117625 0.0603253 22 0.2409724 0.2800064 0.0707900 0.7888971 0.9989514
cor…1470 CitG24m4 Vinorelbine (nM) 70 0.0341696 0.7788502 46 0.0099814 0.9475088 24 0.0807529 0.7075850 -0.0707716 0.7898572 0.9989514
cor…1471 LacQ6m1 EGFR-pY1173 59 -0.0573070 0.6663813 37 -0.1778129 0.2923915 22 -0.1031384 0.6478542 -0.0746745 0.7901697 0.9989514
cor…1472 FumG24m4 Carboplatin (uM) 69 -0.2658634 0.0272454 46 -0.2887286 0.0516513 23 -0.2217005 0.3093111 -0.0670281 0.7909796 0.9989514
cor…1473 CitG24m2 Cisplatin (uM) 68 0.1684688 0.1696556 45 0.1505801 0.3234754 23 0.2197735 0.3136429 -0.0691934 0.7918908 0.9989514
cor…1474 CitG6m3 8-Cl-adenosine (uM) 69 0.0907879 0.4581494 46 0.1118888 0.4591111 23 0.0410992 0.8522948 0.0707895 0.7923976 0.9989514
cor…1475 GlyG6m1 Pemetrexed/Cisplatin (uM) 61 -0.0242536 0.8528093 40 -0.0918507 0.5729664 21 -0.0164855 0.9434576 -0.0753652 0.7924312 0.9989514
cor…1476 MalQ24m4 Sorafenib (multi-kinase) (uM) 73 0.0746185 0.5303891 48 0.1322476 0.3702362 25 0.0645594 0.7591549 0.0676883 0.7926729 0.9989514
cor…1477 LacQ24m1 Gefitinib (EGFR) (uM) 72 0.2266180 0.0555885 47 0.2407858 0.1030210 25 0.3040969 0.1394338 -0.0633111 0.7933003 0.9989514
cor…1478 FumQ6m2 EGFR-pY1173 59 -0.1418946 0.2837070 37 -0.2293226 0.1721546 22 -0.1573442 0.4843609 -0.0719783 0.7939493 0.9989514
cor…1479 CitG24m5 CDH1 64 0.2162513 0.0861096 42 0.1933648 0.2198420 22 0.2625067 0.2379073 -0.0691419 0.7942363 0.9989514
cor…1480 SerG6m1 Paclitaxel (nM) 62 -0.1855727 0.1487276 42 -0.1527722 0.3341026 20 -0.2257370 0.3385905 0.0729648 0.7944601 0.9989514
cor…1481 MalG6m2 Doxorubicin (nM) 73 -0.0659626 0.5792629 48 -0.0899315 0.5432714 25 -0.0225025 0.9149749 -0.0674289 0.7947737 0.9989514
cor…1482 MalG24m3 E-cadherin 59 -0.2111174 0.1084771 37 -0.2426925 0.1478094 22 -0.1715360 0.4452875 -0.0711565 0.7951008 0.9989514
cor…1483 MalQ6m3 E-cadherin 58 0.2401140 0.0694459 36 0.2663061 0.1164273 22 0.1955834 0.3830517 0.0707228 0.7952069 0.9989514
cor…1484 SerG24m3 Paclitaxel (nM) 67 -0.0694084 0.5767661 44 -0.0896373 0.5628347 23 -0.0193378 0.9302129 -0.0702995 0.7959262 0.9989514
cor…1485 CitG24m2 Gefitinib (EGFR) (uM) 70 0.0578330 0.6343937 46 0.0876350 0.5625028 24 0.0190357 0.9296502 0.0685993 0.7960106 0.9989514
cor…1486 CitG24m3 EGFR-pY1173 57 -0.0482662 0.7214386 36 -0.0579912 0.7369084 21 -0.1327705 0.5661542 0.0747794 0.7966584 0.9989514
cor…1487 MalG6m3 Pemetrexed (uM) 70 0.0947391 0.4353148 47 0.0771404 0.6062900 23 0.1455474 0.5075627 -0.0684070 0.7972167 0.9989514
cor…1488 SerG6m2 Vinorelbine (nM) 61 -0.3231464 0.0110792 41 -0.3428378 0.0282120 20 -0.4071717 0.0747796 0.0643339 0.7973845 0.9989514
cor…1489 CitG6m2 Pemetrexed/Cisplatin (uM) 65 -0.0614805 0.6266024 44 -0.0919005 0.5529754 21 -0.0195834 0.9328539 -0.0723172 0.7974279 0.9989514
cor…1490 GlyG24m1 AZD6244 (MEK) (uM) 67 0.1282563 0.3009745 43 0.1088466 0.4871860 24 0.1761347 0.4103474 -0.0672881 0.7987401 0.9989514
cor…1491 MalG6m2 Paclitaxel (nM) 73 -0.0961630 0.4183347 48 -0.0727818 0.6229966 25 -0.1383324 0.5096174 0.0655507 0.7987921 0.9989514
cor…1492 MalG6m1 AZD6244 (MEK) (uM) 71 -0.1640237 0.1716776 47 -0.1900338 0.2007490 24 -0.1241193 0.5633725 -0.0659145 0.7987922 0.9989514
cor…1493 LacQ6m3 Cisplatin (uM) 70 0.0017033 0.9888348 46 0.0371731 0.8062504 24 -0.0305030 0.8874838 0.0676761 0.7992578 0.9989514
cor…1494 MalQ24m2 Etoposide (uM) 71 -0.0791939 0.5115109 47 -0.0613240 0.6821865 24 -0.1277468 0.5519334 0.0664228 0.8004296 0.9989514
cor…1495 FumG6m2 Paclitaxel/Carboplatin (nM) 70 0.1064948 0.3802395 46 0.0826762 0.5848994 24 0.1485701 0.4884053 -0.0658939 0.8018416 0.9989514
cor…1496 LacQ6m2 Sorafenib (multi-kinase) (uM) 73 0.0608128 0.6092877 48 0.0924544 0.5319715 25 0.0276347 0.8956772 0.0648197 0.8024667 0.9989514
cor…1497 FumG6m2 Paclitaxel (nM) 73 0.0611299 0.6074193 48 0.0848500 0.5663752 25 0.0201102 0.9239872 0.0647398 0.8028706 0.9989514
cor…1498 FumQ24m1 Paclitaxel/Carboplatin (nM) 70 0.0106007 0.9305940 46 0.0354006 0.8153233 24 -0.0309593 0.8858114 0.0663599 0.8030848 0.9989514
cor…1499 CitG6m1 Sorafenib (multi-kinase) (uM) 71 -0.2042437 0.0875434 47 -0.2064896 0.1637523 24 -0.1424247 0.5067639 -0.0640649 0.8031850 0.9989514
cor…1500 LacG6m3 Pemetrexed/Cisplatin (uM) 67 -0.0494929 0.6908243 45 -0.0962142 0.5295301 22 -0.0278258 0.9021709 -0.0683884 0.8038188 0.9989514
cor…1501 MalQ6m3 Doxorubicin (nM) 72 -0.1359730 0.2547551 47 -0.1557088 0.2959619 25 -0.0918970 0.6621929 -0.0638118 0.8039212 0.9989514
cor…1502 MalQ6m1 Gemcitabine (nM) 70 -0.1339723 0.2688547 46 -0.1210834 0.4227946 24 -0.1854965 0.3855047 0.0644131 0.8042352 0.9989514
cor…1503 SerG6m3 Gemcitabine (nM) 60 -0.2206973 0.0901671 41 -0.3274589 0.0366245 19 -0.3917294 0.0971863 0.0642705 0.8042561 0.9989514
cor…1504 MalG6m1 Docetaxel (nM) 69 0.0239658 0.8450283 46 -0.0017847 0.9906083 23 0.0651779 0.7676389 -0.0669625 0.8043292 0.9989514
cor…1505 LacG24m1 Paclitaxel/Carboplatin (nM) 70 0.1586136 0.1896949 46 0.1184187 0.4331485 24 0.1827575 0.3926829 -0.0643388 0.8046178 0.9989514
cor…1506 FumG24m4 MK-2206 (AKT) (uM) 71 0.0836457 0.4879849 47 0.0613603 0.6820086 24 0.1260766 0.5571869 -0.0647164 0.8054857 0.9989514
cor…1507 MalG24m4 Etoposide (uM) 71 -0.0964282 0.4237323 47 -0.1207031 0.4189885 24 -0.0560215 0.7948629 -0.0646816 0.8057758 0.9989514
cor…1508 CitQ6m6 Paclitaxel/Carboplatin (nM) 68 -0.0270745 0.8265233 45 -0.0151819 0.9211518 23 -0.0812839 0.7123545 0.0661020 0.8072569 0.9989514
cor…1509 CitQ24m4 8-Cl-adenosine (uM) 69 -0.0758556 0.5355961 46 -0.0566251 0.7085673 23 -0.1218685 0.5796205 0.0652434 0.8079435 0.9989514
cor…1510 LacG6m2 Pemetrexed/Cisplatin (uM) 67 0.0247024 0.8427139 45 0.0390996 0.7987194 22 0.1059156 0.6389890 -0.0668159 0.8079770 0.9989514
cor…1511 LacG6m2 E-cadherin 59 0.0323190 0.8080061 37 -0.0014858 0.9930367 22 0.0679166 0.7639415 -0.0694023 0.8082649 0.9989514
cor…1512 MalQ24m2 Gemcitabine/Cisplatin (nM) 67 0.0909681 0.4640996 45 0.0987955 0.5184910 22 0.1645287 0.4643696 -0.0657332 0.8087496 0.9989514
cor…1513 LacG24m1 Erlotinib (EGFR) (uM) 73 0.0050434 0.9662220 48 -0.0006031 0.9967543 25 0.0621476 0.7679063 -0.0627507 0.8091521 0.9989514
cor…1514 LacG24m2 Doxorubicin (nM) 73 0.0007443 0.9950137 48 0.0229620 0.8768906 25 -0.0397770 0.8502675 0.0627390 0.8093513 0.9989514
cor…1515 FumQ6m1 Etoposide (uM) 71 -0.1086859 0.3669374 47 -0.0868315 0.5616751 24 -0.1495504 0.4855079 0.0627189 0.8104037 0.9989514
cor…1516 FumG6m2 Pemetrexed (uM) 70 -0.0981318 0.4189758 47 -0.0774095 0.6050309 23 -0.1412353 0.5203523 0.0638258 0.8106237 0.9989514
cor…1517 CitG6m4 EGFR-pY1173 57 -0.1941737 0.1478083 36 -0.3295710 0.0496616 21 -0.3901614 0.0803722 0.0605904 0.8121308 0.9989514
cor…1518 MalG24m3 Etoposide (uM) 71 -0.0298020 0.8051302 47 -0.0524112 0.7264300 24 0.0103160 0.9618428 -0.0627273 0.8129011 0.9989514
cor…1519 LacG6m2 8-Cl-adenosine (uM) 71 0.1137379 0.3449497 47 0.1272278 0.3940955 24 0.0650612 0.7626229 0.0621666 0.8129241 0.9989514
cor…1520 CitG6m6 Doxorubicin (nM) 71 0.1212517 0.3138038 47 0.1069229 0.4743975 24 0.1683501 0.4316607 -0.0614272 0.8133127 0.9989514
cor…1521 GlyG6m2 Beta-catenin 53 -0.1978382 0.1556022 32 -0.2090051 0.2509661 21 -0.1403600 0.5439565 -0.0686451 0.8133735 0.9989514
cor…1522 LacQ24m3 Beta-catenin 59 0.1327481 0.3162060 37 0.1040605 0.5399310 22 0.1695952 0.4505310 -0.0655347 0.8155645 0.9989514
cor…1523 CitQ24m6 MK-2206 (AKT) (uM) 69 0.0517528 0.6727909 46 0.0690051 0.6486208 23 0.0065179 0.9764533 0.0624872 0.8170998 0.9989514
cor…1524 MalQ6m2 Etoposide (uM) 70 -0.2009814 0.0952514 46 -0.2216843 0.1386997 24 -0.1624562 0.4481859 -0.0592281 0.8172544 0.9989514
cor…1525 LacQ6m2 Vinorelbine (nM) 72 0.1063752 0.3738134 47 0.1304217 0.3822326 25 0.0708623 0.7364218 0.0595594 0.8177026 0.9989514
cor…1526 CitG24m5 Etoposide (uM) 69 -0.1181182 0.3337299 46 -0.1384327 0.3588885 23 -0.0769778 0.7270114 -0.0614548 0.8182483 0.9989514
cor…1527 LacG24m1 CDH1 66 0.0488657 0.6968068 43 0.0254447 0.8713359 23 0.0881138 0.6893094 -0.0626691 0.8183625 0.9989514
cor…1528 MalQ24m4 Gemcitabine (nM) 71 0.0113673 0.9250414 47 0.0575129 0.7009860 24 -0.0031406 0.9883797 0.0606535 0.8189284 0.9989514
cor…1529 FumQ24m4 MK-2206 (AKT) (uM) 71 -0.1279282 0.2876984 47 -0.1032986 0.4895897 24 -0.1626872 0.4475319 0.0593886 0.8196310 0.9989514
cor…1530 MalQ24m1 Paclitaxel/Carboplatin (nM) 70 0.0657105 0.5888806 46 0.0768838 0.6115562 24 0.0165978 0.9386423 0.0602860 0.8204126 0.9989514
cor…1531 LacG6m3 CDH1 66 0.2855407 0.0201237 43 0.3125688 0.0412806 23 0.2557444 0.2388672 0.0568244 0.8213503 0.9989514
cor…1532 FumG24m2 Paclitaxel/Carboplatin (nM) 70 -0.0482961 0.6913454 46 -0.0261058 0.8632686 24 -0.0857488 0.6903419 0.0596429 0.8221317 0.9989514
cor…1533 FumG6m2 Pemetrexed/Cisplatin (uM) 67 -0.0227266 0.8551530 45 0.0083280 0.9567006 22 -0.0534952 0.8130934 0.0618232 0.8229178 0.9989514
cor…1534 LacQ6m2 Paclitaxel/Carboplatin (nM) 70 0.1665625 0.1681669 46 0.1845390 0.2195458 24 0.1264498 0.5560113 0.0580892 0.8230105 0.9989514
cor…1535 CitG24m2 EGFR-pY1173 57 0.0486684 0.7192127 36 -0.0010759 0.9950310 21 0.0643687 0.7816269 -0.0654446 0.8230280 0.9989514
cor…1536 FumQ24m3 Cisplatin (uM) 70 0.0970925 0.4239432 46 0.0749856 0.6204031 24 0.1337901 0.5331152 -0.0588045 0.8232354 0.9989514
cor…1537 FumQ6m3 8-Cl-adenosine (uM) 71 0.1010546 0.4017295 47 0.0865733 0.5628435 24 0.1448875 0.4993663 -0.0583141 0.8236011 0.9989514
cor…1538 LacQ24m2 Crizotinib (ALK) (uM) 75 -0.2986664 0.0092471 49 -0.2756242 0.0552539 26 -0.3271950 0.1027658 0.0515707 0.8241625 0.9989514
cor…1539 FumQ6m4 AZD6244 (MEK) (uM) 71 -0.0029286 0.9806623 47 0.0286241 0.8485318 24 -0.0301977 0.8886032 0.0588218 0.8244370 0.9989514
cor…1540 MalG6m2 AZD6244 (MEK) (uM) 71 -0.0425974 0.7242977 47 -0.0274317 0.8547725 24 -0.0855570 0.6910011 0.0581253 0.8259364 0.9989514
cor…1541 CitQ6m5 Gefitinib (EGFR) (uM) 70 -0.2536520 0.0341093 46 -0.2597121 0.0813292 24 -0.3133019 0.1360269 0.0535898 0.8263578 0.9989514
cor…1542 GlyG6m2 Gemcitabine (nM) 64 -0.2310202 0.0662590 41 -0.3355679 0.0319641 23 -0.2807507 0.1944140 -0.0548172 0.8263867 0.9989514
cor…1543 CitG24m3 AZD6244 (MEK) (uM) 69 -0.2533967 0.0356552 46 -0.2336033 0.1181755 23 -0.2888045 0.1813838 0.0552012 0.8266790 0.9989514
cor…1544 FumQ6m3 SCH772984 (ERK) (uM) 78 -0.0123063 0.9148402 51 -0.0333626 0.8162159 27 0.0211541 0.9165902 -0.0545167 0.8273287 0.9989514
cor…1545 CitQ6m6 Docetaxel (nM) 67 -0.0674106 0.5878097 45 -0.1021012 0.5045235 22 -0.0422141 0.8520318 -0.0598871 0.8275803 0.9989514
cor…1546 MalQ6m4 EGFR-pY1173 58 0.2125833 0.1091303 36 0.1648796 0.3365710 22 0.2251259 0.3137885 -0.0602464 0.8277802 0.9989514
cor…1547 SerG6m3 Docetaxel (nM) 60 -0.2344106 0.0714275 41 -0.2019500 0.2054360 19 -0.2632478 0.2761887 0.0612978 0.8277901 0.9989514
cor…1548 LacQ6m1 Gemcitabine/Cisplatin (nM) 67 -0.0016672 0.9893170 45 0.0048330 0.9748639 22 0.0648546 0.7743110 -0.0600216 0.8278796 0.9989514
cor…1549 FumG24m1 Gemcitabine (nM) 71 0.0029414 0.9805776 47 0.0059144 0.9685271 24 -0.0516361 0.8106250 0.0575506 0.8280851 0.9989514
cor…1550 MalG24m3 Gemcitabine/Cisplatin (nM) 67 -0.1802701 0.1443466 45 -0.1626206 0.2858279 22 -0.2197744 0.3257323 0.0571538 0.8300534 0.9989514
cor…1551 CitG24m3 SCH772984 (ERK) (uM) 76 -0.2593097 0.0236983 50 -0.2371611 0.0972530 26 -0.2877407 0.1540449 0.0505796 0.8309122 0.9989514
cor…1552 CitQ6m6 Sorafenib (multi-kinase) (uM) 71 -0.1271563 0.2906408 47 -0.0886934 0.5532828 24 -0.1444197 0.5007673 0.0557263 0.8312807 0.9989514
cor…1553 SerG6m2 Gemcitabine/Cisplatin (nM) 59 -0.0792998 0.5504925 40 -0.1542926 0.3418089 19 -0.0920681 0.7077584 -0.0622245 0.8327002 0.9989514
cor…1554 CitQ6m4 Paclitaxel/Carboplatin (nM) 68 -0.1809766 0.1396947 45 -0.1765687 0.2459381 23 -0.2315121 0.2878266 0.0549434 0.8328195 0.9989514
cor…1555 FumG6m2 Docetaxel (nM) 69 0.1275766 0.2961862 46 0.1497906 0.3204224 23 0.0936553 0.6708047 0.0561352 0.8332139 0.9989514
cor…1556 CitQ6m3 Gemcitabine (nM) 69 -0.2119884 0.0803477 46 -0.2355841 0.1150003 23 -0.1815919 0.4069655 -0.0539922 0.8347436 0.9989514
cor…1557 GlyG24m2 Gemcitabine/Cisplatin (nM) 63 -0.1082478 0.3984066 41 -0.1710650 0.2848970 22 -0.1136694 0.6144913 -0.0573956 0.8347904 0.9989514
cor…1558 SerG24m3 Vinorelbine (nM) 66 -0.0450821 0.7192705 43 -0.1015591 0.5169706 23 -0.0447898 0.8391921 -0.0567693 0.8348655 0.9989514
cor…1559 GlyG24m1 8-Cl-adenosine (uM) 67 0.1733981 0.1605365 43 0.1977245 0.2037460 24 0.1434775 0.5035949 0.0542470 0.8357004 0.9989514
cor…1560 MalQ6m2 Carboplatin (uM) 68 -0.1058749 0.3901756 45 -0.1216206 0.4261143 23 -0.0661730 0.7641880 -0.0554476 0.8368200 0.9989514
cor…1561 LacQ6m1 Cisplatin (uM) 70 0.0673428 0.5796372 46 0.0934318 0.5368394 24 0.0389839 0.8564818 0.0544479 0.8372034 0.9989514
cor…1562 FumG24m2 Carboplatin (uM) 69 -0.0031292 0.9796414 46 0.0120122 0.9368484 23 -0.0433503 0.8442980 0.0553626 0.8378452 0.9989514
cor…1563 FumQ24m3 Docetaxel (nM) 69 -0.0097637 0.9365365 46 0.0155360 0.9183784 23 -0.0396489 0.8574543 0.0551849 0.8383745 0.9989514
cor…1564 FumG6m1 Pemetrexed/Cisplatin (uM) 67 -0.0952567 0.4432108 45 -0.0534110 0.7274960 22 -0.1093553 0.6280746 0.0559443 0.8385497 0.9989514
cor…1565 LacG24m2 E-cadherin 59 -0.0301984 0.8203870 37 -0.0597772 0.7252544 22 -0.0015328 0.9945987 -0.0582445 0.8386709 0.9989514
cor…1566 LacG24m3 E-cadherin 59 -0.0986954 0.4570627 37 -0.1187514 0.4839102 22 -0.0613513 0.7862210 -0.0574001 0.8398440 0.9989514
cor…1567 MalQ6m3 Gemcitabine (nM) 70 -0.0261105 0.8301109 46 -0.0315214 0.8352631 24 0.0222401 0.9178440 -0.0537615 0.8399212 0.9989514
cor…1568 CitQ6m2 Paclitaxel/Carboplatin (nM) 68 -0.0657466 0.5942510 45 -0.0904993 0.5543732 23 -0.0367422 0.8678118 -0.0537571 0.8424794 0.9989514
cor…1569 CitG6m1 Gemcitabine/Cisplatin (nM) 65 -0.0737004 0.5595857 44 -0.0380235 0.8064202 21 -0.0934039 0.6871665 0.0553805 0.8440101 0.9989514
cor…1570 CitQ24m3 Gefitinib (EGFR) (uM) 70 -0.2849376 0.0168106 46 -0.3077735 0.0374541 24 -0.2596413 0.2204917 -0.0481322 0.8440794 0.9989514
cor…1571 CitG6m6 EGFR-pY1173 57 -0.1315597 0.3293136 36 -0.3214580 0.0559060 21 -0.2690266 0.2383019 -0.0524313 0.8445385 0.9989514
cor…1572 FumQ6m2 Etoposide (uM) 71 -0.1515646 0.2070421 47 -0.1697952 0.2538613 24 -0.1189891 0.5797293 -0.0508061 0.8448597 0.9989514
cor…1573 CitG24m1 MK-2206 (AKT) (uM) 69 0.0274863 0.8226095 46 0.0499178 0.7418177 23 -0.0029948 0.9891798 0.0529126 0.8448845 0.9989514
cor…1574 CitQ6m4 E-cadherin 57 -0.3639417 0.0053865 36 -0.4241580 0.0099334 21 -0.3762204 0.0927827 -0.0479376 0.8454900 0.9989514
cor…1575 CitQ24m6 AZD6244 (MEK) (uM) 69 0.0892604 0.4657786 46 0.1054641 0.4854547 23 0.0531395 0.8097055 0.0523246 0.8457116 0.9989514
cor…1576 FumQ6m1 Gemcitabine (nM) 71 -0.2115745 0.0765232 47 -0.2139188 0.1487850 24 -0.2624451 0.2153695 0.0485264 0.8461647 0.9989514
cor…1577 GlyG24m1 Docetaxel (nM) 66 0.0441515 0.7248331 43 0.0858621 0.5840649 23 0.0329926 0.8812038 0.0528695 0.8463465 0.9989514
cor…1578 LacG6m1 CDH1 66 -0.1431016 0.2516872 43 -0.1226369 0.4333622 23 -0.1744838 0.4258773 0.0518469 0.8464586 0.9989514
cor…1579 MalG6m1 Carboplatin (uM) 69 0.0781426 0.5233306 46 0.0647665 0.6689219 23 0.1165353 0.5964401 -0.0517689 0.8470373 0.9989514
cor…1580 FumQ24m3 SCH772984 (ERK) (uM) 78 -0.0676121 0.5564202 51 -0.0644614 0.6531420 27 -0.1120818 0.5778042 0.0476205 0.8477301 0.9989514
cor…1581 CitQ6m1 Gemcitabine (nM) 69 -0.2645830 0.0280238 46 -0.2350574 0.1158381 23 -0.2834969 0.1899014 0.0484395 0.8478054 0.9989514
cor…1582 FumG24m4 Erlotinib (EGFR) (uM) 73 -0.1655349 0.1616342 48 -0.1877864 0.2012023 25 -0.1392063 0.5069205 -0.0485801 0.8478108 0.9989514
cor…1583 LacQ24m1 Pemetrexed/Cisplatin (uM) 67 -0.1276399 0.3033231 45 -0.1057137 0.4894815 22 -0.0530632 0.8145775 -0.0526505 0.8479888 0.9989514
cor…1584 MalQ6m2 SCH772984 (ERK) (uM) 77 -0.0750873 0.5163198 50 -0.0579123 0.6895396 27 -0.1056042 0.6001116 0.0476919 0.8482032 0.9989514
cor…1585 LacQ6m1 Doxorubicin (nM) 73 0.0638364 0.5915771 48 0.0572163 0.6992942 25 0.1066359 0.6119209 -0.0494197 0.8482970 0.9989514
cor…1586 SerG24m3 EGFR-pY1173 53 -0.2520644 0.0686337 33 -0.1749274 0.3302207 20 -0.2302803 0.3286952 0.0553529 0.8491507 0.9989514
cor…1587 CitG6m4 Carboplatin (uM) 67 -0.0321010 0.7964998 45 -0.0464974 0.7616604 22 0.0058887 0.9792508 -0.0523861 0.8496250 0.9989514
cor…1588 MalG24m2 SCH772984 (ERK) (uM) 78 -0.0923502 0.4213002 51 -0.0808623 0.5726987 27 -0.1276944 0.5256048 0.0468321 0.8497603 0.9989514
cor…1589 MalQ6m1 Paclitaxel/Carboplatin (nM) 69 0.1791860 0.1406996 45 0.1618296 0.2882097 24 0.2106166 0.3232191 -0.0487871 0.8499777 0.9989514
cor…1590 LacQ6m3 Gemcitabine (nM) 71 0.0183158 0.8794986 47 0.0219018 0.8838223 24 0.0718552 0.7386385 -0.0499534 0.8502533 0.9989514
cor…1591 CitG24m2 E-cadherin 57 -0.0060531 0.9643563 36 -0.0282861 0.8699205 21 0.0263183 0.9098405 -0.0546044 0.8521317 0.9989514
cor…1592 CitG24m6 CDH1 64 0.1617639 0.2015899 42 0.1782249 0.2587959 22 0.1273960 0.5720935 0.0508289 0.8523914 0.9989514
cor…1593 SerG6m3 Etoposide (uM) 61 -0.1114726 0.3923920 41 -0.1144166 0.4762720 20 -0.1674115 0.4805097 0.0529949 0.8529548 0.9989514
cor…1594 MalG6m1 Crizotinib (ALK) (uM) 75 0.1451269 0.2141203 49 0.1253728 0.3907004 26 0.1714292 0.4023928 -0.0460564 0.8536650 0.9989514
cor…1595 FumG6m1 Gemcitabine (nM) 71 -0.0780043 0.5178935 47 -0.0560705 0.7081485 24 -0.1041037 0.6283183 0.0480332 0.8553423 0.9989514
cor…1596 SerG6m3 Vinorelbine (nM) 61 -0.2933397 0.0217683 41 -0.3388759 0.0302087 20 -0.3848314 0.0938467 0.0459555 0.8561437 0.9989514
cor…1597 CitQ6m3 AZD6244 (MEK) (uM) 69 -0.1519004 0.2127741 46 -0.1382441 0.3595500 23 -0.1859959 0.3954854 0.0477518 0.8561870 0.9989514
cor…1598 SerG24m1 Carboplatin (uM) 65 -0.2232396 0.0738526 43 -0.2681517 0.0821100 22 -0.2209184 0.3231565 -0.0472333 0.8568780 0.9989514
cor…1599 CitQ24m5 MK-2206 (AKT) (uM) 69 -0.1424678 0.2428976 46 -0.1373320 0.3627594 23 -0.1847852 0.3986230 0.0474533 0.8571267 0.9989514
cor…1600 LacQ6m3 MK-2206 (AKT) (uM) 71 0.1210622 0.3145663 47 0.1202428 0.4207779 24 0.1669791 0.4354751 -0.0467364 0.8571852 0.9989514
cor…1601 CitQ24m6 E-cadherin 57 -0.0880839 0.5146889 36 -0.1314628 0.4447089 21 -0.0793878 0.7323023 -0.0520750 0.8573403 0.9989514
cor…1602 MalQ6m4 Pemetrexed (uM) 69 -0.1691209 0.1647754 46 -0.1821616 0.2256473 23 -0.1350830 0.5388617 -0.0470785 0.8583557 0.9989514
cor…1603 LacQ6m3 Beta-catenin 59 0.1390970 0.2934044 37 0.1566610 0.3544669 22 0.1066284 0.6367213 0.0500327 0.8588828 0.9989514
cor…1604 CitQ6m6 Vinorelbine (nM) 70 -0.0516003 0.6713990 46 -0.0698618 0.6445475 24 -0.0226399 0.9163722 -0.0472219 0.8588875 0.9989514
cor…1605 MalQ24m4 Cisplatin (uM) 70 0.0227545 0.8516809 46 0.0520626 0.7311309 24 0.0050554 0.9812961 0.0470073 0.8597066 0.9989514
cor…1606 MalG6m3 8-Cl-adenosine (uM) 71 -0.1218188 0.3115290 47 -0.1102181 0.4608052 24 -0.1561589 0.4662045 0.0459408 0.8600001 0.9989514
cor…1607 LacQ24m2 AZD6244 (MEK) (uM) 71 0.1553517 0.1957857 47 0.1517962 0.3084133 24 0.1970652 0.3560194 -0.0452690 0.8602389 0.9989514
cor…1608 FumQ24m1 Gemcitabine/Cisplatin (nM) 67 -0.1002555 0.4195395 45 -0.0890210 0.5608880 22 -0.1367852 0.5438554 0.0477642 0.8610605 0.9989514
cor…1609 CitG6m2 8-Cl-adenosine (uM) 69 -0.1363177 0.2640473 46 -0.1266370 0.4016710 23 -0.1728761 0.4302195 0.0462391 0.8612418 0.9989514
cor…1610 LacG6m2 Gemcitabine (nM) 71 0.0764841 0.5261090 47 0.0891616 0.5511818 24 0.1346554 0.5304457 -0.0454939 0.8620744 0.9989514
cor…1611 LacG24m3 Erlotinib (EGFR) (uM) 73 -0.0552600 0.6423984 48 -0.1092830 0.4596669 25 -0.0645316 0.7592554 -0.0447513 0.8623668 0.9989514
cor…1612 CitG6m1 Erlotinib (EGFR) (uM) 71 -0.0473141 0.6951921 47 -0.0541553 0.7176974 24 -0.0082866 0.9693455 -0.0458687 0.8625420 0.9989514
cor…1613 MalG6m1 Beta-catenin 59 -0.2053812 0.1186426 37 -0.1851593 0.2725786 22 -0.2321000 0.2986285 0.0469407 0.8639270 0.9989514
cor…1614 GlyG6m2 SCH772984 (ERK) (uM) 70 -0.0686373 0.5723546 44 -0.1294904 0.4021713 26 -0.0856267 0.6774798 -0.0438636 0.8647178 0.9989514
cor…1615 CitG24m1 Doxorubicin (nM) 71 -0.0029155 0.9807487 47 -0.0098169 0.9477832 24 0.0353128 0.8698789 -0.0451298 0.8648444 0.9989514
cor…1616 CitQ6m6 SCH772984 (ERK) (uM) 76 0.0027902 0.9809155 50 0.0343389 0.8128580 26 -0.0086243 0.9666475 0.0429632 0.8658848 0.9989514
cor…1617 CitQ24m4 Paclitaxel/Carboplatin (nM) 68 -0.0657065 0.5944763 45 -0.0996252 0.5149672 23 -0.0543849 0.8053279 -0.0452403 0.8669421 0.9989514
cor…1618 FumQ24m1 Pemetrexed (uM) 70 -0.0869776 0.4740145 47 -0.1031109 0.4903833 23 -0.0585209 0.7908305 -0.0445899 0.8677954 0.9989514
cor…1619 MalQ6m4 Gefitinib (EGFR) (uM) 71 -0.2437032 0.0405580 46 -0.2146894 0.1519177 25 -0.2558568 0.2170302 0.0411673 0.8679329 0.9989514
cor…1620 CitG6m6 Carboplatin (uM) 67 -0.0166766 0.8934465 45 0.0007266 0.9962203 22 -0.0451107 0.8419982 0.0458374 0.8682356 0.9989514
cor…1621 GlyG24m1 SCH772984 (ERK) (uM) 73 0.0963350 0.4174986 46 0.0886956 0.5577648 27 0.0467374 0.8169347 0.0419582 0.8685857 0.9989514
cor…1622 LacQ6m1 MK-2206 (AKT) (uM) 71 0.2248647 0.0593847 47 0.2453205 0.0965025 24 0.2039942 0.3390120 0.0413263 0.8696323 0.9989514
cor…1623 MalQ6m4 Beta-catenin 58 0.0442382 0.7415997 36 0.0194721 0.9102525 22 0.0666131 0.7683511 -0.0471410 0.8697092 0.9989514
cor…1624 LacQ6m1 Docetaxel (nM) 69 0.0455965 0.7098728 46 0.0195360 0.8974641 23 0.0638214 0.7723497 -0.0442854 0.8697840 0.9989514
cor…1625 SerG6m3 Paclitaxel/Carboplatin (nM) 59 -0.2344492 0.0738874 40 -0.2416747 0.1329970 19 -0.2872247 0.2331373 0.0455499 0.8699516 0.9989514
cor…1626 CitG24m6 Beta-catenin 57 -0.3426620 0.0090744 36 -0.3593584 0.0313547 21 -0.3169149 0.1615887 -0.0424435 0.8700523 0.9989514
cor…1627 CitQ6m6 MK-2206 (AKT) (uM) 69 0.0815334 0.5054082 46 0.0706480 0.6408185 23 0.1144465 0.6030834 -0.0437985 0.8703235 0.9989514
cor…1628 MalG6m1 Sorafenib (multi-kinase) (uM) 73 -0.2074907 0.0781661 48 -0.2391321 0.1016449 25 -0.1989543 0.3403768 -0.0401778 0.8711063 0.9989514
cor…1629 FumQ6m1 SCH772984 (ERK) (uM) 78 -0.2007183 0.0780599 51 -0.2251580 0.1121598 27 -0.1865768 0.3514267 -0.0385811 0.8719525 0.9989514
cor…1630 MalG24m3 Carboplatin (uM) 69 -0.0960319 0.4324861 46 -0.0850115 0.5743021 23 -0.1280839 0.5602832 0.0430724 0.8720987 0.9989514
cor…1631 LacQ6m1 8-Cl-adenosine (uM) 71 -0.2621339 0.0272202 47 -0.2739838 0.0623784 24 -0.2342695 0.2705329 -0.0397143 0.8728005 0.9989514
cor…1632 MalQ24m1 Paclitaxel (nM) 73 -0.0636106 0.5928914 48 -0.0548352 0.7112530 25 -0.0961336 0.6475843 0.0412984 0.8731310 0.9989514
cor…1633 FumQ6m3 Pemetrexed/Cisplatin (uM) 67 -0.1040338 0.4021406 45 -0.1099882 0.4719887 22 -0.0665264 0.7686447 -0.0434617 0.8740969 0.9989514
cor…1634 CitQ24m2 Gemcitabine/Cisplatin (nM) 65 -0.2066174 0.0986666 44 -0.2110691 0.1690325 21 -0.1681014 0.4663839 -0.0429677 0.8747249 0.9989514
cor…1635 GlyG24m1 Pemetrexed/Cisplatin (uM) 63 -0.0416438 0.7458932 41 -0.0929121 0.5634114 22 -0.1365138 0.5446624 0.0436017 0.8750278 0.9989514
cor…1636 CitG24m3 Docetaxel (nM) 67 -0.0835111 0.5016609 45 -0.1081106 0.4796310 22 -0.0653669 0.7725735 -0.0427437 0.8761936 0.9989514
cor…1637 SerG6m1 E-cadherin 50 -0.0033325 0.9816754 32 0.0175586 0.9240115 18 0.0670091 0.7916397 -0.0494505 0.8761941 0.9989514
cor…1638 FumQ24m4 Pemetrexed/Cisplatin (uM) 67 -0.0974241 0.4328572 45 -0.0610134 0.6905240 22 -0.1037642 0.6458524 0.0427508 0.8762642 0.9989514
cor…1639 LacQ24m2 SCH772984 (ERK) (uM) 78 0.0160517 0.8890668 51 0.0151444 0.9159969 27 0.0539837 0.7891386 -0.0388393 0.8763777 0.9989514
cor…1640 CitG24m1 EGFR-pY1173 57 -0.0020681 0.9878187 36 -0.1091226 0.5263908 21 -0.1529864 0.5079343 0.0438638 0.8789186 0.9989514
cor…1641 MalQ6m3 Paclitaxel (nM) 72 -0.0715052 0.5505825 47 -0.0878176 0.5572230 25 -0.0484463 0.8181192 -0.0393713 0.8795783 0.9989514
cor…1642 CitG24m6 E-cadherin 57 -0.2344175 0.0792336 36 -0.2514737 0.1390103 21 -0.2097043 0.3615874 -0.0417694 0.8803044 0.9989514
cor…1643 SerG6m2 EGFR-pY1173 50 0.0322595 0.8240045 32 0.1652800 0.3659922 18 0.2113294 0.3999024 -0.0460494 0.8806498 0.9989514
cor…1644 SerG24m1 8-Cl-adenosine (uM) 66 -0.1236068 0.3227620 43 -0.1159520 0.4590293 23 -0.1562666 0.4764473 0.0403146 0.8807576 0.9989514
cor…1645 CitG24m4 Gemcitabine (nM) 69 -0.1033742 0.3979594 46 -0.0974625 0.5193370 23 -0.0574240 0.7946690 -0.0400385 0.8816775 0.9989514
cor…1646 LacG24m3 SCH772984 (ERK) (uM) 78 0.2550009 0.0242506 51 0.2281214 0.1073905 27 0.2629459 0.1851330 -0.0348246 0.8821416 0.9989514
cor…1647 MalG24m4 Carboplatin (uM) 69 -0.1533174 0.2084877 46 -0.1684007 0.2632558 23 -0.1291687 0.5569382 -0.0392320 0.8821432 0.9989514
cor…1648 LacQ24m3 Gefitinib (EGFR) (uM) 72 -0.2362466 0.0457260 47 -0.2066027 0.1635164 25 -0.2433202 0.2411837 0.0367174 0.8822371 0.9989514
cor…1649 MalQ24m3 Cisplatin (uM) 70 0.0610146 0.6158354 46 0.0481851 0.7504864 24 0.0873390 0.6848841 -0.0391539 0.8825249 0.9989514
cor…1650 MalG6m1 E-cadherin 59 -0.1499426 0.2569999 37 -0.1298506 0.4436809 22 -0.1703732 0.4484253 0.0405226 0.8849027 0.9989514
cor…1651 SerG6m2 Sorafenib (multi-kinase) (uM) 62 -0.0726567 0.5746615 42 -0.1589201 0.3147789 20 -0.1179919 0.6202927 -0.0409282 0.8858153 0.9989514
cor…1652 FumG24m1 Sorafenib (multi-kinase) (uM) 73 -0.1568091 0.1852156 48 -0.1859659 0.2056848 25 -0.1501680 0.4736960 -0.0357979 0.8873775 0.9989514
cor…1653 CitG24m1 Etoposide (uM) 69 -0.0766284 0.5314357 46 -0.0873250 0.5638910 23 -0.0494906 0.8225631 -0.0378344 0.8882958 0.9989514
cor…1654 MalQ6m3 8-Cl-adenosine (uM) 70 0.0298755 0.8060610 46 0.0211871 0.8888507 24 0.0584593 0.7861341 -0.0372722 0.8884685 0.9989514
cor…1655 LacQ6m2 AZD6244 (MEK) (uM) 71 0.1277778 0.2882699 47 0.1201544 0.4211217 24 0.1565525 0.4650676 -0.0363980 0.8887171 0.9989514
cor…1656 CitQ24m5 Beta-catenin 57 0.3663429 0.0050676 36 0.3908929 0.0184114 21 0.4248911 0.0548595 -0.0339983 0.8892806 0.9989514
cor…1657 CitG6m5 8-Cl-adenosine (uM) 69 -0.2232659 0.0651749 46 -0.2164987 0.1484134 23 -0.2517244 0.2465858 0.0352257 0.8904665 0.9989514
cor…1658 LacG6m3 SCH772984 (ERK) (uM) 78 0.2861813 0.0110839 51 0.2839263 0.0434732 27 0.2521019 0.2045897 0.0318245 0.8908997 0.9989514
cor…1659 LacG6m2 Cisplatin (uM) 70 0.1224515 0.3125613 46 0.1398622 0.3538988 24 0.1039356 0.6288762 0.0359266 0.8910305 0.9989514
cor…1660 FumQ24m1 Paclitaxel (nM) 73 -0.1070804 0.3672157 48 -0.0946900 0.5220559 25 -0.1297466 0.5364817 0.0350566 0.8914338 0.9989514
cor…1661 SerG6m1 Pemetrexed/Cisplatin (uM) 59 -0.2099469 0.1104950 40 -0.3414182 0.0310758 19 -0.3051883 0.2038893 -0.0362299 0.8924197 0.9989514
cor…1662 MalQ24m1 MK-2206 (AKT) (uM) 71 0.0670044 0.5787633 47 0.0836436 0.5761812 24 0.0479875 0.8237942 0.0356561 0.8925843 0.9989514
cor…1663 FumG24m4 SCH772984 (ERK) (uM) 78 -0.0967002 0.3996641 51 -0.0859545 0.5486851 27 -0.1193504 0.5532192 0.0333959 0.8925965 0.9989514
cor…1664 SerG6m1 Carboplatin (uM) 60 -0.2960313 0.0216445 41 -0.3417885 0.0287298 19 -0.3058422 0.2028727 -0.0359463 0.8927939 0.9989514
cor…1665 SerG24m3 Carboplatin (uM) 65 -0.2642207 0.0334336 43 -0.3060331 0.0459524 22 -0.2716403 0.2213710 -0.0343928 0.8928547 0.9989514
cor…1666 MalQ24m4 Pemetrexed/Cisplatin (uM) 67 -0.1008132 0.4169445 45 -0.0661121 0.6661148 22 -0.1030260 0.6482138 0.0369139 0.8930139 0.9989514
cor…1667 CitQ24m1 Pemetrexed/Cisplatin (uM) 65 -0.0889474 0.4810585 44 -0.0788900 0.6107334 21 -0.0413173 0.8588633 -0.0375727 0.8938911 0.9989514
cor…1668 SerG24m2 EGFR-pY1173 53 0.1852531 0.1841676 33 0.3025681 0.0869927 20 0.3385193 0.1443073 -0.0359512 0.8949753 0.9989514
cor…1669 FumQ24m3 Paclitaxel/Carboplatin (nM) 70 0.0464487 0.7025901 46 0.0345593 0.8196385 24 0.0695890 0.7466136 -0.0350297 0.8950225 0.9989514
cor…1670 MalG24m2 CDH1 66 0.2673050 0.0300255 43 0.2616954 0.0900434 23 0.2949235 0.1718944 -0.0332280 0.8953513 0.9989514
cor…1671 CitG6m2 EGFR-pY1173 57 -0.1933823 0.1494990 36 -0.3077736 0.0678380 21 -0.2725212 0.2320227 -0.0352525 0.8954680 0.9989514
cor…1672 FumG24m1 Beta-catenin 59 0.0021367 0.9871855 37 0.0204336 0.9044522 22 -0.0171796 0.9395138 0.0376132 0.8955127 0.9989514
cor…1673 MalQ24m3 Docetaxel (nM) 69 0.0359455 0.7693496 46 0.0502573 0.7401228 23 0.0148501 0.9463824 0.0354072 0.8957978 0.9989514
cor…1674 SerG24m1 Paclitaxel/Carboplatin (nM) 63 -0.1637832 0.1996190 41 -0.1724155 0.2810542 22 -0.2078403 0.3533326 0.0354249 0.8959155 0.9989514
cor…1675 MalG6m1 Paclitaxel/Carboplatin (nM) 70 0.0506630 0.6770351 46 0.0664252 0.6609482 24 0.0327826 0.8791333 0.0336427 0.8991826 0.9989514
cor…1676 LacQ24m1 CDH1 66 0.2886597 0.0187456 43 0.3059729 0.0459973 23 0.2742475 0.2053889 0.0317253 0.8993312 0.9989514
cor…1677 CitG6m3 Doxorubicin (nM) 71 0.0535977 0.6570969 47 0.0674682 0.6522794 24 0.0340560 0.8744737 0.0334122 0.8994846 0.9989514
cor…1678 CitQ6m4 Gemcitabine (nM) 69 -0.1883740 0.1211227 46 -0.1769537 0.2394187 23 -0.1437991 0.5127296 -0.0331546 0.8999353 0.9989514
cor…1679 LacQ6m2 SCH772984 (ERK) (uM) 78 0.1059447 0.3559171 51 0.1058144 0.4599006 27 0.1367804 0.4963087 -0.0309660 0.8999500 0.9989514
cor…1680 CitQ24m1 Carboplatin (uM) 67 -0.1466384 0.2363685 45 -0.1380915 0.3656651 22 -0.1720067 0.4440207 0.0339152 0.8999669 0.9989514
cor…1681 FumQ24m4 Erlotinib (EGFR) (uM) 73 -0.1604753 0.1750214 48 -0.1648780 0.2627639 25 -0.1329175 0.5264835 -0.0319605 0.9000069 0.9989514
cor…1682 LacG24m1 Pemetrexed/Cisplatin (uM) 67 0.0219072 0.8603219 45 0.0749784 0.6244831 22 0.0405739 0.8577232 0.0344045 0.9006290 0.9989514
cor…1683 LacQ24m1 MK-2206 (AKT) (uM) 71 -0.0725214 0.5478253 47 -0.0600648 0.6883777 24 -0.0923497 0.6677872 0.0322849 0.9025451 0.9989514
cor…1684 SerG24m2 Gefitinib (EGFR) (uM) 66 -0.2921082 0.0173166 43 -0.3067375 0.0454291 23 -0.3363373 0.1166057 0.0295999 0.9040391 0.9989514
cor…1685 MalQ6m1 Docetaxel (nM) 68 0.0968426 0.4320853 45 0.1116484 0.4652851 23 0.0794215 0.7186819 0.0322269 0.9047013 0.9989514
cor…1686 CitG6m5 SCH772984 (ERK) (uM) 76 -0.0787308 0.4990188 50 -0.0799247 0.5811247 26 -0.0497038 0.8094583 -0.0302209 0.9050610 0.9989514
cor…1687 CitQ24m6 SCH772984 (ERK) (uM) 76 0.1045348 0.3688256 50 0.1003246 0.4881768 26 0.1300107 0.5267211 -0.0296861 0.9058808 0.9989514
cor…1688 CitQ6m5 Paclitaxel (nM) 71 0.0305717 0.8001999 47 0.0332582 0.8243696 24 0.0641364 0.7659044 -0.0308782 0.9070921 0.9989514
cor…1689 CitQ6m5 Pemetrexed/Cisplatin (uM) 65 -0.0880652 0.4854366 44 -0.1485005 0.3360338 21 -0.1805210 0.4335909 0.0320204 0.9073283 0.9989514
cor…1690 CitG24m3 Cisplatin (uM) 68 -0.0575481 0.6411136 45 -0.0629906 0.6810198 23 -0.0315349 0.8864188 -0.0314558 0.9076116 0.9989514
cor…1691 LacQ6m3 Gemcitabine/Cisplatin (nM) 67 -0.0300569 0.8092058 45 -0.0338410 0.8253361 22 -0.0018455 0.9934966 -0.0319955 0.9078339 0.9989514
cor…1692 FumG24m2 Gefitinib (EGFR) (uM) 72 0.0059072 0.9607219 47 -0.0099169 0.9472521 25 0.0202753 0.9233648 -0.0301923 0.9079383 0.9989514
cor…1693 MalG6m1 CDH1 66 0.1627770 0.1915973 43 0.1732721 0.2664950 23 0.1426451 0.5161541 0.0306270 0.9086783 0.9989514
cor…1694 CitG24m5 Erlotinib (EGFR) (uM) 71 -0.1139155 0.3441917 47 -0.1259098 0.3990529 24 -0.0959292 0.6556710 -0.0299806 0.9088779 0.9989514
cor…1695 MalQ24m3 SCH772984 (ERK) (uM) 78 -0.0943910 0.4110673 51 -0.0947131 0.5085437 27 -0.1227340 0.5419412 0.0280209 0.9096880 0.9989514
cor…1696 SerG24m2 AZD6244 (MEK) (uM) 66 -0.0657082 0.6001507 43 -0.0576024 0.7136945 23 -0.0883578 0.6884911 0.0307553 0.9100995 0.9989514
cor…1697 CitG24m5 8-Cl-adenosine (uM) 69 -0.2605726 0.0305840 46 -0.2712320 0.0682572 23 -0.2427960 0.2643023 -0.0284359 0.9104242 0.9989514
cor…1698 SerG6m2 Cisplatin (uM) 60 -0.2117449 0.1043457 41 -0.2406616 0.1295935 19 -0.2716315 0.2606113 0.0309698 0.9114357 0.9989514
cor…1699 LacG6m3 Beta-catenin 59 -0.2196321 0.0946413 37 -0.2258026 0.1790156 22 -0.1953855 0.3835426 -0.0304171 0.9115119 0.9989514
cor…1700 MalQ24m2 SCH772984 (ERK) (uM) 78 0.0039585 0.9725611 51 0.0374645 0.7940858 27 0.0097382 0.9615506 0.0277263 0.9116369 0.9989514
cor…1701 FumQ6m3 Paclitaxel/Carboplatin (nM) 70 -0.1445865 0.2323986 46 -0.1599157 0.2884161 24 -0.1310634 0.5415683 -0.0288523 0.9118318 0.9989514
cor…1702 MalG24m4 Gemcitabine/Cisplatin (nM) 67 -0.1439951 0.2450163 45 -0.1469943 0.3352628 22 -0.1172196 0.6034036 -0.0297747 0.9127156 0.9989514
cor…1703 LacQ6m3 EGFR-pY1173 59 0.0805619 0.5441462 37 0.0710901 0.6758653 22 0.1020218 0.6514317 -0.0309317 0.9133501 0.9989514
cor…1704 LacG24m1 E-cadherin 59 0.0774569 0.5598224 37 0.0820501 0.6292545 22 0.0510283 0.8215752 0.0310217 0.9133654 0.9989514
cor…1705 FumG24m4 Cisplatin (uM) 70 -0.1472757 0.2237346 46 -0.1395994 0.3548127 24 -0.1675780 0.4338068 0.0279785 0.9142804 0.9989514
cor…1706 LacG24m2 Sorafenib (multi-kinase) (uM) 73 -0.0461240 0.6983949 48 -0.0376042 0.7996871 25 -0.0097637 0.9630551 -0.0278406 0.9147213 0.9989514
cor…1707 MalG24m3 CDH1 66 0.2556999 0.0382458 43 0.2466842 0.1107782 23 0.2738467 0.2060788 -0.0271624 0.9152658 0.9989514
cor…1708 LacQ6m3 Docetaxel (nM) 69 -0.0916054 0.4540945 46 -0.1145090 0.4485936 23 -0.0860189 0.6963508 -0.0284901 0.9153135 0.9989514
cor…1709 CitG6m2 Erlotinib (EGFR) (uM) 71 0.1217417 0.3118379 47 0.1300767 0.3835038 24 0.1023240 0.6342347 0.0277527 0.9155218 0.9989514
cor…1710 CitG6m5 Beta-catenin 57 -0.2148496 0.1085054 36 -0.2300247 0.1771380 21 -0.2005225 0.3834578 -0.0295022 0.9159101 0.9989514
cor…1711 FumG6m4 Gefitinib (EGFR) (uM) 72 0.1803835 0.1294474 47 0.1910302 0.1983543 25 0.2169664 0.2975195 -0.0259362 0.9174485 0.9989514
cor…1712 MalQ24m3 Paclitaxel/Carboplatin (nM) 70 0.1018511 0.4014758 46 0.0916708 0.5445750 24 0.1188638 0.5801312 -0.0271930 0.9177289 0.9989514
cor…1713 FumG6m4 Pemetrexed/Cisplatin (uM) 67 -0.0702486 0.5721505 45 -0.0292101 0.8489380 22 -0.0574755 0.7994511 0.0282654 0.9184134 0.9989514
cor…1714 CitG6m6 MK-2206 (AKT) (uM) 69 0.1464041 0.2299890 46 0.1665020 0.2687545 23 0.1396785 0.5250072 0.0268236 0.9191613 0.9989514
cor…1715 CitG24m3 E-cadherin 57 0.0565299 0.6761883 36 0.0580532 0.7366368 21 0.0283854 0.9027903 0.0296678 0.9191959 0.9989514
cor…1716 FumQ6m1 Erlotinib (EGFR) (uM) 73 0.0686746 0.5637293 48 0.0726908 0.6234320 25 0.0469767 0.8235503 0.0257142 0.9209754 0.9989514
cor…1717 MalG6m2 SCH772984 (ERK) (uM) 78 -0.1165715 0.3094484 51 -0.1240834 0.3856548 27 -0.0997683 0.6205161 -0.0243151 0.9215356 0.9989514
cor…1718 GlyG24m1 Gefitinib (EGFR) (uM) 67 -0.0436693 0.7256712 43 -0.0862721 0.5822637 24 -0.0599374 0.7808536 -0.0263347 0.9217294 0.9989514
cor…1719 LacQ6m3 Paclitaxel/Carboplatin (nM) 70 0.0351144 0.7728971 46 0.0154160 0.9190067 24 0.0413806 0.8477559 -0.0259646 0.9222391 0.9989514
cor…1720 MalG24m1 Carboplatin (uM) 69 0.0555729 0.6501598 46 0.0594245 0.6948428 23 0.0332714 0.8802070 0.0261531 0.9228523 0.9989514
cor…1721 LacQ6m1 Carboplatin (uM) 69 -0.0747399 0.5416307 46 -0.0677357 0.6546748 23 -0.0937333 0.6705458 0.0259975 0.9229735 0.9989514
cor…1722 CitG24m4 Erlotinib (EGFR) (uM) 71 0.0258435 0.8306007 47 0.0226875 0.8796848 24 0.0481749 0.8231165 -0.0254874 0.9233442 0.9989514
cor…1723 FumQ6m3 E-cadherin 59 0.2220554 0.0909665 37 0.2327543 0.1656489 22 0.2065848 0.3563132 0.0261694 0.9235185 0.9989514
cor…1724 CitG24m4 AZD6244 (MEK) (uM) 69 -0.0809719 0.5083542 46 -0.0721017 0.6339461 23 -0.0975298 0.6579751 0.0254281 0.9246046 0.9989514
cor…1725 CitG6m5 CDH1 64 0.1991168 0.1147084 42 0.2091033 0.1838497 22 0.1837274 0.4130961 0.0253759 0.9248329 0.9989514
cor…1726 MalG24m3 SCH772984 (ERK) (uM) 78 -0.0754046 0.5117351 51 -0.0792510 0.5803967 27 -0.0562753 0.7803989 -0.0229757 0.9264350 0.9989514
cor…1727 FumG24m3 CDH1 66 0.2327799 0.0599845 43 0.2454247 0.1126705 23 0.2215300 0.3096928 0.0238947 0.9264700 0.9989514
cor…1728 MalQ6m2 Gefitinib (EGFR) (uM) 71 0.0110201 0.9273247 46 0.0227403 0.8807593 25 -0.0014196 0.9946268 0.0241598 0.9265523 0.9989514
cor…1729 FumQ6m1 Pemetrexed/Cisplatin (uM) 67 -0.0603078 0.6278238 45 -0.0812313 0.5957931 22 -0.0559251 0.8047586 -0.0253062 0.9267239 0.9989514
cor…1730 MalG6m4 8-Cl-adenosine (uM) 71 -0.1950039 0.1031749 47 -0.1938368 0.1917168 24 -0.2171582 0.3080649 0.0233214 0.9268479 0.9989514
cor…1731 MalG24m4 Cisplatin (uM) 70 -0.1297652 0.2843133 46 -0.1368208 0.3645655 24 -0.1130689 0.5988579 -0.0237519 0.9277805 0.9989514
cor…1732 FumQ6m3 Doxorubicin (nM) 73 -0.1498532 0.2057255 48 -0.1564000 0.2884364 25 -0.1334420 0.5248381 -0.0229580 0.9281702 0.9989514
cor…1733 FumQ6m3 Crizotinib (ALK) (uM) 75 0.0666237 0.5700902 49 0.0599632 0.6823378 26 0.0827880 0.6876340 -0.0228248 0.9284154 0.9989514
cor…1734 FumG24m2 SCH772984 (ERK) (uM) 78 -0.0972620 0.3969187 51 -0.1069443 0.4550952 27 -0.0850470 0.6731914 -0.0218973 0.9295527 0.9989514
cor…1735 GlyG6m1 Paclitaxel/Carboplatin (nM) 63 0.2950584 0.0188956 40 0.2993395 0.0605951 23 0.3214288 0.1347656 -0.0220893 0.9298122 0.9989514
cor…1736 FumQ24m3 8-Cl-adenosine (uM) 71 0.1802700 0.1324850 47 0.1767147 0.2347344 24 0.1991985 0.3507306 -0.0224838 0.9299718 0.9989514
cor…1737 FumG24m3 Erlotinib (EGFR) (uM) 73 0.0017997 0.9879432 48 -0.0031309 0.9831501 25 0.0193651 0.9267959 -0.0224960 0.9310821 0.9989514
cor…1738 FumG6m3 MK-2206 (AKT) (uM) 71 0.0666818 0.5805966 47 0.0583457 0.6968624 24 0.0810584 0.7065264 -0.0227127 0.9314217 0.9989514
cor…1739 SerG24m1 CDH1 60 0.2060058 0.1143048 38 0.1915801 0.2492225 22 0.2150622 0.3364716 -0.0234821 0.9314961 0.9989514
cor…1740 CitQ24m4 Docetaxel (nM) 67 -0.0572579 0.6453485 45 -0.0794804 0.6037679 22 -0.0558432 0.8050393 -0.0236373 0.9315532 0.9989514
cor…1741 CitG6m1 Gefitinib (EGFR) (uM) 70 -0.0229828 0.8502102 46 -0.0059276 0.9688130 24 -0.0287621 0.8938689 0.0228345 0.9316242 0.9989514
cor…1742 CitQ6m6 Gemcitabine/Cisplatin (nM) 65 -0.0230764 0.8552202 44 -0.0094792 0.9513040 21 0.0145936 0.9499385 -0.0240728 0.9321471 0.9989514
cor…1743 CitQ24m1 Paclitaxel/Carboplatin (nM) 68 0.0006556 0.9957667 45 0.0026802 0.9860589 23 -0.0200955 0.9274853 0.0227757 0.9331811 0.9989514
cor…1744 MalG6m2 Paclitaxel/Carboplatin (nM) 70 0.1540884 0.2028033 46 0.1629163 0.2793455 24 0.1411707 0.5105507 0.0217456 0.9333598 0.9989514
cor…1745 CitQ6m5 Cisplatin (uM) 68 -0.0255704 0.8360228 45 -0.0466191 0.7610552 23 -0.0241133 0.9130360 -0.0225057 0.9338939 0.9989514
cor…1746 LacQ24m1 Doxorubicin (nM) 73 -0.0923613 0.4370537 48 -0.0817955 0.5804787 25 -0.1029963 0.6241886 0.0212008 0.9344877 0.9989514
cor…1747 SerG24m1 Etoposide (uM) 66 -0.1923405 0.1218122 43 -0.2024524 0.1929232 23 -0.2239336 0.3043372 0.0214812 0.9345059 0.9989514
cor…1748 MalQ6m3 Erlotinib (EGFR) (uM) 72 -0.2918791 0.0128550 47 -0.2813519 0.0553892 25 -0.3005021 0.1444082 0.0191503 0.9361379 0.9989514
cor…1749 CitQ6m3 SCH772984 (ERK) (uM) 76 0.0318313 0.7848774 50 0.0323433 0.8235549 26 0.0122742 0.9525456 0.0200690 0.9371058 0.9989514
cor…1750 LacQ24m3 EGFR-pY1173 59 0.0488429 0.7133491 37 0.0210310 0.9016722 22 -0.0012274 0.9956746 0.0222584 0.9380507 0.9989514
cor…1751 FumQ6m2 Paclitaxel (nM) 73 -0.1927236 0.1023503 48 -0.1849618 0.2081868 25 -0.2043660 0.3271306 0.0194041 0.9382022 0.9989514
cor…1752 CitG6m2 MK-2206 (AKT) (uM) 69 -0.0580384 0.6357174 46 -0.0675632 0.6554995 23 -0.0468996 0.8317200 -0.0206635 0.9389424 0.9989514
cor…1753 GlyG6m1 Carboplatin (uM) 63 0.1195857 0.3505462 41 0.1277822 0.4259310 22 0.1066825 0.6365492 0.0210997 0.9393046 0.9989514
cor…1754 FumG24m1 Gemcitabine/Cisplatin (nM) 67 0.1183723 0.3400610 45 0.1144300 0.4541690 22 0.1349942 0.5491919 -0.0205642 0.9397718 0.9989514
cor…1755 FumQ24m4 Beta-catenin 59 0.0853069 0.5206087 37 0.0695446 0.6825396 22 0.0906634 0.6882328 -0.0211188 0.9408437 0.9989514
cor…1756 CitQ24m5 Doxorubicin (nM) 71 0.0105167 0.9306361 47 0.0121642 0.9353222 24 -0.0074449 0.9724579 0.0196091 0.9410618 0.9989514
cor…1757 FumG6m2 SCH772984 (ERK) (uM) 78 -0.0815615 0.4777750 51 -0.0828449 0.5632921 27 -0.0651052 0.7469747 -0.0177397 0.9431182 0.9989514
cor…1758 MalG6m4 Gemcitabine/Cisplatin (nM) 67 -0.0646242 0.6033700 45 -0.0525428 0.7317592 22 -0.0720729 0.7499285 0.0195300 0.9434648 0.9989514
cor…1759 CitG24m2 8-Cl-adenosine (uM) 69 0.1029993 0.3996820 46 0.0993076 0.5114209 23 0.1181929 0.5911904 -0.0188853 0.9437058 0.9989514
cor…1760 MalG24m2 Sorafenib (multi-kinase) (uM) 73 -0.0831492 0.4843161 48 -0.0917532 0.5351004 25 -0.0735957 0.7266284 -0.0181575 0.9439713 0.9989514
cor…1761 CitG6m5 Carboplatin (uM) 67 -0.0787163 0.5266170 45 -0.0745165 0.6266248 22 -0.0938000 0.6779976 0.0192835 0.9439977 0.9989514
cor…1762 FumQ24m4 Cisplatin (uM) 70 0.0330223 0.7860957 46 0.0349608 0.8175783 24 0.0533949 0.8042948 -0.0184340 0.9446871 0.9989514
cor…1763 LacG6m3 Vinorelbine (nM) 72 -0.1359134 0.2549653 47 -0.1327695 0.3736488 25 -0.1504562 0.4728380 0.0176867 0.9448917 0.9989514
cor…1764 CitG24m5 AZD6244 (MEK) (uM) 69 -0.1023310 0.4027637 46 -0.1008357 0.5049113 23 -0.1191900 0.5880422 0.0183543 0.9452711 0.9989514
cor…1765 FumG6m4 Crizotinib (ALK) (uM) 75 -0.0658654 0.5744974 49 -0.0678486 0.6432111 26 -0.0510959 0.8042217 -0.0167527 0.9475098 0.9989514
cor…1766 CitG6m2 Beta-catenin 57 -0.4317661 0.0007978 36 -0.4351610 0.0079908 21 -0.4504728 0.0404334 0.0153118 0.9481701 0.9989514
cor…1767 SerG6m2 8-Cl-adenosine (uM) 61 -0.1957248 0.1306107 41 -0.2291771 0.1494909 20 -0.2113451 0.3710706 -0.0178320 0.9487860 0.9989514
cor…1768 CitQ24m6 Paclitaxel (nM) 71 -0.1508985 0.2090684 47 -0.1527038 0.3054954 24 -0.1692782 0.4290889 0.0165744 0.9488466 0.9989514
cor…1769 CitQ24m2 Doxorubicin (nM) 71 -0.2713318 0.0220898 47 -0.2764793 0.0599364 24 -0.2607494 0.2184578 -0.0157299 0.9490333 0.9989514
cor…1770 CitG6m2 Gefitinib (EGFR) (uM) 70 0.0531406 0.6621768 46 0.0390122 0.7968627 24 0.0556617 0.7961533 -0.0166495 0.9500200 0.9989514
cor…1771 FumG6m3 Etoposide (uM) 71 -0.1156537 0.3368309 47 -0.1102427 0.4607045 24 -0.1265245 0.5557760 0.0162818 0.9503544 0.9989514
cor…1772 FumG6m2 EGFR-pY1173 59 -0.1207334 0.3623654 37 -0.1756871 0.2982929 22 -0.1921536 0.3916133 0.0164665 0.9525518 0.9989514
cor…1773 CitG24m3 Pemetrexed (uM) 68 -0.1464302 0.2334404 46 -0.1296396 0.3905101 22 -0.1456490 0.5178000 0.0160094 0.9527617 0.9989514
cor…1774 CitQ24m5 EGFR-pY1173 57 0.1833753 0.1721302 36 0.3954221 0.0169865 21 0.4097218 0.0651028 -0.0142997 0.9535554 0.9989514
cor…1775 MalG6m4 Pemetrexed (uM) 70 0.0154838 0.8987647 47 0.0146816 0.9219743 23 0.0302508 0.8910165 -0.0155691 0.9539380 0.9989514
cor…1776 CitG6m3 Paclitaxel (nM) 71 0.0557721 0.6441085 47 0.0440850 0.7685776 24 0.0593448 0.7829695 -0.0152598 0.9539956 0.9989514
cor…1777 FumG24m3 Cisplatin (uM) 70 -0.1953004 0.1051843 46 -0.1894959 0.2071941 24 -0.2041344 0.3386730 0.0146385 0.9543837 0.9989514
cor…1778 FumQ24m4 CDH1 66 -0.1775600 0.1537806 43 -0.1726469 0.2682507 23 -0.1876997 0.3910932 0.0150527 0.9546964 0.9989514
cor…1779 FumQ24m2 Gefitinib (EGFR) (uM) 72 -0.1875874 0.1145848 47 -0.1966073 0.1853213 25 -0.1823494 0.3829810 -0.0142579 0.9548334 0.9989514
cor…1780 MalQ6m4 Vinorelbine (nM) 71 -0.2504912 0.0351238 46 -0.2431046 0.1035321 25 -0.2569729 0.2149617 0.0138683 0.9549942 0.9989514
cor…1781 GlyG24m2 Paclitaxel/Carboplatin (nM) 64 -0.2153263 0.0874941 41 -0.2226486 0.1617552 23 -0.2372523 0.2757014 0.0146036 0.9554886 0.9989514
cor…1782 CitQ6m6 AZD6244 (MEK) (uM) 69 -0.1258094 0.3029824 46 -0.1156928 0.4438853 23 -0.1304813 0.5529029 0.0147885 0.9557555 0.9989514
cor…1783 MalQ6m1 Pemetrexed (uM) 69 -0.0533544 0.6632659 46 -0.0507010 0.7379099 23 -0.0654191 0.7668021 0.0147181 0.9564858 0.9989514
cor…1784 MalQ6m3 Paclitaxel/Carboplatin (nM) 69 -0.1158194 0.3432891 45 -0.1164617 0.4461421 24 -0.1306989 0.5427030 0.0142372 0.9568572 0.9989514
cor…1785 MalQ6m4 Paclitaxel (nM) 72 -0.1905346 0.1088975 47 -0.2057688 0.1652608 25 -0.1926834 0.3561208 -0.0130854 0.9583810 0.9989514
cor…1786 CitQ24m3 E-cadherin 57 0.1834689 0.1719074 36 0.1810484 0.2906407 21 0.1957809 0.3950364 -0.0147325 0.9584247 0.9989514
cor…1787 FumG24m2 EGFR-pY1173 59 0.0605364 0.6487799 37 0.0557847 0.7429617 22 0.0701615 0.7563635 -0.0143769 0.9598087 0.9989514
cor…1788 MalQ24m4 E-cadherin 59 0.0326287 0.8062020 37 0.0248564 0.8838990 22 0.0104371 0.9632322 0.0144192 0.9598376 0.9989514
cor…1789 FumG24m3 EGFR-pY1173 59 -0.0858544 0.5179258 37 -0.1531734 0.3654146 22 -0.1390722 0.5370755 -0.0141012 0.9598789 0.9989514
cor…1790 MalQ6m3 Beta-catenin 58 0.2427300 0.0663728 36 0.2410470 0.1567105 22 0.2542599 0.2535119 -0.0132128 0.9610155 0.9989514
cor…1791 LacQ6m2 8-Cl-adenosine (uM) 71 0.2394916 0.0442675 47 0.2379160 0.1073177 24 0.2500577 0.2386098 -0.0121417 0.9611769 0.9989514
cor…1792 FumG6m2 Carboplatin (uM) 69 0.0159490 0.8965108 46 0.0199953 0.8950669 23 0.0069651 0.9748382 0.0130302 0.9615951 0.9989514
cor…1793 FumG24m3 AZD6244 (MEK) (uM) 71 -0.1173617 0.3296951 47 -0.1223801 0.4125067 24 -0.1099138 0.6091594 -0.0124663 0.9619989 0.9989514
cor…1794 CitQ24m6 Pemetrexed (uM) 68 -0.1077453 0.3818092 46 -0.1043175 0.4902380 22 -0.0914515 0.6856559 -0.0128659 0.9623883 0.9989514
cor…1795 FumG6m3 Gefitinib (EGFR) (uM) 72 0.2216752 0.0612880 47 0.2194698 0.1382786 25 0.2310586 0.2664530 -0.0115889 0.9627084 0.9989514
cor…1796 CitG6m1 EGFR-pY1173 57 -0.1366652 0.3107229 36 -0.2656431 0.1173739 21 -0.2533028 0.2679084 -0.0123403 0.9639833 0.9989514
cor…1797 CitG24m4 EGFR-pY1173 57 -0.1196839 0.3752036 36 -0.2094967 0.2200923 21 -0.1968599 0.3923847 -0.0126368 0.9641198 0.9989514
cor…1798 CitQ6m5 MK-2206 (AKT) (uM) 69 -0.0291008 0.8123750 46 -0.0359306 0.8126077 23 -0.0240246 0.9133549 -0.0119060 0.9648810 0.9989514
cor…1799 CitG24m4 Gemcitabine/Cisplatin (nM) 65 -0.2153399 0.0849404 44 -0.2040204 0.1840527 21 -0.2158223 0.3474230 0.0118019 0.9651714 0.9989514
cor…1800 FumG24m1 Doxorubicin (nM) 73 0.0688141 0.5629360 48 0.0633207 0.6689683 25 0.0743723 0.7238534 -0.0110516 0.9659528 0.9989514
cor…1801 CitQ6m6 Crizotinib (ALK) (uM) 73 -0.0607891 0.6094274 48 -0.0476770 0.7476104 25 -0.0585812 0.7808981 0.0109042 0.9664713 0.9989514
cor…1802 CitG24m6 Erlotinib (EGFR) (uM) 71 -0.2061777 0.0845213 47 -0.2048504 0.1671973 24 -0.2152519 0.3124352 0.0104015 0.9672739 0.9989514
cor…1803 MalG24m1 Gemcitabine/Cisplatin (nM) 67 0.1204767 0.3314839 45 0.1195092 0.4342495 22 0.1086303 0.6303688 0.0108789 0.9681993 0.9989514
cor…1804 CitG24m5 SCH772984 (ERK) (uM) 76 -0.0080834 0.9447488 50 -0.0125781 0.9309145 26 -0.0024655 0.9904627 -0.0101125 0.9682987 0.9989514
cor…1805 FumQ24m4 Carboplatin (uM) 69 0.0997260 0.4149074 46 0.1052359 0.4864047 23 0.1158234 0.5987006 -0.0105875 0.9684105 0.9989514
cor…1806 CitG6m5 AZD6244 (MEK) (uM) 69 -0.1086416 0.3742220 46 -0.1056327 0.4847536 23 -0.1161525 0.5976554 0.0105198 0.9686099 0.9989514
cor…1807 SerG6m3 Paclitaxel (nM) 62 -0.1953197 0.1281734 42 -0.1952116 0.2153838 20 -0.1844074 0.4363898 -0.0108041 0.9692372 0.9989514
cor…1808 CitQ24m3 Pemetrexed/Cisplatin (uM) 65 -0.1511052 0.2295479 44 -0.1824804 0.2357892 21 -0.1920736 0.4042232 0.0095932 0.9719505 0.9989514
cor…1809 GlyG24m2 Docetaxel (nM) 66 -0.2178896 0.0788317 43 -0.2106247 0.1751868 23 -0.2195088 0.3142408 0.0088841 0.9728661 0.9989514
cor…1810 LacQ6m2 Pemetrexed/Cisplatin (uM) 67 0.0269967 0.8283187 45 0.0300500 0.8446470 22 0.0392008 0.8624932 -0.0091508 0.9735649 0.9989514
cor…1811 FumG24m4 CDH1 66 0.2531612 0.0402732 43 0.2499707 0.1059543 23 0.2584253 0.2338083 -0.0084545 0.9736710 0.9989514
cor…1812 MalQ24m1 Cisplatin (uM) 70 -0.0235842 0.8463373 46 -0.0111390 0.9414308 24 -0.0198119 0.9267889 0.0086729 0.9740050 0.9989514
cor…1813 GlyG24m1 Gemcitabine (nM) 66 -0.1004251 0.4223793 43 -0.1515869 0.3318703 23 -0.1602616 0.4651040 0.0086747 0.9741011 0.9989514
cor…1814 CitQ6m5 SCH772984 (ERK) (uM) 76 0.1641018 0.1566235 50 0.1427898 0.3225556 26 0.1348986 0.5111584 0.0078912 0.9747749 0.9989514
cor…1815 MalG24m2 Pemetrexed (uM) 70 -0.1422497 0.2401140 47 -0.1386856 0.3525361 23 -0.1469738 0.5033663 0.0082882 0.9749715 0.9989514
cor…1816 SerG6m2 Etoposide (uM) 61 -0.1017095 0.4354093 41 -0.1062530 0.5084927 20 -0.1152020 0.6286404 0.0089490 0.9752290 0.9989514
cor…1817 LacG24m3 Paclitaxel/Carboplatin (nM) 70 -0.1522335 0.2083588 46 -0.1398979 0.3537747 24 -0.1478069 0.4906670 0.0079090 0.9757989 0.9989514
cor…1818 CitG6m3 Paclitaxel/Carboplatin (nM) 68 0.1598580 0.1928566 45 0.1535814 0.3138119 23 0.1456536 0.5072498 0.0079278 0.9761873 0.9989514
cor…1819 CitG6m5 Etoposide (uM) 69 -0.0540083 0.6593918 46 -0.0567072 0.7081632 23 -0.0488954 0.8246648 -0.0078119 0.9769098 0.9989514
cor…1820 LacG6m1 AZD6244 (MEK) (uM) 71 -0.2816075 0.0173543 47 -0.2822831 0.0545527 24 -0.2752732 0.1929539 -0.0070098 0.9771384 0.9989514
cor…1821 FumG24m1 Erlotinib (EGFR) (uM) 73 -0.0837768 0.4810122 48 -0.0989724 0.5033219 25 -0.0916531 0.6630375 -0.0073193 0.9773486 0.9989514
cor…1822 CitQ6m5 8-Cl-adenosine (uM) 69 0.1198036 0.3268294 46 0.1182949 0.4336330 23 0.1257545 0.5674966 -0.0074596 0.9776800 0.9989514
cor…1823 FumG24m4 8-Cl-adenosine (uM) 71 -0.1656892 0.1673076 47 -0.1664442 0.2634906 24 -0.1735156 0.4174524 0.0070714 0.9780968 0.9989514
cor…1824 CitG24m5 Cisplatin (uM) 68 -0.2751932 0.0231303 45 -0.2754063 0.0670882 23 -0.2821840 0.1920497 0.0067778 0.9784196 0.9989514
cor…1825 CitQ24m3 Vinorelbine (nM) 70 -0.0511561 0.6740677 46 -0.0497919 0.7424464 24 -0.0569333 0.7915954 0.0071413 0.9785385 0.9989514
cor…1826 MalQ6m4 Gemcitabine (nM) 70 -0.0953743 0.4322288 46 -0.0893512 0.5548457 24 -0.0824003 0.7018831 -0.0069509 0.9790155 0.9989514
cor…1827 LacG24m2 8-Cl-adenosine (uM) 71 -0.0116521 0.9231692 47 -0.0124850 0.9336198 24 -0.0055326 0.9795309 -0.0069525 0.9790856 0.9989514
cor…1828 MalQ24m4 MK-2206 (AKT) (uM) 71 -0.0669419 0.5791183 47 -0.0675176 0.6520413 24 -0.0607457 0.7779699 -0.0067719 0.9795462 0.9989514
cor…1829 GlyG24m1 Cisplatin (uM) 66 -0.0106720 0.9322248 43 -0.0185741 0.9058939 23 -0.0254485 0.9082400 0.0068744 0.9799639 0.9989514
cor…1830 FumG24m1 Crizotinib (ALK) (uM) 75 -0.0884523 0.4504683 49 -0.0857834 0.5578326 26 -0.0919461 0.6550733 0.0061627 0.9805941 0.9989514
cor…1831 MalG24m3 MK-2206 (AKT) (uM) 71 0.0950488 0.4304235 47 0.0979877 0.5123000 24 0.0917129 0.6699514 0.0062748 0.9809539 0.9989514
cor…1832 LacG24m1 AZD6244 (MEK) (uM) 71 -0.2370993 0.0464964 47 -0.2372753 0.1082953 24 -0.2429667 0.2526268 0.0056914 0.9818326 0.9989514
cor…1833 CitQ6m5 Gemcitabine/Cisplatin (nM) 65 -0.0221373 0.8610521 44 -0.0522303 0.7363335 21 -0.0459296 0.8432864 -0.0063007 0.9821785 0.9989514
cor…1834 MalG6m4 Crizotinib (ALK) (uM) 75 -0.0685299 0.5590820 49 -0.0656835 0.6538644 26 -0.0711408 0.7298343 0.0054573 0.9828707 0.9989514
cor…1835 CitG6m6 Pemetrexed/Cisplatin (uM) 65 0.0383543 0.7616355 44 0.1172790 0.4483509 21 0.1231277 0.5949183 -0.0058488 0.9832545 0.9989514
cor…1836 FumQ24m2 Gemcitabine/Cisplatin (nM) 67 0.0391830 0.7529042 45 0.0380950 0.8037877 22 0.0324678 0.8859464 0.0056272 0.9837414 0.9989514
cor…1837 MalG24m3 8-Cl-adenosine (uM) 71 -0.2658850 0.0250179 47 -0.2725209 0.0638466 24 -0.2677986 0.2058122 -0.0047223 0.9846764 0.9989514
cor…1838 SerG6m3 E-cadherin 50 -0.1300077 0.3681899 32 -0.0993577 0.5884855 18 -0.1053778 0.6773033 0.0060201 0.9847379 0.9989514
cor…1839 FumQ6m4 Pemetrexed (uM) 70 -0.1382859 0.2536012 47 -0.1233293 0.4088635 23 -0.1283417 0.5594876 0.0050125 0.9849322 0.9989514
cor…1840 CitQ6m6 8-Cl-adenosine (uM) 69 0.0795624 0.5157876 46 0.0839518 0.5791001 23 0.0789297 0.7203559 0.0050221 0.9850970 0.9989514
cor…1841 MalQ6m2 Pemetrexed (uM) 69 -0.2442242 0.0431399 46 -0.2447078 0.1012049 23 -0.2401386 0.2697282 -0.0045692 0.9856900 0.9989514
cor…1842 LacG6m1 Erlotinib (EGFR) (uM) 73 0.0501568 0.6734568 48 0.0741479 0.6164690 25 0.0695168 0.7412574 0.0046311 0.9857231 0.9989514
cor…1843 MalG6m1 Etoposide (uM) 71 0.1530212 0.2026594 47 0.1525294 0.3060546 24 0.1570418 0.4636561 -0.0045123 0.9860931 0.9989514
cor…1844 SerG6m1 Docetaxel (nM) 60 -0.2440309 0.0602434 41 -0.2177910 0.1713429 19 -0.2128967 0.3815252 -0.0048943 0.9862600 0.9989514
cor…1845 CitQ6m4 EGFR-pY1173 57 -0.0770867 0.5687133 36 -0.2392705 0.1598819 21 -0.2436376 0.2872091 0.0043671 0.9873728 0.9989514
cor…1846 MalQ6m1 MK-2206 (AKT) (uM) 70 0.0569000 0.6398796 46 0.0565325 0.7090227 24 0.0523923 0.8079021 0.0041403 0.9875549 0.9989514
cor…1847 MalG6m3 Gemcitabine/Cisplatin (nM) 67 -0.1412756 0.2541366 45 -0.1367542 0.3703711 22 -0.1328519 0.5556065 -0.0039022 0.9885306 0.9989514
cor…1848 FumQ6m4 E-cadherin 59 -0.1284059 0.3324348 37 -0.1418972 0.4021693 22 -0.1378802 0.5406043 -0.0040170 0.9885873 0.9989514
cor…1849 FumG6m2 Gefitinib (EGFR) (uM) 72 0.1294192 0.2785849 47 0.1293519 0.3861821 25 0.1258213 0.5489806 0.0035306 0.9890335 0.9989514
cor…1850 CitQ6m4 8-Cl-adenosine (uM) 69 -0.2181612 0.0717288 46 -0.2246339 0.1333897 23 -0.2281062 0.2951762 0.0034723 0.9892114 0.9989514
cor…1851 LacG24m2 Paclitaxel/Carboplatin (nM) 70 0.1034513 0.3940805 46 0.0967947 0.5222169 24 0.0932896 0.6645978 0.0035051 0.9893997 0.9989514
cor…1852 MalQ24m1 SCH772984 (ERK) (uM) 78 -0.1564057 0.1714786 51 -0.1423851 0.3189030 27 -0.1391450 0.4888210 -0.0032401 0.9894502 0.9989514
cor…1853 CitQ6m5 AZD6244 (MEK) (uM) 69 -0.0494338 0.6866740 46 -0.0571013 0.7062261 23 -0.0605682 0.7836790 0.0034669 0.9897446 0.9989514
cor…1854 FumQ6m4 Docetaxel (nM) 69 -0.2231540 0.0653131 46 -0.2379089 0.1113566 23 -0.2408901 0.2681867 0.0029812 0.9906776 0.9989514
cor…1855 CitG24m6 Cisplatin (uM) 68 -0.2751313 0.0231624 45 -0.2772910 0.0651645 23 -0.2744837 0.2049832 -0.0028073 0.9910764 0.9989514
cor…1856 FumG6m3 Erlotinib (EGFR) (uM) 73 0.0910188 0.4437751 48 0.0936382 0.5267096 25 0.0908368 0.6658678 0.0028014 0.9913345 0.9989514
cor…1857 LacQ6m1 AZD6244 (MEK) (uM) 71 -0.1280382 0.2872806 47 -0.1194165 0.4240006 24 -0.1221665 0.5695741 0.0027501 0.9916046 0.9989514
cor…1858 MalG6m1 Gemcitabine/Cisplatin (nM) 67 0.0181222 0.8842710 45 0.0226664 0.8825077 22 0.0255391 0.9101775 -0.0028727 0.9917050 0.9989514
cor…1859 SerG6m1 Paclitaxel/Carboplatin (nM) 59 -0.1296698 0.3276579 40 -0.1292009 0.4268664 19 -0.1262550 0.6065250 -0.0029459 0.9920142 0.9989514
cor…1860 CitQ24m1 SCH772984 (ERK) (uM) 76 -0.1101781 0.3433942 50 -0.1039989 0.4723037 26 -0.1018098 0.6206793 -0.0021891 0.9930626 0.9994695
cor…1861 CitQ24m5 Carboplatin (uM) 67 0.1297422 0.2953622 45 0.1297010 0.3957855 22 0.1315215 0.5596072 -0.0018205 0.9946551 0.9997173
cor…1862 MalG6m2 Pemetrexed/Cisplatin (uM) 67 -0.0082958 0.9468787 45 0.0032830 0.9829238 22 0.0016571 0.9941604 0.0016259 0.9953079 0.9997173
cor…1863 FumG24m4 AZD6244 (MEK) (uM) 71 -0.2181695 0.0675819 47 -0.2214591 0.1346510 24 -0.2200176 0.3015807 -0.0014416 0.9954413 0.9997173
cor…1864 FumQ6m4 Etoposide (uM) 71 -0.0836325 0.4880534 47 -0.0881684 0.5556431 24 -0.0866838 0.6871307 -0.0014846 0.9954996 0.9997173
cor…1865 CitQ6m4 Gefitinib (EGFR) (uM) 70 0.0102253 0.9330461 46 0.0205318 0.8922678 24 0.0191907 0.9290790 0.0013411 0.9959790 0.9997173
cor…1866 CitQ6m5 E-cadherin 57 0.3698935 0.0046263 36 0.4082713 0.0134374 21 0.4091589 0.0655089 -0.0008876 0.9970983 0.9997339
cor…1867 MalQ24m4 CDH1 66 -0.1666029 0.1812248 43 -0.1676497 0.2825600 23 -0.1686023 0.4418776 0.0009526 0.9971439 0.9997339
cor…1868 FumQ6m3 Gemcitabine (nM) 71 -0.0841747 0.4852278 47 -0.0803448 0.5913691 24 -0.0811381 0.7062503 0.0007934 0.9975977 0.9997339
cor…1869 CitQ24m4 Gemcitabine (nM) 69 0.0421169 0.7311394 46 0.0743658 0.6233037 23 0.0737943 0.7379075 0.0005715 0.9983061 0.9999085
cor…1870 LacG6m1 Beta-catenin 59 0.2123754 0.1063401 37 0.2104541 0.2112032 22 0.2103179 0.3474936 0.0001363 0.9996029 0.9999680
cor…1871 FumG6m4 AZD6244 (MEK) (uM) 71 -0.0109803 0.9275863 47 -0.0040185 0.9786129 24 -0.0039946 0.9852201 -0.0000239 0.9999280 0.9999680
cor…1872 CitQ24m1 Cisplatin (uM) 68 -0.1208266 0.3263507 45 -0.1156176 0.4494676 23 -0.1156068 0.5993892 -0.0000107 0.9999680 0.9999680

Side by side significance bar plot of correlation of SerG6m3 with drug IC50 by Sex

From the side by side bar plot of -log(Pearson correlation p value) of all the drugs’ IC50 by sex for Serine G6 m3, it is correlated with Pemetrexed (uM) in male but not female.

#combine_dat %>% filter(Gender =="M") %>% dplyr::select(!(CellID:Gender))  %>% arrange("SerG6",  "Pemetrexed/Cisplatin (uM)" )
all.equal(TableS1_convolute$CellID, TableS4$CellID) ##make sure TableS1 and TableS4 in same row order
## [1] TRUE
serG6m3_cor = all.out2 %>% filter(metabolite=="SerG6m3") %>% arrange(maleCor.P)

p1 <- ggplot(serG6m3_cor, aes(x=reorder(drug,-log(maleCor.P)), y=-log(maleCor.P), fill=maleCor.P)) + 
   geom_bar(stat="identity", position=position_dodge())  +
  theme(legend.position="none")+labs(title= "Male: Serine G6m3", x="Drug",y="-log(p value)")
p1= p1 +coord_flip()

p2 <- ggplot(serG6m3_cor, aes(x=reorder(drug,-log(femaleCor.P)), y=-log(femaleCor.P), fill=femaleCor.P)) + 
   geom_bar(stat="identity", position=position_dodge())  +
  theme(legend.position="none")+labs(title= "Female: Serine G6m3", x="Drug",y="-log(p value)")
p2= p2 +coord_flip()


grid.arrange(p1, p2, nrow=1, ncol=2) ##make male and female side by side

Part II: Cell ine differential gene expression

What is the best way of picking the cell lines as being sensitive vs. resistant group is still a question. The reference paper (Figure 6D) used \(log(IC50)=1.5\) to define sensitive vs. resistant cell lines.

define male Pemetrexed- sensitive and resistant lines b

We define male Pemetrexed-sensitivity as serine-induced and also by IC50 only based ont he cutoff \(log(IC50)=1.5\).

combine_dat2 = bind_cols(TableS1_convolute, dplyr::select(TableS4, -CellID))
dplyr::select(combine_dat2, CellID,Gender,"Pemetrexed (uM)") %>% na.exclude() %>% dplyr::count(Gender)#23 F and 50 male has permetrexed info
## # A tibble: 2 x 2
##   Gender     n
##   <chr>  <int>
## 1 F         23
## 2 M         50
male_dat = combine_dat2 %>% filter(Gender=="M")  
plot(male_dat$"Pemetrexed (uM)"~male_dat$"SerG6m3",xlab="SerG6m3",ylab="Pemetrexed (uM)")
abline(v=c(5,20),lty=2,col=c("blue","red"))
abline(h=c(-0.5,2),lty=2,col=c("red","blue"))
abline(h=1.5,lty=2,col=c("black"))

##IC50<= -0.5 sensitive
male_sens = subset (male_dat,male_dat$"Pemetrexed (uM)" <= -0.5 & male_dat$"SerG6m3" >= 20) %>% dplyr::select(CellID, SerG6m3, "Pemetrexed (uM)") %>% arrange(-SerG6m3)
male_sens 
## # A tibble: 8 x 3
##   CellID SerG6m3 `Pemetrexed (uM)`
##   <chr>    <dbl>             <dbl>
## 1 H2170     32.7             -0.85
## 2 H522      31.1             -1.75
## 3 HCC95     25.3             -0.54
## 4 PC-9      25.1             -1.69
## 5 H1155     24.6             -1.62
## 6 H460      24.5             -1.17
## 7 HCC15     23.1             -0.82
## 8 H1299     21.3             -1.59
##IC50>2 resistant
male_resist = subset (male_dat,male_dat$"Pemetrexed (uM)" >=2 & male_dat$"SerG6m3" <5) %>% dplyr::select(CellID, SerG6m3, "Pemetrexed (uM)") %>% arrange(-SerG6m3)
male_resist
## # A tibble: 9 x 3
##   CellID  SerG6m3 `Pemetrexed (uM)`
##   <chr>     <dbl>             <dbl>
## 1 H2030     4.44               3   
## 2 HCC1195   4.35               2.61
## 3 H2126     4.27               3   
## 4 H661      3.31               2.7 
## 5 H2291     2.95               3   
## 6 Calu-1    2.68               2.4 
## 7 HCC2450   1.73               2.4 
## 8 H650      0.33               2.7 
## 9 HCC461    0.248              2.4
male_grp = bind_rows(data.frame(male_sens,Gender="M",Resp="Sensitive"),data.frame(male_resist,Gender="M",Resp="Resistant") )
write.csv(male_grp,file="male_sens_vs_resist.csv",row.names=F)

###male sens vs. resist based on pemetrexed IC50>1.5 and <=1.5 only, no serine-specific induced effect
male_sens_IC50 = subset (male_dat,male_dat$"Pemetrexed (uM)" <= 1.5) %>% dplyr::select(CellID,"Pemetrexed (uM)") %>% arrange("Pemetrexed (uM)")
male_sens_IC50
## # A tibble: 22 x 2
##    CellID `Pemetrexed (uM)`
##    <chr>              <dbl>
##  1 A549               -0.39
##  2 H1155              -1.62
##  3 H1299              -1.59
##  4 H1373              -1.52
##  5 H157               -0.7 
##  6 H1581              -1.63
##  7 H2085              -0.79
##  8 H2170              -0.85
##  9 H23                -0.63
## 10 H358               -1.72
## # ... with 12 more rows
male_resist_IC50 = subset (male_dat,male_dat$"Pemetrexed (uM)" > 1.5) %>% dplyr::select(CellID,"Pemetrexed (uM)") %>% arrange("Pemetrexed (uM)")
data.frame(male_resist_IC50)
##     CellID Pemetrexed..uM.
## 1   Calu-1            2.40
## 2   Calu-3            2.40
## 3    H1355            2.40
## 4    H1437            2.40
## 5    H1648            3.00
## 6    H1650            2.40
## 7    H1703            2.40
## 8    H1792            2.70
## 9    H2030            3.00
## 10   H2087            3.00
## 11   H2126            3.00
## 12   H2250            2.40
## 13   H2258            2.40
## 14   H2291            3.00
## 15   H2405            3.00
## 16   H2887            2.40
## 17    H322            3.00
## 18    H441            2.40
## 19    H647            2.18
## 20    H650            2.70
## 21    H661            2.70
## 22 HCC1195            2.61
## 23 HCC2108            3.00
## 24 HCC2450            2.40
## 25 HCC2935            3.00
## 26 HCC4006            3.00
## 27 HCC4011            2.40
## 28  HCC461            2.40
male_grp_byIC50 = bind_rows(data.frame(male_sens_IC50,Gender="M",Resp="Sensitive"),data.frame(male_resist_IC50,Gender="M",Resp="Resistant") )
dim(male_grp_byIC50)##
## [1] 50  4
write.csv(male_grp_byIC50,file="male_sens_vs_resist_byIC50.csv",row.names=F)

We have selected the serine-induced sensitive male NSCLC lines in the bottom right box with \(SerG6m3>=20\) and \(log(IC50)<=-0.5\) , 8 lines which have high Serine level and low pemetrexedand IC50 (cell line ID: H2170 H522 HCC95 PC-9 H1155 H460 HCC15 H1299), and the resistant male NSCLC lines in the top left box with SerG6m3<5 and IC50>=2, 9 lines which have low serine level and high pemetrexedand IC50 (cell line ID: H2030 HCC1195 H2126 H661 H2291 Calu-1 HCC2450 H650 HCC461).

Define female sensitive vs. resistant cell lines

Female cell lines don’t show much serine-induced permetrexed sensitivity and not much variation in serine G6m3 is observed. We simply divided the female lines into sensitive vs. resistant lines by log(IC50)=1.5.

To accompany the same sensitivity definition. We also defined the male group by IC50 sensitivity only (\(log(IC50)=1.5\)) without

female_dat = combine_dat2 %>% filter(Gender=="F")  
plot(female_dat$"Pemetrexed (uM)"~female_dat$"SerG6m3",xlab="SerG6m3",ylab="Pemetrexed (uM)")
abline(h=1.5,lty=2,col=c("red"))

###male sens vs. resist based on pemetrexed IC50>1.5 and <=1.5 only, no serine specific induced effect
female_sens_IC50 = subset (female_dat,female_dat$"Pemetrexed (uM)" <= 1.5) %>% dplyr::select(CellID,Gender,"Pemetrexed (uM)") %>% arrange("Pemetrexed (uM)")
female_sens_IC50
## # A tibble: 13 x 3
##    CellID  Gender `Pemetrexed (uM)`
##    <chr>   <chr>              <dbl>
##  1 H1568   F                  -0.99
##  2 H1693   F                  -1.68
##  3 H1819   F                  -1.42
##  4 H1944   F                   1.35
##  5 H1993   F                  -1.66
##  6 H2009   F                  -1.6 
##  7 H2073   F                  -1.31
##  8 H2228   F                  -1.31
##  9 H2347   F                  -0.7 
## 10 HCC1833 F                  -0.67
## 11 HCC4017 F                  -1.48
## 12 HCC4018 F                   0.83
## 13 HCC827  F                  -1.14
female_resist_IC50 = subset (female_dat,female_dat$"Pemetrexed (uM)" > 1.5) %>% dplyr::select(CellID,Gender,"Pemetrexed (uM)") %>% arrange("Pemetrexed (uM)")
female_resist_IC50
## # A tibble: 10 x 3
##    CellID  Gender `Pemetrexed (uM)`
##    <chr>   <chr>              <dbl>
##  1 Calu-6  F                   2.4 
##  2 H1395   F                   2.4 
##  3 H1975   F                   3   
##  4 H2122   F                   3   
##  5 H2882   F                   2.61
##  6 HCC193  F                   3   
##  7 HCC2279 F                   3   
##  8 HCC366  F                   2.7 
##  9 HCC44   F                   2.4 
## 10 HCC515  F                   2.4
female_grp_byIC50 = bind_rows(data.frame(female_sens_IC50,Resp="Sensitive"),data.frame(female_resist_IC50,Resp="Resistant") )
dim(female_grp_byIC50)
## [1] 23  4
female_grp_byIC50#the defined female sens/resist group
##     CellID Gender Pemetrexed..uM.      Resp
## 1    H1568      F           -0.99 Sensitive
## 2    H1693      F           -1.68 Sensitive
## 3    H1819      F           -1.42 Sensitive
## 4    H1944      F            1.35 Sensitive
## 5    H1993      F           -1.66 Sensitive
## 6    H2009      F           -1.60 Sensitive
## 7    H2073      F           -1.31 Sensitive
## 8    H2228      F           -1.31 Sensitive
## 9    H2347      F           -0.70 Sensitive
## 10 HCC1833      F           -0.67 Sensitive
## 11 HCC4017      F           -1.48 Sensitive
## 12 HCC4018      F            0.83 Sensitive
## 13  HCC827      F           -1.14 Sensitive
## 14  Calu-6      F            2.40 Resistant
## 15   H1395      F            2.40 Resistant
## 16   H1975      F            3.00 Resistant
## 17   H2122      F            3.00 Resistant
## 18   H2882      F            2.61 Resistant
## 19  HCC193      F            3.00 Resistant
## 20 HCC2279      F            3.00 Resistant
## 21  HCC366      F            2.70 Resistant
## 22   HCC44      F            2.40 Resistant
## 23  HCC515      F            2.40 Resistant
write.csv(female_grp_byIC50,file="female_sens_vs_resist.csv",row.names=F)

Read in and preprocess NSCLC cell line GEO expression data

Next, we want to identify genes whose mRNA expression differentiate between these two groups: sensitive vs. resistant male NSCLC lines.

We now read in the cell line gene expression data using R package “GEOquery” directly from GEO GSE32036. The gene expression was log2 transformed and then the selected sensitive and resistant lines were extracted. The box plot of the expression acorss genes for each cell line appear comparable.

gse <- getGEO("GSE32036", GSEMatrix =TRUE, AnnotGPL=TRUE)
#show(gse)#data from two platforms GPL10558 and GPL6884
gse1 = gse[[1]]##platofrm GPL10558
dim(pData(gse1)); #table(pData(gse1)$"histology:ch1")##only 16 samples and 1 is NSCLC cell line
## [1] 16 42
gse2 = gse[[2]]##platform GPL6884 
dim(pData(gse2)); #table(pData(gse2)$"histology:ch1")##206 samples
## [1] 206  47
#get the data on the GPL6884 platform
if (length(gse) > 1) idx <- grep("GPL6884", attr(gse, "names")) else idx <- 1
gse2 <- gse[[idx]]


# make proper column names to match toptable (if space between, make it as .)
fvarLabels(gse2) <- make.names(fvarLabels(gse2))

##get gene annotation data
geneAnnot = fData(gse2)
dim(geneAnnot)#ID, Gene.symbol, Gene.title
## [1] 48803    22
geneAnnot$Gene.symbol[geneAnnot$Gene.symbol==""] = geneAnnot$ID[geneAnnot$Gene.symbol==""]
  
##access phenotype data
pheno = pData(gse2)
#pheno[1:5,1:5]##title has cell line ID, geo_accession has GSM ID

## get gene expresion data
ex <- as.matrix(Biobase::exprs(gse2)) 
dim(ex) #48803 *206
## [1] 48803   206
#ex[1:5,1:5]

# log2 transform (following GEO2R procedure)
qx <- as.numeric(quantile(ex, c(0., 0.25, 0.5, 0.75, 0.99, 1.0), na.rm=T))
LogC <- (qx[5] > 100) ||
          (qx[6]-qx[1] > 50 && qx[2] > 0)
if (LogC) { ex[which(ex <= 0)] <- NaN
  ex <- log2(ex) }


# mean-variance trend
#ex <- na.omit(ex) # eliminate rows with NAs
#plotSA(lmFit(ex), main="Mean variance trend, GSE32036")

# UMAP plot (multi-dimensional scaling)
#ex <- ex[!duplicated(ex), ]  # remove duplicates
#ump <- umap::umap(t(ex), n_neighbors = 15, random_state = 123)
#plot(ump$layout, main="UMAP plot, nbrs=15", xlab="", ylab="", pch=20, cex=1.5)
#pointLabel(ump$layout, labels = rownames(ump$layout), method="SANN", cex=0.6)

We extract the mathcing phenotype and gene expression data of the male sensitive and resistant cell lines (defined based on both Serine and IC50).

##match the male sens and resist cell lines in the  pheno
all(male_grp$CellID%in%pheno$title)##the male sens and resist lines can be matched in the gene expression data
## [1] TRUE
matchID.idx = match(male_grp$CellID,pheno$title) 
#all.equal(male_grp$CellID, pheno$title[matchID.idx]) 

match_pheno = pheno[matchID.idx,]
match_pheno$Resp = male_grp$Resp
table(match_pheno$"histology:ch1")
## 
##            Adenocarcinoma    Adenocarcinoma (mixed)                Large Cell Large Cell Neuroendocrine Muco-epidermoid carcinoma                  Squamous 
##                         7                         1                         2                         2                         1                         4
match_pheno = dplyr::rename(match_pheno, CellID=title)
rownames(match_pheno) = match_pheno$CellID
  
match_ex = ex [, match_pheno$geo_accession]
dim(match_ex)
## [1] 48803    17
colnames(match_ex)
##  [1] "GSM794356" "GSM794291" "GSM794376" "GSM794406" "GSM794308" "GSM794288" "GSM794372" "GSM794311" "GSM794344" "GSM794385" "GSM794354" "GSM794297" "GSM794364" "GSM794261" "GSM794395" "GSM794296" "GSM794380"
match_pheno %>% dplyr::select(CellID, geo_accession, Resp)
##          CellID geo_accession      Resp
## H2170     H2170     GSM794356 Sensitive
## H522       H522     GSM794291 Sensitive
## HCC95     HCC95     GSM794376 Sensitive
## PC-9       PC-9     GSM794406 Sensitive
## H1155     H1155     GSM794308 Sensitive
## H460       H460     GSM794288 Sensitive
## HCC15     HCC15     GSM794372 Sensitive
## H1299     H1299     GSM794311 Sensitive
## H2030     H2030     GSM794344 Resistant
## HCC1195 HCC1195     GSM794385 Resistant
## H2126     H2126     GSM794354 Resistant
## H661       H661     GSM794297 Resistant
## H2291     H2291     GSM794364 Resistant
## Calu-1   Calu-1     GSM794261 Resistant
## HCC2450 HCC2450     GSM794395 Resistant
## H650       H650     GSM794296 Resistant
## HCC461   HCC461     GSM794380 Resistant
colnames(match_ex) = match_pheno$CellID
#all.equal(colnames(match_ex),match_pheno$CellID)

# box-and-whisker plot
title <- paste ("GSE32036", "/", annotation(gse2), ": boxplot of selected male lines", sep ="")
boxplot(match_ex, boxwex=0.7, notch=T, main=title, outline=FALSE, las=2)

# expression value distribution plot
par(mar=c(4,4,2,1))
title <- paste ("GSE32036", "/", annotation(gse2), ": density distribution of selected male cell lines", sep ="")
plotDensities(match_ex, main=title, legend=F)

# UMAP plot (multi-dimensional scaling)
match_ex2 <- match_ex[!duplicated(match_ex), ]  # remove duplicates
ump <- umap::umap(t(match_ex2), n_neighbors = 5, random_state = 123)
plot(ump$layout, main="UMAP plot, nbrs=5", xlab="UMAP1", ylab="UMAP2", pch=20, cex=1.5)
pointLabel(ump$layout, labels = rownames(ump$layout), col=as.character(factor(match_pheno$Resp,levels=c("Sensitive","Resistant"),labels=c("red","blue"))),method="SANN", cex=0.6)

We extract the matching phenotype and gene expression data of the male sensitive and resistant cell lines which was divided by \(log(IC50)=1.5\).

##match the female sens and resist cell lines in the  pheno
all(male_grp_byIC50$CellID%in%pheno$title)##the male sens and resist lines can be matched in the gene expression data
## [1] TRUE
male.matchID.idx = match(male_grp_byIC50$CellID,pheno$title) 
#all.equal(male_grp$CellID, pheno$title[matchID.idx]) 

male.match_pheno = pheno[male.matchID.idx,]
male.match_pheno$Resp = male_grp_byIC50$Resp
#table(male.match_pheno$"histology:ch1")
male.match_pheno = dplyr::rename(male.match_pheno, CellID=title)
rownames(male.match_pheno) = male.match_pheno$CellID
  
male.match_ex = ex [, male.match_pheno$geo_accession]
dim(male.match_ex)
## [1] 48803    50
colnames(male.match_ex)
##  [1] "GSM794260" "GSM794308" "GSM794311" "GSM794313" "GSM794274" "GSM794347" "GSM794348" "GSM794356" "GSM794267" "GSM794285" "GSM794288" "GSM794291" "GSM794294" "GSM794301" "GSM794302" "GSM794306" "GSM794384" "GSM794372" "GSM794403" "GSM794375" "GSM794376" "GSM794406" "GSM794261" "GSM794262"
## [25] "GSM794312" "GSM794316" "GSM794323" "GSM794324" "GSM794329" "GSM794334" "GSM794344" "GSM794350" "GSM794354" "GSM794362" "GSM794363" "GSM794364" "GSM794367" "GSM794369" "GSM794282" "GSM794287" "GSM794295" "GSM794296" "GSM794297" "GSM794385" "GSM794391" "GSM794395" "GSM794397" "GSM794399"
## [49] "GSM794400" "GSM794380"
male.match_pheno %>% dplyr::select(CellID, geo_accession, Resp)
##          CellID geo_accession      Resp
## A549       A549     GSM794260 Sensitive
## H1155     H1155     GSM794308 Sensitive
## H1299     H1299     GSM794311 Sensitive
## H1373     H1373     GSM794313 Sensitive
## H157       H157     GSM794274 Sensitive
## H1581     H1581     GSM794347 Sensitive
## H2085     H2085     GSM794348 Sensitive
## H2170     H2170     GSM794356 Sensitive
## H23         H23     GSM794267 Sensitive
## H358       H358     GSM794285 Sensitive
## H460       H460     GSM794288 Sensitive
## H522       H522     GSM794291 Sensitive
## H596       H596     GSM794294 Sensitive
## H820       H820     GSM794301 Sensitive
## H838       H838     GSM794302 Sensitive
## H920       H920     GSM794306 Sensitive
## HCC1171 HCC1171     GSM794384 Sensitive
## HCC15     HCC15     GSM794372 Sensitive
## HCC4019 HCC4019     GSM794403 Sensitive
## HCC78     HCC78     GSM794375 Sensitive
## HCC95     HCC95     GSM794376 Sensitive
## PC-9       PC-9     GSM794406 Sensitive
## Calu-1   Calu-1     GSM794261 Resistant
## Calu-3   Calu-3     GSM794262 Resistant
## H1355     H1355     GSM794312 Resistant
## H1437     H1437     GSM794316 Resistant
## H1648     H1648     GSM794323 Resistant
## H1650     H1650     GSM794324 Resistant
## H1703     H1703     GSM794329 Resistant
## H1792     H1792     GSM794334 Resistant
## H2030     H2030     GSM794344 Resistant
## H2087     H2087     GSM794350 Resistant
## H2126     H2126     GSM794354 Resistant
## H2250     H2250     GSM794362 Resistant
## H2258     H2258     GSM794363 Resistant
## H2291     H2291     GSM794364 Resistant
## H2405     H2405     GSM794367 Resistant
## H2887     H2887     GSM794369 Resistant
## H322       H322     GSM794282 Resistant
## H441       H441     GSM794287 Resistant
## H647       H647     GSM794295 Resistant
## H650       H650     GSM794296 Resistant
## H661       H661     GSM794297 Resistant
## HCC1195 HCC1195     GSM794385 Resistant
## HCC2108 HCC2108     GSM794391 Resistant
## HCC2450 HCC2450     GSM794395 Resistant
## HCC2935 HCC2935     GSM794397 Resistant
## HCC4006 HCC4006     GSM794399 Resistant
## HCC4011 HCC4011     GSM794400 Resistant
## HCC461   HCC461     GSM794380 Resistant
colnames(male.match_ex) = male.match_pheno$CellID
#all.equal(colnames(male.match_ex), male.match_pheno$CellID)

# box-and-whisker plot
title2 <- paste ("GSE32036", "/", annotation(gse2), ": boxplot of selected male lines (by IC50 only)", sep ="")
boxplot(male.match_ex, boxwex=0.7, notch=T, main=title2, outline=FALSE, las=2)

# male cell lines expression value distribution plot
par(mar=c(4,4,2,1))
title <- paste ("GSE32036", "/", annotation(gse2), ": density distribution of selected male cell lines", sep ="")
plotDensities(male.match_ex, main=title, legend=F)

# UMAP plot (multi-dimensional scaling)
male.match_ex2 <- male.match_ex[!duplicated(male.match_ex), ]  # remove duplicates
male.ump <- umap::umap(t(male.match_ex2), n_neighbors = 5, random_state = 123)
plot(male.ump$layout, main="UMAP plot, nbrs=5", xlab="UMAP1", ylab="UMAP2", pch=20, cex=1.5)
pointLabel(male.ump$layout, labels = rownames(male.ump$layout), col=as.character(factor(male.match_pheno$Resp,levels=c("Sensitive","Resistant"),labels=c("red","blue"))),method="SANN", cex=0.6)

We extract the matching phenotype and gene expression data of the female sensitive and resistant cell lines.

##match the female sens and resist cell lines in the  pheno
all(female_grp_byIC50$CellID%in%pheno$title)##the male sens and resist lines can be matched in the gene expression data
## [1] TRUE
female.matchID.idx = match(female_grp_byIC50$CellID,pheno$title) 
#all.equal(male_grp$CellID, pheno$title[matchID.idx]) 

female.match_pheno = pheno[female.matchID.idx,]
female.match_pheno$Resp = female_grp_byIC50$Resp
table(female.match_pheno$"histology:ch1")
## 
##                Adenocarcinoma Adenocarcinoma (BAC features)                 Adenosquamous                    Large Cell                         NSCLC 
##                            19                             1                             1                             1                             1
female.match_pheno = dplyr::rename(female.match_pheno, CellID=title)
rownames(female.match_pheno) = female.match_pheno$CellID
  
female.match_ex = ex [, female.match_pheno$geo_accession]
dim(female.match_ex)
## [1] 48803    23
colnames(female.match_ex)
##  [1] "GSM794319" "GSM794328" "GSM794336" "GSM794339" "GSM794341" "GSM794342" "GSM794346" "GSM794361" "GSM794366" "GSM794389" "GSM794401" "GSM794402" "GSM794382" "GSM794263" "GSM794315" "GSM794340" "GSM794353" "GSM794368" "GSM794377" "GSM794392" "GSM794379" "GSM794374" "GSM794381"
female.match_pheno %>% dplyr::select(CellID, geo_accession, Resp)
##          CellID geo_accession      Resp
## H1568     H1568     GSM794319 Sensitive
## H1693     H1693     GSM794328 Sensitive
## H1819     H1819     GSM794336 Sensitive
## H1944     H1944     GSM794339 Sensitive
## H1993     H1993     GSM794341 Sensitive
## H2009     H2009     GSM794342 Sensitive
## H2073     H2073     GSM794346 Sensitive
## H2228     H2228     GSM794361 Sensitive
## H2347     H2347     GSM794366 Sensitive
## HCC1833 HCC1833     GSM794389 Sensitive
## HCC4017 HCC4017     GSM794401 Sensitive
## HCC4018 HCC4018     GSM794402 Sensitive
## HCC827   HCC827     GSM794382 Sensitive
## Calu-6   Calu-6     GSM794263 Resistant
## H1395     H1395     GSM794315 Resistant
## H1975     H1975     GSM794340 Resistant
## H2122     H2122     GSM794353 Resistant
## H2882     H2882     GSM794368 Resistant
## HCC193   HCC193     GSM794377 Resistant
## HCC2279 HCC2279     GSM794392 Resistant
## HCC366   HCC366     GSM794379 Resistant
## HCC44     HCC44     GSM794374 Resistant
## HCC515   HCC515     GSM794381 Resistant
colnames(female.match_ex) = female.match_pheno$CellID
#all.equal(colnames(female.match_ex),female.match_pheno$CellID)

# box-and-whisker plot
title2 <- paste ("GSE32036", "/", annotation(gse2), ": boxplot of selected female lines", sep ="")
boxplot(female.match_ex, boxwex=0.7, notch=T, main=title2, outline=FALSE, las=2)

# female cell lines expression value distribution plot
par(mar=c(4,4,2,1))
title <- paste ("GSE32036", "/", annotation(gse2), ": density distribution of selected female cell lines", sep ="")
plotDensities(female.match_ex, main=title, legend=F)

# UMAP plot (multi-dimensional scaling)
female.match_ex2 <- female.match_ex[!duplicated(female.match_ex), ]  # remove duplicates
female.ump <- umap::umap(t(female.match_ex2), n_neighbors = 5, random_state = 123)
plot(female.ump$layout, main="UMAP plot, nbrs=5", xlab="UMAP1", ylab="UMAP2", pch=20, cex=1.5)
pointLabel(female.ump$layout, labels = rownames(female.ump$layout), col=as.character(factor(female.match_pheno$Resp,levels=c("Sensitive","Resistant"),labels=c("red","blue"))),method="SANN", cex=0.6)

Male sensitive vs. resistant (based on both Serine and IC50) differential gene expression analysis

Using LIMMA, we identified the DE genes comparing the Serine-relevant sensitive male cell lines versus the Serine-relevant resistant cell lines.

limma.res_response = RunLIMMA(sample.info=match_pheno,grpID="Resp", gene=match_ex,protein.annot=geneAnnot,proteinID="ID",geneLabelID="Gene.symbol",  save=TRUE,saveplot=FALSE,file_prefix="Male_ByResponse")
##         RespResistant RespSensitive
## H2170               0             1
## H522                0             1
## HCC95               0             1
## PC-9                0             1
## H1155               0             1
## H460                0             1
## HCC15               0             1
## H1299               0             1
## H2030               1             0
## HCC1195             1             0
## H2126               1             0
## H661                1             0
## H2291               1             0
## Calu-1              1             0
## HCC2450             1             0
## H650                1             0
## HCC461              1             0
## attr(,"assign")
## [1] 1 1
## attr(,"contrasts")
## attr(,"contrasts")$Resp
## [1] "contr.treatment"

##FDR P<0.05 significant genes
male.FDRsig.gene = limma.res_response$DE.res %>% dplyr::filter(adj.P.Val<0.05)
nrow(male.FDRsig.gene)##no gene with FDR P<0.05
## [1] 0
##raw P<0.001 significant genes
male.sig.gene = limma.res_response$DE.res %>% dplyr::filter(P.Value<0.001) %>% dplyr::select(Gene.symbol, metabolite, Mean_Resistant:adj.P.Val,  Gene.title)
nrow(male.sig.gene)##124 gene/probes with raw P<0.001
## [1] 124
length(unique(male.sig.gene$Gene.symbol))##116 unique genes
## [1] 116
#pdf("Heatmap_rawP_male.pdf",height=15, width=15)
pheatmap::pheatmap(match_ex[male.sig.gene$metabolite,],scale="row", cluster_rows = TRUE, cluster_col=TRUE,labels_row=geneAnnot[male.sig.gene$metabolite, "Gene.symbol"],annotation_col=subset(match_pheno,select=Resp),main="male DE genes with raw P<0.001",fontsize_row=2) 

#dev.off()

#print top 200 table in nice html format
#top200= dplyr::select(limma.res_response$DE.res, Gene.symbol, metabolite, #Mean_Resistant:adj.P.Val,  Gene.title)[1:200,] 
 

##show significant differential genes
kbl(dplyr::select(male.sig.gene,-metabolite)) %>%  kable_paper(full_width = F) %>%  scroll_box(width = "1000px", height = "500px")
Gene.symbol Mean_Resistant Mean_Sensitive logFC AveExpr t P.Value adj.P.Val Gene.title
PRMT3 9.900000 10.985000 1.0850000 10.410588 6.223981 0.0000076 0.2788773 protein arginine methyltransferase 3
WIPI1 9.216556 7.731750 -1.4848056 8.517824 -5.931903 0.0000138 0.2788773 WD repeat domain, phosphoinositide interacting 1
CALU 11.567111 10.415000 -1.1521111 11.024941 -5.497053 0.0000338 0.2788773 calumenin
KDELR3 10.166889 8.609250 -1.5576389 9.433882 -5.405721 0.0000409 0.2788773 KDEL endoplasmic reticulum protein retention receptor 3
S100A13 5.964778 7.065125 1.1003472 6.482588 5.317925 0.0000492 0.2788773 S100 calcium binding protein A13
HNRNPC 9.194000 10.227750 1.0337500 9.680471 5.254773 0.0000562 0.2788773 heterogeneous nuclear ribonucleoprotein C (C1/C2)
PIGP 6.749667 8.244750 1.4950833 7.453235 5.250509 0.0000567 0.2788773 phosphatidylinositol glycan anchor biosynthesis class P
MRPS27 9.928000 10.946875 1.0188750 10.407471 5.244087 0.0000575 0.2788773 mitochondrial ribosomal protein S27
EIF2S2 7.009889 9.190625 2.1807361 8.036118 5.239829 0.0000580 0.2788773 eukaryotic translation initiation factor 2 subunit beta
ILMN_1744395 6.258667 5.476000 -0.7826667 5.890353 -5.211249 0.0000617 0.2788773
ARL3 6.174000 7.979000 1.8050000 7.023412 5.122269 0.0000745 0.2788773 ADP ribosylation factor like GTPase 3
SLC7A1 10.516000 11.904375 1.3883750 11.169353 5.105050 0.0000773 0.2788773 solute carrier family 7 member 1
C9orf84 6.397222 5.171125 -1.2260972 5.820235 -5.017750 0.0000932 0.2788773 chromosome 9 open reading frame 84
COPG1 10.584889 9.695875 -0.8890139 10.166529 -5.010975 0.0000946 0.2788773 coatomer protein complex subunit gamma 1
ILMN_1890082 5.643556 4.963500 -0.6800556 5.323529 -4.997477 0.0000973 0.2788773
COX15 8.690667 9.709125 1.0184583 9.169941 4.981750 0.0001007 0.2788773 COX15, cytochrome c oxidase assembly homolog
RFXAP 6.727111 8.044875 1.3177639 7.347235 4.977596 0.0001016 0.2788773 regulatory factor X associated protein
ARHGAP21 10.805667 9.379375 -1.4262917 10.134471 -4.971808 0.0001029 0.2788773 Rho GTPase activating protein 21
FAM86C1 7.460000 8.453875 0.9938750 7.927706 4.927962 0.0001130 0.2901105 family with sequence similarity 86 member C1
TMEM261 6.764111 8.178750 1.4146389 7.429824 4.904498 0.0001189 0.2901105 transmembrane protein 261
ADAM33 5.580111 5.058750 -0.5213611 5.334765 -4.828536 0.0001401 0.3010450 ADAM metallopeptidase domain 33
PIGP 9.844333 10.881125 1.0367917 10.332235 4.818900 0.0001430 0.3010450 phosphatidylinositol glycan anchor biosynthesis class P
ILMN_1830069 6.273667 7.598375 1.3247083 6.897059 4.806151 0.0001470 0.3010450
ILMN_1789334 4.715667 5.220875 0.5052083 4.953412 4.758599 0.0001630 0.3010450
AFF1 7.885444 6.385000 -1.5004444 7.179353 -4.745149 0.0001678 0.3010450 AF4/FMR2 family member 1
MSX1 5.949444 9.100000 3.1505556 7.432059 4.734771 0.0001716 0.3010450 msh homeobox 1
NFKBIZ 10.640111 7.801125 -2.8389861 9.304118 -4.731150 0.0001730 0.3010450 NFKB inhibitor zeta
NME1 8.441333 9.379375 0.9380417 8.882765 4.701067 0.0001847 0.3010450 NME/NM23 nucleoside diphosphate kinase 1
GRPEL2 9.244444 10.231250 0.9868056 9.708823 4.689301 0.0001894 0.3010450 GrpE like 2, mitochondrial
LRP10 10.477333 8.721500 -1.7558333 9.651059 -4.678837 0.0001938 0.3010450 LDL receptor related protein 10
SMIM11A 6.487000 7.641875 1.1548750 7.030471 4.668746 0.0001981 0.3010450 small integral membrane protein 11A
ACADSB 5.333111 6.151125 0.8180139 5.718059 4.660565 0.0002017 0.3010450 acyl-CoA dehydrogenase, short/branched chain
BORCS7 7.953111 9.226500 1.2733889 8.552353 4.644810 0.0002087 0.3010450 BLOC-1 related complex subunit 7
ITGB1 13.661222 12.533500 -1.1277222 13.130529 -4.631044 0.0002151 0.3010450 integrin subunit beta 1
GHITM 12.494778 13.281750 0.7869722 12.865118 4.602721 0.0002288 0.3010450 growth hormone inducible transmembrane protein
MVP 9.068667 7.281750 -1.7869167 8.227765 -4.575633 0.0002427 0.3010450 major vault protein
GOLGB1 8.398778 6.700250 -1.6985278 7.599471 -4.563626 0.0002491 0.3010450 golgin B1
ZNF765 4.591556 5.049250 0.4576944 4.806941 4.549545 0.0002569 0.3010450 zinc finger protein 765
TRIM13 6.305778 6.996500 0.6907222 6.630823 4.545349 0.0002593 0.3010450 tripartite motif containing 13
UBE2D2 6.826444 7.768000 0.9415556 7.269529 4.539941 0.0002624 0.3010450 ubiquitin conjugating enzyme E2 D2
MARCH5 5.971667 6.887125 0.9154583 6.402471 4.539501 0.0002626 0.3010450 membrane associated ring-CH-type finger 5
PDE3B 5.362778 6.845000 1.4822222 6.060294 4.518509 0.0002749 0.3010450 phosphodiesterase 3B
ILMN_1741422 8.890667 7.499250 -1.3914167 8.235882 -4.517358 0.0002756 0.3010450
SLC16A10 6.377667 7.572750 1.1950833 6.940059 4.516980 0.0002759 0.3010450 solute carrier family 16 member 10
ILMN_1755134 6.646778 7.498875 0.8520972 7.047765 4.506085 0.0002825 0.3010450
LYRM4 7.294000 8.210750 0.9167500 7.725412 4.491464 0.0002917 0.3010450 LYR motif containing 4
CALR 10.433222 9.485500 -0.9477222 9.987235 -4.487124 0.0002945 0.3010450 calreticulin
ILMN_1904226 4.759222 5.258125 0.4989028 4.994000 4.468550 0.0003067 0.3010450
EPT1 7.768556 8.987250 1.2186944 8.342059 4.464279 0.0003096 0.3010450 ethanolaminephosphotransferase 1
ILMN_1724959 10.095444 8.838750 -1.2566944 9.504059 -4.458213 0.0003137 0.3010450
MVP 10.589556 8.928250 -1.6613056 9.807765 -4.439402 0.0003270 0.3010450 major vault protein
ILMN_1676725 7.058556 5.648375 -1.4101806 6.394941 -4.438586 0.0003275 0.3010450
DET1 6.821222 7.958875 1.1376528 7.356588 4.430713 0.0003332 0.3010450 de-etiolated homolog 1 (Arabidopsis)
HPSE 7.186556 5.839875 -1.3466806 6.552823 -4.417632 0.0003429 0.3010450 heparanase
ECD 6.610667 7.475750 0.8650833 7.017765 4.411942 0.0003473 0.3010450 ecdysoneless cell cycle regulator
UBA52 7.632111 9.726375 2.0942639 8.617647 4.411767 0.0003474 0.3010450 ubiquitin A-52 residue ribosomal protein fusion product 1
ILMN_1795524 7.908444 8.684125 0.7756806 8.273471 4.398887 0.0003573 0.3010450
LYST 6.396333 5.401125 -0.9952083 5.928000 -4.398074 0.0003580 0.3010450 lysosomal trafficking regulator
QSOX1 9.685444 7.968750 -1.7166944 8.877588 -4.390136 0.0003643 0.3010450 quiescin sulfhydryl oxidase 1
TYMP 7.041778 5.485375 -1.5564028 6.309353 -4.382895 0.0003701 0.3010450 thymidine phosphorylase
MARCH2 7.282444 6.168000 -1.1144444 6.758000 -4.373097 0.0003782 0.3020862 membrane associated ring-CH-type finger 2
SEH1L 8.794778 9.683750 0.8889722 9.213118 4.359528 0.0003896 0.3020862 SEH1 like nucleoporin
DAP 10.637111 9.550875 -1.0862361 10.125941 -4.353825 0.0003945 0.3020862 death associated protein
NUMB 9.696000 8.915625 -0.7803750 9.328765 -4.351947 0.0003962 0.3020862 NUMB, endocytic adaptor protein
LYRM7 6.458333 7.503875 1.0455417 6.950353 4.335589 0.0004107 0.3029391 LYR motif containing 7
SFXN4 9.539667 10.382375 0.8427083 9.936235 4.330444 0.0004153 0.3029391 sideroflexin 4
CLYBL 6.459556 8.243875 1.7843194 7.299235 4.329827 0.0004159 0.3029391 citrate lyase beta like
CCDC186 5.891778 5.215875 -0.6759028 5.573706 -4.322025 0.0004231 0.3036493 coiled-coil domain containing 186
ZBTB25 6.943444 6.053125 -0.8903194 6.524471 -4.308013 0.0004363 0.3086165 zinc finger and BTB domain containing 25
RAB24 6.586000 7.561625 0.9756250 7.045118 4.258443 0.0004866 0.3275864 RAB24, member RAS oncogene family
DPH6 6.114111 7.183125 1.0690139 6.617177 4.249378 0.0004965 0.3275864 diphthamine biosynthesis 6
ILMN_1798326 4.728556 5.144500 0.4159444 4.924294 4.246939 0.0004991 0.3275864
CSNK1G3 8.189889 9.070625 0.8807361 8.604353 4.245104 0.0005012 0.3275864 casein kinase 1 gamma 3
VSTM2L 7.554556 5.499125 -2.0554306 6.587294 -4.243318 0.0005031 0.3275864 V-set and transmembrane domain containing 2 like
MFSD8 8.476667 7.728625 -0.7480417 8.124647 -4.243052 0.0005034 0.3275864 major facilitator superfamily domain containing 8
KIAA0368 5.831000 7.584375 1.7533750 6.656118 4.217841 0.0005322 0.3287340 KIAA0368
C21orf33 8.624667 9.465000 0.8403333 9.020118 4.217275 0.0005329 0.3287340 chromosome 21 open reading frame 33
AKAP7 6.972333 8.902375 1.9300417 7.880588 4.211538 0.0005396 0.3287340 A-kinase anchoring protein 7
SNRPB 12.116778 12.919375 0.8025972 12.494471 4.201549 0.0005517 0.3287340 small nuclear ribonucleoprotein polypeptides B and B1
ZNF280D 6.991889 8.193500 1.2016111 7.557353 4.200919 0.0005524 0.3287340 zinc finger protein 280D
KDELR3 7.496889 6.288250 -1.2086389 6.928118 -4.200067 0.0005535 0.3287340 KDEL endoplasmic reticulum protein retention receptor 3
ILMN_1771326 8.125333 9.051500 0.9261667 8.561177 4.191621 0.0005639 0.3287340
DIMT1 10.162222 11.276500 1.1142778 10.686588 4.187042 0.0005696 0.3287340 DIM1 dimethyladenosine transferase 1 homolog
TMEM231 6.269889 7.450000 1.1801111 6.825235 4.184310 0.0005730 0.3287340 transmembrane protein 231
ARID4A 6.366778 5.548625 -0.8181528 5.981765 -4.182339 0.0005755 0.3287340 AT-rich interaction domain 4A
NAGK 10.560778 9.614250 -0.9465278 10.115353 -4.174492 0.0005856 0.3287340 N-acetylglucosamine kinase
CERCAM 8.225333 7.155375 -1.0699583 7.721824 -4.164281 0.0005989 0.3287340 cerebral endothelial cell adhesion molecule
PIK3R4 7.654000 6.893125 -0.7608750 7.295941 -4.160158 0.0006044 0.3287340 phosphoinositide-3-kinase regulatory subunit 4
RPL32 6.851889 8.125750 1.2738611 7.451353 4.150943 0.0006168 0.3287340 ribosomal protein L32
CLYBL 6.447889 8.450125 2.0022361 7.390118 4.138641 0.0006338 0.3287340 citrate lyase beta like
ARFGAP1 6.826667 6.047250 -0.7794167 6.459882 -4.138624 0.0006338 0.3287340 ADP ribosylation factor GTPase activating protein 1
SNX21 7.551111 6.463000 -1.0881111 7.039059 -4.138604 0.0006339 0.3287340 sorting nexin family member 21
L1CAM 6.263667 6.807750 0.5440833 6.519706 4.136061 0.0006374 0.3287340 L1 cell adhesion molecule
TOMM20 10.569000 11.629500 1.0605000 11.068059 4.134986 0.0006389 0.3287340 translocase of outer mitochondrial membrane 20
BORCS7 7.907333 8.880750 0.9734167 8.365412 4.134299 0.0006399 0.3287340 BLOC-1 related complex subunit 7
ILMN_1913586 4.913889 5.479250 0.5653611 5.179941 4.124611 0.0006538 0.3323436
COQ8A 8.062000 9.363750 1.3017500 8.674588 4.115963 0.0006664 0.3352598 coenzyme Q8A
PNPT1 6.602556 7.703875 1.1013194 7.120824 4.110791 0.0006740 0.3356511 polyribonucleotide nucleotidyltransferase 1
MAP3K6 9.496556 8.091000 -1.4055556 8.835118 -4.080775 0.0007202 0.3525361 mitogen-activated protein kinase kinase kinase 6
ILMN_1665601 8.215667 9.060250 0.8445833 8.613118 4.075308 0.0007290 0.3525361
ILMN_1805121 5.330444 4.877125 -0.4533194 5.117118 -4.074928 0.0007296 0.3525361
ZNF586 8.455222 9.650375 1.1951528 9.017647 4.069849 0.0007378 0.3530201 zinc finger protein 586
MORN4 6.937778 7.672500 0.7347222 7.283529 4.064247 0.0007470 0.3539478 MORN repeat containing 4
UBE2L3 9.050000 10.094250 1.0442500 9.541412 4.053979 0.0007642 0.3551857 ubiquitin conjugating enzyme E2 L3
ILMN_1839814 4.897222 5.539500 0.6422778 5.199471 4.053967 0.0007642 0.3551857
ILMN_1883323 5.707222 5.187875 -0.5193472 5.462823 -4.038417 0.0007909 0.3641398
IFT88 6.329333 7.456375 1.1270417 6.859706 4.025042 0.0008147 0.3715650 intraflagellar transport 88
ZNF586 7.717778 8.739125 1.0213472 8.198412 4.018602 0.0008263 0.3734042 zinc finger protein 586
GGA1 5.678333 5.077250 -0.6010833 5.395471 -4.009827 0.0008425 0.3765177 golgi associated, gamma adaptin ear containing, ARF binding protein 1
ILMN_1874848 4.667111 5.175750 0.5086389 4.906471 4.004852 0.0008518 0.3765177
IRF9 10.559222 8.964000 -1.5952222 9.808529 -3.991581 0.0008772 0.3765177 interferon regulatory factor 9
EIF2AK3 6.614333 5.771750 -0.8425833 6.217823 -3.990679 0.0008790 0.3765177 eukaryotic translation initiation factor 2 alpha kinase 3
ILMN_1806109 4.594222 5.011000 0.4167778 4.790353 3.987365 0.0008854 0.3765177
RPL28 7.876667 9.903250 2.0265833 8.830353 3.986831 0.0008865 0.3765177 ribosomal protein L28
RPL32 5.852889 7.060000 1.2071111 6.420941 3.986454 0.0008872 0.3765177 ribosomal protein L32
PDLIM3 5.579333 7.864125 2.2847917 6.654529 3.975453 0.0009091 0.3804484 PDZ and LIM domain 3
ILMN_1870257 4.856222 5.288750 0.4325278 5.059765 3.952906 0.0009556 0.3804484
MAGOHB 5.807111 6.835875 1.0287639 6.291235 3.952593 0.0009563 0.3804484 mago homolog B, exon junction complex core component
ILMN_1705602 7.361556 6.395500 -0.9660556 6.906941 -3.950768 0.0009601 0.3804484
APITD1 7.071444 7.845250 0.7738056 7.435588 3.944369 0.0009738 0.3804484 apoptosis-inducing, TAF9-like domain 1
CFLAR 9.458778 7.887125 -1.5716528 8.719176 -3.940729 0.0009817 0.3804484 CASP8 and FADD like apoptosis regulator
N4BP2L2 7.466667 8.924000 1.4573333 8.152471 3.938594 0.0009863 0.3804484 NEDD4 binding protein 2 like 2
DPH6 5.991667 6.845250 0.8535833 6.393353 3.936846 0.0009902 0.3804484 diphthamine biosynthesis 6
CBLN3 7.162222 5.840375 -1.3218472 6.540177 -3.936827 0.0009902 0.3804484 cerebellin 3 precursor

Male sensitive vs. resistant (based on IC50 only) differential gene expression analysis

Using LIMMA, we identified the DE genes comparing male sensitive cell lines versus female resistant cell lines based on IC50 only.

maleIC50.limma.res_response = RunLIMMA(sample.info=male.match_pheno,grpID="Resp", gene=male.match_ex,protein.annot=geneAnnot,proteinID="ID",geneLabelID="Gene.symbol",  save=TRUE,saveplot=FALSE,file_prefix="MaleIC50_ByResponse")
##         RespResistant RespSensitive
## A549                0             1
## H1155               0             1
## H1299               0             1
## H1373               0             1
## H157                0             1
## H1581               0             1
## H2085               0             1
## H2170               0             1
## H23                 0             1
## H358                0             1
## H460                0             1
## H522                0             1
## H596                0             1
## H820                0             1
## H838                0             1
## H920                0             1
## HCC1171             0             1
## HCC15               0             1
## HCC4019             0             1
## HCC78               0             1
## HCC95               0             1
## PC-9                0             1
## Calu-1              1             0
## Calu-3              1             0
## H1355               1             0
## H1437               1             0
## H1648               1             0
## H1650               1             0
## H1703               1             0
## H1792               1             0
## H2030               1             0
## H2087               1             0
## H2126               1             0
## H2250               1             0
## H2258               1             0
## H2291               1             0
## H2405               1             0
## H2887               1             0
## H322                1             0
## H441                1             0
## H647                1             0
## H650                1             0
## H661                1             0
## HCC1195             1             0
## HCC2108             1             0
## HCC2450             1             0
## HCC2935             1             0
## HCC4006             1             0
## HCC4011             1             0
## HCC461              1             0
## attr(,"assign")
## [1] 1 1
## attr(,"contrasts")
## attr(,"contrasts")$Resp
## [1] "contr.treatment"

##FDR P<0.05 significant genes
maleIC50.FDRsig.gene = maleIC50.limma.res_response$DE.res %>% dplyr::filter(adj.P.Val<0.05)
nrow(male.FDRsig.gene)##only gene with FDR P<0.05
## [1] 0
##raw P<0.001 significant genes
maleIC50.sig.gene = maleIC50.limma.res_response$DE.res %>% dplyr::filter(P.Value<0.001) %>%
dplyr::select(Gene.symbol, metabolite, Mean_Resistant:adj.P.Val,  Gene.title)
  
nrow(maleIC50.sig.gene)##genes with raw P<0.001
## [1] 81
length(unique(male.sig.gene$Gene.symbol)) ##unique genes for female sens/resist
## [1] 116
#pdf("Heatmap_rawP_female.pdf",height=15, width=15)
pheatmap::pheatmap(male.match_ex[maleIC50.sig.gene$metabolite,],scale="row", cluster_rows = TRUE, cluster_col=TRUE,labels_row=geneAnnot[maleIC50.sig.gene$metabolite, "Gene.symbol"],annotation_col=subset(male.match_pheno,select=Resp),main="female DE genes with raw P<0.001",fontsize_row=2) 

#dev.off()

#print top 200 table in nice html format
#maleIC50.top200= dplyr::select(maleIC50.limma.res_response$DE.res, Gene.symbol, metabolite, Mean_Resistant:adj.P.Val,  Gene.title)[1:200,] 
 

##show top 200 differential genes
kbl(dplyr::select(maleIC50.sig.gene,-metabolite)) %>%  kable_paper(full_width = F) %>%  scroll_box(width = "1000px", height = "500px")
Gene.symbol Mean_Resistant Mean_Sensitive logFC AveExpr t P.Value adj.P.Val Gene.title
WIPI1 9.208750 8.174773 -1.0339773 8.75380 -5.118943 0.0000048 0.1287352 WD repeat domain, phosphoinositide interacting 1
ILMN_1834901 5.538964 5.936864 0.3978994 5.71404 5.089119 0.0000053 0.1287352
KDELR3 9.826536 8.730318 -1.0962175 9.34420 -4.912090 0.0000098 0.1587069 KDEL endoplasmic reticulum protein retention receptor 3
ILMN_1906520 5.777286 6.597409 0.8201234 6.13814 4.797117 0.0000145 0.1708387
MRPS26 9.802786 10.621000 0.8182143 10.16280 4.725882 0.0000185 0.1708387 mitochondrial ribosomal protein S26
C19orf48 10.746036 11.566500 0.8204643 11.10704 4.688633 0.0000210 0.1708387 chromosome 19 open reading frame 48
C19orf48 9.149321 10.020682 0.8713604 9.53272 4.569668 0.0000314 0.1723050 chromosome 19 open reading frame 48
KDELR3 9.909964 8.815182 -1.0947825 9.42826 -4.533309 0.0000355 0.1723050 KDEL endoplasmic reticulum protein retention receptor 3
COPG1 10.626143 10.024818 -0.6013247 10.36156 -4.526623 0.0000364 0.1723050 coatomer protein complex subunit gamma 1
MON1B 8.530464 7.819773 -0.7106916 8.21776 -4.518180 0.0000374 0.1723050 MON1 homolog B, secretory trafficking associated
LRP10 10.359571 9.423773 -0.9357987 9.94782 -4.507013 0.0000388 0.1723050 LDL receptor related protein 10
EXOSC3 9.239786 9.974091 0.7343052 9.56288 4.451424 0.0000468 0.1903203 exosome component 3
GLG1 11.854107 11.203682 -0.6504253 11.56792 -4.410348 0.0000537 0.1951080 golgi glycoprotein 1
ITGA1 6.541929 5.323500 -1.2184286 6.00582 -4.397823 0.0000560 0.1951080 integrin subunit alpha 1
CYP4A11 5.556821 5.193227 -0.3635942 5.39684 -4.341306 0.0000675 0.2197360 cytochrome P450 family 4 subfamily A member 11
ILMN_1699121 5.114393 5.637864 0.5234708 5.34472 4.319761 0.0000725 0.2212437
DPCR1 5.476464 5.081500 -0.3949643 5.30268 -4.276003 0.0000838 0.2406132 diffuse panbronchiolitis critical region 1
TMEM261 6.734286 7.641364 0.9070779 7.13340 4.256337 0.0000894 0.2424543 transmembrane protein 261
RPL28 8.272071 9.603682 1.3316104 8.85798 4.177641 0.0001158 0.2973176 ribosomal protein L28
APP 8.188429 7.202000 -0.9864286 7.75440 -4.104850 0.0001467 0.3579790 amyloid beta precursor protein
IFT88 6.523750 7.228091 0.7043409 6.83366 4.060101 0.0001696 0.3940631 intraflagellar transport 88
NMS 5.011750 5.306591 0.2948409 5.14148 4.029710 0.0001870 0.3997073 neuromedin S
N4BP2L2 7.596643 8.449364 0.8527208 7.97184 4.027469 0.0001884 0.3997073 NEDD4 binding protein 2 like 2
ILMN_1829902 4.933821 5.274409 0.3405877 5.08368 4.011870 0.0001981 0.4027562
ASB2 5.576571 5.260409 -0.3161623 5.43746 -3.997857 0.0002072 0.4044378 ankyrin repeat and SOCS box containing 2
ILMN_1701871 5.107071 5.430091 0.3230195 5.24920 3.962054 0.0002323 0.4180799
CCDC172 4.893250 5.213727 0.3204773 5.03426 3.948110 0.0002429 0.4180799 coiled-coil domain containing 172
SOCS7 5.955750 5.541318 -0.4144318 5.77340 -3.941436 0.0002482 0.4180799 suppressor of cytokine signaling 7
ILMN_1834022 4.836679 5.158136 0.3214578 4.97812 3.938114 0.0002508 0.4180799
KDELR3 7.158321 6.209682 -0.9486396 6.74092 -3.930440 0.0002570 0.4180799 KDEL endoplasmic reticulum protein retention receptor 3
P4HB 13.486750 12.947636 -0.5391136 13.24954 -3.908921 0.0002752 0.4235949 prolyl 4-hydroxylase subunit beta
ARFGAP3 10.248464 9.606500 -0.6419643 9.96600 -3.896772 0.0002860 0.4235949 ADP ribosylation factor GTPase activating protein 3
TRMT10B 6.068143 6.550727 0.4825844 6.28048 3.896332 0.0002864 0.4235949 tRNA methyltransferase 10B
ILMN_1691611 12.932607 13.407864 0.4752565 13.14172 3.862941 0.0003184 0.4339300
SQRDL 9.128214 7.940545 -1.1876688 8.60564 -3.858605 0.0003228 0.4339300 sulfide quinone reductase-like (yeast)
ILMN_1676091 11.548821 12.128955 0.5801331 11.80408 3.845462 0.0003364 0.4339300
ILMN_1751146 4.960500 5.331682 0.3711818 5.12382 3.845115 0.0003368 0.4339300
NOP56 10.892036 11.554046 0.6620097 11.18332 3.844109 0.0003379 0.4339300 NOP56 ribonucleoprotein
PRKCB 4.887321 5.209864 0.3225422 5.02924 3.807594 0.0003790 0.4556401 protein kinase C beta
RRBP1 7.795286 6.983591 -0.8116948 7.43814 -3.805310 0.0003817 0.4556401 ribosome binding protein 1
NDUFS7 11.431071 11.941727 0.5106558 11.65576 3.800495 0.0003876 0.4556401 NADH:ubiquinone oxidoreductase core subunit S7
SEH1L 8.560500 9.215500 0.6550000 8.84870 3.796760 0.0003921 0.4556401 SEH1 like nucleoporin
ILMN_1667330 8.735929 9.710773 0.9748442 9.16486 3.779263 0.0004142 0.4624785
ILMN_1766920 4.843393 5.118455 0.2750617 4.96442 3.768474 0.0004284 0.4624785
RPL32 5.999893 6.751318 0.7514253 6.33052 3.764015 0.0004344 0.4624785 ribosomal protein L32
GRM2 5.958321 6.483091 0.5247695 6.18922 3.762932 0.0004359 0.4624785 glutamate metabotropic receptor 2
EIF2AK3 6.616429 6.070955 -0.5454740 6.37642 -3.720681 0.0004972 0.4836011 eukaryotic translation initiation factor 2 alpha kinase 3
ZNF473 6.836750 7.401318 0.5645682 7.08516 3.715794 0.0005048 0.4836011 zinc finger protein 473
ILMN_1893904 5.179143 4.937409 -0.2417338 5.07278 -3.715107 0.0005059 0.4836011
THG1L 5.964071 6.359909 0.3958377 6.13824 3.714626 0.0005067 0.4836011 tRNA-histidine guanylyltransferase 1 like
TOP1MT 9.416571 10.154773 0.7382013 9.74138 3.711223 0.0005121 0.4836011 topoisomerase (DNA) I, mitochondrial
RNF103 10.499679 9.868136 -0.6315422 10.22180 -3.709198 0.0005153 0.4836011 ring finger protein 103
RPN1 13.039786 12.653273 -0.3865130 12.86972 -3.677942 0.0005676 0.5097921 ribophorin I
TIMM44 8.705964 9.345818 0.6398539 8.98750 3.667765 0.0005858 0.5097921 translocase of inner mitochondrial membrane 44
SRGAP1 8.354643 7.497546 -0.8570974 7.97752 -3.656360 0.0006067 0.5097921 SLIT-ROBO Rho GTPase activating protein 1
EXOSC3 9.787857 10.440273 0.6524156 10.07492 3.651400 0.0006161 0.5097921 exosome component 3
ILMN_1766446 8.221857 9.025273 0.8034156 8.57536 3.649338 0.0006200 0.5097921
UBA52 7.814429 8.871818 1.0573896 8.27968 3.644118 0.0006300 0.5097921 ubiquitin A-52 residue ribosomal protein fusion product 1
ATPAF1 8.286643 8.948409 0.6617662 8.57782 3.644031 0.0006302 0.5097921 ATP synthase mitochondrial F1 complex assembly factor 1
ILMN_1656292 10.876929 11.475955 0.5990260 11.14050 3.640512 0.0006371 0.5097921
PHC3 7.168893 6.556136 -0.6127565 6.89928 -3.636285 0.0006454 0.5097921 polyhomeotic homolog 3
LOC101927690 5.246357 5.554045 0.3076883 5.38174 3.635155 0.0006476 0.5097921 uncharacterized LOC101927690
ILMN_1904445 4.766321 5.024818 0.2584968 4.88006 3.627465 0.0006631 0.5136914
SYTL5 5.571214 5.175954 -0.3952597 5.39730 -3.618613 0.0006814 0.5167862 synaptotagmin like 5
MMEL1 5.169214 4.871182 -0.2980325 5.03808 -3.615319 0.0006883 0.5167862 membrane metallo-endopeptidase-like 1
ILMN_1862001 5.261250 5.657727 0.3964773 5.43570 3.583428 0.0007588 0.5460693
ILMN_1844102 4.921357 5.222773 0.3014156 5.05398 3.580314 0.0007661 0.5460693
ILMN_1740910 5.150357 4.837546 -0.3128117 5.01272 -3.579757 0.0007674 0.5460693
NRP1 8.100643 6.848182 -1.2524610 7.54956 -3.577758 0.0007721 0.5460693 neuropilin 1
WBP4 7.689321 8.256455 0.5671331 7.93886 3.557637 0.0008209 0.5583504 WW domain binding protein 4
ILMN_1786606 6.931929 7.541727 0.6097987 7.20024 3.554207 0.0008295 0.5583504
GOLGB1 8.490893 7.586455 -0.9044383 8.09294 -3.524855 0.0009067 0.5583504 golgin B1
BIRC3 10.435786 9.473318 -0.9624675 10.01230 -3.523349 0.0009108 0.5583504 baculoviral IAP repeat containing 3
ILMN_1845475 5.432714 5.692091 0.2593766 5.54684 3.522641 0.0009128 0.5583504
ILMN_1854015 6.146000 6.401773 0.2557727 6.25854 3.515130 0.0009338 0.5583504
ILMN_1719224 13.379250 13.936864 0.5576136 13.62460 3.514320 0.0009361 0.5583504
ILMN_1840462 4.981500 5.196682 0.2151818 5.07618 3.513775 0.0009376 0.5583504
ORC5 9.918679 10.415818 0.4971396 10.13742 3.512751 0.0009405 0.5583504 origin recognition complex subunit 5
TPCN1 7.093964 6.326182 -0.7677825 6.75614 -3.504918 0.0009630 0.5583504 two pore segment channel 1
POLR1E 9.562357 10.214545 0.6521883 9.84932 3.501358 0.0009734 0.5583504 RNA polymerase I subunit E
NDE1 9.851393 9.208364 -0.6430292 9.56846 -3.499521 0.0009789 0.5583504 nudE neurodevelopment protein 1

Female sensitive vs. resistant (based on IC50 only) differential gene expression analysis

Using LIMMA, we identified the DE genes comparing female sensitive cell lines versus female resistant cell lines based on IC50 only.

female.limma.res_response = RunLIMMA(sample.info=female.match_pheno,grpID="Resp", gene=female.match_ex,protein.annot=geneAnnot,proteinID="ID",geneLabelID="Gene.symbol",  save=TRUE,saveplot=FALSE,file_prefix="Female_ByResponse")
##         RespResistant RespSensitive
## H1568               0             1
## H1693               0             1
## H1819               0             1
## H1944               0             1
## H1993               0             1
## H2009               0             1
## H2073               0             1
## H2228               0             1
## H2347               0             1
## HCC1833             0             1
## HCC4017             0             1
## HCC4018             0             1
## HCC827              0             1
## Calu-6              1             0
## H1395               1             0
## H1975               1             0
## H2122               1             0
## H2882               1             0
## HCC193              1             0
## HCC2279             1             0
## HCC366              1             0
## HCC44               1             0
## HCC515              1             0
## attr(,"assign")
## [1] 1 1
## attr(,"contrasts")
## attr(,"contrasts")$Resp
## [1] "contr.treatment"

##FDR P<0.05 significant genes
female.FDRsig.gene = female.limma.res_response$DE.res %>% dplyr::filter(adj.P.Val<0.05)
nrow(female.FDRsig.gene)##only 1 gene with FDR P<0.05
## [1] 0
##raw P<0.001 significant genes
female.sig.gene = female.limma.res_response$DE.res %>% dplyr::filter(P.Value<0.001) %>%
dplyr::select(Gene.symbol, metabolite, Mean_Resistant:adj.P.Val,  Gene.title)
  
nrow(female.sig.gene)##43 genes with raw P<0.001
## [1] 36
length(unique(female.sig.gene$Gene.symbol)) ##42 unqiue genes for female sens/resist
## [1] 34
#pdf("Heatmap_rawP_female.pdf",height=15, width=15)
pheatmap::pheatmap(female.match_ex[female.sig.gene$metabolite,],scale="row", cluster_rows = TRUE, cluster_col=TRUE,labels_row=geneAnnot[female.sig.gene$metabolite, "Gene.symbol"],annotation_col=subset(female.match_pheno,select=Resp),main="female DE genes with raw P<0.001",fontsize_row=2) 

#dev.off()

#print top 200 table in nice html format
#female.top200= dplyr::select(female.limma.res_response$DE.res, Gene.symbol, metabolite, Mean_Resistant:adj.P.Val,  Gene.title)[1:200,] 
 

##show top 200 differential genes
kbl(dplyr::select(female.sig.gene,-metabolite)) %>%  kable_paper(full_width = F) %>%  scroll_box(width = "1000px", height = "500px")
Gene.symbol Mean_Resistant Mean_Sensitive logFC AveExpr t P.Value adj.P.Val Gene.title
TSPYL5 5.9608 9.787000 3.8262000 8.123435 6.500094 0.0000011 0.0515707 TSPY like 5
RMI1 8.3901 9.294000 0.9039000 8.901000 6.054620 0.0000031 0.0756174 RecQ mediated genome instability 1
SLC4A7 7.6009 6.403692 -1.1972077 6.924217 -5.181252 0.0000270 0.3524196 solute carrier family 4 member 7
EPHX2 5.5662 7.396000 1.8298000 6.600435 5.145148 0.0000296 0.3524196 epoxide hydrolase 2
ILMN_1877067 5.3867 4.872846 -0.5138538 5.096261 -5.065957 0.0000361 0.3524196
RUNX2 7.6576 5.632846 -2.0247538 6.513174 -4.566663 0.0001276 0.9415647 runt related transcription factor 2
GCDH 7.4368 6.719000 -0.7178000 7.031087 -4.493224 0.0001536 0.9415647 glutaryl-CoA dehydrogenase
ABHD17B 6.1614 7.043231 0.8818308 6.659826 4.461714 0.0001664 0.9415647 abhydrolase domain containing 17B
AGAP2 5.1351 4.668154 -0.4669462 4.871174 -4.444934 0.0001736 0.9415647 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
LILRB5 5.7272 5.306615 -0.4205846 5.489478 -4.276330 0.0002661 0.9839395 leukocyte immunoglobulin like receptor B5
RPA2 10.9211 11.643462 0.7223615 11.329391 4.253133 0.0002822 0.9839395 replication protein A2
ILMN_1674285 6.5669 8.311308 1.7444077 7.552870 4.242428 0.0002899 0.9839395
ILMN_1910893 6.2784 5.640923 -0.6374769 5.918087 -4.226733 0.0003017 0.9839395
FBLN2 5.4667 7.666077 2.1993769 6.709826 4.200100 0.0003227 0.9839395 fibulin 2
GBP2 11.0228 8.378692 -2.6441077 9.528304 -4.184664 0.0003355 0.9839395 guanylate binding protein 2
ILMN_1887680 4.9687 5.364692 0.3959923 5.192522 4.153727 0.0003628 0.9839395
GADD45B 8.4138 7.334231 -1.0795692 7.803609 -4.141820 0.0003738 0.9839395 growth arrest and DNA damage inducible beta
ILMN_1671844 5.0821 7.087308 2.0052077 6.215478 4.128430 0.0003867 0.9839395
CACNB1 5.4092 4.828000 -0.5812000 5.080696 -4.116942 0.0003981 0.9839395 calcium voltage-gated channel auxiliary subunit beta 1
EYA4 4.7420 6.250846 1.5088462 5.594826 4.111838 0.0004032 0.9839395 EYA transcriptional coactivator and phosphatase 4
SLC25A26 8.3666 7.736923 -0.6296769 8.010696 -4.065762 0.0004529 0.9954941 solute carrier family 25 member 26
BRCA2 4.7793 5.271385 0.4920846 5.057435 4.055665 0.0004646 0.9954941 BRCA2, DNA repair associated
MAPK8IP3 5.5319 5.077154 -0.4547462 5.274870 -4.022982 0.0005045 0.9954941 mitogen-activated protein kinase 8 interacting protein 3
ILMN_1911981 5.0772 4.733923 -0.3432769 4.883174 -4.012613 0.0005178 0.9954941
ILMN_1881749 5.6712 5.259692 -0.4115077 5.438609 -4.009201 0.0005223 0.9954941
MAPK8IP2 5.6464 5.170154 -0.4762462 5.377217 -3.997707 0.0005376 0.9954941 mitogen-activated protein kinase 8 interacting protein 2
ILMN_1749646 4.9834 4.594154 -0.3892462 4.763391 -3.962285 0.0005877 0.9954941
ILMN_1893681 5.1668 4.803000 -0.3638000 4.961174 -3.904528 0.0006795 0.9954941
GLIPR1 8.7677 6.278077 -2.4896231 7.360522 -3.846684 0.0007856 0.9954941 GLI pathogenesis related 1
DCLRE1A 7.8772 8.660308 0.7831077 8.319826 3.842183 0.0007945 0.9954941 DNA cross-link repair 1A
ILMN_1655940 5.2025 4.774000 -0.4285000 4.960304 -3.821811 0.0008361 0.9954941
RMI1 8.1948 8.985154 0.7903538 8.641522 3.812962 0.0008548 0.9954941 RecQ mediated genome instability 1
ZDHHC12 8.4051 9.377692 0.9725923 8.954826 3.782906 0.0009216 0.9954941 zinc finger DHHC-type containing 12
PNPLA4 5.1479 5.820538 0.6726385 5.528087 3.781042 0.0009259 0.9954941 patatin like phospholipase domain containing 4
PXK 6.8426 5.826154 -1.0164462 6.268087 -3.763282 0.0009679 0.9954941 PX domain containing serine/threonine kinase like
SLC4A7 9.1205 8.316462 -0.8040385 8.666044 -3.756098 0.0009854 0.9954941 solute carrier family 4 member 7

Overlapping and unique differential genes between male and female cell line DE analysis

We query among the DE genes at the raw P value<0.001, which are overlapping between male and female and which are unique to each other.

commonG = intersect(male.sig.gene$Gene.symbol, female.sig.gene$Gene.symbol) #common gene to both male and female
cat(length(commonG), " genes common to male and female\n")
## 0  genes common to male and female
commonG 
## character(0)
maleG= setdiff(male.sig.gene$Gene.symbol, female.sig.gene$Gene.symbol)#116 genes in male but not female
cat(length(maleG), " genes unique to male but not female\n")
## 116  genes unique to male but not female
maleG
##   [1] "PRMT3"        "WIPI1"        "CALU"         "KDELR3"       "S100A13"      "HNRNPC"       "PIGP"         "MRPS27"       "EIF2S2"       "ILMN_1744395" "ARL3"         "SLC7A1"       "C9orf84"      "COPG1"        "ILMN_1890082" "COX15"        "RFXAP"        "ARHGAP21"     "FAM86C1"     
##  [20] "TMEM261"      "ADAM33"       "ILMN_1830069" "ILMN_1789334" "AFF1"         "MSX1"         "NFKBIZ"       "NME1"         "GRPEL2"       "LRP10"        "SMIM11A"      "ACADSB"       "BORCS7"       "ITGB1"        "GHITM"        "MVP"          "GOLGB1"       "ZNF765"       "TRIM13"      
##  [39] "UBE2D2"       "MARCH5"       "PDE3B"        "ILMN_1741422" "SLC16A10"     "ILMN_1755134" "LYRM4"        "CALR"         "ILMN_1904226" "EPT1"         "ILMN_1724959" "ILMN_1676725" "DET1"         "HPSE"         "ECD"          "UBA52"        "ILMN_1795524" "LYST"         "QSOX1"       
##  [58] "TYMP"         "MARCH2"       "SEH1L"        "DAP"          "NUMB"         "LYRM7"        "SFXN4"        "CLYBL"        "CCDC186"      "ZBTB25"       "RAB24"        "DPH6"         "ILMN_1798326" "CSNK1G3"      "VSTM2L"       "MFSD8"        "KIAA0368"     "C21orf33"     "AKAP7"       
##  [77] "SNRPB"        "ZNF280D"      "ILMN_1771326" "DIMT1"        "TMEM231"      "ARID4A"       "NAGK"         "CERCAM"       "PIK3R4"       "RPL32"        "ARFGAP1"      "SNX21"        "L1CAM"        "TOMM20"       "ILMN_1913586" "COQ8A"        "PNPT1"        "MAP3K6"       "ILMN_1665601"
##  [96] "ILMN_1805121" "ZNF586"       "MORN4"        "UBE2L3"       "ILMN_1839814" "ILMN_1883323" "IFT88"        "GGA1"         "ILMN_1874848" "IRF9"         "EIF2AK3"      "ILMN_1806109" "RPL28"        "PDLIM3"       "ILMN_1870257" "MAGOHB"       "ILMN_1705602" "APITD1"       "CFLAR"       
## [115] "N4BP2L2"      "CBLN3"
femaleG = setdiff(female.sig.gene$Gene.symbol, male.sig.gene$Gene.symbol)##42 genes in female list but not male
cat(length(femaleG), " genes unique to female but not male\n")
## 34  genes unique to female but not male
femaleG
##  [1] "TSPYL5"       "RMI1"         "SLC4A7"       "EPHX2"        "ILMN_1877067" "RUNX2"        "GCDH"         "ABHD17B"      "AGAP2"        "LILRB5"       "RPA2"         "ILMN_1674285" "ILMN_1910893" "FBLN2"        "GBP2"         "ILMN_1887680" "GADD45B"      "ILMN_1671844" "CACNB1"      
## [20] "EYA4"         "SLC25A26"     "BRCA2"        "MAPK8IP3"     "ILMN_1911981" "ILMN_1881749" "MAPK8IP2"     "ILMN_1749646" "ILMN_1893681" "GLIPR1"       "DCLRE1A"      "ILMN_1655940" "ZDHHC12"      "PNPLA4"       "PXK"
##intersection of male sig genes (male sensitivity defined by IC50 only)

commonG = intersect(maleIC50.sig.gene$Gene.symbol, female.sig.gene$Gene.symbol) #common gene to both male and female
cat(length(commonG), " genes common to male (IC50 only) and female\n")
## 0  genes common to male (IC50 only) and female
commonG 
## character(0)
maleG= setdiff(maleIC50.sig.gene$Gene.symbol, female.sig.gene$Gene.symbol)#116 genes in male but not female
cat(length(maleG), " genes unique to male (IC50)  but not female\n")
## 77  genes unique to male (IC50)  but not female
maleG
##  [1] "WIPI1"        "ILMN_1834901" "KDELR3"       "ILMN_1906520" "MRPS26"       "C19orf48"     "COPG1"        "MON1B"        "LRP10"        "EXOSC3"       "GLG1"         "ITGA1"        "CYP4A11"      "ILMN_1699121" "DPCR1"        "TMEM261"      "RPL28"        "APP"          "IFT88"       
## [20] "NMS"          "N4BP2L2"      "ILMN_1829902" "ASB2"         "ILMN_1701871" "CCDC172"      "SOCS7"        "ILMN_1834022" "P4HB"         "ARFGAP3"      "TRMT10B"      "ILMN_1691611" "SQRDL"        "ILMN_1676091" "ILMN_1751146" "NOP56"        "PRKCB"        "RRBP1"        "NDUFS7"      
## [39] "SEH1L"        "ILMN_1667330" "ILMN_1766920" "RPL32"        "GRM2"         "EIF2AK3"      "ZNF473"       "ILMN_1893904" "THG1L"        "TOP1MT"       "RNF103"       "RPN1"         "TIMM44"       "SRGAP1"       "ILMN_1766446" "UBA52"        "ATPAF1"       "ILMN_1656292" "PHC3"        
## [58] "LOC101927690" "ILMN_1904445" "SYTL5"        "MMEL1"        "ILMN_1862001" "ILMN_1844102" "ILMN_1740910" "NRP1"         "WBP4"         "ILMN_1786606" "GOLGB1"       "BIRC3"        "ILMN_1845475" "ILMN_1854015" "ILMN_1719224" "ILMN_1840462" "ORC5"         "TPCN1"        "POLR1E"      
## [77] "NDE1"
femaleG = setdiff(female.sig.gene$Gene.symbol, maleIC50.sig.gene$Gene.symbol)##42 genes in female list but not male
cat(length(femaleG), " genes unique to female but not male (IC50) \n")
## 34  genes unique to female but not male (IC50)
femaleG
##  [1] "TSPYL5"       "RMI1"         "SLC4A7"       "EPHX2"        "ILMN_1877067" "RUNX2"        "GCDH"         "ABHD17B"      "AGAP2"        "LILRB5"       "RPA2"         "ILMN_1674285" "ILMN_1910893" "FBLN2"        "GBP2"         "ILMN_1887680" "GADD45B"      "ILMN_1671844" "CACNB1"      
## [20] "EYA4"         "SLC25A26"     "BRCA2"        "MAPK8IP3"     "ILMN_1911981" "ILMN_1881749" "MAPK8IP2"     "ILMN_1749646" "ILMN_1893681" "GLIPR1"       "DCLRE1A"      "ILMN_1655940" "ZDHHC12"      "PNPLA4"       "PXK"

116 DE genes were identified for male sensitive vs. resistant (based on Serine&IC50) with raw \(P<0.001\), while 34 DE genes were identified for female sensitive vs. resistant with raw \(P<0.001\), all unique to themselves and thus no overlapping genes.

Pathway and GO term analysis of male cell ine serine-induced sensitivity genes and female cell line sensitivity genes

<!Joe comments: In the sensitive cell lines, serine biosynthesis is flagged as a significant pathway. In the resistant cell lines, glutamine metabolism is flagged as a significant pathway. !>

<!MSigDB 50 hallmark gene set analysis not meaningful using the SKAT method in the logistic regression model setting to examine the overall significance of a gene set!>

GO term analysis for biological process (BP),molecular function(MF) and cellular component (cc) using male and female DE genes genes with raw \(P<0.001\) was performed using R .

allGene = limma.res_response$DE.res  %>%  dplyr::select(Gene.ID) %>%  dplyr::filter(Gene.ID!="") %>% unlist() %>% as.numeric()

maleSigGene = limma.res_response$DE.res  %>% dplyr::filter(P.Value<0.001) %>% dplyr::select(Gene.ID) %>% dplyr::filter(Gene.ID!="") %>% unlist() %>% as.numeric()

GO.Analysis(all.entrezID=allGene,sig.entrezID=maleSigGene,file="male_GOanalysis")
## mapped  92  significant genes
## mapped  16369  genes in the universe
## mapped  91  significant genes
## mapped  16715  genes in the universe
## mapped  93  significant genes
## mapped  17076  genes in the universe
maleIC50SigGene = maleIC50.limma.res_response$DE.res  %>% dplyr::filter(P.Value<0.001) %>% dplyr::select(Gene.ID) %>% dplyr::filter(Gene.ID!="") %>% unlist() %>% as.numeric()

GO.Analysis(all.entrezID=allGene,sig.entrezID=maleIC50SigGene,file="maleIC50_GOanalysis")
## mapped  51  significant genes
## mapped  16369  genes in the universe
## mapped  51  significant genes
## mapped  16715  genes in the universe
## mapped  52  significant genes
## mapped  17076  genes in the universe
femaleSigGene = female.limma.res_response$DE.res  %>% dplyr::filter(P.Value<0.001) %>% dplyr::select(Gene.ID) %>% dplyr::filter(Gene.ID!="") %>% unlist() %>% as.numeric()

GO.Analysis(all.entrezID=allGene,sig.entrezID=femaleSigGene,file="female_GOanalysis")
## mapped  24  significant genes
## mapped  16369  genes in the universe
## mapped  23  significant genes
## mapped  16715  genes in the universe
## mapped  24  significant genes
## mapped  17076  genes in the universe

Glycine Foliate Candidate pathway genes

The PI (Ippolito) sent the glycine and folate pathway genes. The heatmap and clustering of the male and female samples on these genes does not separate the samples by sensitivity.

serine_folate_gene = read_excel("C:/Users/jingqinluo/Box/Sex Differences in Lung Cancer/Serine_Glycine_Folate Pathway List for TCGA analysis.xlsx",sheet=1,col_names=FALSE)

colnames(serine_folate_gene) = c("Gene.symbol","Pathway")

with(serine_folate_gene,table(Pathway))#8 Folate cycle and 27 glucose to glycine synthesis gene
## Pathway
##                 Folate Cycle Glucose to glycine synthesis 
##                            8                           27
kbl(serine_folate_gene) %>%  kable_paper(full_width = F) %>%  scroll_box(width = "1000px", height = "500px")
Gene.symbol Pathway
SLC2A1 Glucose to glycine synthesis
SLC2A2 Glucose to glycine synthesis
SLC2A3 Glucose to glycine synthesis
SLC2A4 Glucose to glycine synthesis
SLC5A1 Glucose to glycine synthesis
SLC5A2 Glucose to glycine synthesis
HK1 Glucose to glycine synthesis
HK2 Glucose to glycine synthesis
HK3 Glucose to glycine synthesis
GCK Glucose to glycine synthesis
GPI Glucose to glycine synthesis
PFKM Glucose to glycine synthesis
PFKL Glucose to glycine synthesis
PFKP Glucose to glycine synthesis
ALDOA Glucose to glycine synthesis
ALDOB Glucose to glycine synthesis
ALDOC Glucose to glycine synthesis
TPI1 Glucose to glycine synthesis
GAPDH Glucose to glycine synthesis
GAPDHS Glucose to glycine synthesis
PGK1 Glucose to glycine synthesis
PGK2 Glucose to glycine synthesis
PHGDH Glucose to glycine synthesis
PSAT1 Glucose to glycine synthesis
PSPH Glucose to glycine synthesis
SHMT1 Glucose to glycine synthesis
SHMT2 Glucose to glycine synthesis
DHFR Folate Cycle
TYMS Folate Cycle
GART Folate Cycle
ATIC Folate Cycle
MTHFD1 Folate Cycle
MTHFD2 Folate Cycle
MTHFD1L Folate Cycle
MTHFD2L Folate Cycle 
##find the illumina probe ID matching the glycine and folate genes
all.equal(rownames(ex), geneAnnot$ID)
## [1] TRUE
serine_folate_gene = dplyr::left_join(serine_folate_gene, dplyr::select(geneAnnot, ID, Gene.symbol)) %>% mutate(geneLabel=paste(Gene.symbol,ID,sep=";"))

##MTHFD2L does not have a match
#serine_folate_gene %>% dplyr::filter(is.na(ID))

serine_folate_gene = na.exclude(serine_folate_gene)
dim(serine_folate_gene)#58 pathway genes found (with one gene "MTHFD2L" not found)
## [1] 58  4
##put male grp (by serine and IC50) and female grp resp data together
all_resp_dat = rbind(dplyr::select(male_grp, -SerG6m3,-Pemetrexed..uM.), dplyr::select(female_grp_byIC50, -Pemetrexed..uM.))
rownames(all_resp_dat) = all_resp_dat$CellID

##put male and female gene exp data together
all.equal(match_pheno$CellID,male_grp$CellID)
## [1] TRUE
all.equal(female.match_pheno$CellID,female_grp_byIC50$CellID)
## [1] TRUE
length(serine_folate_gene$ID %n% rownames(ex))
## [1] 58
all_match_ex = ex [serine_folate_gene$ID, c(match_pheno$geo_accession, female.match_pheno$geo_accession)]

dim(all_match_ex) ##58*40
## [1] 58 40
colnames(all_match_ex) = all_resp_dat$CellID

##heatmap of glycine and folate gene expression
#pdf("Heatmap_GlycineFolate.pdf",height=15, width=15)
pheatmap::pheatmap(all_match_ex,scale="row", cluster_rows = TRUE, cluster_col=TRUE,labels_row=serine_folate_gene$geneLabel,annotation_col=subset(all_resp_dat,select=c(Gender,Resp)),main="Glycine and Folate pathway genes: all samples",fontsize_row=6)

#dev.off()

##male cell lines
pheatmap::pheatmap(all_match_ex[,all_resp_dat$CellID[all_resp_dat$Gender=="M"]],scale="row", cluster_rows = TRUE, cluster_col=TRUE,labels_row=serine_folate_gene$geneLabel,annotation_col=subset(all_resp_dat,subset=(Gender=="M"), select=c(Resp)),main="Glycine and Folate pathway genes: male samples",fontsize_row=5)

##female cell lines
pheatmap::pheatmap(all_match_ex[,all_resp_dat$CellID[all_resp_dat$Gender=="F"]],scale="row", cluster_rows = TRUE, cluster_col=TRUE,labels_row=serine_folate_gene$geneLabel,annotation_col=subset(all_resp_dat,subset=(Gender=="F"), select=c(Resp)),main="Glycine and Folate pathway genes: female samples",fontsize_row=5)

##put male grp (by IC50 only ) and female grp resp data together
all_resp_dat_byIC50 = rbind(dplyr::select(male_grp_byIC50, -Pemetrexed..uM.), dplyr::select(female_grp_byIC50, -Pemetrexed..uM.))
rownames(all_resp_dat_byIC50) = all_resp_dat_byIC50$CellID

##put male and female gene exp data together
all.equal(male.match_pheno$CellID,male_grp_byIC50$CellID)
## [1] TRUE
all.equal(female.match_pheno$CellID,female_grp_byIC50$CellID)
## [1] TRUE
length(serine_folate_gene$ID %n% rownames(ex))
## [1] 58
all_match_ex_byIC50 = ex [serine_folate_gene$ID, c(male.match_pheno$geo_accession, female.match_pheno$geo_accession)]

dim(all_match_ex_byIC50) ##58*40
## [1] 58 73
colnames(all_match_ex_byIC50) = all_resp_dat_byIC50$CellID

##heatmap of glycine and folate gene expression
pheatmap::pheatmap(all_match_ex_byIC50,scale="row", cluster_rows = TRUE, cluster_col=TRUE,labels_row=serine_folate_gene$geneLabel,annotation_col=subset(all_resp_dat_byIC50,select=c(Gender,Resp)),main="Glycine and Folate pathway genes: all samples (based on IC50 only) ",fontsize_row=6)

##male cell lines based on IC50 only
pheatmap::pheatmap(all_match_ex_byIC50[,all_resp_dat_byIC50$CellID[all_resp_dat_byIC50$Gender=="M"]],scale="row", cluster_rows = TRUE, cluster_col=TRUE,labels_row=serine_folate_gene$geneLabel,annotation_col=subset(all_resp_dat_byIC50,subset=(Gender=="M"), select=c(Resp)),main="Glycine and Folate pathway genes: male samples (based on IC50 only)",fontsize_row=6)

Part III: TCGA gene expression data and patient outcome

read in TCGA LUAD gene exp and clinic data

We continue to examine the differential genes identified from the cell line data in the TCGA LUAD dataset with the hypothesis that the NCI cell line derived DE genes for permetrexed response may be used to cluster patients into groups corresponding to distinct survival pattern.

Non small cell lung cancer (NSCLC) includes 2 primary subtypes, lung adenocarcinoma (LUAD) and lung squamous Cell Carcinoma (LUSC).

The TCGA LUAD (TCGA, PanCancer Atlas, Cell 2018) RNAseq V2 Z-score gene expression data and clinical data were downloaded from cbioportal website.

We load in the data and extract the data on the male (female) significant genes (cell line data at raw P<0.01) on the male (female) patients.

##TCGA LUAD (TCGA, PanCancer Atlas) Cell 2018 gene expression data downloaded from cbioportal
TCGA_luad = data.table::fread("W:/Jingqin/JosephIppolito/Lung cancer metabolite Sex difference/Data/luad_tcga_pan_can_atlas_2018/data_RNA_Seq_v2_mRNA_median_all_sample_Zscores.txt",header=T)

dim(TCGA_luad) #20531*512
## [1] 20531   512
TCGA_luad[1:5,1:5]
##    Hugo_Symbol Entrez_Gene_Id TCGA-05-4244-01 TCGA-05-4249-01 TCGA-05-4250-01
## 1:                  100130426         -2.2883         -2.2883         -2.2883
## 2:                  100133144          0.0422         -0.3456         -0.3377
## 3:                  100134869          0.0641          0.1921         -0.7281
## 4:                      10357         -1.9056         -0.2903         -1.9090
## 5:                      10431         -0.0365          0.1977          0.7798
tail(TCGA_luad)[,1:5]
##    Hugo_Symbol Entrez_Gene_Id TCGA-05-4244-01 TCGA-05-4249-01 TCGA-05-4250-01
## 1:        ZXDC          79364         -0.2382          0.4244         -0.6492
## 2:      ZYG11A         440590         -1.8735         -0.1741         -0.0012
## 3:      ZYG11B          79699          0.9837         -0.1096         -1.8172
## 4:         ZYX           7791         -0.4952         -0.8769          0.8246
## 5:       ZZEF1          23140         -0.2830          0.3123          0.3748
## 6:        ZZZ3          26009         -0.4416          0.1053         -0.6713
PID = colnames(TCGA_luad) [-c(1:2)]
PID = unlist(lapply(str_split(PID, "-01"),function(xx) xx[1]))
colnames(TCGA_luad) [-c(1:2)] = PID

TCGA_clinic = data.table::fread("W:/Jingqin/JosephIppolito/Lung cancer metabolite Sex difference/Data/luad_tcga_pan_can_atlas_2018/data_clinical_patient.txt",header=T,skip=4)
dim(TCGA_clinic)##566*38
## [1] 566  38
TCGA_clinic[1:5,1:5]
##      PATIENT_ID SUBTYPE CANCER_TYPE_ACRONYM                     OTHER_PATIENT_ID AGE
## 1: TCGA-05-4244    LUAD                LUAD 34040b83-7e8a-4264-a551-b16621843e28  70
## 2: TCGA-05-4249    LUAD                LUAD 4addf05f-3668-4b3f-a17f-c0227329ca52  67
## 3: TCGA-05-4250    LUAD                LUAD f98ecd8a-b878-4f53-b911-20cd8e17281c  79
## 4: TCGA-05-4382    LUAD                LUAD 3434b91a-c05f-460f-a078-7b1bb6e7085d  68
## 5: TCGA-05-4384    LUAD                LUAD 9a50e7e4-831d-489f-87d2-979e987561cc  66
names(TCGA_clinic)
##  [1] "PATIENT_ID"                                 "SUBTYPE"                                    "CANCER_TYPE_ACRONYM"                        "OTHER_PATIENT_ID"                           "AGE"                                        "SEX"                                       
##  [7] "AJCC_PATHOLOGIC_TUMOR_STAGE"                "AJCC_STAGING_EDITION"                       "DAYS_LAST_FOLLOWUP"                         "DAYS_TO_BIRTH"                              "DAYS_TO_INITIAL_PATHOLOGIC_DIAGNOSIS"       "ETHNICITY"                                 
## [13] "FORM_COMPLETION_DATE"                       "HISTORY_NEOADJUVANT_TRTYN"                  "ICD_10"                                     "ICD_O_3_HISTOLOGY"                          "ICD_O_3_SITE"                               "INFORMED_CONSENT_VERIFIED"                 
## [19] "NEW_TUMOR_EVENT_AFTER_INITIAL_TREATMENT"    "PATH_M_STAGE"                               "PATH_N_STAGE"                               "PATH_T_STAGE"                               "PERSON_NEOPLASM_CANCER_STATUS"              "PRIMARY_LYMPH_NODE_PRESENTATION_ASSESSMENT"
## [25] "PRIOR_DX"                                   "RACE"                                       "RADIATION_THERAPY"                          "WEIGHT"                                     "CENTER"                                     "IN_PANCANPATHWAYS_FREEZE"                  
## [31] "OS_STATUS"                                  "OS_MONTHS"                                  "DSS_STATUS"                                 "DSS_MONTHS"                                 "DFS_STATUS"                                 "DFS_MONTHS"                                
## [37] "PFS_STATUS"                                 "PFS_MONTHS"
with(TCGA_clinic,table(CANCER_TYPE_ACRONYM))##all 510 are LUAD 
## CANCER_TYPE_ACRONYM
## LUAD 
##  566
all(PID%in%TCGA_clinic$"PATIENT_ID")
## [1] TRUE
setkey(TCGA_clinic, PATIENT_ID)
TCGA_clinic = TCGA_clinic[PID,]
#all.equal(PID, TCGA_clinic$PATIENT_ID)

with(TCGA_clinic,table(SEX)) ##274 Female and 236 Male 
## SEX
## Female   Male 
##    274    236
##male significant genes and male patients in TCGA
male.sig.gene %>% dplyr::select(Gene.symbol, Gene.title) %>% unique() %>% dplyr::inner_join(TCGA_luad, by=c("Gene.symbol"="Hugo_Symbol")) -> male.TCGA_luad 

tcga.maleID = TCGA_clinic %>% dplyr:: filter(SEX=="Male")%>% dplyr::select(PATIENT_ID) %>% unlist() 

length(tcga.maleID)
## [1] 236
male.TCGA_luad = male.TCGA_luad[, c("Gene.symbol", "Gene.title", "Entrez_Gene_Id", tcga.maleID)]

dim(male.TCGA_luad)##86 * 239 (236 male patients)
## [1]  86 239
male.TCGA_luad[1:5,1:10]
##   Gene.symbol                                              Gene.title Entrez_Gene_Id TCGA-05-4244 TCGA-05-4249 TCGA-05-4382 TCGA-05-4384 TCGA-05-4389 TCGA-05-4395 TCGA-05-4396
## 1       PRMT3                    protein arginine methyltransferase 3          10196       0.4659      -0.4398      -0.7332       0.1736       1.3644       2.9655      -0.1289
## 2       WIPI1        WD repeat domain, phosphoinositide interacting 1          55062      -0.0456       0.0474       1.4279      -0.8389       0.2542      -1.0178      -0.0217
## 3        CALU                                               calumenin            813      -0.4346      -0.0740       0.9818      -1.4104      -0.4292       1.4367       0.4478
## 4      KDELR3 KDEL endoplasmic reticulum protein retention receptor 3          11015       0.3708       1.4285       0.1458      -1.3348      -0.6767       0.2389       0.1265
## 5     S100A13                        S100 calcium binding protein A13           6284       2.5778       0.3363      -0.5153       0.3684       0.7110       0.3849      -1.5242
write.csv(male.TCGA_luad, file="TCGA_LUAD_malePatient_maleCellLineSigGene.csv",row.names=F)

##female significant genes and female patients in TCGA
female.sig.gene %>% dplyr::select(Gene.symbol, Gene.title) %>% unique() %>% dplyr::inner_join(TCGA_luad, by=c("Gene.symbol"="Hugo_Symbol")) -> female.TCGA_luad

tcga.femaleID = TCGA_clinic %>% dplyr:: filter(SEX=="Female")%>% dplyr::select(PATIENT_ID) %>% unlist() 

length(tcga.femaleID)
## [1] 274
female.TCGA_luad = female.TCGA_luad[, c("Gene.symbol", "Gene.title", "Entrez_Gene_Id", tcga.femaleID)]

dim(female.TCGA_luad)##30 * 277 (274 female patients)
## [1]  23 277
write.csv(female.TCGA_luad, file="TCGA_LUAD_femalePatient_femaleCellLineSigGene.csv",row.names=F)

female.TCGA_luad[1:5,1:20]
##   Gene.symbol                          Gene.title Entrez_Gene_Id TCGA-05-4250 TCGA-05-4390 TCGA-05-4398 TCGA-05-4402 TCGA-05-4405 TCGA-05-4417 TCGA-05-4425 TCGA-05-4427 TCGA-05-4430 TCGA-05-4434 TCGA-05-5715 TCGA-38-4625 TCGA-38-4626 TCGA-38-4627 TCGA-38-4628 TCGA-38-4631 TCGA-38-6178
## 1      TSPYL5                         TSPY like 5          85453      -0.4142       0.6596      -1.3057       1.1179      -1.4373       0.8892      -1.3621      -1.5831      -0.8042       0.8664       0.4877      -1.6502       0.1743       0.8929       0.9415      -0.2436       1.6699
## 2        RMI1  RecQ mediated genome instability 1          80010      -0.1791       0.4390       1.2065       0.3055      -0.1726      -0.2224      -0.6283       0.5151       0.0026       0.4937      -0.1084       0.7850      -1.3009      -1.0307       0.2222       1.1473      -0.7576
## 3      SLC4A7    solute carrier family 4 member 7           9497       0.1690      -0.2075       0.4249      -0.1443       0.8827       0.0562       2.0456       0.8708      -0.0303       0.5359      -0.8466       0.2825      -0.1495       0.3090      -0.5604       0.2787       0.2592
## 4       EPHX2                 epoxide hydrolase 2           2053       0.1575       1.0318      -0.0992      -0.2956       0.4110       0.7804       0.3397      -2.7598      -0.2232       0.3292       0.0532      -0.8954       0.1084      -0.4892      -0.2200       0.2978      -0.4163
## 5       RUNX2 runt related transcription factor 2            860       0.3987       0.5546       0.4592       0.3679       1.2723       1.5214       0.8068      -0.3265      -0.0212      -0.1019      -1.5962      -0.2663      -1.1015       1.5798      -0.6183      -1.5245       0.8986
##heatmap of male TCGA gene expression

#apply(as.matrix(male.TCGA_luad[,-c(1:3)]),1,summary)

male.geneAnnot = male.TCGA_luad[,1:3]
male.TCGA_gene = male.TCGA_luad[,-c(1:3)]
rownames(male.TCGA_gene) = male.geneAnnot$Gene.symbol
male.TCGA_gene[male.TCGA_gene >= 3] =3 
male.TCGA_gene[male.TCGA_gene<= -3] = -3 

#pdf("Heatmap_maleTCGA.pdf",height=15, width=15)
pheatmap::pheatmap(male.TCGA_gene,scale="none", clustering_method = "complete", cluster_rows = TRUE, cluster_col=TRUE,labels_row=male.geneAnnot$Gene.symbol,labels_col=NA, main="TCGA LUAD : male patients",fontsize_row=3)

#dev.off()

female.geneAnnot = female.TCGA_luad[,1:3]
female.TCGA_gene = female.TCGA_luad[,-c(1:3)]
rownames(female.TCGA_gene) = female.geneAnnot$Gene.symbol
female.TCGA_gene[female.TCGA_gene>=3] =3 
female.TCGA_gene[female.TCGA_gene<= -3] = -3 

#pdf("Heatmap_femaleTCGA.pdf",height=15, width=15)
pheatmap::pheatmap(female.TCGA_gene,scale="none", clustering_method = "complete", cluster_rows = TRUE, cluster_col=TRUE,labels_row=female.geneAnnot$Gene.symbol,labels_col=NA, main="TCGA LUAD: female patients",fontsize_row=5)

#dev.off()

construct single sample score for TCGA LUAD patients

Based on the matched male cell line genes and the female cell line genes, we construct single sample score using the “plage” method (i.e., singular value decomposition) and the “zscore” method (sum of z-score of all the genes) using R package gsva, where the expression-level statistic is rank ordered for each sample and for a gene set, the Kolmogorov-Smirnov-like rank statistic is calculated. Z-score is calculated for each gene and average z-score (for the “zscore” method) and the first right eigen vector (for “Plage” method) is extracted to summarize the gene set.

signature genes and then use latent Gaussian mixture model to get the two groups.

male.TCGA_luad =read.csv("TCGA_LUAD_malePatient_maleCellLineSigGene.csv", header=T,stringsAsFactors = FALSE,check.names=F)
male.geneAnnot = male.TCGA_luad[,1:3]
male.TCGA_gene = male.TCGA_luad[,-c(1:3)]
rownames(male.TCGA_gene) = male.geneAnnot$Gene.symbol

male.TCGA_gene[1:5,1:5]
##         TCGA-05-4244 TCGA-05-4249 TCGA-05-4382 TCGA-05-4384 TCGA-05-4389
## PRMT3         0.4659      -0.4398      -0.7332       0.1736       1.3644
## WIPI1        -0.0456       0.0474       1.4279      -0.8389       0.2542
## CALU         -0.4346      -0.0740       0.9818      -1.4104      -0.4292
## KDELR3        0.3708       1.4285       0.1458      -1.3348      -0.6767
## S100A13       2.5778       0.3363      -0.5153       0.3684       0.7110
male_ssGSEA = sapply(c("zscore", "plage"), function(method0) 
  gsva(as.matrix(male.TCGA_gene),gset.idx.list=list(maleSigGene=rownames(male.TCGA_gene)), method=method0,kcdf="Gaussian", parallel.sz=2L,verbose=FALSE))####"gsva", "ssgsea" not working

male_ssGSEA = data.frame(PATIENT_ID=colnames(male.TCGA_gene), male_ssGSEA) 

##merge with TCGA clinic data
male_ssGSEA_clinic = male_ssGSEA %>% dplyr::left_join(TCGA_clinic, by = "PATIENT_ID")


dim(male_ssGSEA_clinic)##236*40
## [1] 236  40
rownames(male_ssGSEA_clinic) = male_ssGSEA_clinic$PATIENT_ID


female.TCGA_luad =read.csv("TCGA_LUAD_femalePatient_femaleCellLineSigGene.csv", header=T,stringsAsFactors = FALSE,check.names=F)
female.geneAnnot = female.TCGA_luad[,1:3]
female.TCGA_gene = female.TCGA_luad[,-c(1:3)]
rownames(female.TCGA_gene) = female.geneAnnot$Gene.symbol


female_ssGSEA = sapply(c("zscore", "plage"), function(method0) gsva(as.matrix(female.TCGA_gene),gset.idx.list=list(femaleSigGene=rownames(female.TCGA_gene)), method=method0,kcdf="Gaussian", parallel.sz=2L,verbose=FALSE))

head(female_ssGSEA)
##          zscore       plage
## [1,]  0.9000733 -0.05589305
## [2,] -0.8594951  0.02676111
## [3,]  1.5396954 -0.05092430
## [4,]  0.1559488  0.02587938
## [5,]  0.1384905 -0.03487715
## [6,]  0.5567817 -0.06237727
female_ssGSEA = data.frame(PATIENT_ID=colnames(female.TCGA_gene), female_ssGSEA) 

##merge with TCGA clinic data
female_ssGSEA_clinic = female_ssGSEA %>% dplyr::left_join(TCGA_clinic, by = "PATIENT_ID") 

rownames(female_ssGSEA_clinic) = female_ssGSEA_clinic$PATIENT_ID

head(female_ssGSEA_clinic)[,1:5]
##                PATIENT_ID     zscore       plage SUBTYPE CANCER_TYPE_ACRONYM
## TCGA-05-4250 TCGA-05-4250  0.9000733 -0.05589305    LUAD                LUAD
## TCGA-05-4390 TCGA-05-4390 -0.8594951  0.02676111    LUAD                LUAD
## TCGA-05-4398 TCGA-05-4398  1.5396954 -0.05092430    LUAD                LUAD
## TCGA-05-4402 TCGA-05-4402  0.1559488  0.02587938    LUAD                LUAD
## TCGA-05-4405 TCGA-05-4405  0.1384905 -0.03487715    LUAD                LUAD
## TCGA-05-4417 TCGA-05-4417  0.5567817 -0.06237727    LUAD                LUAD
write.csv(male_ssGSEA,file="male_TCGA_LUAD_ssGSEA_clinic.csv",row.names=F)

write.csv(female_ssGSEA,file="female_TCGA_LUAD_ssGSEA_clinic.csv",row.names=F)

define 2 patient groups for male and female TCGA LUAD patients

Using the zscore and plage, We will apply the Gaussian Mixture model with 2 latent classes to identify the 2-class labels for male and female patients separately.

male_zscore_fit = Mclust(male_ssGSEA$zscore, G=2, model="V")
table(male_zscore_fit$classification)
## 
##   1   2 
## 222  14
plot(male_zscore_fit,what="classification",xlab="male z score")

plot(male_zscore_fit,what="density",xlab="male z score")

male_plage_fit = Mclust(male_ssGSEA$plage, G=2, model="V")
table(male_plage_fit$classification)
## 
##   1   2 
##  41 195
plot(male_plage_fit,what="classification",xlab="male plage")

plot(male_plage_fit,what="density",xlab="male plage")

male_ssGSEA_clinic=data.frame(male_ssGSEA_clinic,grp_zscore=factor(male_zscore_fit$classification), grp_plage=factor(male_plage_fit$classification))

table(male_ssGSEA_clinic$grp_plage)
## 
##   1   2 
##  41 195
##add the groups by median split
male_ssGSEA_clinic = male_ssGSEA_clinic %>% mutate(grp_zscore_byMedian = ifelse(zscore>= median(zscore,na.rm=T),"high","low"),grp_plage_byMedian = ifelse(plage>= median(plage,na.rm=T),"high","low") )

with(male_ssGSEA_clinic, table(grp_zscore_byMedian))
## grp_zscore_byMedian
## high  low 
##  118  118
with(male_ssGSEA_clinic, table(grp_plage_byMedian))
## grp_plage_byMedian
## high  low 
##  118  118
#sampleLabel = dplyr::select(male_ssGSEA_clinic,zscore, plage, grp_zscore, #grp_plage, grp_zscore_byMedian, grp_plage_byMedian)

#pheatmap::pheatmap(male.TCGA_gene,scale="none", clustering_method = "complete", cluster_rows = TRUE, cluster_col=TRUE,labels_row=male.geneAnnot$Gene.symbol,labels_col=sampleLabel, main="TCGA LUAD : male patients",fontsize_row=3)


##define female 2 groups
female_zscore_fit = Mclust(female_ssGSEA$zscore, G=2, model="V")
table(female_zscore_fit$classification)
## 
##   1   2 
##  88 186
plot(female_zscore_fit,what="classification",xlab="female z score")

plot(female_zscore_fit,what="density",xlab="female z score")

female_plage_fit = Mclust(female_ssGSEA$plage, G=2, model="V")
table(female_plage_fit$classification)
## 
##   1   2 
## 155 119
plot(female_plage_fit,what="classification",xlab="female plage")

plot(female_plage_fit,what="density",xlab="female plage")

female_ssGSEA_clinic=data.frame(female_ssGSEA_clinic,grp_zscore=factor(female_zscore_fit$classification), grp_plage=factor(female_plage_fit$classification))

##add the groups by median split
female_ssGSEA_clinic = female_ssGSEA_clinic %>% mutate(grp_zscore_byMedian = ifelse(zscore>= median(zscore,na.rm=T),"high","low"),grp_plage_byMedian = ifelse(plage>= median(plage,na.rm=T),"high","low") )

with(female_ssGSEA_clinic, table(grp_zscore_byMedian))
## grp_zscore_byMedian
## high  low 
##  137  137
with(female_ssGSEA_clinic, table(grp_plage_byMedian))
## grp_plage_byMedian
## high  low 
##  137  137
#female_sampleLabel = dplyr::select(female_ssGSEA_clinic,zscore, plage, grp_zscore, grp_plage, grp_zscore_byMedian, grp_plage_byMedian)

#pheatmap::pheatmap(female.TCGA_gene,scale="none", clustering_method = "complete", cluster_rows = TRUE, cluster_col=TRUE,labels_row=female.geneAnnot$Gene.symbol,labels_col=female_sampleLabel, main="TCGA LUAD : female patients",fontsize_row=3)

TCGA male and female KM curves

We examine the survival Kaplan-Meier curves by the 2 male (female) groups identified by the gaussian mixture models, as well as the 2 groups split by the median of the zscore or plage score patterns of the male (female) patients groups

male_ssGSEA_clinic$Death = ifelse(male_ssGSEA_clinic$OS_STATUS=="1:DECEASED", 1,0) 
male_ssGSEA_clinic$Progression = ifelse(male_ssGSEA_clinic$PFS_STATUS=="1:PROGRESSION", 1,0)

with(male_ssGSEA_clinic,table(Death, OS_STATUS))
##      OS_STATUS
## Death 0:LIVING 1:DECEASED
##     0      148          0
##     1        0         88
with(male_ssGSEA_clinic,table(Progression, PFS_STATUS))
##            PFS_STATUS
## Progression 0:CENSORED 1:PROGRESSION
##           0        142             0
##           1          0            94
#pdf("KM_Male.pdf",height=15,width=15)
par(mfrow=c(2,2),pty="m")
for (varID in c("grp_zscore", "grp_plage", "grp_zscore_byMedian", "grp_plage_byMedian"))
{
  xx=factor(male_ssGSEA_clinic[,varID])
  with(male_ssGSEA_clinic, LogRank.Pvalue.KM(OS=OS_MONTHS, Event=Death, xx=xx,xlab="OS(months)",main=paste("male TCGA LUAD: ", varID,sep="")))
}

par(mfrow=c(2,2),pty="s")
for (varID in c("grp_zscore", "grp_plage", "grp_zscore_byMedian", "grp_plage_byMedian"))
{
  xx=factor(male_ssGSEA_clinic[,varID])
  with(male_ssGSEA_clinic, LogRank.Pvalue.KM(OS=PFS_MONTHS, Event=Progression, xx=xx,xlab="PFS(months)",main=paste("male TCGA LUAD: ", varID,sep="")))
}

#dev.off()
female_ssGSEA_clinic$Death = ifelse(female_ssGSEA_clinic$OS_STATUS=="1:DECEASED", 1,0) 
female_ssGSEA_clinic$Progression = ifelse(female_ssGSEA_clinic$PFS_STATUS=="1:PROGRESSION", 1,0)

with(female_ssGSEA_clinic,table(Death, OS_STATUS))
##      OS_STATUS
## Death 0:LIVING 1:DECEASED
##     0      177          0
##     1        0         97
with(female_ssGSEA_clinic,table(Progression, PFS_STATUS))
##            PFS_STATUS
## Progression 0:CENSORED 1:PROGRESSION
##           0        162             0
##           1          0           112
#pdf("KM_Female.pdf",height=15,width=15)
par(mfrow=c(2,2),pty="m")
for (varID in c("grp_zscore", "grp_plage", "grp_zscore_byMedian", "grp_plage_byMedian"))
{
  xx=factor(female_ssGSEA_clinic[,varID])
  with(female_ssGSEA_clinic, LogRank.Pvalue.KM(OS=OS_MONTHS, Event=Death, xx=xx,xlab="OS(months)",main=paste("female TCGA LUAD: ", varID,sep="")))
}

par(mfrow=c(2,2),pty="s")
for (varID in c("grp_zscore", "grp_plage", "grp_zscore_byMedian", "grp_plage_byMedian"))
{
  xx=factor(female_ssGSEA_clinic[,varID])
  with(female_ssGSEA_clinic, LogRank.Pvalue.KM(OS=PFS_MONTHS, Event=Progression, xx=xx,xlab="PFS(months)",main=paste("female TCGA LUAD: ", varID,sep="")))
}

#dev.off()